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Elevated circulating porphyrin concentration

MedGen UID:
1842079
•Concept ID:
C5826518
•
Finding
Synonym: Porphyrin high in blood
 
HPO: HP:0034606

Definition

Concentration of porphyrins or of a specific porphryin above the upper limit of normal. The most commonly tested circulating porphyrins are coproporphyrin, protoporphyrin, and uroporphyrin. Normally protoporphyrin is present in the highest concentration. [from HPO]

Recent clinical studies

Etiology

Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression.
Tullie S, Nicholson T, Bishop JRB, McGee KC, Asiri A, Sullivan J, Chen YY, Sardeli AV, Belli A, Harrison P, Moiemen NS, Lord JM, Hazeldine J
Front Immunol 2024;15:1416820. Epub 2024 Jun 14 doi: 10.3389/fimmu.2024.1416820. PMID: 38947312Free PMC Article
Effects of Iron Supplements on Heme Scavengers in Pregnancy.
Nti AM, Botchway F, Salifu H, Cespedes JC, Harbuzariu A, Onyekaba J, Chambliss C, Liu M, Adjei A, Jolly P, Stiles JK
Am J Trop Med Hyg 2021 Sep 27;105(5):1163-1172. doi: 10.4269/ajtmh.20-0413. PMID: 34583348Free PMC Article
Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas.
Yang X, Liu J, Yang MM, Wang SH, Xu L, Ke S, Ding XM, Sun WB, Gao J
Eur J Gastroenterol Hepatol 2020 Sep;32(9):1200-1206. doi: 10.1097/MEG.0000000000001636. PMID: 31851092
Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.
Wallner M, Bulmer AC, Mölzer C, Müllner E, Marculescu R, Doberer D, Wolzt M, Wagner OF, Wagner KH
Eur J Clin Invest 2013 Sep;43(9):912-9. Epub 2013 Jul 19 doi: 10.1111/eci.12120. PMID: 23865893

Diagnosis

Design of Tumor Acidity-Responsive Sheddable Nanoparticles for Fluorescence/Magnetic Resonance Imaging-Guided Photodynamic Therapy.
Fan F, Yu Y, Zhong F, Gao M, Sun T, Liu J, Zhang H, Qian H, Tao W, Yang X
Theranostics 2017;7(5):1290-1302. Epub 2017 Mar 7 doi: 10.7150/thno.18557. PMID: 28435466Free PMC Article
Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.
Wallner M, Bulmer AC, Mölzer C, Müllner E, Marculescu R, Doberer D, Wolzt M, Wagner OF, Wagner KH
Eur J Clin Invest 2013 Sep;43(9):912-9. Epub 2013 Jul 19 doi: 10.1111/eci.12120. PMID: 23865893
Association of erythrocyte protoporphyrin with blood lead level and iron status in the second National Health and Nutrition Examination Survey, 1976-1980.
Mahaffey KR, Annest JL
Environ Res 1986 Oct;41(1):327-38. doi: 10.1016/s0013-9351(86)80194-3. PMID: 3489614

Therapy

Effects of Iron Supplements on Heme Scavengers in Pregnancy.
Nti AM, Botchway F, Salifu H, Cespedes JC, Harbuzariu A, Onyekaba J, Chambliss C, Liu M, Adjei A, Jolly P, Stiles JK
Am J Trop Med Hyg 2021 Sep 27;105(5):1163-1172. doi: 10.4269/ajtmh.20-0413. PMID: 34583348Free PMC Article
Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas.
Yang X, Liu J, Yang MM, Wang SH, Xu L, Ke S, Ding XM, Sun WB, Gao J
Eur J Gastroenterol Hepatol 2020 Sep;32(9):1200-1206. doi: 10.1097/MEG.0000000000001636. PMID: 31851092
Design of Tumor Acidity-Responsive Sheddable Nanoparticles for Fluorescence/Magnetic Resonance Imaging-Guided Photodynamic Therapy.
Fan F, Yu Y, Zhong F, Gao M, Sun T, Liu J, Zhang H, Qian H, Tao W, Yang X
Theranostics 2017;7(5):1290-1302. Epub 2017 Mar 7 doi: 10.7150/thno.18557. PMID: 28435466Free PMC Article
Chlorin e6 combined with albumin nanoparticles as a potential composite photosensitizer for photodynamic therapy of tumors.
Shton IO, Sarnatskaya VV, Prokopenko IV, Gamaleia NF
Exp Oncol 2015 Dec;37(4):250-4. PMID: 26710836

Prognosis

Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.
Wallner M, Bulmer AC, Mölzer C, Müllner E, Marculescu R, Doberer D, Wolzt M, Wagner OF, Wagner KH
Eur J Clin Invest 2013 Sep;43(9):912-9. Epub 2013 Jul 19 doi: 10.1111/eci.12120. PMID: 23865893

Clinical prediction guides

Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression.
Tullie S, Nicholson T, Bishop JRB, McGee KC, Asiri A, Sullivan J, Chen YY, Sardeli AV, Belli A, Harrison P, Moiemen NS, Lord JM, Hazeldine J
Front Immunol 2024;15:1416820. Epub 2024 Jun 14 doi: 10.3389/fimmu.2024.1416820. PMID: 38947312Free PMC Article
Haem catabolism: a novel modulator of inflammation in Gilbert's syndrome.
Wallner M, Bulmer AC, Mölzer C, Müllner E, Marculescu R, Doberer D, Wolzt M, Wagner OF, Wagner KH
Eur J Clin Invest 2013 Sep;43(9):912-9. Epub 2013 Jul 19 doi: 10.1111/eci.12120. PMID: 23865893
The anti-mutagenic properties of bile pigments.
Bulmer AC, Ried K, Blanchfield JT, Wagner KH
Mutat Res 2008 Jan-Feb;658(1-2):28-41. Epub 2007 May 18 doi: 10.1016/j.mrrev.2007.05.001. PMID: 17602853
Turnover of erythrocyte protoporphyrin, with special reference to bovine porphyria and iron deficiency anemia.
Schwartz S, O'Connor N, Stephenson BD, Anderson AS, Johnson LW, Johnson J
Ann Clin Res 1976;8 Suppl 17:203-12. PMID: 1008492

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