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Abnormal urinary uromodulin level

MedGen UID:
1842098
•Concept ID:
C5826735
•
Finding
HPO: HP:0034885

Definition

The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for usine concentration, is outside the limits of normal. [from HPO]

Recent clinical studies

Etiology

Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study.
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook HR, Jia Y, Kimmel PL, Kaufman JS, Devarajan P, Parikh CR, Greenberg JH
Pediatr Nephrol 2023 Aug;38(8):2851-2860. Epub 2023 Feb 15 doi: 10.1007/s00467-023-05886-1. PMID: 36790467
Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial.
Ikeme JC, Katz R, Muiru AN, Estrella MM, Scherzer R, Garimella PS, Hallan SI, Peralta CA, Ix JH, Shlipak MG
Am J Hypertens 2022 Dec 8;35(12):1006-1013. doi: 10.1093/ajh/hpac102. PMID: 36094158Free PMC Article
Kidney tubule health, mineral metabolism and adverse events in persons with CKD in SPRINT.
Ascher SB, Scherzer R, Estrella MM, Berry JD, de Lemos JA, Jotwani VK, Garimella PS, Malhotra R, Bullen AL, Katz R, Ambrosius WT, Cheung AK, Chonchol M, Killeen AA, Ix JH, Shlipak MG; SPRINT Research Group
Nephrol Dial Transplant 2022 Aug 22;37(9):1637-1646. doi: 10.1093/ndt/gfab255. PMID: 34473302Free PMC Article
Evidence for a role of uromodulin in chronic kidney disease progression.
Prajczer S, Heidenreich U, Pfaller W, Kotanko P, Lhotta K, Jennings P
Nephrol Dial Transplant 2010 Jun;25(6):1896-903. Epub 2010 Jan 14 doi: 10.1093/ndt/gfp748. PMID: 20075439
Quantitation of urinary Tamm-Horsfall protein in children with urinary tract infection.
Reinhart HH, Spencer JR, Zaki NF, Sobel JD
Eur Urol 1992;22(3):194-9. doi: 10.1159/000474754. PMID: 1468474

Diagnosis

Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy.
Tanaka K, Sugiyama H, Yamanari T, Mise K, Morinaga H, Kitagawa M, Onishi A, Ogawa-Akiyama A, Tanabe K, Eguchi J, Ohmoto Y, Shikata K, Wada J
Nephrology (Carlton) 2018 Sep;23(9):855-862. Epub 2018 Jul 26 doi: 10.1111/nep.13444. PMID: 29987860Free PMC Article
Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations.
Haumaitre C, Fabre M, Cormier S, Baumann C, Delezoide AL, Cereghini S
Hum Mol Genet 2006 Aug 1;15(15):2363-75. Epub 2006 Jun 26 doi: 10.1093/hmg/ddl161. PMID: 16801329

Therapy

Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study.
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook HR, Jia Y, Kimmel PL, Kaufman JS, Devarajan P, Parikh CR, Greenberg JH
Pediatr Nephrol 2023 Aug;38(8):2851-2860. Epub 2023 Feb 15 doi: 10.1007/s00467-023-05886-1. PMID: 36790467
Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial.
Ikeme JC, Katz R, Muiru AN, Estrella MM, Scherzer R, Garimella PS, Hallan SI, Peralta CA, Ix JH, Shlipak MG
Am J Hypertens 2022 Dec 8;35(12):1006-1013. doi: 10.1093/ajh/hpac102. PMID: 36094158Free PMC Article
Kidney tubule health, mineral metabolism and adverse events in persons with CKD in SPRINT.
Ascher SB, Scherzer R, Estrella MM, Berry JD, de Lemos JA, Jotwani VK, Garimella PS, Malhotra R, Bullen AL, Katz R, Ambrosius WT, Cheung AK, Chonchol M, Killeen AA, Ix JH, Shlipak MG; SPRINT Research Group
Nephrol Dial Transplant 2022 Aug 22;37(9):1637-1646. doi: 10.1093/ndt/gfab255. PMID: 34473302Free PMC Article

Prognosis

Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study.
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook HR, Jia Y, Kimmel PL, Kaufman JS, Devarajan P, Parikh CR, Greenberg JH
Pediatr Nephrol 2023 Aug;38(8):2851-2860. Epub 2023 Feb 15 doi: 10.1007/s00467-023-05886-1. PMID: 36790467
Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations.
Haumaitre C, Fabre M, Cormier S, Baumann C, Delezoide AL, Cereghini S
Hum Mol Genet 2006 Aug 1;15(15):2363-75. Epub 2006 Jun 26 doi: 10.1093/hmg/ddl161. PMID: 16801329

Clinical prediction guides

Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study.
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook HR, Jia Y, Kimmel PL, Kaufman JS, Devarajan P, Parikh CR, Greenberg JH
Pediatr Nephrol 2023 Aug;38(8):2851-2860. Epub 2023 Feb 15 doi: 10.1007/s00467-023-05886-1. PMID: 36790467
Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy.
Tanaka K, Sugiyama H, Yamanari T, Mise K, Morinaga H, Kitagawa M, Onishi A, Ogawa-Akiyama A, Tanabe K, Eguchi J, Ohmoto Y, Shikata K, Wada J
Nephrology (Carlton) 2018 Sep;23(9):855-862. Epub 2018 Jul 26 doi: 10.1111/nep.13444. PMID: 29987860Free PMC Article
Evidence for a role of uromodulin in chronic kidney disease progression.
Prajczer S, Heidenreich U, Pfaller W, Kotanko P, Lhotta K, Jennings P
Nephrol Dial Transplant 2010 Jun;25(6):1896-903. Epub 2010 Jan 14 doi: 10.1093/ndt/gfp748. PMID: 20075439
Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations.
Haumaitre C, Fabre M, Cormier S, Baumann C, Delezoide AL, Cereghini S
Hum Mol Genet 2006 Aug 1;15(15):2363-75. Epub 2006 Jun 26 doi: 10.1093/hmg/ddl161. PMID: 16801329

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