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Reduced gamma-glutamyltransferase level

MedGen UID:
1842159
•Concept ID:
C5826398
•
Finding
Synonym: Gamma-glutamyl transferase low in blood
 
HPO: HP:0034445

Definition

Decreased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced gamma-glutamyltransferase level

Conditions with this feature

gamma-Glutamyltransferase deficiency
MedGen UID:
82813
•Concept ID:
C0268524
•
Disease or Syndrome
A disorder that is characterized by increased glutathione concentration in the plasma and urine.
See: Condition Record
gamma-Glutamyltransferase deficiency

Professional guidelines

PubMed

World Health Organization risk drinking levels as a treatment outcome measure in topiramate trials.
Hartwell EE, Feinn R, Witkiewitz K, Pond T, Kranzler HR
Alcohol Clin Exp Res 2021 Aug;45(8):1664-1671. Epub 2021 Jul 5 doi: 10.1111/acer.14652. PMID: 34120366Free PMC Article
Laboratory test based assessment of WHO alcohol risk drinking levels.
Niemelä O, Nivukoski U, Bloigu A, Bloigu R, Aalto M, Laatikainen T
Scand J Clin Lab Invest 2019 Feb-Apr;79(1-2):58-64. Epub 2019 Feb 5 doi: 10.1080/00365513.2019.1571625. PMID: 30721633
AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article

Recent clinical studies

Etiology

Topiramate Versus Naltrexone for Alcohol Use Disorder: A Genotype-Stratified Double-Blind Randomized Controlled Trial.
Morley KC, Kranzler HR, Luquin N, Jamshidi N, Adams C, Montebello M, Tremonti C, Dali G, Logge W, Baillie A, Teesson M, Trent R, Haber PS
Am J Psychiatry 2024 May 1;181(5):403-411. doi: 10.1176/appi.ajp.20230666. PMID: 38706338
Higher ultra-processed food intake is associated with adverse liver outcomes: a prospective cohort study of UK Biobank participants.
Zhao L, Clay-Gilmour A, Zhang J, Zhang X, Steck SE
Am J Clin Nutr 2024 Jan;119(1):49-57. Epub 2023 Oct 21 doi: 10.1016/j.ajcnut.2023.10.014. PMID: 37871746
A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA.
Schattenberg JM, Pares A, Kowdley KV, Heneghan MA, Caldwell S, Pratt D, Bonder A, Hirschfield GM, Levy C, Vierling J, Jones D, Tailleux A, Staels B, Megnien S, Hanf R, Magrez D, Birman P, Luketic V
J Hepatol 2021 Jun;74(6):1344-1354. Epub 2021 Jan 21 doi: 10.1016/j.jhep.2021.01.013. PMID: 33484775
Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial.
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
gamma-L-glutamyltaurine.
Bittner S, Win T, Gupta R
Amino Acids 2005 Jun;28(4):343-56. Epub 2005 Apr 21 doi: 10.1007/s00726-005-0196-7. PMID: 15838590

Diagnosis

Nonalcoholic Fatty Liver Disease and Staging of Hepatic Fibrosis.
Engin A
Adv Exp Med Biol 2024;1460:539-574. doi: 10.1007/978-3-031-63657-8_18. PMID: 39287864
Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial.
Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA.
Schattenberg JM, Pares A, Kowdley KV, Heneghan MA, Caldwell S, Pratt D, Bonder A, Hirschfield GM, Levy C, Vierling J, Jones D, Tailleux A, Staels B, Megnien S, Hanf R, Magrez D, Birman P, Luketic V
J Hepatol 2021 Jun;74(6):1344-1354. Epub 2021 Jan 21 doi: 10.1016/j.jhep.2021.01.013. PMID: 33484775
AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Association between Gamma-Glutamyltransferase Level and Risk of Stroke: A Systematic Review and Meta-analysis of Prospective Studies.
Zhang XW, Li M, Hou WS, Li K, Zhou JR, Tang ZY
J Stroke Cerebrovasc Dis 2015 Dec;24(12):2816-23. Epub 2015 Sep 12 doi: 10.1016/j.jstrokecerebrovasdis.2015.08.015. PMID: 26372100

Therapy

Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme.
Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M
Eur Heart J 2022 Dec 21;43(48):4991-5002. doi: 10.1093/eurheartj/ehac495. PMID: 36017745Free PMC Article
Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial.
Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA.
Schattenberg JM, Pares A, Kowdley KV, Heneghan MA, Caldwell S, Pratt D, Bonder A, Hirschfield GM, Levy C, Vierling J, Jones D, Tailleux A, Staels B, Megnien S, Hanf R, Magrez D, Birman P, Luketic V
J Hepatol 2021 Jun;74(6):1344-1354. Epub 2021 Jan 21 doi: 10.1016/j.jhep.2021.01.013. PMID: 33484775
Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial.
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
Fitzgerald K, White S, Borodovsky A, Bettencourt BR, Strahs A, Clausen V, Wijngaard P, Horton JD, Taubel J, Brooks A, Fernando C, Kauffman RS, Kallend D, Vaishnaw A, Simon A
N Engl J Med 2017 Jan 5;376(1):41-51. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1609243. PMID: 27959715Free PMC Article

Prognosis

Prevalence and Clinical Predictors of Hyperuricemia in Chinese Bariatric Surgery Patients.
Qu X, Zheng L, Zu B, Jia B, Lin W
Obes Surg 2022 May;32(5):1508-1515. Epub 2022 Jan 21 doi: 10.1007/s11695-021-05852-6. PMID: 35061156
Corneal Stiffness and Collagen Cross-Linking Proteins in Glaucoma: Potential for Novel Therapeutic Strategy.
Rahman N, O'Neill E, Irnaten M, Wallace D, O'Brien C
J Ocul Pharmacol Ther 2020 Oct;36(8):582-594. Epub 2020 Jul 13 doi: 10.1089/jop.2019.0118. PMID: 32667842
Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial.
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Is serum gamma glutamyltransferase a marker of oxidative stress?
Lee DH, Blomhoff R, Jacobs DR Jr
Free Radic Res 2004 Jun;38(6):535-9. doi: 10.1080/10715760410001694026. PMID: 15346644

Clinical prediction guides

Topiramate Versus Naltrexone for Alcohol Use Disorder: A Genotype-Stratified Double-Blind Randomized Controlled Trial.
Morley KC, Kranzler HR, Luquin N, Jamshidi N, Adams C, Montebello M, Tremonti C, Dali G, Logge W, Baillie A, Teesson M, Trent R, Haber PS
Am J Psychiatry 2024 May 1;181(5):403-411. doi: 10.1176/appi.ajp.20230666. PMID: 38706338
Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial.
Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial.
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
Fitzgerald K, White S, Borodovsky A, Bettencourt BR, Strahs A, Clausen V, Wijngaard P, Horton JD, Taubel J, Brooks A, Fernando C, Kauffman RS, Kallend D, Vaishnaw A, Simon A
N Engl J Med 2017 Jan 5;376(1):41-51. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1609243. PMID: 27959715Free PMC Article

Recent systematic reviews

Licorice and liver function in patients with primary liver disease: A systematic review and meta-analysis of RCTs.
Giangrandi I, Dinu M, Napoletano A, Maggini V, Lombardi N, Crescioli G, Gallo E, Mascherini V, Antonelli M, Donelli D, Vannacci A, Firenzuoli F, Sofi F
Phytother Res 2024 Sep;38(9):4614-4627. Epub 2024 Jul 30 doi: 10.1002/ptr.8288. PMID: 39079711
Efficacy of statins in treatment and development of non-alcoholic fatty liver disease and steatohepatitis: A systematic review and meta-analysis.
Fatima K, Moeed A, Waqar E, Atif AR, Kamran A, Rizvi H, Suri NF, Haider H, Shuja SH, Khalid M, Minhas AMK
Clin Res Hepatol Gastroenterol 2022 Apr;46(4):101816. Epub 2021 Oct 2 doi: 10.1016/j.clinre.2021.101816. PMID: 34607067
Statin liver safety in non-alcoholic fatty liver disease: A systematic review and metanalysis.
Pastori D, Pani A, Di Rocco A, Menichelli D, Gazzaniga G, Farcomeni A, D'Erasmo L, Angelico F, Del Ben M, Baratta F
Br J Clin Pharmacol 2022 Feb;88(2):441-451. Epub 2021 Jun 28 doi: 10.1111/bcp.14943. PMID: 34133035Free PMC Article
Effect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis.
de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPM
World J Gastroenterol 2017 Jul 21;23(27):5004-5017. doi: 10.3748/wjg.v23.i27.5004. PMID: 28785154Free PMC Article
Association between Gamma-Glutamyltransferase Level and Risk of Stroke: A Systematic Review and Meta-analysis of Prospective Studies.
Zhang XW, Li M, Hou WS, Li K, Zhou JR, Tang ZY
J Stroke Cerebrovasc Dis 2015 Dec;24(12):2816-23. Epub 2015 Sep 12 doi: 10.1016/j.jstrokecerebrovasdis.2015.08.015. PMID: 26372100

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