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Reduced gamma-glutamyltransferase level

MedGen UID:
1842159
Concept ID:
C5826398
Finding
Synonym: Gamma-glutamyl transferase low in blood
 
HPO: HP:0034445

Definition

Decreased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced gamma-glutamyltransferase level

Conditions with this feature

gamma-Glutamyltransferase deficiency
MedGen UID:
82813
Concept ID:
C0268524
Disease or Syndrome
Level of glutathione in the urine above the upper limit of normal.

Professional guidelines

PubMed

Hartwell EE, Feinn R, Witkiewitz K, Pond T, Kranzler HR
Alcohol Clin Exp Res 2021 Aug;45(8):1664-1671. Epub 2021 Jul 5 doi: 10.1111/acer.14652. PMID: 34120366Free PMC Article
Niemelä O, Nivukoski U, Bloigu A, Bloigu R, Aalto M, Laatikainen T
Scand J Clin Lab Invest 2019 Feb-Apr;79(1-2):58-64. Epub 2019 Feb 5 doi: 10.1080/00365513.2019.1571625. PMID: 30721633
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article

Recent clinical studies

Etiology

Park MJ, Choi KM
Diabetes Metab J 2022 Jan;46(1):49-62. Epub 2022 Jan 27 doi: 10.4093/dmj.2021.0316. PMID: 35135078Free PMC Article
Schattenberg JM, Pares A, Kowdley KV, Heneghan MA, Caldwell S, Pratt D, Bonder A, Hirschfield GM, Levy C, Vierling J, Jones D, Tailleux A, Staels B, Megnien S, Hanf R, Magrez D, Birman P, Luketic V
J Hepatol 2021 Jun;74(6):1344-1354. Epub 2021 Jan 21 doi: 10.1016/j.jhep.2021.01.013. PMID: 33484775
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
Zhang XW, Li M, Hou WS, Li K, Zhou JR, Tang ZY
J Stroke Cerebrovasc Dis 2015 Dec;24(12):2816-23. Epub 2015 Sep 12 doi: 10.1016/j.jstrokecerebrovasdis.2015.08.015. PMID: 26372100
Bittner S, Win T, Gupta R
Amino Acids 2005 Jun;28(4):343-56. Epub 2005 Apr 21 doi: 10.1007/s00726-005-0196-7. PMID: 15838590

Diagnosis

Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
Schattenberg JM, Pares A, Kowdley KV, Heneghan MA, Caldwell S, Pratt D, Bonder A, Hirschfield GM, Levy C, Vierling J, Jones D, Tailleux A, Staels B, Megnien S, Hanf R, Magrez D, Birman P, Luketic V
J Hepatol 2021 Jun;74(6):1344-1354. Epub 2021 Jan 21 doi: 10.1016/j.jhep.2021.01.013. PMID: 33484775
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Zhang XW, Li M, Hou WS, Li K, Zhou JR, Tang ZY
J Stroke Cerebrovasc Dis 2015 Dec;24(12):2816-23. Epub 2015 Sep 12 doi: 10.1016/j.jstrokecerebrovasdis.2015.08.015. PMID: 26372100
Lee DH, Blomhoff R, Jacobs DR Jr
Free Radic Res 2004 Jun;38(6):535-9. doi: 10.1080/10715760410001694026. PMID: 15346644

Therapy

Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M
Eur Heart J 2022 Dec 21;43(48):4991-5002. doi: 10.1093/eurheartj/ehac495. PMID: 36017745Free PMC Article
Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
Schattenberg JM, Pares A, Kowdley KV, Heneghan MA, Caldwell S, Pratt D, Bonder A, Hirschfield GM, Levy C, Vierling J, Jones D, Tailleux A, Staels B, Megnien S, Hanf R, Magrez D, Birman P, Luketic V
J Hepatol 2021 Jun;74(6):1344-1354. Epub 2021 Jan 21 doi: 10.1016/j.jhep.2021.01.013. PMID: 33484775
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
Fitzgerald K, White S, Borodovsky A, Bettencourt BR, Strahs A, Clausen V, Wijngaard P, Horton JD, Taubel J, Brooks A, Fernando C, Kauffman RS, Kallend D, Vaishnaw A, Simon A
N Engl J Med 2017 Jan 5;376(1):41-51. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1609243. PMID: 27959715Free PMC Article

Prognosis

Qu X, Zheng L, Zu B, Jia B, Lin W
Obes Surg 2022 May;32(5):1508-1515. Epub 2022 Jan 21 doi: 10.1007/s11695-021-05852-6. PMID: 35061156
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Teramoto T
Atheroscler Suppl 2011 Nov;12(3):285-8. doi: 10.1016/S1567-5688(11)70888-1. PMID: 22152283
Lee DH, Blomhoff R, Jacobs DR Jr
Free Radic Res 2004 Jun;38(6):535-9. doi: 10.1080/10715760410001694026. PMID: 15346644

Clinical prediction guides

Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR
JAMA Neurol 2020 Sep 1;77(9):1122-1131. doi: 10.1001/jamaneurol.2020.1484. PMID: 32539076Free PMC Article
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Fitzgerald K, White S, Borodovsky A, Bettencourt BR, Strahs A, Clausen V, Wijngaard P, Horton JD, Taubel J, Brooks A, Fernando C, Kauffman RS, Kallend D, Vaishnaw A, Simon A
N Engl J Med 2017 Jan 5;376(1):41-51. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1609243. PMID: 27959715Free PMC Article
Zhang XW, Li M, Hou WS, Li K, Zhou JR, Tang ZY
J Stroke Cerebrovasc Dis 2015 Dec;24(12):2816-23. Epub 2015 Sep 12 doi: 10.1016/j.jstrokecerebrovasdis.2015.08.015. PMID: 26372100

Recent systematic reviews

Dehzad MJ, Ghalandari H, Amini MR, Askarpour M
Complement Ther Med 2023 Jun;74:102952. Epub 2023 May 11 doi: 10.1016/j.ctim.2023.102952. PMID: 37178581
Fatima K, Moeed A, Waqar E, Atif AR, Kamran A, Rizvi H, Suri NF, Haider H, Shuja SH, Khalid M, Minhas AMK
Clin Res Hepatol Gastroenterol 2022 Apr;46(4):101816. Epub 2021 Oct 2 doi: 10.1016/j.clinre.2021.101816. PMID: 34607067
Pastori D, Pani A, Di Rocco A, Menichelli D, Gazzaniga G, Farcomeni A, D'Erasmo L, Angelico F, Del Ben M, Baratta F
Br J Clin Pharmacol 2022 Feb;88(2):441-451. Epub 2021 Jun 28 doi: 10.1111/bcp.14943. PMID: 34133035Free PMC Article
de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPM
World J Gastroenterol 2017 Jul 21;23(27):5004-5017. doi: 10.3748/wjg.v23.i27.5004. PMID: 28785154Free PMC Article
Zhang XW, Li M, Hou WS, Li K, Zhou JR, Tang ZY
J Stroke Cerebrovasc Dis 2015 Dec;24(12):2816-23. Epub 2015 Sep 12 doi: 10.1016/j.jstrokecerebrovasdis.2015.08.015. PMID: 26372100

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