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Long telomere length

MedGen UID:
1843862
•Concept ID:
C5883398
•
Finding
Synonym: Long telomeres
 
HPO: HP:6000036

Definition

Abnormally long telomeres in somatic cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLong telomere length

Professional guidelines

PubMed

Mechanisms and treatment of late-life depression.
Alexopoulos GS
Transl Psychiatry 2019 Aug 5;9(1):188. doi: 10.1038/s41398-019-0514-6. PMID: 31383842Free PMC Article
Breast cancer treatment and its effects on aging.
Chang L, Weiner LS, Hartman SJ, Horvath S, Jeste D, Mischel PS, Kado DM
J Geriatr Oncol 2019 Mar;10(2):346-355. Epub 2018 Aug 2 doi: 10.1016/j.jgo.2018.07.010. PMID: 30078714Free PMC Article
The New News about Lithium: An Underutilized Treatment in the United States.
Post RM
Neuropsychopharmacology 2018 Apr;43(5):1174-1179. Epub 2017 Oct 4 doi: 10.1038/npp.2017.238. PMID: 28976944Free PMC Article

Recent clinical studies

Etiology

Telomere-lengthening germline variants predispose to a syndromic papillary thyroid cancer subtype.
DeBoy EA, Nicosia AM, Liyanarachchi S, Iyer SS, Shah MH, Ringel MD, Brock P, Armanios M
Am J Hum Genet 2024 Jun 6;111(6):1114-1124. Epub 2024 Apr 29 doi: 10.1016/j.ajhg.2024.04.006. PMID: 38688277Free PMC Article
The association between telomere length and non-alcoholic fatty liver disease: a prospective study.
Tang L, Li D, Ma Y, Cui F, Wang J, Tian Y
BMC Med 2023 Nov 9;21(1):427. doi: 10.1186/s12916-023-03136-7. PMID: 37940980Free PMC Article
Familial Clonal Hematopoiesis in a Long Telomere Syndrome.
DeBoy EA, Tassia MG, Schratz KE, Yan SM, Cosner ZL, McNally EJ, Gable DL, Xiang Z, Lombard DB, Antonarakis ES, Gocke CD, McCoy RC, Armanios M
N Engl J Med 2023 Jun 29;388(26):2422-2433. Epub 2023 May 4 doi: 10.1056/NEJMoa2300503. PMID: 37140166Free PMC Article
Long telomeres and cancer risk: the price of cellular immortality.
McNally EJ, Luncsford PJ, Armanios M
J Clin Invest 2019 Aug 5;129(9):3474-3481. doi: 10.1172/JCI120851. PMID: 31380804Free PMC Article
Long telomere length and a TERT-CLPTM1 locus polymorphism association with melanoma risk.
Llorca-Cardeñosa MJ, Peña-Chilet M, Mayor M, Gomez-Fernandez C, Casado B, Martin-Gonzalez M, Carretero G, Lluch A, Martinez-Cadenas C, Ibarrola-Villava M, Ribas G
Eur J Cancer 2014 Dec;50(18):3168-77. Epub 2014 Oct 31 doi: 10.1016/j.ejca.2014.09.017. PMID: 25457634

Diagnosis

Bone marrow mononuclear cell telomere length in acute myeloid leukaemia and high-risk myelodysplastic syndrome.
Warny M, Helby J, Sengeløv H, Nordestgaard BG, Birgens H, Bojesen SE
Eur J Haematol 2019 Mar;102(3):218-226. Epub 2019 Jan 22 doi: 10.1111/ejh.13196. PMID: 30427547
Hyperglycemia attenuates the association between telomere length and age in Ukrainian population.
Krasnienkov DS, Khalangot MD, Kravchenko VI, Kovtun VA, Guryanov VG, Chizhova VP, Korkushko OV, Shatilo VB, Kukharsky VM, Vaiserman AM
Exp Gerontol 2018 Sep;110:247-252. Epub 2018 Jun 26 doi: 10.1016/j.exger.2018.06.027. PMID: 29958997
Telomere length variation: A potential new telomere biomarker for lung cancer risk.
Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC, Zheng YL
Lung Cancer 2015 Jun;88(3):297-303. Epub 2015 Mar 20 doi: 10.1016/j.lungcan.2015.03.011. PMID: 25840848Free PMC Article
Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients.
Lin J, Blalock JA, Chen M, Ye Y, Gu J, Cohen L, Cinciripini PM, Wu X
Cancer Epidemiol Biomarkers Prev 2015 Feb;24(2):336-43. Epub 2014 Nov 21 doi: 10.1158/1055-9965.EPI-14-0992. PMID: 25416716Free PMC Article
Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts.
Seow WJ, Cawthon RM, Purdue MP, Hu W, Gao YT, Huang WY, Weinstein SJ, Ji BT, Virtamo J, Hosgood HD 3rd, Bassig BA, Shu XO, Cai Q, Xiang YB, Min S, Chow WH, Berndt SI, Kim C, Lim U, Albanes D, Caporaso NE, Chanock S, Zheng W, Rothman N, Lan Q
Cancer Res 2014 Aug 1;74(15):4090-8. Epub 2014 May 22 doi: 10.1158/0008-5472.CAN-14-0459. PMID: 24853549Free PMC Article

Therapy

Bone marrow mononuclear cell telomere length in acute myeloid leukaemia and high-risk myelodysplastic syndrome.
Warny M, Helby J, Sengeløv H, Nordestgaard BG, Birgens H, Bojesen SE
Eur J Haematol 2019 Mar;102(3):218-226. Epub 2019 Jan 22 doi: 10.1111/ejh.13196. PMID: 30427547
Nested case-control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial.
Doherty JA, Grieshober L, Houck JR, Barnett MJ, De Dieu Tapsoba J, Thornquist MD, Wang CY, Goodman GE, Chen C
Br J Cancer 2018 May;118(11):1513-1517. Epub 2018 Apr 19 doi: 10.1038/s41416-018-0075-0. PMID: 29670295Free PMC Article
Genetic association of telomere length with hepatocellular carcinoma risk: A Mendelian randomization analysis.
Cheng Y, Yu C, Huang M, Du F, Song C, Ma Z, Zhai X, Yang Y, Liu J, Bei JX, Jia W, Jin G, Li S, Zhou W, Liu J, Dai J, Hu Z
Cancer Epidemiol 2017 Oct;50(Pt A):39-45. Epub 2017 Aug 7 doi: 10.1016/j.canep.2017.07.011. PMID: 28797893
Telomere Length as a Prognostic Factor for Overall Survival in Colorectal Cancer Patients.
Jia H, Wang Z
Cell Physiol Biochem 2016;38(1):122-8. Epub 2016 Jan 8 doi: 10.1159/000438614. PMID: 26741140
TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas.
Gao K, Li G, Qu Y, Wang M, Cui B, Ji M, Shi B, Hou P
Oncotarget 2016 Feb 23;7(8):8712-25. doi: 10.18632/oncotarget.6007. PMID: 26556853Free PMC Article

Prognosis

Familial Clonal Hematopoiesis in a Long Telomere Syndrome.
DeBoy EA, Tassia MG, Schratz KE, Yan SM, Cosner ZL, McNally EJ, Gable DL, Xiang Z, Lombard DB, Antonarakis ES, Gocke CD, McCoy RC, Armanios M
N Engl J Med 2023 Jun 29;388(26):2422-2433. Epub 2023 May 4 doi: 10.1056/NEJMoa2300503. PMID: 37140166Free PMC Article
Long telomeres and cancer risk: the price of cellular immortality.
McNally EJ, Luncsford PJ, Armanios M
J Clin Invest 2019 Aug 5;129(9):3474-3481. doi: 10.1172/JCI120851. PMID: 31380804Free PMC Article
Long telomere length predicts poor clinical outcome in esophageal cancer patients.
Lv Y, Zhang Y, Li X, Ren X, Wang M, Tian S, Hou P, Shi B, Yang Q
Pathol Res Pract 2017 Feb;213(2):113-118. Epub 2016 Nov 16 doi: 10.1016/j.prp.2016.11.010. PMID: 28027815
Telomere Length as a Prognostic Factor for Overall Survival in Colorectal Cancer Patients.
Jia H, Wang Z
Cell Physiol Biochem 2016;38(1):122-8. Epub 2016 Jan 8 doi: 10.1159/000438614. PMID: 26741140
TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas.
Gao K, Li G, Qu Y, Wang M, Cui B, Ji M, Shi B, Hou P
Oncotarget 2016 Feb 23;7(8):8712-25. doi: 10.18632/oncotarget.6007. PMID: 26556853Free PMC Article

Clinical prediction guides

The association between telomere length and non-alcoholic fatty liver disease: a prospective study.
Tang L, Li D, Ma Y, Cui F, Wang J, Tian Y
BMC Med 2023 Nov 9;21(1):427. doi: 10.1186/s12916-023-03136-7. PMID: 37940980Free PMC Article
Long telomeres and cancer risk: the price of cellular immortality.
McNally EJ, Luncsford PJ, Armanios M
J Clin Invest 2019 Aug 5;129(9):3474-3481. doi: 10.1172/JCI120851. PMID: 31380804Free PMC Article
Hyperglycemia attenuates the association between telomere length and age in Ukrainian population.
Krasnienkov DS, Khalangot MD, Kravchenko VI, Kovtun VA, Guryanov VG, Chizhova VP, Korkushko OV, Shatilo VB, Kukharsky VM, Vaiserman AM
Exp Gerontol 2018 Sep;110:247-252. Epub 2018 Jun 26 doi: 10.1016/j.exger.2018.06.027. PMID: 29958997
Long telomere length predicts poor clinical outcome in esophageal cancer patients.
Lv Y, Zhang Y, Li X, Ren X, Wang M, Tian S, Hou P, Shi B, Yang Q
Pathol Res Pract 2017 Feb;213(2):113-118. Epub 2016 Nov 16 doi: 10.1016/j.prp.2016.11.010. PMID: 28027815
Telomere length variation: A potential new telomere biomarker for lung cancer risk.
Sun B, Wang Y, Kota K, Shi Y, Motlak S, Makambi K, Loffredo CA, Shields PG, Yang Q, Harris CC, Zheng YL
Lung Cancer 2015 Jun;88(3):297-303. Epub 2015 Mar 20 doi: 10.1016/j.lungcan.2015.03.011. PMID: 25840848Free PMC Article

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