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Elevated circulating hyaluronic acid concentration

MedGen UID:
1853205
•Concept ID:
C5872962
•
Finding
Synonym: Hyaluronic acid high in blood
 
HPO: HP:4000213

Definition

Concentration of hyaluronic acid in the blood circulation above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating hyaluronic acid concentration

Recent clinical studies

Etiology

Circulating Monocyte Chemoattractant Protein-1 (MCP-1) in Patients with Primary Biliary Cholangitis.
Bauer A, Rawa T
Int J Mol Sci 2024 Jan 22;25(2) doi: 10.3390/ijms25021333. PMID: 38279333Free PMC Article
Extensive blood transcriptome analysis reveals cellular signaling networks activated by circulating glycocalyx components reflecting vascular injury in COVID-19.
Borrmann M, Brandes F, Kirchner B, Klein M, Billaud JN, Reithmair M, Rehm M, Schelling G, Pfaffl MW, Meidert AS
Front Immunol 2023;14:1129766. Epub 2023 Jan 26 doi: 10.3389/fimmu.2023.1129766. PMID: 36776845Free PMC Article
The circulating glycosaminoglycan signature of respiratory failure in critically ill adults.
Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ
J Biol Chem 2014 Mar 21;289(12):8194-202. Epub 2014 Feb 7 doi: 10.1074/jbc.M113.539452. PMID: 24509853Free PMC Article
Hyaluronan in serum as an indicator of progressive disease in hyaluronan-producing malignant mesothelioma.
Thylén A, Wallin J, Martensson G
Cancer 1999 Nov 15;86(10):2000-5. PMID: 10570424
Biochemical markers of hepatic fibrosis.
Plebani M, Burlina A
Clin Biochem 1991 Jun;24(3):219-39. doi: 10.1016/0009-9120(91)80013-s. PMID: 1651819

Diagnosis

Circulating Monocyte Chemoattractant Protein-1 (MCP-1) in Patients with Primary Biliary Cholangitis.
Bauer A, Rawa T
Int J Mol Sci 2024 Jan 22;25(2) doi: 10.3390/ijms25021333. PMID: 38279333Free PMC Article
Hyaluronan concentration and molecular mass in psoriatic arthritis: biomarkers of disease severity, resistance to treatment, and outcome.
Hellman U, Engström-Laurent A, Larsson A, Lindqvist U
Scand J Rheumatol 2019 Jul;48(4):284-293. Epub 2019 Apr 29 doi: 10.1080/03009742.2019.1577490. PMID: 31032710
The circulating glycosaminoglycan signature of respiratory failure in critically ill adults.
Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ
J Biol Chem 2014 Mar 21;289(12):8194-202. Epub 2014 Feb 7 doi: 10.1074/jbc.M113.539452. PMID: 24509853Free PMC Article
Biochemical markers of hepatic fibrosis.
Plebani M, Burlina A
Clin Biochem 1991 Jun;24(3):219-39. doi: 10.1016/0009-9120(91)80013-s. PMID: 1651819
Changes in hyaluronan concentration in tissues and body fluids in disease states.
Engström-Laurent A
Ciba Found Symp 1989;143:233-40; discussion 240-7, 281-5. doi: 10.1002/9780470513774.ch14. PMID: 2680345

Therapy

Hyaluronan concentration and molecular mass in psoriatic arthritis: biomarkers of disease severity, resistance to treatment, and outcome.
Hellman U, Engström-Laurent A, Larsson A, Lindqvist U
Scand J Rheumatol 2019 Jul;48(4):284-293. Epub 2019 Apr 29 doi: 10.1080/03009742.2019.1577490. PMID: 31032710
The circulating glycosaminoglycan signature of respiratory failure in critically ill adults.
Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ
J Biol Chem 2014 Mar 21;289(12):8194-202. Epub 2014 Feb 7 doi: 10.1074/jbc.M113.539452. PMID: 24509853Free PMC Article
Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis.
Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen YR, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T, Miyajima A
Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4263-8. Epub 2012 Feb 27 doi: 10.1073/pnas.1117560109. PMID: 22371575Free PMC Article

Prognosis

Circulating Monocyte Chemoattractant Protein-1 (MCP-1) in Patients with Primary Biliary Cholangitis.
Bauer A, Rawa T
Int J Mol Sci 2024 Jan 22;25(2) doi: 10.3390/ijms25021333. PMID: 38279333Free PMC Article
Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.
Weissgerber TL, Garcia-Valencia O, Milic NM, Codsi E, Cubro H, Nath MC, White WM, Nath KA, Garovic VD
J Am Heart Assoc 2019 Feb 19;8(4):e010647. doi: 10.1161/JAHA.118.010647. PMID: 30764695Free PMC Article
The circulating glycosaminoglycan signature of respiratory failure in critically ill adults.
Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ
J Biol Chem 2014 Mar 21;289(12):8194-202. Epub 2014 Feb 7 doi: 10.1074/jbc.M113.539452. PMID: 24509853Free PMC Article
Hyaluronan in serum as an indicator of progressive disease in hyaluronan-producing malignant mesothelioma.
Thylén A, Wallin J, Martensson G
Cancer 1999 Nov 15;86(10):2000-5. PMID: 10570424
Biochemical markers of hepatic fibrosis.
Plebani M, Burlina A
Clin Biochem 1991 Jun;24(3):219-39. doi: 10.1016/0009-9120(91)80013-s. PMID: 1651819

Clinical prediction guides

Circulating Monocyte Chemoattractant Protein-1 (MCP-1) in Patients with Primary Biliary Cholangitis.
Bauer A, Rawa T
Int J Mol Sci 2024 Jan 22;25(2) doi: 10.3390/ijms25021333. PMID: 38279333Free PMC Article
High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity.
Lin CY, Kolliopoulos C, Huang CH, Tenhunen J, Heldin CH, Chen YH, Heldin P
EBioMedicine 2019 Oct;48:425-441. Epub 2019 Sep 13 doi: 10.1016/j.ebiom.2019.09.014. PMID: 31526718Free PMC Article
Hyaluronan concentration and molecular mass in psoriatic arthritis: biomarkers of disease severity, resistance to treatment, and outcome.
Hellman U, Engström-Laurent A, Larsson A, Lindqvist U
Scand J Rheumatol 2019 Jul;48(4):284-293. Epub 2019 Apr 29 doi: 10.1080/03009742.2019.1577490. PMID: 31032710
Increased intrahepatic and circulating levels of endoglin, a TGF-beta1 co-receptor, in patients with chronic hepatitis C virus infection: relationship to histological and serum markers of hepatic fibrosis.
Clemente M, Núñez O, Lorente R, Rincón D, Matilla A, Salcedo M, Catalina MV, Ripoll C, Iacono OL, Bañares R, Clemente G, García-Monzón C
J Viral Hepat 2006 Sep;13(9):625-32. doi: 10.1111/j.1365-2893.2006.00733.x. PMID: 16907850
Biochemical markers of hepatic fibrosis.
Plebani M, Burlina A
Clin Biochem 1991 Jun;24(3):219-39. doi: 10.1016/0009-9120(91)80013-s. PMID: 1651819

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