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Postherpetic neuralgia

MedGen UID:
18589
Concept ID:
C0032768
Disease or Syndrome
Synonyms: Neuralgia, Postherpetic; Postherpetic Neuralgia
SNOMED CT: PHN - Post-herpetic neuralgia (2177002); Post-zoster neuralgia (2177002); Postherpetic neuralgia (2177002)
 
Monarch Initiative: MONDO:0041052
Orphanet: ORPHA466673

Definition

Pain that occurs after the disappearance of herpes zoster infection lesions. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostherpetic neuralgia

Professional guidelines

PubMed

Patil A, Goldust M, Wollina U
Viruses 2022 Jan 19;14(2) doi: 10.3390/v14020192. PMID: 35215786Free PMC Article
Finnerup NB, Kuner R, Jensen TS
Physiol Rev 2021 Jan 1;101(1):259-301. Epub 2020 Jun 25 doi: 10.1152/physrev.00045.2019. PMID: 32584191
Baron R, Binder A, Wasner G
Lancet Neurol 2010 Aug;9(8):807-19. doi: 10.1016/S1474-4422(10)70143-5. PMID: 20650402

Curated

UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

Recent clinical studies

Etiology

Gross GE, Eisert L, Doerr HW, Fickenscher H, Knuf M, Maier P, Maschke M, Müller R, Pleyer U, Schäfer M, Sunderkötter C, Werner RN, Wutzler P, Nast A
J Dtsch Dermatol Ges 2020 Jan;18(1):55-78. Epub 2020 Jan 17 doi: 10.1111/ddg.14013. PMID: 31951098
Lin CS, Lin YC, Lao HC, Chen CC
Pain Physician 2019 May;22(3):209-228. PMID: 31151330
Saguil A, Kane S, Mercado M, Lauters R
Am Fam Physician 2017 Nov 15;96(10):656-663. PMID: 29431387
Forbes HJ, Thomas SL, Smeeth L, Clayton T, Farmer R, Bhaskaran K, Langan SM
Pain 2016 Jan;157(1):30-54. doi: 10.1097/j.pain.0000000000000307. PMID: 26218719Free PMC Article
Sampathkumar P, Drage LA, Martin DP
Mayo Clin Proc 2009 Mar;84(3):274-80. doi: 10.4065/84.3.274. PMID: 19252116Free PMC Article

Diagnosis

Kennedy PGE, Gershon AA
Viruses 2018 Nov 2;10(11) doi: 10.3390/v10110609. PMID: 30400213Free PMC Article
John AR, Canaday DH
Infect Dis Clin North Am 2017 Dec;31(4):811-826. doi: 10.1016/j.idc.2017.07.016. PMID: 29079160Free PMC Article
Gershon AA, Breuer J, Cohen JI, Cohrs RJ, Gershon MD, Gilden D, Grose C, Hambleton S, Kennedy PG, Oxman MN, Seward JF, Yamanishi K
Nat Rev Dis Primers 2015 Jul 2;1:15016. doi: 10.1038/nrdp.2015.16. PMID: 27188665Free PMC Article
Baron R, Binder A, Wasner G
Lancet Neurol 2010 Aug;9(8):807-19. doi: 10.1016/S1474-4422(10)70143-5. PMID: 20650402
Sampathkumar P, Drage LA, Martin DP
Mayo Clin Proc 2009 Mar;84(3):274-80. doi: 10.4065/84.3.274. PMID: 19252116Free PMC Article

Therapy

Jiang X, Li Y, Chen N, Zhou M, He L
Cochrane Database Syst Rev 2023 Dec 5;12(12):CD005582. doi: 10.1002/14651858.CD005582.pub5. PMID: 38050854Free PMC Article
Tang J, Zhang Y, Liu C, Zeng A, Song L
Curr Pain Headache Rep 2023 Sep;27(9):307-319. Epub 2023 Jul 26 doi: 10.1007/s11916-023-01146-x. PMID: 37493871
Lin CS, Lin YC, Lao HC, Chen CC
Pain Physician 2019 May;22(3):209-228. PMID: 31151330
Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD
Pain 2013 Nov;154(11):2249-2261. Epub 2013 Jun 6 doi: 10.1016/j.pain.2013.06.004. PMID: 23748119Free PMC Article
Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW Jr, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL; Shingles Prevention Study Group
N Engl J Med 2005 Jun 2;352(22):2271-84. doi: 10.1056/NEJMoa051016. PMID: 15930418

Prognosis

Patil A, Goldust M, Wollina U
Viruses 2022 Jan 19;14(2) doi: 10.3390/v14020192. PMID: 35215786Free PMC Article
Gross GE, Eisert L, Doerr HW, Fickenscher H, Knuf M, Maier P, Maschke M, Müller R, Pleyer U, Schäfer M, Sunderkötter C, Werner RN, Wutzler P, Nast A
J Dtsch Dermatol Ges 2020 Jan;18(1):55-78. Epub 2020 Jan 17 doi: 10.1111/ddg.14013. PMID: 31951098
Koshy E, Mengting L, Kumar H, Jianbo W
Indian J Dermatol Venereol Leprol 2018 May-Jun;84(3):251-262. doi: 10.4103/ijdvl.IJDVL_1021_16. PMID: 29516900
Kawai K, Gebremeskel BG, Acosta CJ
BMJ Open 2014 Jun 10;4(6):e004833. doi: 10.1136/bmjopen-2014-004833. PMID: 24916088Free PMC Article
Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW Jr, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL; Shingles Prevention Study Group
N Engl J Med 2005 Jun 2;352(22):2271-84. doi: 10.1056/NEJMoa051016. PMID: 15930418

Clinical prediction guides

Jiang X, Li Y, Chen N, Zhou M, He L
Cochrane Database Syst Rev 2023 Dec 5;12(12):CD005582. doi: 10.1002/14651858.CD005582.pub5. PMID: 38050854Free PMC Article
Zhang Z, Liu X, Suo L, Zhao D, Pan J, Lu L
Hum Vaccin Immunother 2023 Aug 1;19(2):2228169. Epub 2023 Jul 9 doi: 10.1080/21645515.2023.2228169. PMID: 37424092Free PMC Article
Mbinta JF, Nguyen BP, Awuni PMA, Paynter J, Simpson CR
Lancet Healthy Longev 2022 Apr;3(4):e263-e275. Epub 2022 Apr 4 doi: 10.1016/S2666-7568(22)00039-3. PMID: 36098300
Izurieta HS, Wu X, Forshee R, Lu Y, Sung HM, Agger PE, Chillarige Y, Link-Gelles R, Lufkin B, Wernecke M, MaCurdy TE, Kelman J, Dooling K
Clin Infect Dis 2021 Sep 15;73(6):941-948. doi: 10.1093/cid/ciab125. PMID: 33580242
Goodman CW, Brett AS
JAMA Intern Med 2019 May 1;179(5):695-701. doi: 10.1001/jamainternmed.2019.0086. PMID: 30907944

Recent systematic reviews

Jiang X, Li Y, Chen N, Zhou M, He L
Cochrane Database Syst Rev 2023 Dec 5;12(12):CD005582. doi: 10.1002/14651858.CD005582.pub5. PMID: 38050854Free PMC Article
Lin CS, Lin YC, Lao HC, Chen CC
Pain Physician 2019 May;22(3):209-228. PMID: 31151330
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA
Cochrane Database Syst Rev 2019 Jan 23;1(1):CD007076. doi: 10.1002/14651858.CD007076.pub3. PMID: 30673120Free PMC Article
Forbes HJ, Thomas SL, Smeeth L, Clayton T, Farmer R, Bhaskaran K, Langan SM
Pain 2016 Jan;157(1):30-54. doi: 10.1097/j.pain.0000000000000307. PMID: 26218719Free PMC Article
Kawai K, Gebremeskel BG, Acosta CJ
BMJ Open 2014 Jun 10;4(6):e004833. doi: 10.1136/bmjopen-2014-004833. PMID: 24916088Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Clinical Guideline CG173, Neuropathic pain in adults: pharmacological management in non-specialist settings, 2020

    Consumer resources

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