U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign intracranial hypertension

MedGen UID:
18732
Concept ID:
C0033845
Disease or Syndrome
Synonyms: Idiopathic intracranial hypertension; Pseudotumor Cerebri
SNOMED CT: Benign intracranial hypertension (68267002); Pseudotumor cerebri (68267002); Nonne's syndrome (68267002); Otitic hydrocephalus syndrome (68267002); Noninfective serous meningitis (68267002); BIH - Benign intracranial hypertension (68267002); IIH - Idiopathic intracranial hypertension (68267002); Idiopathic intracranial hypertension (68267002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0009468
OMIM®: 243200
Orphanet: ORPHA238624

Definition

Idiopathic intracranial hypertension is a neurological disorder characterized by isolated increased intracranial pressure manifesting with recurrent and persistent headaches, nausea, vomiting, progressive and transient obstruction of the visual field, papilledema. Visual loss can be irreversible. [from ORDO]

Clinical features

From HPO
Hypertensive disorder
MedGen UID:
6969
Concept ID:
C0020538
Disease or Syndrome
The presence of chronic increased pressure in the systemic arterial system.
Increased intracranial pressure
MedGen UID:
56241
Concept ID:
C0151740
Finding
An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.
Papilledema
MedGen UID:
10565
Concept ID:
C0030353
Finding
Papilledema refers to edema (swelling) of the optic disc secondary to any factor which increases cerebral spinal fluid pressure.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign intracranial hypertension
Follow this link to review classifications for Benign intracranial hypertension in Orphanet.

Professional guidelines

PubMed

Galgano MA, Deshaies EM
Clin Neurol Neurosurg 2013 Mar;115(3):252-9. Epub 2012 Dec 21 doi: 10.1016/j.clineuro.2012.11.018. PMID: 23265564
Karmaniolou I, Petropoulos G, Theodoraki K
Can J Anaesth 2011 Jul;58(7):650. Epub 2011 Apr 26 doi: 10.1007/s12630-011-9508-4. PMID: 21519980
Schaefer F, Haffner D, Wühl E, Mehls O
Perit Dial Int 1999;19 Suppl 2:S467-72. PMID: 10406566

Recent clinical studies

Etiology

Hanna FA, Jabaly-Habib H, Halachmi-Eyal O, Hujierat M, Sakran W, Spiegel R
J Child Neurol 2022 Mar;37(4):281-287. Epub 2021 Dec 8 doi: 10.1177/08830738211035912. PMID: 34879720
Wakerley BR, Tan MH, Ting EY
Cephalalgia 2015 Mar;35(3):248-61. Epub 2014 May 20 doi: 10.1177/0333102414534329. PMID: 24847166
Galgano MA, Deshaies EM
Clin Neurol Neurosurg 2013 Mar;115(3):252-9. Epub 2012 Dec 21 doi: 10.1016/j.clineuro.2012.11.018. PMID: 23265564
Shehata HA, Okosun H
Curr Opin Obstet Gynecol 2004 Apr;16(2):117-22. doi: 10.1097/00001703-200404000-00004. PMID: 15017339
Abraham S, Rajeev E, Girija AS
J Assoc Physicians India 2000 Aug;48(8):838-41. PMID: 11273484

Diagnosis

Thanki S, Guerrero W, Mokin M
Neurosurg Clin N Am 2022 Apr;33(2):207-214. Epub 2022 Mar 2 doi: 10.1016/j.nec.2021.11.002. PMID: 35346452
Wakerley BR, Tan MH, Ting EY
Cephalalgia 2015 Mar;35(3):248-61. Epub 2014 May 20 doi: 10.1177/0333102414534329. PMID: 24847166
Shehata HA, Okosun H
Curr Opin Obstet Gynecol 2004 Apr;16(2):117-22. doi: 10.1097/00001703-200404000-00004. PMID: 15017339
Abraham S, Rajeev E, Girija AS
J Assoc Physicians India 2000 Aug;48(8):838-41. PMID: 11273484
Weissman JL, Hirsch BE
Radiology 2000 Aug;216(2):342-9. doi: 10.1148/radiology.216.2.r00au45342. PMID: 10924551

Therapy

Wakerley BR, Tan MH, Ting EY
Cephalalgia 2015 Mar;35(3):248-61. Epub 2014 May 20 doi: 10.1177/0333102414534329. PMID: 24847166
Orion E, Matz H, Wolf R
Clin Dermatol 2005 Mar-Apr;23(2):182-92. doi: 10.1016/j.clindermatol.2004.06.013. PMID: 15802212
Shehata HA, Okosun H
Curr Opin Obstet Gynecol 2004 Apr;16(2):117-22. doi: 10.1097/00001703-200404000-00004. PMID: 15017339
Digre KB
BMJ 2003 Mar 22;326(7390):613-4. doi: 10.1136/bmj.326.7390.613. PMID: 12649214Free PMC Article
Taylor F
Aust Fam Physician 1985 Aug;14(8):744-5. PMID: 2864912

Prognosis

Liu X, Chen H, Ma X, Yu H, Yang H, Ai L, Liu Q, Wu L
Sci Rep 2023 Jul 5;13(1):10847. doi: 10.1038/s41598-023-35571-0. PMID: 37407586Free PMC Article
Mehndiratta MM, Garg S, Gurnani M
J Pak Med Assoc 2006 Nov;56(11):513-6. PMID: 17183979
Czosnyka M, Pickard JD
J Neurol Neurosurg Psychiatry 2004 Jun;75(6):813-21. doi: 10.1136/jnnp.2003.033126. PMID: 15145991Free PMC Article
Abraham S, Rajeev E, Girija AS
J Assoc Physicians India 2000 Aug;48(8):838-41. PMID: 11273484
Bjerre P
Acta Neurol Scand Suppl 1990;130:1-25. PMID: 2220326

Clinical prediction guides

Liu X, Chen H, Ma X, Yu H, Yang H, Ai L, Liu Q, Wu L
Sci Rep 2023 Jul 5;13(1):10847. doi: 10.1038/s41598-023-35571-0. PMID: 37407586Free PMC Article
Hodson EM, Willis NS, Craig JC
Cochrane Database Syst Rev 2012 Feb 15;2012(2):CD003264. doi: 10.1002/14651858.CD003264.pub3. PMID: 22336787Free PMC Article
Vimalachandra D, Hodson EM, Willis NS, Craig JC, Cowell C, Knight JF
Cochrane Database Syst Rev 2006 Jul 19;(3):CD003264. doi: 10.1002/14651858.CD003264.pub2. PMID: 16856001
Czosnyka M, Pickard JD
J Neurol Neurosurg Psychiatry 2004 Jun;75(6):813-21. doi: 10.1136/jnnp.2003.033126. PMID: 15145991Free PMC Article
Clayton PE, Cowell CT
Growth Horm IGF Res 2000 Dec;10(6):306-17. doi: 10.1054/ghir.2000.0175. PMID: 11161961

Recent systematic reviews

Onyia CU, Ogunbameru IO, Dada OA, Owagbemi OF, Ige-Orhionkpaibima FS, Olarewaju OA, Komolafe EO
Clin Neurol Neurosurg 2019 Apr;179:35-41. Epub 2019 Feb 15 doi: 10.1016/j.clineuro.2019.02.013. PMID: 30818126
Manfield JH, Yu KK, Efthimiou E, Darzi A, Athanasiou T, Ashrafian H
Obes Surg 2017 Feb;27(2):513-521. doi: 10.1007/s11695-016-2467-7. PMID: 27981458Free PMC Article
Handley JD, Baruah BP, Williams DM, Horner M, Barry J, Stephens JW
Surg Obes Relat Dis 2015 Nov-Dec;11(6):1396-403. Epub 2015 Aug 12 doi: 10.1016/j.soard.2015.08.497. PMID: 26499350
Hodson EM, Willis NS, Craig JC
Cochrane Database Syst Rev 2012 Feb 15;2012(2):CD003264. doi: 10.1002/14651858.CD003264.pub3. PMID: 22336787Free PMC Article
Vimalachandra D, Hodson EM, Willis NS, Craig JC, Cowell C, Knight JF
Cochrane Database Syst Rev 2006 Jul 19;(3):CD003264. doi: 10.1002/14651858.CD003264.pub2. PMID: 16856001

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...