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Mycoplasma pneumoniae pneumonia

MedGen UID:
19363
•Concept ID:
C0032302
•
Disease or Syndrome
Synonym: Mycoplasmal pneumonia
SNOMED CT: Pneumonia due to Mycoplasma pneumoniae (46970008); Eaton's agent pneumonia (46970008); Pneumonia caused by Mycoplasma pneumoniae (46970008); Primary atypical pneumonia caused by Mycoplasma pneumoniae (46970008); Mycoplasma pneumoniae pneumonia (46970008); Mycoplasmal pneumonia (46970008); Mycoplasma pneumonia (46970008); Primary atypical pneumonia due to Mycoplasma pneumoniae (46970008); Endemic pneumonia (46970008)
 
Monarch Initiative: MONDO:0005867

Definition

Pneumonia caused by Mycoplasma pneumoniae. Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMycoplasma pneumoniae pneumonia

Professional guidelines

PubMed

Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis.
Ahn JG, Cho HK, Li D, Choi M, Lee J, Eun BW, Jo DS, Park SE, Choi EH, Yang HJ, Kim KH
BMC Infect Dis 2021 Sep 25;21(1):1003. doi: 10.1186/s12879-021-06508-7. PMID: 34563128Free PMC Article
The treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Dai FF, Liu FQ, Chen X, Yang J, Wang K, Guo CY
J Clin Pharm Ther 2021 Jun;46(3):705-710. Epub 2021 Jan 6 doi: 10.1111/jcpt.13331. PMID: 33403672
Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: a review of the Japanese literature.
Izumikawa K, Izumikawa K, Takazono T, Kosai K, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Tsukamoto M, Yanagihara K, Hara K, Kohno S
J Infect Chemother 2014 Mar;20(3):181-5. Epub 2013 Dec 11 doi: 10.1016/j.jiac.2013.09.009. PMID: 24462437

Recent clinical studies

Etiology

Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia.
Wang Y, Yu X, Liu F, Tian X, Quan S, Jiao A, Yang X, Zeng X, Jiao W, Qi H, Xu F, Li Q, Liu S, Xu B, Sun L, Shen A
Emerg Microbes Infect 2023 Dec;12(1):2202272. doi: 10.1080/22221751.2023.2202272. PMID: 37132354Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis.
Ahn JG, Cho HK, Li D, Choi M, Lee J, Eun BW, Jo DS, Park SE, Choi EH, Yang HJ, Kim KH
BMC Infect Dis 2021 Sep 25;21(1):1003. doi: 10.1186/s12879-021-06508-7. PMID: 34563128Free PMC Article
Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Lee H, Yun KW, Lee HJ, Choi EH
Expert Rev Anti Infect Ther 2018 Jan;16(1):23-34. Epub 2017 Dec 11 doi: 10.1080/14787210.2018.1414599. PMID: 29212389
Mycoplasma pneumoniae pneumonia.
Mansel JK, Rosenow EC 3rd, Smith TF, Martin JW Jr
Chest 1989 Mar;95(3):639-46. doi: 10.1378/chest.95.3.639. PMID: 2646077

Diagnosis

Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia.
Wang Y, Yu X, Liu F, Tian X, Quan S, Jiao A, Yang X, Zeng X, Jiao W, Qi H, Xu F, Li Q, Liu S, Xu B, Sun L, Shen A
Emerg Microbes Infect 2023 Dec;12(1):2202272. doi: 10.1080/22221751.2023.2202272. PMID: 37132354Free PMC Article
Diagnosis and Prognostic Analysis of Mycoplasma pneumoniae Pneumonia in Children Based on High-Resolution Computed Tomography.
Leng J, Yang Z, Wang W
Contrast Media Mol Imaging 2022;2022:1985531. Epub 2022 Apr 22 doi: 10.1155/2022/1985531. PMID: 35542756Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children.
Tsai TA, Tsai CK, Kuo KC, Yu HR
J Microbiol Immunol Infect 2021 Aug;54(4):557-565. Epub 2020 Oct 17 doi: 10.1016/j.jmii.2020.10.002. PMID: 33268306
Mycoplasma pneumoniae pneumonia.
Mansel JK, Rosenow EC 3rd, Smith TF, Martin JW Jr
Chest 1989 Mar;95(3):639-46. doi: 10.1378/chest.95.3.639. PMID: 2646077

Therapy

Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis.
Ahn JG, Cho HK, Li D, Choi M, Lee J, Eun BW, Jo DS, Park SE, Choi EH, Yang HJ, Kim KH
BMC Infect Dis 2021 Sep 25;21(1):1003. doi: 10.1186/s12879-021-06508-7. PMID: 34563128Free PMC Article
Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children.
Tsai TA, Tsai CK, Kuo KC, Yu HR
J Microbiol Immunol Infect 2021 Aug;54(4):557-565. Epub 2020 Oct 17 doi: 10.1016/j.jmii.2020.10.002. PMID: 33268306
Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Lee H, Yun KW, Lee HJ, Choi EH
Expert Rev Anti Infect Ther 2018 Jan;16(1):23-34. Epub 2017 Dec 11 doi: 10.1080/14787210.2018.1414599. PMID: 29212389
Overview of antimicrobial options for Mycoplasma pneumoniae pneumonia: focus on macrolide resistance.
Cao B, Qu JX, Yin YD, Eldere JV
Clin Respir J 2017 Jul;11(4):419-429. Epub 2015 Oct 13 doi: 10.1111/crj.12379. PMID: 26365811

Prognosis

Application value of antibody titres and RNA detection in the early prediction of Mycoplasma pneumoniae pneumonia in children: a retrospective study.
Tuo W, Guo X, Wu M, Xie S, Shen X, Wang J, Cai Q, Yuan C, Yao C, Xiang Y
BMC Infect Dis 2023 Apr 7;23(1):220. doi: 10.1186/s12879-023-08161-8. PMID: 37029345Free PMC Article
Clinical characteristics of 14 pediatric mycoplasma pneumoniae pneumonia associated thrombosis: a retrospective study.
Fu Y, Zhang TQ, Dong CJ, Xu YS, Dong HQ, Ning J
BMC Cardiovasc Disord 2023 Jan 4;23(1):1. doi: 10.1186/s12872-022-03030-9. PMID: 36600223Free PMC Article
Development and validation of a nomogram for predicting Mycoplasma pneumoniae pneumonia in adults.
Ren Y, Wang Y, Liang R, Hao B, Wang H, Yuan J, Wang L, Guo Z, Zhang J
Sci Rep 2022 Dec 17;12(1):21859. doi: 10.1038/s41598-022-26565-5. PMID: 36528731Free PMC Article
Monitoring Mycoplasma pneumoniae-Specific Antibody, C-Reactive Protein, and Procalcitonin Levels in Children with Mycoplasma Pneumonia Is Important.
Cao X
Comput Math Methods Med 2022;2022:7976858. Epub 2022 Jun 28 doi: 10.1155/2022/7976858. PMID: 35799649Free PMC Article
Diagnosis and Prognostic Analysis of Mycoplasma pneumoniae Pneumonia in Children Based on High-Resolution Computed Tomography.
Leng J, Yang Z, Wang W
Contrast Media Mol Imaging 2022;2022:1985531. Epub 2022 Apr 22 doi: 10.1155/2022/1985531. PMID: 35542756Free PMC Article

Clinical prediction guides

Prediction Model for Severe Mycoplasma pneumoniae Pneumonia in Pediatric Patients by Admission Laboratory Indicators.
Chang Q, Chen HL, Wu NS, Gao YM, Yu R, Zhu WM
J Trop Pediatr 2022 Jun 6;68(4) doi: 10.1093/tropej/fmac059. PMID: 35903920
Clinical Usefulness of Serum Lactate Dehydrogenase Levels in Mycoplasma pneumoniae Pneumonia in Children.
Lee E, Choi I
Indian J Pediatr 2022 Oct;89(10):1003-1009. Epub 2022 Jun 6 doi: 10.1007/s12098-022-04205-0. PMID: 35665905
Clinical features of Mycoplasma pneumoniae pneumonia with adenovirus infection in children.
Peng L, Zhong LL, Huang Z, Li Y, Zhang B
Zhongguo Dang Dai Er Ke Za Zhi 2021 Oct 15;23(10):1033-1037. doi: 10.7499/j.issn.1008-8830.2107080. PMID: 34719419Free PMC Article
Clinical significance of D-dimer levels in refractory Mycoplasma pneumoniae pneumonia.
Huang X, Li D, Liu F, Zhao D, Zhu Y, Tang H
BMC Infect Dis 2021 Jan 6;21(1):14. doi: 10.1186/s12879-020-05700-5. PMID: 33407216Free PMC Article
Molecular and clinical characteristics of severe Mycoplasma pneumoniae pneumonia in children.
Yan C, Xue G, Zhao H, Feng Y, Li S, Cui J, Ni S, Sun H
Pediatr Pulmonol 2019 Jul;54(7):1012-1021. Epub 2019 May 22 doi: 10.1002/ppul.24327. PMID: 31119869

Recent systematic reviews

Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.
Huang W, Xu X, Zhao W, Cheng Q
J Immunol Res 2022;2022:9227838. Epub 2022 Jun 26 doi: 10.1155/2022/9227838. PMID: 35795531Free PMC Article
Combined therapy of Xiaoer Feire Kechuan oral liquid and azithromycin for mycoplasma Pneumoniae pneumonia in children: A systematic review & meta-analysis.
Peng Y, Chen Z, Li Y, Lu Q, Li H, Han Y, Sun D, Li X
Phytomedicine 2022 Feb;96:153899. Epub 2021 Dec 30 doi: 10.1016/j.phymed.2021.153899. PMID: 35026500
Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis.
Ahn JG, Cho HK, Li D, Choi M, Lee J, Eun BW, Jo DS, Park SE, Choi EH, Yang HJ, Kim KH
BMC Infect Dis 2021 Sep 25;21(1):1003. doi: 10.1186/s12879-021-06508-7. PMID: 34563128Free PMC Article
Shuanghuanglian oral preparations combined with azithromycin for treatment of Mycoplasma pneumoniae pneumonia in Asian children: A systematic review and meta-analysis of randomized controlled trials.
Peng Y, Chen Z, Li Y, Lu Q, Li H, Han Y, Sun D, Li X
PLoS One 2021;16(7):e0254405. Epub 2021 Jul 13 doi: 10.1371/journal.pone.0254405. PMID: 34255785Free PMC Article
The risk factors of children acquiring refractory mycoplasma pneumoniae pneumonia: A meta-analysis.
Gong H, Sun B, Chen Y, Chen H
Medicine (Baltimore) 2021 Mar 19;100(11):e24894. doi: 10.1097/MD.0000000000024894. PMID: 33725960Free PMC Article

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