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Mycoplasma pneumoniae pneumonia

MedGen UID:
19363
•Concept ID:
C0032302
•
Disease or Syndrome
Synonym: Mycoplasmal pneumonia
SNOMED CT: Eaton's agent pneumonia (46970008); Pneumonia caused by Mycoplasma pneumoniae (46970008); Primary atypical pneumonia caused by Mycoplasma pneumoniae (46970008); Mycoplasma pneumoniae pneumonia (46970008); Mycoplasmal pneumonia (46970008); Mycoplasma pneumonia (46970008); Endemic pneumonia (46970008)
 
Monarch Initiative: MONDO:0005867

Definition

Pneumonia caused by Mycoplasma pneumoniae. Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMycoplasma pneumoniae pneumonia

Professional guidelines

PubMed

Laboratory diagnosis and treatment of Mycoplasma pneumoniae infection in children: a review.
Gao L, Sun Y
Ann Med 2024 Dec;56(1):2386636. Epub 2024 Aug 3 doi: 10.1080/07853890.2024.2386636. PMID: 39097794Free PMC Article
Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia.
Ding G, Zhang X, Vinturache A, van Rossum AMC, Yin Y, Zhang Y
Eur J Pediatr 2024 Jul;183(7):3001-3011. Epub 2024 Apr 18 doi: 10.1007/s00431-024-05519-1. PMID: 38634891
Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article

Recent clinical studies

Etiology

Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia.
Ding G, Zhang X, Vinturache A, van Rossum AMC, Yin Y, Zhang Y
Eur J Pediatr 2024 Jul;183(7):3001-3011. Epub 2024 Apr 18 doi: 10.1007/s00431-024-05519-1. PMID: 38634891
Immune response plays a role in Mycoplasma pneumoniae pneumonia.
Zhu Y, Luo Y, Li L, Jiang X, Du Y, Wang J, Li H, Gu H, Li D, Tang H, Qin H, Xu C, Liu Y, Zhao D, Guo Y, Liu F
Front Immunol 2023;14:1189647. Epub 2023 May 26 doi: 10.3389/fimmu.2023.1189647. PMID: 37304280Free PMC Article
Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia.
Wang Y, Yu X, Liu F, Tian X, Quan S, Jiao A, Yang X, Zeng X, Jiao W, Qi H, Xu F, Li Q, Liu S, Xu B, Sun L, Shen A
Emerg Microbes Infect 2023 Dec;12(1):2202272. doi: 10.1080/22221751.2023.2202272. PMID: 37132354Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Lee H, Yun KW, Lee HJ, Choi EH
Expert Rev Anti Infect Ther 2018 Jan;16(1):23-34. Epub 2017 Dec 11 doi: 10.1080/14787210.2018.1414599. PMID: 29212389

Diagnosis

Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia.
Ding G, Zhang X, Vinturache A, van Rossum AMC, Yin Y, Zhang Y
Eur J Pediatr 2024 Jul;183(7):3001-3011. Epub 2024 Apr 18 doi: 10.1007/s00431-024-05519-1. PMID: 38634891
Clinical characteristics and serum inflammatory markers of community-acquired mycoplasma pneumonia in children.
Fan F, Lv J, Yang Q, Jiang F
Clin Respir J 2023 Jul;17(7):607-617. Epub 2023 May 4 doi: 10.1111/crj.13620. PMID: 37142438Free PMC Article
Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia.
Wang Y, Yu X, Liu F, Tian X, Quan S, Jiao A, Yang X, Zeng X, Jiao W, Qi H, Xu F, Li Q, Liu S, Xu B, Sun L, Shen A
Emerg Microbes Infect 2023 Dec;12(1):2202272. doi: 10.1080/22221751.2023.2202272. PMID: 37132354Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children.
Tsai TA, Tsai CK, Kuo KC, Yu HR
J Microbiol Immunol Infect 2021 Aug;54(4):557-565. Epub 2020 Oct 17 doi: 10.1016/j.jmii.2020.10.002. PMID: 33268306

Therapy

Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia.
Ding G, Zhang X, Vinturache A, van Rossum AMC, Yin Y, Zhang Y
Eur J Pediatr 2024 Jul;183(7):3001-3011. Epub 2024 Apr 18 doi: 10.1007/s00431-024-05519-1. PMID: 38634891
Mycoplasma pneumoniae triggers pneumonia epidemic in autumn and winter in Beijing: a multicentre, population-based epidemiological study between 2015 and 2020.
Wang X, Li M, Luo M, Luo Q, Kang L, Xie H, Wang Y, Yu X, Li A, Dong M, Huang F, Gong C
Emerg Microbes Infect 2022 Dec;11(1):1508-1517. doi: 10.1080/22221751.2022.2078228. PMID: 35582916Free PMC Article
Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia.
Li J, Luu LDW, Wang X, Cui X, Huang X, Fu J, Zhu X, Li Z, Wang Y, Tai J
Emerg Microbes Infect 2022 Dec;11(1):593-605. doi: 10.1080/22221751.2022.2036582. PMID: 35094669Free PMC Article
Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children.
Tsai TA, Tsai CK, Kuo KC, Yu HR
J Microbiol Immunol Infect 2021 Aug;54(4):557-565. Epub 2020 Oct 17 doi: 10.1016/j.jmii.2020.10.002. PMID: 33268306
Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children.
Lee H, Yun KW, Lee HJ, Choi EH
Expert Rev Anti Infect Ther 2018 Jan;16(1):23-34. Epub 2017 Dec 11 doi: 10.1080/14787210.2018.1414599. PMID: 29212389

Prognosis

Laboratory diagnosis and treatment of Mycoplasma pneumoniae infection in children: a review.
Gao L, Sun Y
Ann Med 2024 Dec;56(1):2386636. Epub 2024 Aug 3 doi: 10.1080/07853890.2024.2386636. PMID: 39097794Free PMC Article
Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia.
Ding G, Zhang X, Vinturache A, van Rossum AMC, Yin Y, Zhang Y
Eur J Pediatr 2024 Jul;183(7):3001-3011. Epub 2024 Apr 18 doi: 10.1007/s00431-024-05519-1. PMID: 38634891
Clinical characteristics and serum inflammatory markers of community-acquired mycoplasma pneumonia in children.
Fan F, Lv J, Yang Q, Jiang F
Clin Respir J 2023 Jul;17(7):607-617. Epub 2023 May 4 doi: 10.1111/crj.13620. PMID: 37142438Free PMC Article
Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.
Huang W, Xu X, Zhao W, Cheng Q
J Immunol Res 2022;2022:9227838. Epub 2022 Jun 26 doi: 10.1155/2022/9227838. PMID: 35795531Free PMC Article

Clinical prediction guides

Molecular epidemiology of Mycoplasma pneumoniae pneumonia in children, Wuhan, 2020-2022.
Xu M, Li Y, Shi Y, Liu H, Tong X, Ma L, Gao J, Du Q, Du H, Liu D, Lu X, Yan Y
BMC Microbiol 2024 Jan 17;24(1):23. doi: 10.1186/s12866-024-03180-0. PMID: 38229068Free PMC Article
Clinical characteristics and serum inflammatory markers of community-acquired mycoplasma pneumonia in children.
Fan F, Lv J, Yang Q, Jiang F
Clin Respir J 2023 Jul;17(7):607-617. Epub 2023 May 4 doi: 10.1111/crj.13620. PMID: 37142438Free PMC Article
Clinical features and "early" corticosteroid treatment outcome of pediatric mycoplasma pneumoniae pneumonia.
Liu J, He R, Zhang X, Zhao F, Liu L, Wang H, Zhao S
Front Cell Infect Microbiol 2023;13:1135228. Epub 2023 Apr 4 doi: 10.3389/fcimb.2023.1135228. PMID: 37082710Free PMC Article
Clinical features and risk factors of plastic bronchitis caused by refractory Mycoplasma pneumoniae pneumonia in children: a practical nomogram prediction model.
Zhang H, Yang J, Zhao W, Zhou J, He S, Shang Y, Cheng Q
Eur J Pediatr 2023 Mar;182(3):1239-1249. Epub 2023 Jan 12 doi: 10.1007/s00431-022-04761-9. PMID: 36633659Free PMC Article
Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.
Huang W, Xu X, Zhao W, Cheng Q
J Immunol Res 2022;2022:9227838. Epub 2022 Jun 26 doi: 10.1155/2022/9227838. PMID: 35795531Free PMC Article

Recent systematic reviews

Azithromycin sequential therapy plus inhaled terbutaline for Mycoplasma Pneumoniae pneumonia in children: a systematic review and meta-analysis.
Sheng Y, Liang Y, Zhao C, Kang D, Liu X
BMC Infect Dis 2024 Jun 28;24(1):653. doi: 10.1186/s12879-024-09564-x. PMID: 38944667Free PMC Article
Cytokines and refractory mycoplasma pneumoniae pneumonia in children: a systematic review.
Yu M, Zhang Q, Yan H
Minerva Pediatr (Torino) 2024 Apr;76(2):259-267. Epub 2023 May 8 doi: 10.23736/S2724-5276.23.07158-6. PMID: 37155205
Refractory Mycoplasma Pneumonia in Children: A Systematic Review and Meta-analysis of Laboratory Features and Predictors.
Huang W, Xu X, Zhao W, Cheng Q
J Immunol Res 2022;2022:9227838. Epub 2022 Jun 26 doi: 10.1155/2022/9227838. PMID: 35795531Free PMC Article
Combined therapy of Xiaoer Feire Kechuan oral liquid and azithromycin for mycoplasma Pneumoniae pneumonia in children: A systematic review & meta-analysis.
Peng Y, Chen Z, Li Y, Lu Q, Li H, Han Y, Sun D, Li X
Phytomedicine 2022 Feb;96:153899. Epub 2021 Dec 30 doi: 10.1016/j.phymed.2021.153899. PMID: 35026500
Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis.
Ahn JG, Cho HK, Li D, Choi M, Lee J, Eun BW, Jo DS, Park SE, Choi EH, Yang HJ, Kim KH
BMC Infect Dis 2021 Sep 25;21(1):1003. doi: 10.1186/s12879-021-06508-7. PMID: 34563128Free PMC Article

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