U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rubral tremor

MedGen UID:
196693
•Concept ID:
C0750940
•
Disease or Syndrome
Synonyms: Rubral Tremor; Rubral Tremors; Tremor, Rubral; Tremors, Rubral
SNOMED CT: Rubral tremor (350561000119109)
 
HPO: HP:0030665

Definition

Rubral tremor is characterized by a slow coarse tremor at rest that is exacerbated by postural adjustments and by guided voluntary movements. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRubral tremor

Professional guidelines

PubMed

Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making.
Hey G, Hu W, Wong J, Tsuboi T, Burns MR, Ramirez-Zamora A
Tremor Other Hyperkinet Mov (N Y) 2022;12:18. Epub 2022 May 26 doi: 10.5334/tohm.683. PMID: 35651920Free PMC Article
Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.
Wang KL, Wong JK, Eisinger RS, Carbunaru S, Smith C, Hu W, Shukla AW, Hess CW, Okun MS, Ramirez-Zamora A
Neuromodulation 2022 Aug;25(6):796-803. Epub 2022 Feb 15 doi: 10.1111/ner.13220. PMID: 32578304
Deep brain stimulation for the treatment of uncommon tremor syndromes.
Ramirez-Zamora A, Okun MS
Expert Rev Neurother 2016 Aug;16(8):983-97. Epub 2016 Jun 9 doi: 10.1080/14737175.2016.1194756. PMID: 27228280Free PMC Article

Recent clinical studies

Etiology

Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.
Wang KL, Wong JK, Eisinger RS, Carbunaru S, Smith C, Hu W, Shukla AW, Hess CW, Okun MS, Ramirez-Zamora A
Neuromodulation 2022 Aug;25(6):796-803. Epub 2022 Feb 15 doi: 10.1111/ner.13220. PMID: 32578304
Holmes tremor in a monocentric series of resected brainstem cavernomas.
Del Gaudio N, Vaz G, Duprez T, Raftopoulos C
Neurochirurgie 2021 Jul;67(4):315-324. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.03.001. PMID: 33753127
Radiofrequency Ablation of Prelemniscal Radiations for the Treatment of Non-Parkinsonian Tremor.
Navarro-Olvera JL, Diaz-Martinez JA, Covaleda-Rodriguez JC, Carrillo-Ruiz JD, Soto-Abraham JE, Aguado-Carrillo G, Velasco-Campos F
Stereotact Funct Neurosurg 2020;98(3):160-166. Epub 2020 Apr 27 doi: 10.1159/000505699. PMID: 32340019
Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients.
Xu SS, Alexander PK, Lie Y, Dore V, Bozinovski S, Mulligan RS, Young K, Villemagne VL, Rowe CC
BMJ Open 2018 Nov 15;8(11):e025533. doi: 10.1136/bmjopen-2018-025533. PMID: 30446576Free PMC Article
Spinocerebellar degenerations.
Perlman SL
Handb Clin Neurol 2011;100:113-40. doi: 10.1016/B978-0-444-52014-2.00006-9. PMID: 21496573

Diagnosis

Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making.
Hey G, Hu W, Wong J, Tsuboi T, Burns MR, Ramirez-Zamora A
Tremor Other Hyperkinet Mov (N Y) 2022;12:18. Epub 2022 May 26 doi: 10.5334/tohm.683. PMID: 35651920Free PMC Article
Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients.
Xu SS, Alexander PK, Lie Y, Dore V, Bozinovski S, Mulligan RS, Young K, Villemagne VL, Rowe CC
BMJ Open 2018 Nov 15;8(11):e025533. doi: 10.1136/bmjopen-2018-025533. PMID: 30446576Free PMC Article
Spinocerebellar degenerations.
Perlman SL
Handb Clin Neurol 2011;100:113-40. doi: 10.1016/B978-0-444-52014-2.00006-9. PMID: 21496573
Pathology of symptomatic tremors.
Vidailhet M, Jedynak CP, Pollak P, Agid Y
Mov Disord 1998;13 Suppl 3:49-54. doi: 10.1002/mds.870131309. PMID: 9827595
Clinical neurophysiology of tremor.
Deuschl G, Krack P, Lauk M, Timmer J
J Clin Neurophysiol 1996 Mar;13(2):110-21. doi: 10.1097/00004691-199603000-00002. PMID: 8849966

Therapy

Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.
Wang KL, Wong JK, Eisinger RS, Carbunaru S, Smith C, Hu W, Shukla AW, Hess CW, Okun MS, Ramirez-Zamora A
Neuromodulation 2022 Aug;25(6):796-803. Epub 2022 Feb 15 doi: 10.1111/ner.13220. PMID: 32578304
Holmes tremor in a monocentric series of resected brainstem cavernomas.
Del Gaudio N, Vaz G, Duprez T, Raftopoulos C
Neurochirurgie 2021 Jul;67(4):315-324. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.03.001. PMID: 33753127
Functional lesional neurosurgery for tremor: a systematic review and meta-analysis.
Schreglmann SR, Krauss JK, Chang JW, Bhatia KP, Kägi G
J Neurol Neurosurg Psychiatry 2018 Jul;89(7):717-726. Epub 2018 Jan 11 doi: 10.1136/jnnp-2017-316302. PMID: 29326290
Functional lesional neurosurgery for tremor-a protocol for a systematic review and meta-analysis.
Schreglmann SR, Krauss JK, Chang JW, Bhatia KP, Kägi G
BMJ Open 2017 May 9;7(5):e015409. doi: 10.1136/bmjopen-2016-015409. PMID: 28487460Free PMC Article
Rubral tremor: clinical features and treatment of three cases.
Berkovic SF, Bladin PF
Clin Exp Neurol 1984;20:119-28. PMID: 6568936

Prognosis

Prevalence and Clinical Types of Tremor in Multiple Sclerosis and its Associated Disability: A Systematic Review.
Luitel P, Neupane N, Paudel S, Adhikari N, Timilsina B, Suryabanshi A, Gyawali P, Ojha R
Tremor Other Hyperkinet Mov (N Y) 2023;13:34. Epub 2023 Sep 13 doi: 10.5334/tohm.776. PMID: 37719089Free PMC Article
Long-Term Outcome and Neuroimaging of Deep Brain Stimulation in Holmes Tremor: A Case Series.
Bargiotas P, Nguyen TAK, Bracht T, Mürset M, Nowacki A, Debove I, Muellner J, Michelis JP, Pollo C, Schüpbach WMM, Lachenmayer ML
Neuromodulation 2021 Feb;24(2):392-399. Epub 2021 Jan 3 doi: 10.1111/ner.13352. PMID: 33389771
Vim stereotactic radiosurgical thalamotomy for drug-resistant idiopathic Holmes tremor: a case report.
Tripathi M, Mehta S, Singla R, Ahuja CK, Tandalya N, Tuleasca C, Batish A, Mohindra S, Agrahari A, Kaur R
Acta Neurochir (Wien) 2021 Jul;163(7):1867-1871. Epub 2020 Jul 17 doi: 10.1007/s00701-020-04489-1. PMID: 32676689
Radiofrequency Ablation of Prelemniscal Radiations for the Treatment of Non-Parkinsonian Tremor.
Navarro-Olvera JL, Diaz-Martinez JA, Covaleda-Rodriguez JC, Carrillo-Ruiz JD, Soto-Abraham JE, Aguado-Carrillo G, Velasco-Campos F
Stereotact Funct Neurosurg 2020;98(3):160-166. Epub 2020 Apr 27 doi: 10.1159/000505699. PMID: 32340019
Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients.
Xu SS, Alexander PK, Lie Y, Dore V, Bozinovski S, Mulligan RS, Young K, Villemagne VL, Rowe CC
BMJ Open 2018 Nov 15;8(11):e025533. doi: 10.1136/bmjopen-2018-025533. PMID: 30446576Free PMC Article

Clinical prediction guides

Prevalence and Clinical Types of Tremor in Multiple Sclerosis and its Associated Disability: A Systematic Review.
Luitel P, Neupane N, Paudel S, Adhikari N, Timilsina B, Suryabanshi A, Gyawali P, Ojha R
Tremor Other Hyperkinet Mov (N Y) 2023;13:34. Epub 2023 Sep 13 doi: 10.5334/tohm.776. PMID: 37719089Free PMC Article
Holmes tremor in a monocentric series of resected brainstem cavernomas.
Del Gaudio N, Vaz G, Duprez T, Raftopoulos C
Neurochirurgie 2021 Jul;67(4):315-324. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.03.001. PMID: 33753127
Long-Term Outcome and Neuroimaging of Deep Brain Stimulation in Holmes Tremor: A Case Series.
Bargiotas P, Nguyen TAK, Bracht T, Mürset M, Nowacki A, Debove I, Muellner J, Michelis JP, Pollo C, Schüpbach WMM, Lachenmayer ML
Neuromodulation 2021 Feb;24(2):392-399. Epub 2021 Jan 3 doi: 10.1111/ner.13352. PMID: 33389771
Vim stereotactic radiosurgical thalamotomy for drug-resistant idiopathic Holmes tremor: a case report.
Tripathi M, Mehta S, Singla R, Ahuja CK, Tandalya N, Tuleasca C, Batish A, Mohindra S, Agrahari A, Kaur R
Acta Neurochir (Wien) 2021 Jul;163(7):1867-1871. Epub 2020 Jul 17 doi: 10.1007/s00701-020-04489-1. PMID: 32676689
Rubral tremor: clinical features and treatment of three cases.
Berkovic SF, Bladin PF
Clin Exp Neurol 1984;20:119-28. PMID: 6568936

Recent systematic reviews

Prevalence and Clinical Types of Tremor in Multiple Sclerosis and its Associated Disability: A Systematic Review.
Luitel P, Neupane N, Paudel S, Adhikari N, Timilsina B, Suryabanshi A, Gyawali P, Ojha R
Tremor Other Hyperkinet Mov (N Y) 2023;13:34. Epub 2023 Sep 13 doi: 10.5334/tohm.776. PMID: 37719089Free PMC Article
Treatment-responsive Holmes tremor in a child with low-pressure hydrocephalus: video case report and systematic review of the literature.
Chang SJ, Mitchell R, Hukin J, Singhal A
J Neurosurg Pediatr 2022 May 1;29(5):520-527. Epub 2022 Feb 11 doi: 10.3171/2021.12.PEDS21539. PMID: 35148507
Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.
Wang KL, Wong JK, Eisinger RS, Carbunaru S, Smith C, Hu W, Shukla AW, Hess CW, Okun MS, Ramirez-Zamora A
Neuromodulation 2022 Aug;25(6):796-803. Epub 2022 Feb 15 doi: 10.1111/ner.13220. PMID: 32578304
Functional lesional neurosurgery for tremor: a systematic review and meta-analysis.
Schreglmann SR, Krauss JK, Chang JW, Bhatia KP, Kägi G
J Neurol Neurosurg Psychiatry 2018 Jul;89(7):717-726. Epub 2018 Jan 11 doi: 10.1136/jnnp-2017-316302. PMID: 29326290

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...