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Rubral tremor

MedGen UID:
196693
•Concept ID:
C0750940
•
Disease or Syndrome
Synonyms: Rubral Tremor; Rubral Tremors; Tremor, Rubral; Tremors, Rubral
SNOMED CT: Rubral tremor (350561000119109)
 
HPO: HP:0030665

Definition

Rubral tremor is characterized by a slow coarse tremor at rest that is exacerbated by postural adjustments and by guided voluntary movements. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRubral tremor

Professional guidelines

PubMed

Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making.
Hey G, Hu W, Wong J, Tsuboi T, Burns MR, Ramirez-Zamora A
Tremor Other Hyperkinet Mov (N Y) 2022;12:18. Epub 2022 May 26 doi: 10.5334/tohm.683. PMID: 35651920Free PMC Article
Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.
Wang KL, Wong JK, Eisinger RS, Carbunaru S, Smith C, Hu W, Shukla AW, Hess CW, Okun MS, Ramirez-Zamora A
Neuromodulation 2022 Aug;25(6):796-803. Epub 2022 Feb 15 doi: 10.1111/ner.13220. PMID: 32578304
Deep brain stimulation for the treatment of uncommon tremor syndromes.
Ramirez-Zamora A, Okun MS
Expert Rev Neurother 2016 Aug;16(8):983-97. Epub 2016 Jun 9 doi: 10.1080/14737175.2016.1194756. PMID: 27228280Free PMC Article

Recent clinical studies

Etiology

Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.
Wang KL, Wong JK, Eisinger RS, Carbunaru S, Smith C, Hu W, Shukla AW, Hess CW, Okun MS, Ramirez-Zamora A
Neuromodulation 2022 Aug;25(6):796-803. Epub 2022 Feb 15 doi: 10.1111/ner.13220. PMID: 32578304
Vim stereotactic radiosurgical thalamotomy for drug-resistant idiopathic Holmes tremor: a case report.
Tripathi M, Mehta S, Singla R, Ahuja CK, Tandalya N, Tuleasca C, Batish A, Mohindra S, Agrahari A, Kaur R
Acta Neurochir (Wien) 2021 Jul;163(7):1867-1871. Epub 2020 Jul 17 doi: 10.1007/s00701-020-04489-1. PMID: 32676689
Spinocerebellar degenerations.
Perlman SL
Handb Clin Neurol 2011;100:113-40. doi: 10.1016/B978-0-444-52014-2.00006-9. PMID: 21496573
"Rubral" tremor after cardiac catheterization: report of 2 cases.
Restrepo L, Quiroga-Chand A, Tomatore C, Balish M
Tex Heart Inst J 2005;32(3):427-9. PMID: 16392236Free PMC Article
Hyperekplexia exacerbated by occlusion of posterior thalamic arteries.
Fariello RG, Schwartzman RJ, Beall SS
Arch Neurol 1983 Apr;40(4):244-6. doi: 10.1001/archneur.1983.04050040074014. PMID: 6830475

Diagnosis

Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making.
Hey G, Hu W, Wong J, Tsuboi T, Burns MR, Ramirez-Zamora A
Tremor Other Hyperkinet Mov (N Y) 2022;12:18. Epub 2022 May 26 doi: 10.5334/tohm.683. PMID: 35651920Free PMC Article
Spinocerebellar degenerations.
Perlman SL
Handb Clin Neurol 2011;100:113-40. doi: 10.1016/B978-0-444-52014-2.00006-9. PMID: 21496573
Pathology of symptomatic tremors.
Vidailhet M, Jedynak CP, Pollak P, Agid Y
Mov Disord 1998;13 Suppl 3:49-54. doi: 10.1002/mds.870131309. PMID: 9827595
Clinical neurophysiology of tremor.
Deuschl G, Krack P, Lauk M, Timmer J
J Clin Neurophysiol 1996 Mar;13(2):110-21. doi: 10.1097/00004691-199603000-00002. PMID: 8849966
Brainstem toxoplasmosis in patients with acquired immunodeficiency syndrome.
Daras M, Koppel BS, Samkoff L, Marc J
J Neuroimaging 1994 Apr;4(2):85-90. doi: 10.1111/jon19944285. PMID: 8186535

Therapy

Vim stereotactic radiosurgical thalamotomy for drug-resistant idiopathic Holmes tremor: a case report.
Tripathi M, Mehta S, Singla R, Ahuja CK, Tandalya N, Tuleasca C, Batish A, Mohindra S, Agrahari A, Kaur R
Acta Neurochir (Wien) 2021 Jul;163(7):1867-1871. Epub 2020 Jul 17 doi: 10.1007/s00701-020-04489-1. PMID: 32676689
Functional lesional neurosurgery for tremor: a systematic review and meta-analysis.
Schreglmann SR, Krauss JK, Chang JW, Bhatia KP, Kägi G
J Neurol Neurosurg Psychiatry 2018 Jul;89(7):717-726. Epub 2018 Jan 11 doi: 10.1136/jnnp-2017-316302. PMID: 29326290
A case of chemotherapy-responsive paraneoplastic rubral tremor.
Kiriyama T, Hirano M, Kitauchi T, Saito K, Kataoka H, Ueno S
Clin Neurol Neurosurg 2011 Oct;113(8):693-5. Epub 2011 May 26 doi: 10.1016/j.clineuro.2011.04.011. PMID: 21616585
Benedikt's syndrome with delayed-onset rubral tremor and hemidystonia: a complication of tic douloureux surgery.
Fernandez HH, Friedman JH, Centofanti JV
Mov Disord 1999 Jul;14(4):695-7. doi: 10.1002/1531-8257(199907)14:4<695::aid-mds1024>3.0.co;2-3. PMID: 10435512
Posttraumatic rubral tremor responsive to clonazepam.
Jacob PC, Pratap Chand R
Mov Disord 1998 Nov;13(6):977-8. doi: 10.1002/mds.870130622. PMID: 9827628

Prognosis

Prevalence and Clinical Types of Tremor in Multiple Sclerosis and its Associated Disability: A Systematic Review.
Luitel P, Neupane N, Paudel S, Adhikari N, Timilsina B, Suryabanshi A, Gyawali P, Ojha R
Tremor Other Hyperkinet Mov (N Y) 2023;13:34. Epub 2023 Sep 13 doi: 10.5334/tohm.776. PMID: 37719089Free PMC Article
Vim stereotactic radiosurgical thalamotomy for drug-resistant idiopathic Holmes tremor: a case report.
Tripathi M, Mehta S, Singla R, Ahuja CK, Tandalya N, Tuleasca C, Batish A, Mohindra S, Agrahari A, Kaur R
Acta Neurochir (Wien) 2021 Jul;163(7):1867-1871. Epub 2020 Jul 17 doi: 10.1007/s00701-020-04489-1. PMID: 32676689
Radiofrequency Ablation of Prelemniscal Radiations for the Treatment of Non-Parkinsonian Tremor.
Navarro-Olvera JL, Diaz-Martinez JA, Covaleda-Rodriguez JC, Carrillo-Ruiz JD, Soto-Abraham JE, Aguado-Carrillo G, Velasco-Campos F
Stereotact Funct Neurosurg 2020;98(3):160-166. Epub 2020 Apr 27 doi: 10.1159/000505699. PMID: 32340019
"Rubral" tremor after cardiac catheterization: report of 2 cases.
Restrepo L, Quiroga-Chand A, Tomatore C, Balish M
Tex Heart Inst J 2005;32(3):427-9. PMID: 16392236Free PMC Article
Hyperekplexia exacerbated by occlusion of posterior thalamic arteries.
Fariello RG, Schwartzman RJ, Beall SS
Arch Neurol 1983 Apr;40(4):244-6. doi: 10.1001/archneur.1983.04050040074014. PMID: 6830475

Clinical prediction guides

Prevalence and Clinical Types of Tremor in Multiple Sclerosis and its Associated Disability: A Systematic Review.
Luitel P, Neupane N, Paudel S, Adhikari N, Timilsina B, Suryabanshi A, Gyawali P, Ojha R
Tremor Other Hyperkinet Mov (N Y) 2023;13:34. Epub 2023 Sep 13 doi: 10.5334/tohm.776. PMID: 37719089Free PMC Article
Holmes tremor in a monocentric series of resected brainstem cavernomas.
Del Gaudio N, Vaz G, Duprez T, Raftopoulos C
Neurochirurgie 2021 Jul;67(4):315-324. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.03.001. PMID: 33753127
Long-Term Outcome and Neuroimaging of Deep Brain Stimulation in Holmes Tremor: A Case Series.
Bargiotas P, Nguyen TAK, Bracht T, Mürset M, Nowacki A, Debove I, Muellner J, Michelis JP, Pollo C, Schüpbach WMM, Lachenmayer ML
Neuromodulation 2021 Feb;24(2):392-399. Epub 2021 Jan 3 doi: 10.1111/ner.13352. PMID: 33389771
Vim stereotactic radiosurgical thalamotomy for drug-resistant idiopathic Holmes tremor: a case report.
Tripathi M, Mehta S, Singla R, Ahuja CK, Tandalya N, Tuleasca C, Batish A, Mohindra S, Agrahari A, Kaur R
Acta Neurochir (Wien) 2021 Jul;163(7):1867-1871. Epub 2020 Jul 17 doi: 10.1007/s00701-020-04489-1. PMID: 32676689
Rubral tremor: clinical features and treatment of three cases.
Berkovic SF, Bladin PF
Clin Exp Neurol 1984;20:119-28. PMID: 6568936

Recent systematic reviews

Prevalence and Clinical Types of Tremor in Multiple Sclerosis and its Associated Disability: A Systematic Review.
Luitel P, Neupane N, Paudel S, Adhikari N, Timilsina B, Suryabanshi A, Gyawali P, Ojha R
Tremor Other Hyperkinet Mov (N Y) 2023;13:34. Epub 2023 Sep 13 doi: 10.5334/tohm.776. PMID: 37719089Free PMC Article
Treatment-responsive Holmes tremor in a child with low-pressure hydrocephalus: video case report and systematic review of the literature.
Chang SJ, Mitchell R, Hukin J, Singhal A
J Neurosurg Pediatr 2022 May 1;29(5):520-527. Epub 2022 Feb 11 doi: 10.3171/2021.12.PEDS21539. PMID: 35148507
Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review.
Wang KL, Wong JK, Eisinger RS, Carbunaru S, Smith C, Hu W, Shukla AW, Hess CW, Okun MS, Ramirez-Zamora A
Neuromodulation 2022 Aug;25(6):796-803. Epub 2022 Feb 15 doi: 10.1111/ner.13220. PMID: 32578304
Functional lesional neurosurgery for tremor: a systematic review and meta-analysis.
Schreglmann SR, Krauss JK, Chang JW, Bhatia KP, Kägi G
J Neurol Neurosurg Psychiatry 2018 Jul;89(7):717-726. Epub 2018 Jan 11 doi: 10.1136/jnnp-2017-316302. PMID: 29326290

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