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Short bowel syndrome

MedGen UID:
19966
•Concept ID:
C0036992
•
Disease or Syndrome
Synonyms: Bowel Syndrome, Short; Bowel Syndromes, Short; Short Bowel Syndrome; Short Bowel Syndromes; Syndrome, Short Bowel; Syndromes, Short Bowel
SNOMED CT: Acquired short bowel syndrome (235724004); Post-resection short bowel syndrome (235724004); Short bowel syndrome (26629001); SGS - Short gut syndrome (26629001); Short intestine syndrome (26629001); SBS - Short bowel syndrome (26629001); Short gut syndrome (26629001)
 
Monarch Initiative: MONDO:0015183
Orphanet: ORPHA104008

Definition

An intestinal failure due to either a congenital defect, intestinal infarction or extensive surgical resection of the intestinal tract that results in a functional small intestine of less than 200cm in length and is characterized by diarrhea, nutrient malabsorption, bowel dilation and dysmobility. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShort bowel syndrome
Follow this link to review classifications for Short bowel syndrome in Orphanet.

Professional guidelines

PubMed

Nutritional Management of Short Bowel Syndrome.
Premkumar MH, Soraisham A, Bagga N, Massieu LA, Maheshwari A
Clin Perinatol 2022 Jun;49(2):557-572. Epub 2022 Apr 21 doi: 10.1016/j.clp.2022.02.016. PMID: 35659103
Medical and surgical management of short bowel syndrome.
Billiauws L, Maggiori L, Joly F, Panis Y
J Visc Surg 2018 Sep;155(4):283-291. Epub 2018 Jul 21 doi: 10.1016/j.jviscsurg.2017.12.012. PMID: 30041905
Current treatment paradigms in pediatric short bowel syndrome.
Chandra R, Kesavan A
Clin J Gastroenterol 2018 Apr;11(2):103-112. Epub 2017 Dec 26 doi: 10.1007/s12328-017-0811-7. PMID: 29280097

Recent clinical studies

Etiology

Management of pediatric intestinal failure related to short bowel syndrome.
Belza C, Wales PW
Semin Pediatr Surg 2022 Jun;31(3):151175. Epub 2022 May 14 doi: 10.1016/j.sempedsurg.2022.151175. PMID: 35725052
Short Bowel Syndrome in Adults.
Bering J, DiBaise JK
Am J Gastroenterol 2022 Jun 1;117(6):876-883. Epub 2022 Apr 5 doi: 10.14309/ajg.0000000000001763. PMID: 35383576
Short bowel syndrome in children and adults: from rehabilitation to transplantation.
Lauro A, Lacaille F
Expert Rev Gastroenterol Hepatol 2019 Jan;13(1):55-70. Epub 2018 Oct 31 doi: 10.1080/17474124.2019.1541736. PMID: 30791840
Medical and surgical management of short bowel syndrome.
Billiauws L, Maggiori L, Joly F, Panis Y
J Visc Surg 2018 Sep;155(4):283-291. Epub 2018 Jul 21 doi: 10.1016/j.jviscsurg.2017.12.012. PMID: 30041905
Parenteral Nutrition and Intestinal Failure.
Bielawska B, Allard JP
Nutrients 2017 May 6;9(5) doi: 10.3390/nu9050466. PMID: 28481229Free PMC Article

Diagnosis

Chronic intestinal failure and short bowel syndrome in Crohn's disease.
Aksan A, Farrag K, Blumenstein I, Schröder O, Dignass AU, Stein J
World J Gastroenterol 2021 Jun 28;27(24):3440-3465. doi: 10.3748/wjg.v27.i24.3440. PMID: 34239262Free PMC Article
D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection.
Pohanka M
Biomed Res Int 2020;2020:3419034. Epub 2020 Jun 17 doi: 10.1155/2020/3419034. PMID: 32685468Free PMC Article
Necrotizing Enterocolitis: Long Term Complications.
Bazacliu C, Neu J
Curr Pediatr Rev 2019;15(2):115-124. doi: 10.2174/1573396315666190312093119. PMID: 30864508
Malabsorption Syndromes.
Clark R, Johnson R
Nurs Clin North Am 2018 Sep;53(3):361-374. Epub 2018 Jul 11 doi: 10.1016/j.cnur.2018.05.001. PMID: 30100002
Medical and surgical management of short bowel syndrome.
Billiauws L, Maggiori L, Joly F, Panis Y
J Visc Surg 2018 Sep;155(4):283-291. Epub 2018 Jul 21 doi: 10.1016/j.jviscsurg.2017.12.012. PMID: 30041905

Therapy

Teduglutide for pediatric short bowel syndrome patients.
Rosete BE, Wendel D, Horslen SP
Expert Rev Gastroenterol Hepatol 2021 Jul;15(7):727-733. Epub 2021 Apr 26 doi: 10.1080/17474124.2021.1913052. PMID: 33798402
Understanding short bowel syndrome: Current status and future perspectives.
Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M
Dig Liver Dis 2020 Mar;52(3):253-261. Epub 2019 Dec 28 doi: 10.1016/j.dld.2019.11.013. PMID: 31892505
Short bowel syndrome in children and adults: from rehabilitation to transplantation.
Lauro A, Lacaille F
Expert Rev Gastroenterol Hepatol 2019 Jan;13(1):55-70. Epub 2018 Oct 31 doi: 10.1080/17474124.2019.1541736. PMID: 30791840
Medical and surgical management of short bowel syndrome.
Billiauws L, Maggiori L, Joly F, Panis Y
J Visc Surg 2018 Sep;155(4):283-291. Epub 2018 Jul 21 doi: 10.1016/j.jviscsurg.2017.12.012. PMID: 30041905
Current treatment paradigms in pediatric short bowel syndrome.
Chandra R, Kesavan A
Clin J Gastroenterol 2018 Apr;11(2):103-112. Epub 2017 Dec 26 doi: 10.1007/s12328-017-0811-7. PMID: 29280097

Prognosis

Short Bowel Syndrome in Adults.
Bering J, DiBaise JK
Am J Gastroenterol 2022 Jun 1;117(6):876-883. Epub 2022 Apr 5 doi: 10.14309/ajg.0000000000001763. PMID: 35383576
An overview of the current management of short-bowel syndrome in pediatric patients.
Muto M, Kaji T, Onishi S, Yano K, Yamada W, Ieiri S
Surg Today 2022 Jan;52(1):12-21. Epub 2021 Jan 19 doi: 10.1007/s00595-020-02207-z. PMID: 33464414
Short bowel syndrome in children and adults: from rehabilitation to transplantation.
Lauro A, Lacaille F
Expert Rev Gastroenterol Hepatol 2019 Jan;13(1):55-70. Epub 2018 Oct 31 doi: 10.1080/17474124.2019.1541736. PMID: 30791840
Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.
Rao SSC, Rehman A, Yu S, Andino NM
Clin Transl Gastroenterol 2018 Jun 19;9(6):162. doi: 10.1038/s41424-018-0030-7. PMID: 29915215Free PMC Article
Management and Complications of Short Bowel Syndrome: an Updated Review.
Carroll RE, Benedetti E, Schowalter JP, Buchman AL
Curr Gastroenterol Rep 2016 Jul;18(7):40. doi: 10.1007/s11894-016-0511-3. PMID: 27324885

Clinical prediction guides

Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis.
Bioletto F, D'Eusebio C, Merlo FD, Aimasso U, Ossola M, Pellegrini M, Ponzo V, Chiarotto A, De Francesco A, Ghigo E, Bo S
Nutrients 2022 Feb 14;14(4) doi: 10.3390/nu14040796. PMID: 35215445Free PMC Article
Gastroschisis: a systematic review of diagnosis, prognosis and treatment.
Ferreira RG, Mendonça CR, Gonçalves Ramos LL, de Abreu Tacon FS, Naves do Amaral W, Ruano R
J Matern Fetal Neonatal Med 2022 Dec;35(25):6199-6212. Epub 2021 Apr 25 doi: 10.1080/14767058.2021.1909563. PMID: 33899664
Changes of Drug Pharmacokinetics in Patients with Short Bowel Syndrome: A Systematic Review.
Hong WB, Tan WK, Law LS, Ong DE, Lo EA
Eur J Drug Metab Pharmacokinet 2021 Jul;46(4):465-478. Epub 2021 Jul 1 doi: 10.1007/s13318-021-00696-y. PMID: 34196913
Mesenteric tumors: diagnosis and treatment.
Dufay C, Abdelli A, Le Pennec V, Chiche L
J Visc Surg 2012 Aug;149(4):e239-51. Epub 2012 Jul 15 doi: 10.1016/j.jviscsurg.2012.05.005. PMID: 22796300
Short bowel syndrome.
Wilmore DW, Robinson MK
World J Surg 2000 Dec;24(12):1486-92. doi: 10.1007/s002680010266. PMID: 11193712

Recent systematic reviews

Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis.
Bioletto F, D'Eusebio C, Merlo FD, Aimasso U, Ossola M, Pellegrini M, Ponzo V, Chiarotto A, De Francesco A, Ghigo E, Bo S
Nutrients 2022 Feb 14;14(4) doi: 10.3390/nu14040796. PMID: 35215445Free PMC Article
Gastroschisis: a systematic review of diagnosis, prognosis and treatment.
Ferreira RG, Mendonça CR, Gonçalves Ramos LL, de Abreu Tacon FS, Naves do Amaral W, Ruano R
J Matern Fetal Neonatal Med 2022 Dec;35(25):6199-6212. Epub 2021 Apr 25 doi: 10.1080/14767058.2021.1909563. PMID: 33899664
Changes of Drug Pharmacokinetics in Patients with Short Bowel Syndrome: A Systematic Review.
Hong WB, Tan WK, Law LS, Ong DE, Lo EA
Eur J Drug Metab Pharmacokinet 2021 Jul;46(4):465-478. Epub 2021 Jul 1 doi: 10.1007/s13318-021-00696-y. PMID: 34196913
Selecting End Points for Disease-Modification Trials in Inflammatory Bowel Disease: the SPIRIT Consensus From the IOIBD.
Le Berre C, Peyrin-Biroulet L; SPIRIT-IOIBD study group
Gastroenterology 2021 Apr;160(5):1452-1460.e21. Epub 2021 Jan 6 doi: 10.1053/j.gastro.2020.10.065. PMID: 33421515
Role of probiotics in short bowel syndrome in infants and children--a systematic review.
Reddy VS, Patole SK, Rao S
Nutrients 2013 Mar 5;5(3):679-99. doi: 10.3390/nu5030679. PMID: 23462584Free PMC Article

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