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Short bowel syndrome

MedGen UID:
19966
•Concept ID:
C0036992
•
Disease or Syndrome
Synonyms: Bowel Syndrome, Short; Bowel Syndromes, Short; Short Bowel Syndrome; Short Bowel Syndromes; Syndrome, Short Bowel; Syndromes, Short Bowel
SNOMED CT: Acquired short bowel syndrome (235724004); Post-resection short bowel syndrome (235724004); Short bowel syndrome (26629001); SGS - Short gut syndrome (26629001); Short intestine syndrome (26629001); SBS - Short bowel syndrome (26629001); Short gut syndrome (26629001)
 
Monarch Initiative: MONDO:0015183
Orphanet: ORPHA104008

Definition

An intestinal failure due to either a congenital defect, intestinal infarction or extensive surgical resection of the intestinal tract that results in a functional small intestine of less than 200cm in length and is characterized by diarrhea, nutrient malabsorption, bowel dilation and dysmobility. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVShort bowel syndrome
Follow this link to review classifications for Short bowel syndrome in Orphanet.

Professional guidelines

PubMed

Short bowel syndrome: Complications and management.
Bering J, DiBaise JK
Nutr Clin Pract 2023 May;38 Suppl 1:S46-S58. doi: 10.1002/ncp.10978. PMID: 37115034
Nutritional Management of Short Bowel Syndrome.
Premkumar MH, Soraisham A, Bagga N, Massieu LA, Maheshwari A
Clin Perinatol 2022 Jun;49(2):557-572. Epub 2022 Apr 21 doi: 10.1016/j.clp.2022.02.016. PMID: 35659103
Mesenteric tumors: diagnosis and treatment.
Dufay C, Abdelli A, Le Pennec V, Chiche L
J Visc Surg 2012 Aug;149(4):e239-51. Epub 2012 Jul 15 doi: 10.1016/j.jviscsurg.2012.05.005. PMID: 22796300

Recent clinical studies

Etiology

Short Bowel Syndrome and Dysmotility.
Premkumar MH
Clin Perinatol 2022 Jun;49(2):521-536. Epub 2022 Apr 21 doi: 10.1016/j.clp.2022.02.013. PMID: 35659101
Enterohormone therapy for short bowel syndrome.
Verbiest A, Wauters L, Vanuytsel T
Curr Opin Endocrinol Diabetes Obes 2022 Apr 1;29(2):207-218. doi: 10.1097/MED.0000000000000710. PMID: 35034035
Safety and Efficacy of Teduglutide in Pediatric Patients With Intestinal Failure due to Short Bowel Syndrome: A 24-Week, Phase III Study.
Kocoshis SA, Merritt RJ, Hill S, Protheroe S, Carter BA, Horslen S, Hu S, Kaufman SS, Mercer DF, Pakarinen MP, Venick RS, Wales PW, Grimm AA
JPEN J Parenter Enteral Nutr 2020 May;44(4):621-631. Epub 2019 Sep 8 doi: 10.1002/jpen.1690. PMID: 31495952Free PMC Article
Inflammatory Bowel Disease and Short Bowel Syndrome.
Fuglestad MA, Thompson JS
Surg Clin North Am 2019 Dec;99(6):1209-1221. Epub 2019 Sep 23 doi: 10.1016/j.suc.2019.08.010. PMID: 31676059
Medical and surgical management of short bowel syndrome.
Billiauws L, Maggiori L, Joly F, Panis Y
J Visc Surg 2018 Sep;155(4):283-291. Epub 2018 Jul 21 doi: 10.1016/j.jviscsurg.2017.12.012. PMID: 30041905

Diagnosis

Short bowel syndrome: Complications and management.
Bering J, DiBaise JK
Nutr Clin Pract 2023 May;38 Suppl 1:S46-S58. doi: 10.1002/ncp.10978. PMID: 37115034
Chronic intestinal failure and short bowel syndrome in Crohn's disease.
Aksan A, Farrag K, Blumenstein I, Schröder O, Dignass AU, Stein J
World J Gastroenterol 2021 Jun 28;27(24):3440-3465. doi: 10.3748/wjg.v27.i24.3440. PMID: 34239262Free PMC Article
Necrotizing Enterocolitis: Long Term Complications.
Bazacliu C, Neu J
Curr Pediatr Rev 2019;15(2):115-124. doi: 10.2174/1573396315666190312093119. PMID: 30864508
Malabsorption Syndromes.
Clark R, Johnson R
Nurs Clin North Am 2018 Sep;53(3):361-374. Epub 2018 Jul 11 doi: 10.1016/j.cnur.2018.05.001. PMID: 30100002
Medical and surgical management of short bowel syndrome.
Billiauws L, Maggiori L, Joly F, Panis Y
J Visc Surg 2018 Sep;155(4):283-291. Epub 2018 Jul 21 doi: 10.1016/j.jviscsurg.2017.12.012. PMID: 30041905

Therapy

An Overview of Short-Bowel Syndrome in Pediatric Patients: Focus on Clinical Management and Prevention of Complications.
Caporilli C, Giannì G, Grassi F, Esposito S
Nutrients 2023 May 17;15(10) doi: 10.3390/nu15102341. PMID: 37242224Free PMC Article
Short bowel syndrome: Complications and management.
Bering J, DiBaise JK
Nutr Clin Pract 2023 May;38 Suppl 1:S46-S58. doi: 10.1002/ncp.10978. PMID: 37115034
Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis.
Bioletto F, D'Eusebio C, Merlo FD, Aimasso U, Ossola M, Pellegrini M, Ponzo V, Chiarotto A, De Francesco A, Ghigo E, Bo S
Nutrients 2022 Feb 14;14(4) doi: 10.3390/nu14040796. PMID: 35215445Free PMC Article
Understanding short bowel syndrome: Current status and future perspectives.
Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M
Dig Liver Dis 2020 Mar;52(3):253-261. Epub 2019 Dec 28 doi: 10.1016/j.dld.2019.11.013. PMID: 31892505
Medical and surgical management of short bowel syndrome.
Billiauws L, Maggiori L, Joly F, Panis Y
J Visc Surg 2018 Sep;155(4):283-291. Epub 2018 Jul 21 doi: 10.1016/j.jviscsurg.2017.12.012. PMID: 30041905

Prognosis

Current short bowel syndrome management: An era of improved outcomes and continued challenges.
Jaksic T
J Pediatr Surg 2023 May;58(5):789-798. Epub 2023 Jan 20 doi: 10.1016/j.jpedsurg.2023.01.011. PMID: 36870826
Etiology and prognosis of pediatric short bowel syndrome.
Mutanen A, Wales PW
Semin Pediatr Surg 2018 Aug;27(4):209-217. Epub 2018 Jul 29 doi: 10.1053/j.sempedsurg.2018.07.009. PMID: 30342594
Starch Tolerance and the Short Bowel.
de Laffolie J, Naim HY, Rudloff S, Zimmer KP
J Pediatr Gastroenterol Nutr 2018 Jun;66 Suppl 3:S68-S71. doi: 10.1097/MPG.0000000000001962. PMID: 29762383
Short bowel syndrome.
Donohoe CL, Reynolds JV
Surgeon 2010 Oct;8(5):270-9. doi: 10.1016/j.surge.2010.06.004. PMID: 20709285
Short bowel syndrome.
Vanderhoof JA, Langnas AN, Pinch LW, Thompson JS, Kaufman SS
J Pediatr Gastroenterol Nutr 1992 May;14(4):359-70. doi: 10.1097/00005176-199205000-00001. PMID: 1517941

Clinical prediction guides

AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert Review.
Hashash JG, Elkins J, Lewis JD, Binion DG
Gastroenterology 2024 Mar;166(3):521-532. Epub 2024 Jan 23 doi: 10.1053/j.gastro.2023.11.303. PMID: 38276922
Clinical management of high-output stoma: a systematic literature review and meta-analysis.
Lederhuber H, Massey LH, Kantola VE, Siddiqui MRS, Sayers AE, McDermott FD, Daniels IR, Smart NJ
Tech Coloproctol 2023 Dec;27(12):1139-1154. Epub 2023 Jun 18 doi: 10.1007/s10151-023-02830-1. PMID: 37330988
Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis.
Bioletto F, D'Eusebio C, Merlo FD, Aimasso U, Ossola M, Pellegrini M, Ponzo V, Chiarotto A, De Francesco A, Ghigo E, Bo S
Nutrients 2022 Feb 14;14(4) doi: 10.3390/nu14040796. PMID: 35215445Free PMC Article
Changes of Drug Pharmacokinetics in Patients with Short Bowel Syndrome: A Systematic Review.
Hong WB, Tan WK, Law LS, Ong DE, Lo EA
Eur J Drug Metab Pharmacokinet 2021 Jul;46(4):465-478. Epub 2021 Jul 1 doi: 10.1007/s13318-021-00696-y. PMID: 34196913
Mesenteric tumors: diagnosis and treatment.
Dufay C, Abdelli A, Le Pennec V, Chiche L
J Visc Surg 2012 Aug;149(4):e239-51. Epub 2012 Jul 15 doi: 10.1016/j.jviscsurg.2012.05.005. PMID: 22796300

Recent systematic reviews

Clinical management of high-output stoma: a systematic literature review and meta-analysis.
Lederhuber H, Massey LH, Kantola VE, Siddiqui MRS, Sayers AE, McDermott FD, Daniels IR, Smart NJ
Tech Coloproctol 2023 Dec;27(12):1139-1154. Epub 2023 Jun 18 doi: 10.1007/s10151-023-02830-1. PMID: 37330988
Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis.
Bioletto F, D'Eusebio C, Merlo FD, Aimasso U, Ossola M, Pellegrini M, Ponzo V, Chiarotto A, De Francesco A, Ghigo E, Bo S
Nutrients 2022 Feb 14;14(4) doi: 10.3390/nu14040796. PMID: 35215445Free PMC Article
Gastroschisis: a systematic review of diagnosis, prognosis and treatment.
Ferreira RG, Mendonça CR, Gonçalves Ramos LL, de Abreu Tacon FS, Naves do Amaral W, Ruano R
J Matern Fetal Neonatal Med 2022 Dec;35(25):6199-6212. Epub 2021 Apr 25 doi: 10.1080/14767058.2021.1909563. PMID: 33899664
Changes of Drug Pharmacokinetics in Patients with Short Bowel Syndrome: A Systematic Review.
Hong WB, Tan WK, Law LS, Ong DE, Lo EA
Eur J Drug Metab Pharmacokinet 2021 Jul;46(4):465-478. Epub 2021 Jul 1 doi: 10.1007/s13318-021-00696-y. PMID: 34196913
Selecting End Points for Disease-Modification Trials in Inflammatory Bowel Disease: the SPIRIT Consensus From the IOIBD.
Le Berre C, Peyrin-Biroulet L; SPIRIT-IOIBD study group
Gastroenterology 2021 Apr;160(5):1452-1460.e21. Epub 2021 Jan 6 doi: 10.1053/j.gastro.2020.10.065. PMID: 33421515

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