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Pill-rolling tremor

MedGen UID:
199684
Concept ID:
C0751564
Sign or Symptom
Synonyms: Pill Rolling Tremor; Pill Rolling Tremors; Tremor, Pill Rolling
SNOMED CT: Pill rolling (112108005)
 
HPO: HP:0025387

Definition

A type of resting tremor characterized by simultaneous rubbing movements of thumb and index fingers against each other. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPill-rolling tremor

Conditions with this feature

Autosomal recessive juvenile Parkinson disease 2
MedGen UID:
401500
Concept ID:
C1868675
Disease or Syndrome
Parkin type of early-onset Parkinson disease (PARK-Parkin) is characterized by the cardinal signs of Parkinson disease (PD): bradykinesia, resting tremor, and rigidity. The median age at onset is 31 years (range: 3-81 years). The disease is slowly progressive: disease duration of more than 50 years has been reported. Clinical findings vary; hyperreflexia is common. Lower-limb dystonia may be a presenting sign and cognitive decline appears to be no more frequent than in the general population. Dyskinesia as a result of treatment with levodopa frequently occurs.
Autosomal recessive Parkinson disease 14
MedGen UID:
414488
Concept ID:
C2751842
Disease or Syndrome
Generally, Parkinson's disease that begins after age 50 is called late-onset disease. The condition is described as early-onset disease if signs and symptoms begin before age 50. Early-onset cases that begin before age 20 are sometimes referred to as juvenile-onset Parkinson's disease.\n\nParkinson's disease can also affect emotions and thinking ability (cognition). Some affected individuals develop psychiatric conditions such as depression and visual hallucinations. People with Parkinson's disease also have an increased risk of developing dementia, which is a decline in intellectual functions including judgment and memory.\n\nOften the first symptom of Parkinson's disease is trembling or shaking (tremor) of a limb, especially when the body is at rest. Typically, the tremor begins on one side of the body, usually in one hand. Tremors can also affect the arms, legs, feet, and face. Other characteristic symptoms of Parkinson's disease include rigidity or stiffness of the limbs and torso, slow movement (bradykinesia) or an inability to move (akinesia), and impaired balance and coordination (postural instability). These symptoms worsen slowly over time.\n\nParkinson's disease is a progressive disorder of the nervous system. The disorder affects several regions of the brain, especially an area called the substantia nigra that controls balance and movement.
Juvenile onset Parkinson disease 19A
MedGen UID:
816141
Concept ID:
C3809811
Disease or Syndrome
DNAJC6 Parkinson disease is a complex early-onset neurologic disorder whose core features are typical parkinsonian symptoms including bradykinesia, resting tremor, rigidity, and postural instability. The majority of individuals have juvenile onset and develop symptoms before age 21 years. Developmental delay, intellectual disability, seizures, other movement disorders (e.g., dystonia, spasticity, myoclonus), and neuropsychiatric features occur in the majority of individuals with juvenile onset and often precede parkinsonism. The onset of parkinsonian features usually occurs toward the end of the first or beginning of the second decade and the disease course is rapidly progressive with loss of ambulation in mid-adolescence in the majority of individuals. Additional features include gastrointestinal manifestations and bulbar dysfunction. A minority of individuals with DNAJC6 Parkinson disease develop early-onset parkinsonism with symptom onset in the third to fourth decade and absence of additional neurologic features.

Professional guidelines

PubMed

Tater P, Pandey S
Neurol India 2021 Mar-Apr;69(2):272-283. doi: 10.4103/0028-3886.314574. PMID: 33904435
Armstrong MJ, Okun MS
JAMA 2020 Feb 11;323(6):548-560. doi: 10.1001/jama.2019.22360. PMID: 32044947
Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G
Mov Disord 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424. PMID: 26474316

Recent clinical studies

Etiology

Miki Y, Foti SC, Asi YT, Tsushima E, Quinn N, Ling H, Holton JL
Brain 2019 Sep 1;142(9):2813-2827. doi: 10.1093/brain/awz189. PMID: 31289815

Diagnosis

Du Y, Liu Y, Lu W, Zhang X, Wang A, Kong J
ACS Appl Mater Interfaces 2023 Nov 1;15(43):50413-50426. Epub 2023 Oct 19 doi: 10.1021/acsami.3c13815. PMID: 37857376
Miki Y, Foti SC, Asi YT, Tsushima E, Quinn N, Ling H, Holton JL
Brain 2019 Sep 1;142(9):2813-2827. doi: 10.1093/brain/awz189. PMID: 31289815
Salazar G, Valls-Solé J, Martí MJ, Chang H, Tolosa ES
Mov Disord 2000 Jan;15(1):77-83. doi: 10.1002/1531-8257(200001)15:1<77::aid-mds1013>3.0.co;2-n. PMID: 10634245

Clinical prediction guides

Sun H, Satake W, Zhang C, Nagai Y, Tian Y, Fu S, Yu J, Qian Y, Qian Y, Chu J, Toda T
J Hum Genet 2011 Apr;56(4):330-4. Epub 2011 Feb 10 doi: 10.1038/jhg.2011.14. PMID: 21307863
Salazar G, Valls-Solé J, Martí MJ, Chang H, Tolosa ES
Mov Disord 2000 Jan;15(1):77-83. doi: 10.1002/1531-8257(200001)15:1<77::aid-mds1013>3.0.co;2-n. PMID: 10634245

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