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Brain hypoxia - ischemia

MedGen UID:
199862
•Concept ID:
C0752308
•
Disease or Syndrome
Synonyms: Brain Hypoxia Ischemia; Brain Hypoxia-Ischemia; Brain Hypoxia-Ischemias; Brain Ischemia Hypoxia; Brain Ischemia-Hypoxia; Brain Ischemia-Hypoxias; Hypoxia Ischemia, Brain; Hypoxia-Ischemia, Brain; Hypoxia-Ischemias, Brain; Ischemia Hypoxia, Brain; Ischemia-Hypoxia, Brain; Ischemia-Hypoxias, Brain
 
Monarch Initiative: MONDO:0006685

Definition

A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ischemia) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrain hypoxia - ischemia

Professional guidelines

PubMed

Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society.
Hirsch KG, Abella BS, Amorim E, Bader MK, Barletta JF, Berg K, Callaway CW, Friberg H, Gilmore EJ, Greer DM, Kern KB, Livesay S, May TL, Neumar RW, Nolan JP, Oddo M, Peberdy MA, Poloyac SM, Seder D, Taccone FS, Uzendu A, Walsh B, Zimmerman JL, Geocadin RG; American Heart Association, Neurocritical Care Society
Neurocrit Care 2024 Feb;40(1):1-37. Epub 2023 Dec 1 doi: 10.1007/s12028-023-01871-6. PMID: 38040992Free PMC Article
Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society.
Hirsch KG, Abella BS, Amorim E, Bader MK, Barletta JF, Berg K, Callaway CW, Friberg H, Gilmore EJ, Greer DM, Kern KB, Livesay S, May TL, Neumar RW, Nolan JP, Oddo M, Peberdy MA, Poloyac SM, Seder D, Taccone FS, Uzendu A, Walsh B, Zimmerman JL, Geocadin RG; American Heart Association and Neurocritical Care Society
Circulation 2024 Jan 9;149(2):e168-e200. Epub 2023 Nov 28 doi: 10.1161/CIR.0000000000001163. PMID: 38014539Free PMC Article
Technical Update No. 429: Maternal Heart Rate Artefact During Intrapartum Fetal Health Surveillance.
Kiely DJ, Hobson S, Tyndall K, Oppenheimer L
J Obstet Gynaecol Can 2022 Sep;44(9):1016-1027.e1. doi: 10.1016/j.jogc.2022.06.002. PMID: 36109100

Recent clinical studies

Etiology

Retinal hemorrhage variation in inertial versus contact head injuries.
Sokoloff M, Feldman KW, Levin AV, Rockter A, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Hymel KP; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2024 Mar;149:106606. Epub 2023 Dec 21 doi: 10.1016/j.chiabu.2023.106606. PMID: 38134727
The fetal scalp electrode shortage is an urgent patient safety issue.
Kiely DJ, Oppenheimer LW
Am J Obstet Gynecol MFM 2023 Aug;5(8):101021. Epub 2023 May 17 doi: 10.1016/j.ajogmf.2023.101021. PMID: 37201795
Pregnancy as a valuable period for preventing hypoxia-ischemia brain damage.
Netto CA, Sanches EF, Odorcyk F, Duran-Carabali LE, Sizonenko SV
Int J Dev Neurosci 2018 Nov;70:12-24. Epub 2018 Jun 18 doi: 10.1016/j.ijdevneu.2018.06.004. PMID: 29920306
Proteomic Analysis of Mouse Cortex Postsynaptic Density following Neonatal Brain Hypoxia-Ischemia.
Shao G, Wang Y, Guan S, Burlingame AL, Lu F, Knox R, Ferriero DM, Jiang X
Dev Neurosci 2017;39(1-4):66-81. Epub 2017 Mar 18 doi: 10.1159/000456030. PMID: 28315865Free PMC Article
Hypothermia for perinatal brain hypoxia-ischemia in different resource settings: a systematic review.
Galvao TF, Silva MT, Marques MC, de Oliveira ND, Pereira MG
J Trop Pediatr 2013 Dec;59(6):453-9. Epub 2013 Jun 18 doi: 10.1093/tropej/fmt047. PMID: 23780995

Diagnosis

Retinal hemorrhage variation in inertial versus contact head injuries.
Sokoloff M, Feldman KW, Levin AV, Rockter A, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Hymel KP; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2024 Mar;149:106606. Epub 2023 Dec 21 doi: 10.1016/j.chiabu.2023.106606. PMID: 38134727
An analysis of physicians' diagnostic reasoning regarding pediatric abusive head trauma.
Hymel KP, Boos SC, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Even K, Wang M; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2022 Jul;129:105666. Epub 2022 May 11 doi: 10.1016/j.chiabu.2022.105666. PMID: 35567958Free PMC Article
Neurodevelopmental effect of intracranial hemorrhage observed in hypoxic ischemic brain injury in hypothermia-treated asphyxiated neonates - an MRI study.
Lakatos A, Kolossváry M, Szabó M, Jermendy Á, Barta H, Gyebnár G, Rudas G, Kozák LR
BMC Pediatr 2019 Nov 12;19(1):430. doi: 10.1186/s12887-019-1777-z. PMID: 31718607Free PMC Article
Head injury depth as an indicator of causes and mechanisms.
Hymel KP, Stoiko MA, Herman BE, Combs A, Harper NS, Lowen D, Deye KP, Homa K, Blackman JA
Pediatrics 2010 Apr;125(4):712-20. Epub 2010 Mar 29 doi: 10.1542/peds.2009-2133. PMID: 20351004
Value of (1)H-MRS using different echo times in neonates with cerebral hypoxia-ischemia.
Roelants-Van Rijn AM, van der Grond J, de Vries LS, Groenendaal F
Pediatr Res 2001 Mar;49(3):356-62. doi: 10.1203/00006450-200103000-00009. PMID: 11228261

Therapy

Nitric oxide and the brain. Part 2: Effects following neonatal brain injury-friend or foe?
Angelis D, Savani R, Chalak L
Pediatr Res 2021 Mar;89(4):746-752. Epub 2020 Jun 20 doi: 10.1038/s41390-020-1021-4. PMID: 32563184
Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia.
Winerdal M, Urmaliya V, Winerdal ME, Fredholm BB, Winqvist O, Ådén U
PLoS One 2017;12(1):e0170545. Epub 2017 Jan 27 doi: 10.1371/journal.pone.0170545. PMID: 28129361Free PMC Article
Erythropoietin as a new therapeutic opportunity in brain inflammation and neurodegenerative diseases.
Merelli A, Czornyj L, Lazarowski A
Int J Neurosci 2015;125(11):793-7. Epub 2015 Jan 9 doi: 10.3109/00207454.2014.989321. PMID: 25405533
Neonatal therapeutic hypothermia-associated hypomagnesemia during parenteral nutrition therapy.
Tocco NM, Hodge AE, Jones AA, Wispe JR, Valentine CJ
Nutr Clin Pract 2014 Apr;29(2):246-8. Epub 2014 Feb 18 doi: 10.1177/0884533614522835. PMID: 24549013
Hypothermia for perinatal brain hypoxia-ischemia in different resource settings: a systematic review.
Galvao TF, Silva MT, Marques MC, de Oliveira ND, Pereira MG
J Trop Pediatr 2013 Dec;59(6):453-9. Epub 2013 Jun 18 doi: 10.1093/tropej/fmt047. PMID: 23780995

Prognosis

Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.
Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E
Dev Neurosci 2022;44(4-5):277-294. Epub 2022 May 19 doi: 10.1159/000525150. PMID: 35588703Free PMC Article
An analysis of physicians' diagnostic reasoning regarding pediatric abusive head trauma.
Hymel KP, Boos SC, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Even K, Wang M; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2022 Jul;129:105666. Epub 2022 May 11 doi: 10.1016/j.chiabu.2022.105666. PMID: 35567958Free PMC Article
Neurodevelopmental effect of intracranial hemorrhage observed in hypoxic ischemic brain injury in hypothermia-treated asphyxiated neonates - an MRI study.
Lakatos A, Kolossváry M, Szabó M, Jermendy Á, Barta H, Gyebnár G, Rudas G, Kozák LR
BMC Pediatr 2019 Nov 12;19(1):430. doi: 10.1186/s12887-019-1777-z. PMID: 31718607Free PMC Article
Methodical approach to brain hypoxia/ischemia as a fundamental problem in forensic neuropathology.
Oehmichen M, Meissner C, von Wurmb-Schwark N, Schwark T
Leg Med (Tokyo) 2003 Dec;5(4):190-201. doi: 10.1016/s1344-6223(03)00077-4. PMID: 14602162
Value of (1)H-MRS using different echo times in neonates with cerebral hypoxia-ischemia.
Roelants-Van Rijn AM, van der Grond J, de Vries LS, Groenendaal F
Pediatr Res 2001 Mar;49(3):356-62. doi: 10.1203/00006450-200103000-00009. PMID: 11228261

Clinical prediction guides

Differential Glial Chitotriosidase 1 and Chitinase 3-like Protein 1 Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia.
Yilmazer-Hanke D, Ouali Alami N, Fang L, Klotz S, Kovacs GG, Pankratz H, Weis J, Katona I, Scheuerle A, Streit WJ, Del Tredici K
Neuroscience 2022 Dec 1;506:91-113. Epub 2022 Nov 1 doi: 10.1016/j.neuroscience.2022.10.018. PMID: 36332693
Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.
Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E
Dev Neurosci 2022;44(4-5):277-294. Epub 2022 May 19 doi: 10.1159/000525150. PMID: 35588703Free PMC Article
An analysis of physicians' diagnostic reasoning regarding pediatric abusive head trauma.
Hymel KP, Boos SC, Armijo-Garcia V, Musick M, Weeks K, Haney SB, Marinello M, Herman BE, Frazier TN, Carroll CL, Even K, Wang M; Pediatric Brain Injury Research Network (PediBIRN) Investigators
Child Abuse Negl 2022 Jul;129:105666. Epub 2022 May 11 doi: 10.1016/j.chiabu.2022.105666. PMID: 35567958Free PMC Article
Cerebral Autoregulation and Conventional and Diffusion Tensor Imaging Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy.
Carrasco M, Perin J, Jennings JM, Parkinson C, Gilmore MM, Chavez-Valdez R, Massaro AN, Koehler RC, Northington FJ, Tekes A, Lee JK
Pediatr Neurol 2018 May;82:36-43. Epub 2018 Apr 2 doi: 10.1016/j.pediatrneurol.2018.02.004. PMID: 29622488Free PMC Article
Erythropoietin as a new therapeutic opportunity in brain inflammation and neurodegenerative diseases.
Merelli A, Czornyj L, Lazarowski A
Int J Neurosci 2015;125(11):793-7. Epub 2015 Jan 9 doi: 10.3109/00207454.2014.989321. PMID: 25405533

Recent systematic reviews

Hypothermia for perinatal brain hypoxia-ischemia in different resource settings: a systematic review.
Galvao TF, Silva MT, Marques MC, de Oliveira ND, Pereira MG
J Trop Pediatr 2013 Dec;59(6):453-9. Epub 2013 Jun 18 doi: 10.1093/tropej/fmt047. PMID: 23780995

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