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Hypoxia of brain

MedGen UID:
287140
•Concept ID:
C1527348
•
Pathologic Function
Synonyms: Brain Hypoxia; Cerebral Hypoxia; Hypoxia, Brain; Hypoxia, Cerebral
SNOMED CT: Hypoxia of brain (389088001); Cerebral hypoxia (389088001)

Definition

A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypoxia of brain

Professional guidelines

PubMed

A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).
Chesnut R, Aguilera S, Buki A, Bulger E, Citerio G, Cooper DJ, Arrastia RD, Diringer M, Figaji A, Gao G, Geocadin R, Ghajar J, Harris O, Hoffer A, Hutchinson P, Joseph M, Kitagawa R, Manley G, Mayer S, Menon DK, Meyfroidt G, Michael DB, Oddo M, Okonkwo D, Patel M, Robertson C, Rosenfeld JV, Rubiano AM, Sahuquillo J, Servadei F, Shutter L, Stein D, Stocchetti N, Taccone FS, Timmons S, Tsai E, Ullman JS, Vespa P, Videtta W, Wright DW, Zammit C, Hawryluk GWJ
Intensive Care Med 2020 May;46(5):919-929. Epub 2020 Jan 21 doi: 10.1007/s00134-019-05900-x. PMID: 31965267Free PMC Article
Medical management of compromised brain oxygen in patients with severe traumatic brain injury.
Bohman LE, Heuer GG, Macyszyn L, Maloney-Wilensky E, Frangos S, Le Roux PD, Kofke A, Levine JM, Stiefel MF
Neurocrit Care 2011 Jun;14(3):361-9. doi: 10.1007/s12028-011-9526-7. PMID: 21394543
Does adherence to treatment targets in children with severe traumatic brain injury avoid brain hypoxia? A brain tissue oxygenation study.
Figaji AA, Fieggen AG, Argent AC, Leroux PD, Peter JC
Neurosurgery 2008 Jul;63(1):83-91; discussion 91-2. doi: 10.1227/01.NEU.0000335074.39728.00. PMID: 18728572

Recent clinical studies

Etiology

Subtle brain abnormalities in children with sickle cell disease: relationship to blood hematocrit.
Steen RG, Xiong X, Mulhern RK, Langston JW, Wang WC
Ann Neurol 1999 Mar;45(3):279-86. doi: 10.1002/1531-8249(199903)45:3<279::aid-ana2>3.0.co;2-7. PMID: 10072041

Therapy

Subtle brain abnormalities in children with sickle cell disease: relationship to blood hematocrit.
Steen RG, Xiong X, Mulhern RK, Langston JW, Wang WC
Ann Neurol 1999 Mar;45(3):279-86. doi: 10.1002/1531-8249(199903)45:3<279::aid-ana2>3.0.co;2-7. PMID: 10072041

Clinical prediction guides

Subtle brain abnormalities in children with sickle cell disease: relationship to blood hematocrit.
Steen RG, Xiong X, Mulhern RK, Langston JW, Wang WC
Ann Neurol 1999 Mar;45(3):279-86. doi: 10.1002/1531-8249(199903)45:3<279::aid-ana2>3.0.co;2-7. PMID: 10072041

Supplemental Content

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