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Refractory epilepsy

MedGen UID:
203330
Concept ID:
C1096063
Disease or Syndrome
Synonym: Intractable epilepsy

Definition

Epilepsy that is refractory to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Refractory epilepsy

Professional guidelines

PubMed

Shao P, Li H, Jiang J, Guan Y, Chen X, Wang Y
Neuroimmunomodulation 2023;30(1):167-183. Epub 2023 Jun 27 doi: 10.1159/000531626. PMID: 37369181Free PMC Article
Hon KL, Leung AKC, Torres AR
Recent Pat Inflamm Allergy Drug Discov 2018;12(2):128-135. doi: 10.2174/1872213X12666180508122450. PMID: 29745347
Sampaio LP
Arq Neuropsiquiatr 2016 Oct;74(10):842-848. doi: 10.1590/0004-282X20160116. PMID: 27759811

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

Masemer DA, Yu H, Konrad PE, Englot DJ
J Neurosci Nurs 2020 Jun;52(3):103-105. doi: 10.1097/JNN.0000000000000504. PMID: 32175990
Harijan P, Seal AK, Prasad M, Whitehouse WP
Arch Dis Child Educ Pract Ed 2019 Jun;104(3):135-140. Epub 2018 Nov 24 doi: 10.1136/archdischild-2018-316035. PMID: 30472655
van der Louw E, van den Hurk D, Neal E, Leiendecker B, Fitzsimmon G, Dority L, Thompson L, Marchió M, Dudzińska M, Dressler A, Klepper J, Auvin S, Cross JH
Eur J Paediatr Neurol 2016 Nov;20(6):798-809. Epub 2016 Jul 17 doi: 10.1016/j.ejpn.2016.07.009. PMID: 27470655
Campistol J, Plecko B
Epileptic Disord 2015 Sep;17(3):229-42. doi: 10.1684/epd.2015.0754. PMID: 26234933
Kutlu G, Erdal A, Gomceli YB, Inan LE
Neurosciences (Riyadh) 2013 Jul;18(3):284-6. PMID: 23887223

Diagnosis

Liang C, Chu E, Kuoy E, Soun JE
J Neuroimaging 2023 Jan;33(1):19-34. Epub 2022 Oct 10 doi: 10.1111/jon.13060. PMID: 36217010
Ali I, Houck K
Neurol Clin 2021 Aug;39(3):797-810. doi: 10.1016/j.ncl.2021.04.003. PMID: 34215387
Foit NA, Bernasconi A, Bernasconi N
Neurosurg Clin N Am 2020 Jul;31(3):395-405. Epub 2020 Apr 23 doi: 10.1016/j.nec.2020.03.004. PMID: 32475488
Greco A, Rizzo MI, De Virgilio A, Conte M, Gallo A, Attanasio G, Ruoppolo G, de Vincentiis M
Autoimmun Rev 2016 Mar;15(3):221-5. Epub 2015 Nov 25 doi: 10.1016/j.autrev.2015.11.007. PMID: 26626229
Kutlu G, Erdal A, Gomceli YB, Inan LE
Neurosciences (Riyadh) 2013 Jul;18(3):284-6. PMID: 23887223

Therapy

Courties A, Berenbaum F, Sellam J
Joint Bone Spine 2021 May;88(3):105149. Epub 2021 Feb 3 doi: 10.1016/j.jbspin.2021.105149. PMID: 33548494
Singh J, Antimisiaris MF
Epileptic Disord 2020 Aug 1;22(4):511-514. doi: 10.1684/epd.2020.1189. PMID: 32729550
Banerjee TK, Das SK
J Assoc Physicians India 2013 Aug;61(8 Suppl):52-4. PMID: 24818331
Ravat SH, Jain V
J Indian Med Assoc 2010 Jul;108(7):418, 427-30. PMID: 21192500
Hovinga CA
Curr Opin Investig Drugs 2004 Jan;5(1):101-6. PMID: 14983982

Prognosis

Cooper MS, Mcintosh A, Crompton DE, McMahon JM, Schneider A, Farrell K, Ganesan V, Gill D, Kivity S, Lerman-Sagie T, McLellan A, Pelekanos J, Ramesh V, Sadleir L, Wirrell E, Scheffer IE
Epilepsy Res 2016 Dec;128:43-47. Epub 2016 Oct 26 doi: 10.1016/j.eplepsyres.2016.10.006. PMID: 27810515
Banerjee TK, Das SK
J Assoc Physicians India 2013 Aug;61(8 Suppl):52-4. PMID: 24818331
Palencia G, Martinez-Juarez IE, Calderon A, Artigas C, Sotelo J
Epilepsy Res 2010 Dec;92(2-3):253-7. Epub 2010 Oct 28 doi: 10.1016/j.eplepsyres.2010.10.003. PMID: 21035311
Halpern CH, Samadani U, Litt B, Jaggi JL, Baltuch GH
Neurotherapeutics 2008 Jan;5(1):59-67. doi: 10.1016/j.nurt.2007.10.065. PMID: 18164484Free PMC Article
Sheth RD, Ronen GM, Goulden KJ, Penney S, Bodensteiner JB
J Child Neurol 1995 May;10(3):205-8. doi: 10.1177/088307389501000306. PMID: 7642889

Clinical prediction guides

Aicua-Rapun I, André P, Novy J
Curr Neuropharmacol 2019;17(5):447-458. doi: 10.2174/1570159X16666180308154646. PMID: 29521237Free PMC Article
Banerjee TK, Das SK
J Assoc Physicians India 2013 Aug;61(8 Suppl):52-4. PMID: 24818331
Noh HS, Kim YS, Choi WS
Epilepsia 2008 Nov;49 Suppl 8:120-3. doi: 10.1111/j.1528-1167.2008.01855.x. PMID: 19049608
Boon P, Moors I, De Herdt V, Vonck K
Seizure 2006 Jun;15(4):259-63. Epub 2006 May 2 doi: 10.1016/j.seizure.2006.02.014. PMID: 16651013
Kwan P, Brodie MJ
N Engl J Med 2000 Feb 3;342(5):314-9. doi: 10.1056/NEJM200002033420503. PMID: 10660394

Recent systematic reviews

Devi N, Madaan P, Kandoth N, Bansal D, Sahu JK
JAMA Pediatr 2023 Mar 1;177(3):258-266. doi: 10.1001/jamapediatrics.2022.5648. PMID: 36716045Free PMC Article
Mhanna A, Mhanna M, Beran A, Al-Chalabi M, Aladamat N, Mahfooz N
Clin Nutr ESPEN 2022 Oct;51:112-119. Epub 2022 Sep 10 doi: 10.1016/j.clnesp.2022.09.004. PMID: 36184195
Scullen T, Teja N, Song SH, Couldwell M, Carr C, Mathkour M, Lee DJ, Tubbs RS, Dallapiazza RF
World Neurosurg 2021 Nov;155:96-108. Epub 2021 Jul 1 doi: 10.1016/j.wneu.2021.06.105. PMID: 34217862
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K
Seizure 2019 May;68:9-15. Epub 2018 May 21 doi: 10.1016/j.seizure.2018.05.013. PMID: 29871784
Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V
Epilepsia 2018 Dec;59(12):2179-2193. Epub 2018 Nov 13 doi: 10.1111/epi.14596. PMID: 30426482

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

    Consumer resources

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