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Tick-borne relapsing fever

MedGen UID:
20515
•Concept ID:
C0035022
•
Disease or Syndrome
Synonyms: Relapsing fever, tick-borne; Tick-Borne Relapsing Fever; tick-borne relapsing fever
SNOMED CT: Tick-borne relapsing fever (10301003)
 
Monarch Initiative: MONDO:0001621

Definition

An infection that is caused by certain species of Rickettsia or Borrelia, which are transmitted to humans from infected ticks; it is characterized by sudden fever, chills, headaches, myalgia, arthralgia, nausea, and possibly a rash. Symptoms usually persist for two to nine days, then disappear, with recurrence after several weeks if the patient remains untreated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTick-borne relapsing fever

Professional guidelines

PubMed

Recombinant protein immunoblots for differential diagnosis of tick-borne relapsing fever and Lyme disease.
Shah JS, Burrascano JJ, Ramasamy R
J Vector Borne Dis 2023 Oct-Dec;60(4):353-364. doi: 10.4103/0972-9062.383641. PMID: 38174512
Tick-borne infections in children: epidemiology, clinical manifestations, and optimal management strategies.
Buckingham SC
Paediatr Drugs 2005;7(3):163-76. doi: 10.2165/00148581-200507030-00003. PMID: 15977962
Neuroborreliosis during relapsing fever: review of the clinical manifestations, pathology, and treatment of infections in humans and experimental animals.
Cadavid D, Barbour AG
Clin Infect Dis 1998 Jan;26(1):151-64. doi: 10.1086/516276. PMID: 9455525

Recent clinical studies

Etiology

Recombinant protein immunoblots for differential diagnosis of tick-borne relapsing fever and Lyme disease.
Shah JS, Burrascano JJ, Ramasamy R
J Vector Borne Dis 2023 Oct-Dec;60(4):353-364. doi: 10.4103/0972-9062.383641. PMID: 38174512
Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand.
Takhampunya R, Longkunan A, Somchaimongkol S, Youngdech N, Chanarat N, Sakolvaree J, Tippayachai B, Promsathaporn S, Phanpheuch B, Poole-Smith BK, McCardle PW, Lindroth EJ
PLoS Negl Trop Dis 2023 Feb;17(2):e0011159. Epub 2023 Feb 21 doi: 10.1371/journal.pntd.0011159. PMID: 36809255Free PMC Article
Louse-borne relapsing fever (Borrelia recurrentis infection).
Warrell DA
Epidemiol Infect 2019 Jan;147:e106. doi: 10.1017/S0950268819000116. PMID: 30869050Free PMC Article
Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete.
Wagemakers A, Staarink PJ, Sprong H, Hovius JW
Trends Parasitol 2015 Jun;31(6):260-9. Epub 2015 Apr 16 doi: 10.1016/j.pt.2015.03.008. PMID: 25892254
Dermatoses from ticks.
McGinley-Smith DE, Tsao SS
J Am Acad Dermatol 2003 Sep;49(3):363-92; quiz 393-6. doi: 10.1067/s0190-9622(03)01868-1. PMID: 12963900

Diagnosis

Recombinant protein immunoblots for differential diagnosis of tick-borne relapsing fever and Lyme disease.
Shah JS, Burrascano JJ, Ramasamy R
J Vector Borne Dis 2023 Oct-Dec;60(4):353-364. doi: 10.4103/0972-9062.383641. PMID: 38174512
Louse-borne relapsing fever (Borrelia recurrentis infection).
Warrell DA
Epidemiol Infect 2019 Jan;147:e106. doi: 10.1017/S0950268819000116. PMID: 30869050Free PMC Article
The eye and tick-borne disease in the United States.
Sathiamoorthi S, Smith WM
Curr Opin Ophthalmol 2016 Nov;27(6):530-537. doi: 10.1097/ICU.0000000000000308. PMID: 27585218
Tick-Borne Illnesses.
Choi E, Pyzocha NJ, Maurer DM
Curr Sports Med Rep 2016 Mar-Apr;15(2):98-104. doi: 10.1249/JSR.0000000000000238. PMID: 26963018
Tick-borne relapsing fever.
Dworkin MS, Schwan TG, Anderson DE Jr, Borchardt SM
Infect Dis Clin North Am 2008 Sep;22(3):449-68, viii. doi: 10.1016/j.idc.2008.03.006. PMID: 18755384Free PMC Article

Therapy

Tick borne relapsing fever - a systematic review and analysis of the literature.
Jakab Á, Kahlig P, Kuenzli E, Neumayr A
PLoS Negl Trop Dis 2022 Feb;16(2):e0010212. Epub 2022 Feb 16 doi: 10.1371/journal.pntd.0010212. PMID: 35171908Free PMC Article
Tick-borne relapsing fever.
Aviles ES, Oakes M, Algranati M, Mansoor AM
BMJ Case Rep 2020 Jul 16;13(7) doi: 10.1136/bcr-2020-237296. PMID: 32675137Free PMC Article
Louse-borne relapsing fever (Borrelia recurrentis infection).
Warrell DA
Epidemiol Infect 2019 Jan;147:e106. doi: 10.1017/S0950268819000116. PMID: 30869050Free PMC Article
Tick-borne relapsing fever.
Dworkin MS, Schwan TG, Anderson DE Jr, Borchardt SM
Infect Dis Clin North Am 2008 Sep;22(3):449-68, viii. doi: 10.1016/j.idc.2008.03.006. PMID: 18755384Free PMC Article
Tick-borne relapsing fever.
Roscoe C, Epperly T
Am Fam Physician 2005 Nov 15;72(10):2039-44. PMID: 16342834

Prognosis

Gastrointestinal and hepatic symptoms of tickborne diseases.
Budzáková M, Trna J
Vnitr Lek 2020 Summer;66(4):232-235. PMID: 32972180
Relapsing Fever Borreliae: A Global Review.
Cutler SJ
Clin Lab Med 2015 Dec;35(4):847-65. Epub 2015 Aug 22 doi: 10.1016/j.cll.2015.07.001. PMID: 26593261
Post exposure prophylaxis of tick-borne relapsing fever.
Balicer RD, Mimouni D, Bar-Zeev Y, Levine H, Davidovitch N, Ankol OH, Zarka SS
Eur J Clin Microbiol Infect Dis 2010 Mar;29(3):253-8. Epub 2009 Dec 13 doi: 10.1007/s10096-009-0846-x. PMID: 20012878
Relapsing fever borreliosis in Eurasia--forgotten, but certainly not gone!
Assous MV, Wilamowski A
Clin Microbiol Infect 2009 May;15(5):407-14. doi: 10.1111/j.1469-0691.2009.02767.x. PMID: 19489923
Dermatoses from ticks.
McGinley-Smith DE, Tsao SS
J Am Acad Dermatol 2003 Sep;49(3):363-92; quiz 393-6. doi: 10.1067/s0190-9622(03)01868-1. PMID: 12963900

Clinical prediction guides

Borrelia miyamotoi a neglected tick-borne relapsing fever spirochete in Thailand.
Takhampunya R, Longkunan A, Somchaimongkol S, Youngdech N, Chanarat N, Sakolvaree J, Tippayachai B, Promsathaporn S, Phanpheuch B, Poole-Smith BK, McCardle PW, Lindroth EJ
PLoS Negl Trop Dis 2023 Feb;17(2):e0011159. Epub 2023 Feb 21 doi: 10.1371/journal.pntd.0011159. PMID: 36809255Free PMC Article
Comparative genomics of the Western Hemisphere soft tick-borne relapsing fever borreliae highlights extensive plasmid diversity.
Kneubehl AR, Krishnavajhala A, Leal SM, Replogle AJ, Kingry LC, Bermúdez SE, Labruna MB, Lopez JE
BMC Genomics 2022 May 31;23(1):410. doi: 10.1186/s12864-022-08523-7. PMID: 35641918Free PMC Article
Tick-borne relapsing fever Borreliosis, a major public health problem overlooked in Senegal.
Ndiaye EHI, Diouf FS, Ndiaye M, Bassene H, Raoult D, Sokhna C, Parola P, Diatta G
PLoS Negl Trop Dis 2021 Apr;15(4):e0009184. Epub 2021 Apr 22 doi: 10.1371/journal.pntd.0009184. PMID: 33886571Free PMC Article
Molecular prevalence and ecoregion distribution of select tick-borne pathogens in Texas dogs.
Modarelli JJ, Tomeček JM, Piccione J, Ferro PJ, Esteve-Gasent MD
Transbound Emerg Dis 2019 May;66(3):1291-1300. Epub 2019 Mar 6 doi: 10.1111/tbed.13145. PMID: 30739394
Relapsing fever--a forgotten disease revealed.
Cutler SJ
J Appl Microbiol 2010 Apr;108(4):1115-22. Epub 2009 Oct 20 doi: 10.1111/j.1365-2672.2009.04598.x. PMID: 19886891

Recent systematic reviews

Tick borne relapsing fever - a systematic review and analysis of the literature.
Jakab Á, Kahlig P, Kuenzli E, Neumayr A
PLoS Negl Trop Dis 2022 Feb;16(2):e0010212. Epub 2022 Feb 16 doi: 10.1371/journal.pntd.0010212. PMID: 35171908Free PMC Article

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