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Rheumatic heart disease

MedGen UID:
20565
Concept ID:
C0035439
Disease or Syndrome
Synonyms: Disease, Rheumatic Heart; Diseases, Rheumatic Heart; Heart Disease, Rheumatic; Heart Diseases, Rheumatic; Rheumatic Heart Disease; Rheumatic Heart Diseases
SNOMED CT: Rheumatic heart disease (23685000); Chronic rheumatic heart disease (23685000); Chronic rheumatic fever (23685000)
 
Monarch Initiative: MONDO:0006955

Definition

An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction. [from NCI]

Professional guidelines

PubMed

Ralph AP, Noonan S, Wade V, Currie BJ
Med J Aust 2021 Mar;214(5):220-227. Epub 2020 Nov 15 doi: 10.5694/mja2.50851. PMID: 33190309
Kumar RK, Antunes MJ, Beaton A, Mirabel M, Nkomo VT, Okello E, Regmi PR, Reményi B, Sliwa-Hähnle K, Zühlke LJ, Sable C; American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology
Circulation 2020 Nov 17;142(20):e337-e357. Epub 2020 Oct 19 doi: 10.1161/CIR.0000000000000921. PMID: 33073615
Wunderlich NC, Dalvi B, Ho SY, Küx H, Siegel RJ
Curr Cardiol Rep 2019 Feb 28;21(3):14. doi: 10.1007/s11886-019-1099-7. PMID: 30815750

Recent clinical studies

Etiology

de Loizaga SR, Beaton AZ
Pediatr Ann 2021 Mar;50(3):e98-e104. Epub 2021 Mar 1 doi: 10.3928/19382359-20210221-01. PMID: 34038651
Ralph AP, Noonan S, Wade V, Currie BJ
Med J Aust 2021 Mar;214(5):220-227. Epub 2020 Nov 15 doi: 10.5694/mja2.50851. PMID: 33190309
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Karthikeyan G, Guilherme L
Lancet 2018 Jul 14;392(10142):161-174. Epub 2018 Jun 29 doi: 10.1016/S0140-6736(18)30999-1. PMID: 30025809
Marijon E, Mirabel M, Celermajer DS, Jouven X
Lancet 2012 Mar 10;379(9819):953-964. doi: 10.1016/S0140-6736(11)61171-9. PMID: 22405798

Diagnosis

de Loizaga SR, Beaton AZ
Pediatr Ann 2021 Mar;50(3):e98-e104. Epub 2021 Mar 1 doi: 10.3928/19382359-20210221-01. PMID: 34038651
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Leal MTBC, Passos LSA, Guarçoni FV, Aguiar JMS, Silva RBRD, Paula TMN, Santos RFD, Nassif MCL, Gomes NFA, Tan TC, Nunes MCP
Rev Soc Bras Med Trop 2019 Mar 14;52:e20180041. doi: 10.1590/0037-8682-0041-2019. PMID: 30892546
Karthikeyan G, Guilherme L
Lancet 2018 Jul 14;392(10142):161-174. Epub 2018 Jun 29 doi: 10.1016/S0140-6736(18)30999-1. PMID: 30025809
Marijon E, Mirabel M, Celermajer DS, Jouven X
Lancet 2012 Mar 10;379(9819):953-964. doi: 10.1016/S0140-6736(11)61171-9. PMID: 22405798

Therapy

Connolly SJ, Karthikeyan G, Ntsekhe M, Haileamlak A, El Sayed A, El Ghamrawy A, Damasceno A, Avezum A, Dans AML, Gitura B, Hu D, Kamanzi ER, Maklady F, Fana G, Gonzalez-Hermosillo JA, Musuku J, Kazmi K, Zühlke L, Gondwe L, Ma C, Paniagua M, Ogah OS, Molefe-Baikai OJ, Lwabi P, Chillo P, Sharma SK, Cabral TTJ, Tarhuni WM, Benz A, van Eikels M, Krol A, Pattath D, Balasubramanian K, Rangarajan S, Ramasundarahettige C, Mayosi B, Yusuf S; INVICTUS Investigators
N Engl J Med 2022 Sep 15;387(11):978-988. Epub 2022 Aug 28 doi: 10.1056/NEJMoa2209051. PMID: 36036525
Beaton A, Okello E, Rwebembera J, Grobler A, Engelman D, Alepere J, Canales L, Carapetis J, DeWyer A, Lwabi P, Mirabel M, Mocumbi AO, Murali M, Nakitto M, Ndagire E, Nunes MCP, Omara IO, Sarnacki R, Scheel A, Wilson N, Zimmerman M, Zühlke L, Karthikeyan G, Sable CA, Steer AC
N Engl J Med 2022 Jan 20;386(3):230-240. Epub 2021 Nov 13 doi: 10.1056/NEJMoa2102074. PMID: 34767321
Karthikeyan G, Connolly SJ, Ntsekhe M, Benz A, Rangarajan S, Lewis G, Yun Y, Sharma SK, Maklady F, Elghamrawy AE, Kazmi K, Cabral TTJ, Dayi H, Changsheng M, Gitura BM, Avezum A, Zuhlke L, Lwabi P, Haileamlak A, Ogah O, Chillo P, Paniagua M, ElSayed A, Dans A, Gondwe-Chunda L, Molefe-Baikai OJ, Gonzalez-Hermosillo JA, Hakim J, Damasceno A, Kamanzi ER, Musuku J, Davletov K, Connolly K, Mayosi BM, Yusuf S; INVICTUS Investigators
Am Heart J 2020 Jul;225:69-77. Epub 2020 Mar 25 doi: 10.1016/j.ahj.2020.03.018. PMID: 32474206
Karthikeyan G, Guilherme L
Lancet 2018 Jul 14;392(10142):161-174. Epub 2018 Jun 29 doi: 10.1016/S0140-6736(18)30999-1. PMID: 30025809
Guilherme L, de Barros SF, Kohler KF, Santos SR, Ferreira FM, Silva WR, Alencar R, Postol E, Kalil J
Curr Protein Pept Sci 2018;19(9):900-908. doi: 10.2174/1389203718666170725115855. PMID: 28745221

Prognosis

Lahiri S, Sanyahumbi A
Pediatr Rev 2021 May;42(5):221-232. doi: 10.1542/pir.2019-0288. PMID: 33931507
Karthikeyan G
Heart 2021 May;107(9):694-696. Epub 2021 Jan 18 doi: 10.1136/heartjnl-2020-318756. PMID: 33462122
Muhamed B, Mutithu D, Aremu O, Zühlke L, Sliwa K
Int J Cardiol 2019 Nov 15;295:48-55. Epub 2019 Jul 29 doi: 10.1016/j.ijcard.2019.07.079. PMID: 31405583
Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, Forouzanfar MH, Longenecker CT, Mayosi BM, Mensah GA, Nascimento BR, Ribeiro ALP, Sable CA, Steer AC, Naghavi M, Mokdad AH, Murray CJL, Vos T, Carapetis JR, Roth GA
N Engl J Med 2017 Aug 24;377(8):713-722. doi: 10.1056/NEJMoa1603693. PMID: 28834488
Feldman T
Curr Opin Cardiol 1996 Mar;11(2):126-30. doi: 10.1097/00001573-199603000-00005. PMID: 8736683

Clinical prediction guides

Katsanos AH, Kamel H, Healey JS, Hart RG
Circulation 2020 Dec 15;142(24):2371-2388. Epub 2020 Dec 14 doi: 10.1161/CIRCULATIONAHA.120.049768. PMID: 33315494
Goldstein SA, Ward CC
Curr Cardiol Rep 2017 Aug 24;19(10):96. doi: 10.1007/s11886-017-0910-6. PMID: 28840470
Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, Forouzanfar MH, Longenecker CT, Mayosi BM, Mensah GA, Nascimento BR, Ribeiro ALP, Sable CA, Steer AC, Naghavi M, Mokdad AH, Murray CJL, Vos T, Carapetis JR, Roth GA
N Engl J Med 2017 Aug 24;377(8):713-722. doi: 10.1056/NEJMoa1603693. PMID: 28834488
Que YA, Moreillon P
Nat Rev Cardiol 2011 Jun;8(6):322-36. Epub 2011 Apr 12 doi: 10.1038/nrcardio.2011.43. PMID: 21487430
Hajsadeghi F, Ahmadi N, Eshaghian S, Budoff M
J Cardiovasc Comput Tomogr 2011 May-Jun;5(3):183-5. Epub 2011 Jan 28 doi: 10.1016/j.jcct.2011.01.010. PMID: 21367683

Recent systematic reviews

Lamichhane P, Pokhrel KM, Pokharel P, Bhandari B, Lamichhane P, Regmi PR
Int J Cardiol 2022 Jul 1;358:110-119. Epub 2022 Apr 11 doi: 10.1016/j.ijcard.2022.04.010. PMID: 35504739
Opara CC, Aghassibake N, Watkins DA
Int J Cardiol 2021 Jan 15;323:235-241. Epub 2020 Sep 10 doi: 10.1016/j.ijcard.2020.09.020. PMID: 32920073
Pearce S, Bowen AC, Engel ME, de la Lande M, Barth DD
PLoS One 2020;15(11):e0242107. Epub 2020 Nov 18 doi: 10.1371/journal.pone.0242107. PMID: 33206687Free PMC Article
Russell EA, Walsh WF, Costello B, McLellan AJA, Brown A, Reid CM, Tran L, Maguire GP
Cardiol Rev 2018 Jul/Aug;26(4):187-195. doi: 10.1097/CRD.0000000000000185. PMID: 29608495
Wang D, Liu M, Lin S, Hao Z, Tao W, Chen X, Luan R, Dong W
Clin Neurol Neurosurg 2013 Sep;115(9):1575-82. Epub 2013 Jul 25 doi: 10.1016/j.clineuro.2013.06.017. PMID: 23890677

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