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Rheumatic heart disease

MedGen UID:
20565
Concept ID:
C0035439
Disease or Syndrome
Synonyms: Disease, Rheumatic Heart; Diseases, Rheumatic Heart; Heart Disease, Rheumatic; Heart Diseases, Rheumatic; Rheumatic Heart Disease; Rheumatic Heart Diseases
SNOMED CT: Rheumatic heart disease (23685000); Chronic rheumatic heart disease (23685000); Chronic rheumatic fever (23685000)
 
Monarch Initiative: MONDO:0006955

Definition

An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction. [from NCI]

Professional guidelines

PubMed

Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B
J Am Coll Cardiol 2024 Jan 23;83(3):444-465. doi: 10.1016/j.jacc.2023.10.038. PMID: 38233019
Ralph AP, Noonan S, Wade V, Currie BJ
Med J Aust 2021 Mar;214(5):220-227. Epub 2020 Nov 15 doi: 10.5694/mja2.50851. PMID: 33190309
Wunderlich NC, Dalvi B, Ho SY, Küx H, Siegel RJ
Curr Cardiol Rep 2019 Feb 28;21(3):14. doi: 10.1007/s11886-019-1099-7. PMID: 30815750

Recent clinical studies

Etiology

de Loizaga SR, Beaton AZ
Pediatr Ann 2021 Mar;50(3):e98-e104. Epub 2021 Mar 1 doi: 10.3928/19382359-20210221-01. PMID: 34038651
Ralph AP, Noonan S, Wade V, Currie BJ
Med J Aust 2021 Mar;214(5):220-227. Epub 2020 Nov 15 doi: 10.5694/mja2.50851. PMID: 33190309
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Karthikeyan G, Guilherme L
Lancet 2018 Jul 14;392(10142):161-174. Epub 2018 Jun 29 doi: 10.1016/S0140-6736(18)30999-1. PMID: 30025809
Marijon E, Mirabel M, Celermajer DS, Jouven X
Lancet 2012 Mar 10;379(9819):953-964. doi: 10.1016/S0140-6736(11)61171-9. PMID: 22405798

Diagnosis

de Loizaga SR, Beaton AZ
Pediatr Ann 2021 Mar;50(3):e98-e104. Epub 2021 Mar 1 doi: 10.3928/19382359-20210221-01. PMID: 34038651
Arvind B, Ramakrishnan S
Indian J Pediatr 2020 Apr;87(4):305-311. Epub 2020 Jan 11 doi: 10.1007/s12098-019-03128-7. PMID: 31925717
Leal MTBC, Passos LSA, Guarçoni FV, Aguiar JMS, Silva RBRD, Paula TMN, Santos RFD, Nassif MCL, Gomes NFA, Tan TC, Nunes MCP
Rev Soc Bras Med Trop 2019 Mar 14;52:e20180041. doi: 10.1590/0037-8682-0041-2019. PMID: 30892546
Marijon E, Mirabel M, Celermajer DS, Jouven X
Lancet 2012 Mar 10;379(9819):953-964. doi: 10.1016/S0140-6736(11)61171-9. PMID: 22405798
Brown A, Kritharides L
Heart Lung Circ 2010 May-Jun;19(5-6):263. Epub 2010 Apr 2 doi: 10.1016/j.hlc.2010.02.012. PMID: 20363188

Therapy

Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B
J Am Coll Cardiol 2024 Jan 23;83(3):444-465. doi: 10.1016/j.jacc.2023.10.038. PMID: 38233019
Connolly SJ, Karthikeyan G, Ntsekhe M, Haileamlak A, El Sayed A, El Ghamrawy A, Damasceno A, Avezum A, Dans AML, Gitura B, Hu D, Kamanzi ER, Maklady F, Fana G, Gonzalez-Hermosillo JA, Musuku J, Kazmi K, Zühlke L, Gondwe L, Ma C, Paniagua M, Ogah OS, Molefe-Baikai OJ, Lwabi P, Chillo P, Sharma SK, Cabral TTJ, Tarhuni WM, Benz A, van Eikels M, Krol A, Pattath D, Balasubramanian K, Rangarajan S, Ramasundarahettige C, Mayosi B, Yusuf S; INVICTUS Investigators
N Engl J Med 2022 Sep 15;387(11):978-988. Epub 2022 Aug 28 doi: 10.1056/NEJMoa2209051. PMID: 36036525
Beaton A, Okello E, Rwebembera J, Grobler A, Engelman D, Alepere J, Canales L, Carapetis J, DeWyer A, Lwabi P, Mirabel M, Mocumbi AO, Murali M, Nakitto M, Ndagire E, Nunes MCP, Omara IO, Sarnacki R, Scheel A, Wilson N, Zimmerman M, Zühlke L, Karthikeyan G, Sable CA, Steer AC
N Engl J Med 2022 Jan 20;386(3):230-240. Epub 2021 Nov 13 doi: 10.1056/NEJMoa2102074. PMID: 34767321
Karthikeyan G, Guilherme L
Lancet 2018 Jul 14;392(10142):161-174. Epub 2018 Jun 29 doi: 10.1016/S0140-6736(18)30999-1. PMID: 30025809
Guilherme L, de Barros SF, Kohler KF, Santos SR, Ferreira FM, Silva WR, Alencar R, Postol E, Kalil J
Curr Protein Pept Sci 2018;19(9):900-908. doi: 10.2174/1389203718666170725115855. PMID: 28745221

Prognosis

Sun J, Qiao Y, Zhao M, Magnussen CG, Xi B
BMC Med 2023 Jun 26;21(1):222. doi: 10.1186/s12916-023-02925-4. PMID: 37365627Free PMC Article
Lahiri S, Sanyahumbi A
Pediatr Rev 2021 May;42(5):221-232. doi: 10.1542/pir.2019-0288. PMID: 33931507
Karthikeyan G
Heart 2021 May;107(9):694-696. Epub 2021 Jan 18 doi: 10.1136/heartjnl-2020-318756. PMID: 33462122
Muhamed B, Mutithu D, Aremu O, Zühlke L, Sliwa K
Int J Cardiol 2019 Nov 15;295:48-55. Epub 2019 Jul 29 doi: 10.1016/j.ijcard.2019.07.079. PMID: 31405583
Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, Forouzanfar MH, Longenecker CT, Mayosi BM, Mensah GA, Nascimento BR, Ribeiro ALP, Sable CA, Steer AC, Naghavi M, Mokdad AH, Murray CJL, Vos T, Carapetis JR, Roth GA
N Engl J Med 2017 Aug 24;377(8):713-722. doi: 10.1056/NEJMoa1603693. PMID: 28834488

Clinical prediction guides

Asmare MH, Filtjens B, Woldehanna F, Janssens L, Vanrumste B
Sensors (Basel) 2021 Sep 30;21(19) doi: 10.3390/s21196558. PMID: 34640876Free PMC Article
Goldstein SA, Ward CC
Curr Cardiol Rep 2017 Aug 24;19(10):96. doi: 10.1007/s11886-017-0910-6. PMID: 28840470
Watkins DA, Johnson CO, Colquhoun SM, Karthikeyan G, Beaton A, Bukhman G, Forouzanfar MH, Longenecker CT, Mayosi BM, Mensah GA, Nascimento BR, Ribeiro ALP, Sable CA, Steer AC, Naghavi M, Mokdad AH, Murray CJL, Vos T, Carapetis JR, Roth GA
N Engl J Med 2017 Aug 24;377(8):713-722. doi: 10.1056/NEJMoa1603693. PMID: 28834488
Mocumbi AO
Cardiovasc J Afr 2015 Mar-Apr;26(2 Suppl 1):S21-6. doi: 10.5830/CVJA-2015-037. PMID: 25962944Free PMC Article
Que YA, Moreillon P
Nat Rev Cardiol 2011 Jun;8(6):322-36. Epub 2011 Apr 12 doi: 10.1038/nrcardio.2011.43. PMID: 21487430

Recent systematic reviews

Lamichhane P, Pokhrel KM, Pokharel P, Bhandari B, Lamichhane P, Regmi PR
Int J Cardiol 2022 Jul 1;358:110-119. Epub 2022 Apr 11 doi: 10.1016/j.ijcard.2022.04.010. PMID: 35504739
Opara CC, Aghassibake N, Watkins DA
Int J Cardiol 2021 Jan 15;323:235-241. Epub 2020 Sep 10 doi: 10.1016/j.ijcard.2020.09.020. PMID: 32920073
Russell EA, Walsh WF, Costello B, McLellan AJA, Brown A, Reid CM, Tran L, Maguire GP
Cardiol Rev 2018 Jul/Aug;26(4):187-195. doi: 10.1097/CRD.0000000000000185. PMID: 29608495
Agbor VN, Essouma M, Ntusi NAB, Nyaga UF, Bigna JJ, Noubiap JJ
Int J Cardiol 2018 Apr 15;257:207-215. doi: 10.1016/j.ijcard.2017.12.048. PMID: 29506693
Wang D, Liu M, Lin S, Hao Z, Tao W, Chen X, Luan R, Dong W
Clin Neurol Neurosurg 2013 Sep;115(9):1575-82. Epub 2013 Jul 25 doi: 10.1016/j.clineuro.2013.06.017. PMID: 23890677

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