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Arteriolosclerosis

MedGen UID:
209223
•Concept ID:
C0878486
•
Disease or Syndrome
Synonym: Arterioloscleroses
SNOMED CT: Arteriolosclerosis (17941002)
 
Monarch Initiative: MONDO:0006658

Definition

The thickening of the wall of the small arteries and arterioles. It is caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy. It results in lumen narrowing and tissue ischemia. [from NCI]

Professional guidelines

PubMed

Cardiovascular Management in Asymptomatic (Silent) Cerebral Microbleeds and Suspected Cerebral Amyloid Angiopathy.
Charidimou A, Smith EE
Stroke 2024 Apr;55(4):1101-1112. Epub 2024 Mar 11 doi: 10.1161/STROKEAHA.123.044167. PMID: 38465605
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study.
Rodrigues MA, Samarasekera N, Lerpiniere C, Humphreys C, McCarron MO, White PM, Nicoll JAR, Sudlow CLM, Cordonnier C, Wardlaw JM, Smith C, Al-Shahi Salman R
Lancet Neurol 2018 Mar;17(3):232-240. Epub 2018 Jan 10 doi: 10.1016/S1474-4422(18)30006-1. PMID: 29331631Free PMC Article
The contribution of MRI in the differential diagnosis of posterior fossa damage.
Gass A, Filippi M, Grossman RI
J Neurol Sci 2000 Jan 15;172 Suppl 1:S43-9. doi: 10.1016/s0022-510x(99)00278-6. PMID: 10606806

Recent clinical studies

Etiology

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.
Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208Free PMC Article
Cerebral small vessel disease: Recent advances and future directions.
Markus HS, de Leeuw FE
Int J Stroke 2023 Jan;18(1):4-14. doi: 10.1177/17474930221144911. PMID: 36575578Free PMC Article
Vascular Cognitive Impairment and Dementia.
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article
Epidemiology of Vascular Dementia.
Wolters FJ, Ikram MA
Arterioscler Thromb Vasc Biol 2019 Aug;39(8):1542-1549. Epub 2019 Jul 11 doi: 10.1161/ATVBAHA.119.311908. PMID: 31294622
Structural and Functional Changes in Human Kidneys with Healthy Aging.
Hommos MS, Glassock RJ, Rule AD
J Am Soc Nephrol 2017 Oct;28(10):2838-2844. Epub 2017 Aug 8 doi: 10.1681/ASN.2017040421. PMID: 28790143Free PMC Article

Diagnosis

Molecular biomarkers for vascular cognitive impairment and dementia.
Hosoki S, Hansra GK, Jayasena T, Poljak A, Mather KA, Catts VS, Rust R, Sagare A, Kovacic JC, Brodtmann A, Wallin A, Zlokovic BV, Ihara M, Sachdev PS
Nat Rev Neurol 2023 Dec;19(12):737-753. Epub 2023 Nov 13 doi: 10.1038/s41582-023-00884-1. PMID: 37957261
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.
Inoue Y, Shue F, Bu G, Kanekiyo T
Mol Neurodegener 2023 Jul 11;18(1):46. doi: 10.1186/s13024-023-00640-5. PMID: 37434208Free PMC Article
Cerebral small vessel disease: Recent advances and future directions.
Markus HS, de Leeuw FE
Int J Stroke 2023 Jan;18(1):4-14. doi: 10.1177/17474930221144911. PMID: 36575578Free PMC Article
Vascular Cognitive Impairment and Dementia.
Chang Wong E, Chang Chui H
Continuum (Minneap Minn) 2022 Jun 1;28(3):750-780. doi: 10.1212/CON.0000000000001124. PMID: 35678401Free PMC Article
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521

Therapy

Cardiovascular Management in Asymptomatic (Silent) Cerebral Microbleeds and Suspected Cerebral Amyloid Angiopathy.
Charidimou A, Smith EE
Stroke 2024 Apr;55(4):1101-1112. Epub 2024 Mar 11 doi: 10.1161/STROKEAHA.123.044167. PMID: 38465605
Cerebral small vessel disease: Recent advances and future directions.
Markus HS, de Leeuw FE
Int J Stroke 2023 Jan;18(1):4-14. doi: 10.1177/17474930221144911. PMID: 36575578Free PMC Article
Cerebral Small Vessel Disease.
Li Q, Yang Y, Reis C, Tao T, Li W, Li X, Zhang JH
Cell Transplant 2018 Dec;27(12):1711-1722. Epub 2018 Sep 25 doi: 10.1177/0963689718795148. PMID: 30251566Free PMC Article
Asymptomatic Cerebrovascular Disease in Dialysis Patients.
Naganuma T, Takemoto Y
Contrib Nephrol 2018;196:22-26. Epub 2018 Jul 24 doi: 10.1159/000485692. PMID: 30041200
The Role of Colchicine in the Prevention of Cerebrovascular Ischemia.
Tsivgoulis G, Katsanos AH, Giannopoulos G, Panagopoulou V, Jatuzis D, Lemmens R, Deftereos S, Kelly PJ
Curr Pharm Des 2018;24(6):668-674. doi: 10.2174/1381612824666180116100310. PMID: 29336246

Prognosis

Cerebral small vessel disease: neuroimaging markers and clinical implication.
Chen X, Wang J, Shan Y, Cai W, Liu S, Hu M, Liao S, Huang X, Zhang B, Wang Y, Lu Z
J Neurol 2019 Oct;266(10):2347-2362. Epub 2018 Oct 5 doi: 10.1007/s00415-018-9077-3. PMID: 30291424
Asymptomatic Cerebrovascular Disease in Dialysis Patients.
Naganuma T, Takemoto Y
Contrib Nephrol 2018;196:22-26. Epub 2018 Jul 24 doi: 10.1159/000485692. PMID: 30041200
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Impact of multiple pathologies on the threshold for clinically overt dementia.
Kapasi A, DeCarli C, Schneider JA
Acta Neuropathol 2017 Aug;134(2):171-186. Epub 2017 May 9 doi: 10.1007/s00401-017-1717-7. PMID: 28488154Free PMC Article
Uric acid and chronic kidney disease: which is chasing which?
Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E
Nephrol Dial Transplant 2013 Sep;28(9):2221-8. Epub 2013 Mar 29 doi: 10.1093/ndt/gft029. PMID: 23543594Free PMC Article

Clinical prediction guides

Brain arteriolosclerosis.
Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, Nelson KB, Magaki SD, Schmitt FA, Teylan MA, Ighodaro ET, Phe P, Abner EL, Cykowski MD, Van Eldik LJ, Nelson PT
Acta Neuropathol 2021 Jan;141(1):1-24. Epub 2020 Oct 24 doi: 10.1007/s00401-020-02235-6. PMID: 33098484Free PMC Article
Epidemiology of Vascular Dementia.
Wolters FJ, Ikram MA
Arterioscler Thromb Vasc Biol 2019 Aug;39(8):1542-1549. Epub 2019 Jul 11 doi: 10.1161/ATVBAHA.119.311908. PMID: 31294622
Cerebral small vessel disease: neuroimaging markers and clinical implication.
Chen X, Wang J, Shan Y, Cai W, Liu S, Hu M, Liao S, Huang X, Zhang B, Wang Y, Lu Z
J Neurol 2019 Oct;266(10):2347-2362. Epub 2018 Oct 5 doi: 10.1007/s00415-018-9077-3. PMID: 30291424
The pathology and pathophysiology of vascular dementia.
Kalaria RN
Neuropharmacology 2018 May 15;134(Pt B):226-239. Epub 2017 Dec 19 doi: 10.1016/j.neuropharm.2017.12.030. PMID: 29273521
Uric acid and chronic kidney disease: which is chasing which?
Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E
Nephrol Dial Transplant 2013 Sep;28(9):2221-8. Epub 2013 Mar 29 doi: 10.1093/ndt/gft029. PMID: 23543594Free PMC Article

Recent systematic reviews

Pathological Changes of Small Vessel Disease in Intracerebral Hemorrhage: a Systematic Review and Meta-analysis.
Xu M, Zhu Y, Song X, Zhong X, Yu X, Wang D, Cheng Y, Tao W, Wu B, Liu M
Transl Stroke Res 2024 Jun;15(3):533-544. Epub 2023 Jun 6 doi: 10.1007/s12975-023-01154-4. PMID: 37280502Free PMC Article

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