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Trench fever

MedGen UID:
21637
•Concept ID:
C0040830
•
Disease or Syndrome
Synonyms: Bartonella quintana Infection; Bartonella quintana Infections; Fever, Trench; Infection, Bartonella quintana; Trench Fever
SNOMED CT: Trench fever (82214002); Quintan fever (82214002); Wolhynian fever (82214002); Fever due to Rochalimaea quintana (82214002); Fever due to Bartonella quintana (82214002); Five day fever (82214002); Febris quintata (82214002)
 
Monarch Initiative: MONDO:0005991
Orphanet: ORPHA64694

Definition

A rare bacterial infectious disease caused by the louse-borne bacterium <i>Bartonella quintana</i> and characterized by a variable clinical picture with acute or insidious onset of a (potentially relapsing) febrile illness, headache, leg pain (most typically the shinbone), endocarditis, and thrombocytopenia. There may also be only non-specific symptoms that mimic other infections. The disease nowadays most commonly affects socially disadvantaged persons in urban areas. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrench fever
Follow this link to review classifications for Trench fever in Orphanet.

Professional guidelines

PubMed

Management and Treatment of Human Lice.
Sangaré AK, Doumbo OK, Raoult D
Biomed Res Int 2016;2016:8962685. Epub 2016 Jul 27 doi: 10.1155/2016/8962685. PMID: 27529073Free PMC Article
Bartonella infection: treatment and drug resistance.
Biswas S, Rolain JM
Future Microbiol 2010 Nov;5(11):1719-31. doi: 10.2217/fmb.10.133. PMID: 21133691
Bartonella quintana characteristics and clinical management.
Foucault C, Brouqui P, Raoult D
Emerg Infect Dis 2006 Feb;12(2):217-23. doi: 10.3201/eid1202.050874. PMID: 16494745Free PMC Article

Recent clinical studies

Etiology

Bartonella quintana Infection in People Experiencing Homelessness in the Denver Metropolitan Area.
Shepard Z, Vargas Barahona L, Montalbano G, Rowan SE, Franco-Paredes C, Madinger N
J Infect Dis 2022 Oct 7;226(Suppl 3):S315-S321. doi: 10.1093/infdis/jiac238. PMID: 35749315
Ectoparasites: Pediculosis and tungiasis.
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Human louse-transmitted infectious diseases.
Badiaga S, Brouqui P
Clin Microbiol Infect 2012 Apr;18(4):332-7. Epub 2012 Feb 23 doi: 10.1111/j.1469-0691.2012.03778.x. PMID: 22360386
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
Infections in the homeless.
Raoult D, Foucault C, Brouqui P
Lancet Infect Dis 2001 Sep;1(2):77-84. doi: 10.1016/S1473-3099(01)00062-7. PMID: 11871479

Diagnosis

Ectoparasites: Pediculosis and tungiasis.
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Cutaneous manifestations of bartonellosis.
Lins KA, Drummond MR, Velho PENF
An Bras Dermatol 2019 Sep-Oct;94(5):594-602. Epub 2019 Oct 2 doi: 10.1016/j.abd.2019.09.024. PMID: 31780437Free PMC Article
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
Pediculosis.
Ko CJ, Elston DM
J Am Acad Dermatol 2004 Jan;50(1):1-12; quiz 13-4. doi: 10.1016/s0190-9622(03)02729-4. PMID: 14699358
Bartonella-associated infections.
Spach DH, Koehler JE
Infect Dis Clin North Am 1998 Mar;12(1):137-55. doi: 10.1016/s0891-5520(05)70414-1. PMID: 9494835

Therapy

Bartonella quintana Endocarditis: A Systematic Review of Individual Cases.
Boodman C, Gupta N, Nelson CA, van Griensven J
Clin Infect Dis 2024 Mar 20;78(3):554-561. doi: 10.1093/cid/ciad706. PMID: 37976173
Ectoparasites: Pediculosis and tungiasis.
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Human pediculosis: a critical health problem and what about nursing policy?
El-Bahnasawy MM, Abdel FE, Morsy TA
J Egypt Soc Parasitol 2012 Dec;42(3):541-62. doi: 10.12816/0006340. PMID: 23469630
Bartonella-associated infections.
Spach DH, Koehler JE
Infect Dis Clin North Am 1998 Mar;12(1):137-55. doi: 10.1016/s0891-5520(05)70414-1. PMID: 9494835
Bartonella (Rochalimaea) quintana infections.
Maurin M, Raoult D
Clin Microbiol Rev 1996 Jul;9(3):273-92. doi: 10.1128/CMR.9.3.273. PMID: 8809460Free PMC Article

Prognosis

Detection of Bartonella bovis DNA in blood samples from a veterinarian in Mexico.
Gamboa-Prieto J, Cruz-Romero A, Jiménez-Hernández JA, Ramos-Vázquez JR, Ballados-González GG, Romero-Salas D, Pardío-Sedas VT, Esparza-Gonzalez SC, Becker I, Sánchez-Montes S
Rev Inst Med Trop Sao Paulo 2023;65:e62. Epub 2023 Dec 4 doi: 10.1590/S1678-9946202365062. PMID: 38055380Free PMC Article
Five millennia of Bartonella quintana bacteraemia.
Mai BH, Barbieri R, Chenal T, Castex D, Jonvel R, Tanasi D, Georges-Zimmermann P, Dutour O, Peressinotto D, Demangeot C, Drancourt M, Aboudharam G
PLoS One 2020;15(11):e0239526. Epub 2020 Nov 4 doi: 10.1371/journal.pone.0239526. PMID: 33147255Free PMC Article
A Case of Bartonella Quintana Culture-Negative Endocarditis.
Patel S, Richert ME, White R, Lambing T, Saleeb P
Am J Case Rep 2019 Apr 26;20:602-606. doi: 10.12659/AJCR.915215. PMID: 31026253Free PMC Article
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012.
Umulisa I, Omolo J, Muldoon KA, Condo J, Habiyaremye F, Uwimana JM, Muhimpundu MA, Galgalo T, Rwunganira S, Dahourou AG, Tongren E, Koama JB, McQuiston J, Raghunathan PL, Massung R, Gatei W, Boer K, Nyatanyi T, Mills EJ, Binagwaho A
Am J Trop Med Hyg 2016 Aug 3;95(2):452-6. Epub 2016 Jun 27 doi: 10.4269/ajtmh.15-0643. PMID: 27352876Free PMC Article
Bartonella (Rochalimaea) quintana infections.
Maurin M, Raoult D
Clin Microbiol Rev 1996 Jul;9(3):273-92. doi: 10.1128/CMR.9.3.273. PMID: 8809460Free PMC Article

Clinical prediction guides

Cat Scratch Disease and Bartonellaceae: The Known, the Unknown and the Curious.
Zangwill KM
Pediatr Infect Dis J 2021 May 1;40(5S):S11-S15. doi: 10.1097/INF.0000000000002776. PMID: 34042905
The activation of vivax malaria hypnozoites by infectious diseases.
Shanks GD, White NJ
Lancet Infect Dis 2013 Oct;13(10):900-6. Epub 2013 Jun 26 doi: 10.1016/S1473-3099(13)70095-1. PMID: 23809889
The Janus face of Bartonella quintana recognition by Toll-like receptors (TLRs): a review.
Matera G, Liberto MC, Joosten LA, Vinci M, Quirino A, Pulicari MC, Kullberg BJ, Van der Meer JW, Netea MG, Focà A
Eur Cytokine Netw 2008 Sep;19(3):113-8. Epub 2008 Sep 8 doi: 10.1684/ecn.2008.0128. PMID: 18775802
The body louse as a vector of reemerging human diseases.
Raoult D, Roux V
Clin Infect Dis 1999 Oct;29(4):888-911. doi: 10.1086/520454. PMID: 10589908
Bartonella (Rochalimaea) quintana infections.
Maurin M, Raoult D
Clin Microbiol Rev 1996 Jul;9(3):273-92. doi: 10.1128/CMR.9.3.273. PMID: 8809460Free PMC Article

Recent systematic reviews

Bartonella quintana detection among arthropods and their hosts: a systematic review and meta-analysis.
Boodman C, Gupta N, van Griensven J, Van Bortel W
Parasit Vectors 2024 Aug 2;17(1):328. doi: 10.1186/s13071-024-06413-3. PMID: 39095833Free PMC Article
Bartonella quintana Endocarditis: A Systematic Review of Individual Cases.
Boodman C, Gupta N, Nelson CA, van Griensven J
Clin Infect Dis 2024 Mar 20;78(3):554-561. doi: 10.1093/cid/ciad706. PMID: 37976173

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