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Bartonellosis

MedGen UID:
504
•Concept ID:
C0004771
•
Disease or Syndrome
Synonyms: Bartonella Infection; Bartonella Infections; Bartonelloses; Infection, Bartonella; Infection, Rochalimaea; Infections, Bartonella; Infections, Rochalimaea; Rochalimaea Infection; Rochalimaea Infections
SNOMED CT: Rochalimaea infection (266123003); Bartonellosis (266123003); Guaitara fever (266123003)
 
Monarch Initiative: MONDO:0005664

Definition

A gram-negative bacterial infection caused by bacteria of the genus Bartonella. It is transmitted by ticks, flies and mosquitoes. Signs and symptoms include fever, headache, muscle pain, enlargement of the lymph nodes and anemia. [from NCI]

Professional guidelines

PubMed

The efficacy of a selamectin (Stronghold ®) spot on treatment in the prevention of Bartonella henselae transmission by Ctenocephalides felis in cats, using a new high-challenge model.
Bouhsira E, Franc M, Lienard E, Bouillin C, Gandoin C, Geurden T, Becskei C, Jacquiet P, Thomas A, Boulouis HJ
Parasitol Res 2015 Mar;114(3):1045-50. Epub 2015 Jan 14 doi: 10.1007/s00436-014-4271-4. PMID: 25582566Free PMC Article
Treatment outcomes of human bartonellosis: a systematic review and meta-analysis.
Prutsky G, Domecq JP, Mori L, Bebko S, Matzumura M, Sabouni A, Shahrour A, Erwin PJ, Boyce TG, Montori VM, Malaga G, Murad MH
Int J Infect Dis 2013 Oct;17(10):e811-9. Epub 2013 Apr 18 doi: 10.1016/j.ijid.2013.02.016. PMID: 23602630
Identification of Bartonella bacilliformis genotypes and their relevance to epidemiological investigations of human bartonellosis.
Birtles RJ, Fry NK, Ventosilla P, Cáceres AG, Sánchez E, Vizcarra H, Raoult D
J Clin Microbiol 2002 Oct;40(10):3606-12. doi: 10.1128/JCM.40.10.3606-3612.2002. PMID: 12354853Free PMC Article

Recent clinical studies

Etiology

Ocular manifestations of bartonellosis.
Mabra D, Yeh S, Shantha JG
Curr Opin Ophthalmol 2018 Nov;29(6):582-587. doi: 10.1097/ICU.0000000000000522. PMID: 30124532
Bartonella infections in humans dogs and cats.
Iannino F, Salucci S, Di Provvido A, Paolini A, Ruggieri E
Vet Ital 2018 Mar 31;54(1):63-72. doi: 10.12834/VetIt.398.1883.2. PMID: 29631316
Pet-Related Infections.
Day MJ
Am Fam Physician 2016 Nov 15;94(10):794-802. PMID: 27929279
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
Ocular bartonellosis.
Cunningham ET, Koehler JE
Am J Ophthalmol 2000 Sep;130(3):340-9. doi: 10.1016/s0002-9394(00)00573-0. PMID: 11020414

Diagnosis

Cutaneous manifestations of bartonellosis.
Lins KA, Drummond MR, Velho PENF
An Bras Dermatol 2019 Sep-Oct;94(5):594-602. Epub 2019 Oct 2 doi: 10.1016/j.abd.2019.09.024. PMID: 31780437Free PMC Article
Ocular manifestations of bartonellosis.
Mabra D, Yeh S, Shantha JG
Curr Opin Ophthalmol 2018 Nov;29(6):582-587. doi: 10.1097/ICU.0000000000000522. PMID: 30124532
Bartonellosis.
Guptill L
Vet Microbiol 2010 Jan 27;140(3-4):347-59. Epub 2009 Nov 18 doi: 10.1016/j.vetmic.2009.11.011. PMID: 20018462
Bartonellosis.
Maguiña C, Guerra H, Ventosilla P
Clin Dermatol 2009 May-Jun;27(3):271-80. doi: 10.1016/j.clindermatol.2008.10.006. PMID: 19362689
Ocular bartonellosis.
Cunningham ET, Koehler JE
Am J Ophthalmol 2000 Sep;130(3):340-9. doi: 10.1016/s0002-9394(00)00573-0. PMID: 11020414

Therapy

Atypical bartonellosis in children: What do we know?
Lemos AP, Domingues R, Gouveia C, de Sousa R, Brito MJ
J Paediatr Child Health 2021 May;57(5):653-658. Epub 2020 Dec 10 doi: 10.1111/jpc.15304. PMID: 33301212
Ocular manifestations of bartonellosis.
Mabra D, Yeh S, Shantha JG
Curr Opin Ophthalmol 2018 Nov;29(6):582-587. doi: 10.1097/ICU.0000000000000522. PMID: 30124532
Treatment outcomes of human bartonellosis: a systematic review and meta-analysis.
Prutsky G, Domecq JP, Mori L, Bebko S, Matzumura M, Sabouni A, Shahrour A, Erwin PJ, Boyce TG, Montori VM, Malaga G, Murad MH
Int J Infect Dis 2013 Oct;17(10):e811-9. Epub 2013 Apr 18 doi: 10.1016/j.ijid.2013.02.016. PMID: 23602630
Bartonellosis: light and shadows in diagnostic and therapeutic issues.
Manfredi R, Sabbatani S, Chiodo F
Clin Microbiol Infect 2005 Mar;11(3):167-9. doi: 10.1111/j.1469-0691.2004.01010.x. PMID: 15715712
Ocular bartonellosis.
Cunningham ET, Koehler JE
Am J Ophthalmol 2000 Sep;130(3):340-9. doi: 10.1016/s0002-9394(00)00573-0. PMID: 11020414

Prognosis

Liver abscesses in the Western pediatric population.
Grossar L, Hoffman I, Sokal E, Stéphenne X, Witters P
Acta Gastroenterol Belg 2022 Jul-Sep;85(3):439-445. Epub 2022 Jun 30 doi: 10.51821/85.3.10211. PMID: 35833905
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
Ophthalmic manifestations of bartonella infection.
Amer R, Tugal-Tutkun I
Curr Opin Ophthalmol 2017 Nov;28(6):607-612. doi: 10.1097/ICU.0000000000000419. PMID: 28984726
Bartonellosis: light and shadows in diagnostic and therapeutic issues.
Manfredi R, Sabbatani S, Chiodo F
Clin Microbiol Infect 2005 Mar;11(3):167-9. doi: 10.1111/j.1469-0691.2004.01010.x. PMID: 15715712
Presumed ocular bartonellosis.
Kerkhoff FT, Ossewaarde JM, de Loos WS, Rothova A
Br J Ophthalmol 1999 Mar;83(3):270-5. doi: 10.1136/bjo.83.3.270. PMID: 10365031Free PMC Article

Clinical prediction guides

Cat Scratch Disease and Bartonellaceae: The Known, the Unknown and the Curious.
Zangwill KM
Pediatr Infect Dis J 2021 May 1;40(5S):S11-S15. doi: 10.1097/INF.0000000000002776. PMID: 34042905
Atypical bartonellosis in children: What do we know?
Lemos AP, Domingues R, Gouveia C, de Sousa R, Brito MJ
J Paediatr Child Health 2021 May;57(5):653-658. Epub 2020 Dec 10 doi: 10.1111/jpc.15304. PMID: 33301212
Human Tick-Borne Diseases in Australia.
Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ
Front Cell Infect Microbiol 2019;9:3. Epub 2019 Jan 28 doi: 10.3389/fcimb.2019.00003. PMID: 30746341Free PMC Article
Feline bartonellosis key issues and possible vectors.
Mazurek Ł, Winiarczyk S, Adaszek Ł
Ann Parasitol 2018;64(4):309-315. doi: 10.17420/ap6404.165. PMID: 30720968
Treatment outcomes of human bartonellosis: a systematic review and meta-analysis.
Prutsky G, Domecq JP, Mori L, Bebko S, Matzumura M, Sabouni A, Shahrour A, Erwin PJ, Boyce TG, Montori VM, Malaga G, Murad MH
Int J Infect Dis 2013 Oct;17(10):e811-9. Epub 2013 Apr 18 doi: 10.1016/j.ijid.2013.02.016. PMID: 23602630

Recent systematic reviews

Phlebotomine sand flies (Diptera: Psychodidae) and sand fly-borne pathogens in the Greater Mekong Subregion: a systematic review.
Hustedt J, Prasetyo DB, Fiorenzano JM, von Fricken ME, Hertz JC
Parasit Vectors 2022 Oct 5;15(1):355. doi: 10.1186/s13071-022-05464-8. PMID: 36199150Free PMC Article
Laboratory Methods for Detection of Infectious Agents and Serological Response in Humans With Tick-Borne Infections: A Systematic Review of Evaluations Based on Clinical Patient Samples.
Henningsson AJ, Aase A, Bavelaar H, Flottorp S, Forsberg P, Kirkehei I, Lövmar M, Nilsson K, Nyman D, Ornstein K, Sjöwall J, Skogman BH, Tjernberg I, Aaberge I
Front Public Health 2021;9:580102. Epub 2021 Sep 20 doi: 10.3389/fpubh.2021.580102. PMID: 34616701Free PMC Article
Bartonellosis in Chronic Kidney Disease: An Unrecognized and Unsuspected Diagnosis.
Shamekhi Amiri F
Ther Apher Dial 2017 Oct;21(5):430-440. Epub 2017 Sep 8 doi: 10.1111/1744-9987.12571. PMID: 28884961
Treatment outcomes of human bartonellosis: a systematic review and meta-analysis.
Prutsky G, Domecq JP, Mori L, Bebko S, Matzumura M, Sabouni A, Shahrour A, Erwin PJ, Boyce TG, Montori VM, Malaga G, Murad MH
Int J Infect Dis 2013 Oct;17(10):e811-9. Epub 2013 Apr 18 doi: 10.1016/j.ijid.2013.02.016. PMID: 23602630
Fever of unknown origin in children: a systematic review.
Chow A, Robinson JL
World J Pediatr 2011 Feb;7(1):5-10. Epub 2010 Dec 30 doi: 10.1007/s12519-011-0240-5. PMID: 21191771

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