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Tuberculosis of meninges

MedGen UID:
21725
Concept ID:
C0041318
Disease or Syndrome
Synonyms: Meningeal tuberculosis; TB meningitis; Tubercular meningitis; Tuberculous meningitis
SNOMED CT: TB - Tuberculous meningitis (58437007); TBM - Tuberculous meningitis (58437007); Tuberculosis of meninges (58437007); Tuberculous meningitis (58437007)
 
Monarch Initiative: MONDO:0006042
Orphanet: ORPHA499004

Definition

A rare bacterial infectious disease caused by <i>Mycobacterium tuberculosis</i>, characterized by a variable clinical picture comprising classic manifestations of meningitis, i. e. headache, fever, and stiff neck, in addition to cranial nerve palsies (most commonly III, VI, and VII), altered mental status, and seizures, among others. Basal meningeal enhancement in neuroimaging, cerebrospinal fluid abnormalities (moderate lymphocytic pleocytosis, moderately elevated protein concentration, low glucose), and a chest x-ray suggestive of pulmonary tuberculosis may support the diagnosis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTuberculosis of meninges

Professional guidelines

PubMed

Méchaï F, Bouchaud O
Rev Neurol (Paris) 2019 Sep-Oct;175(7-8):451-457. Epub 2019 Aug 2 doi: 10.1016/j.neurol.2019.07.007. PMID: 31383464
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246
Carod Artal FJ
Expert Rev Neurother 2016;16(2):205-21. Epub 2016 Jan 19 doi: 10.1586/14737175.2015.1134321. PMID: 26689107

Supplemental Content

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