U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bacterial infection of central nervous system

MedGen UID:
199829
•Concept ID:
C0752180
•
Disease or Syndrome
Synonyms: Bacterial Infections, Central Nervous System; Central Nervous System Bacterial Infections; Infections, Bacterial, Central Nervous System
SNOMED CT: Bacterial infection of central nervous system (128119004)

Definition

Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces. [from MeSH]

Professional guidelines

PubMed

Application of therapeutic drug monitoring to the treatment of bacterial central nervous system infection: a scoping review.
Arkell P, Wilson R, Watkins K, Antcliffe DB, Gilchrist M, Wilson M, Rawson TM, Holmes A
J Antimicrob Chemother 2022 Nov 28;77(12):3408-3413. doi: 10.1093/jac/dkac332. PMID: 36227686Free PMC Article

Recent clinical studies

Etiology

Group B Streptococcal Neonatal Meningitis.
Tavares T, Pinho L, Bonifácio Andrade E
Clin Microbiol Rev 2022 Apr 20;35(2):e0007921. Epub 2022 Feb 16 doi: 10.1128/cmr.00079-21. PMID: 35170986Free PMC Article
High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram.
Grégoire M, Dailly E, Le Turnier P, Garot D, Guimard T, Bernard L, Tattevin P, Vandamme YM, Hoff J, Lemaitre F, Verdier MC, Deslandes G, Bellouard R, Sébille V, Chiffoleau A, Boutoille D, Navas D, Asseray N
Antimicrob Agents Chemother 2019 Sep;63(9) Epub 2019 Aug 23 doi: 10.1128/AAC.00634-19. PMID: 31235630Free PMC Article
Bacterial Infections of the Central Nervous System.
Suthar R, Sankhyan N
Indian J Pediatr 2019 Jan;86(1):60-69. Epub 2018 Jan 3 doi: 10.1007/s12098-017-2477-z. PMID: 29297142
Clinical management of non-faecium non-faecalis vancomycin-resistant enterococci infection. Focus on Enterococcus gallinarum and Enterococcus casseliflavus/flavescens.
Monticelli J, Knezevich A, Luzzati R, Di Bella S
J Infect Chemother 2018 Apr;24(4):237-246. Epub 2018 Feb 1 doi: 10.1016/j.jiac.2018.01.001. PMID: 29396199
ESCMID guideline: diagnosis and treatment of acute bacterial meningitis.
van de Beek D, Cabellos C, Dzupova O, Esposito S, Klein M, Kloek AT, Leib SL, Mourvillier B, Ostergaard C, Pagliano P, Pfister HW, Read RC, Sipahi OR, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2016 May;22 Suppl 3:S37-62. Epub 2016 Apr 7 doi: 10.1016/j.cmi.2016.01.007. PMID: 27062097

Diagnosis

Group B Streptococcal Neonatal Meningitis.
Tavares T, Pinho L, Bonifácio Andrade E
Clin Microbiol Rev 2022 Apr 20;35(2):e0007921. Epub 2022 Feb 16 doi: 10.1128/cmr.00079-21. PMID: 35170986Free PMC Article
Cerebrospinal Fluid Analysis.
Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511
Acute bacterial meningitis.
Wall EC, Chan JM, Gil E, Heyderman RS
Curr Opin Neurol 2021 Jun 1;34(3):386-395. doi: 10.1097/WCO.0000000000000934. PMID: 33767093Free PMC Article
Bacterial Infections of the Central Nervous System.
Suthar R, Sankhyan N
Indian J Pediatr 2019 Jan;86(1):60-69. Epub 2018 Jan 3 doi: 10.1007/s12098-017-2477-z. PMID: 29297142
Central Nervous System Infections.
Giovane RA, Lavender PD
Prim Care 2018 Sep;45(3):505-518. Epub 2018 Jul 9 doi: 10.1016/j.pop.2018.05.007. PMID: 30115337

Therapy

Group B Streptococcal Neonatal Meningitis.
Tavares T, Pinho L, Bonifácio Andrade E
Clin Microbiol Rev 2022 Apr 20;35(2):e0007921. Epub 2022 Feb 16 doi: 10.1128/cmr.00079-21. PMID: 35170986Free PMC Article
Acute bacterial meningitis.
Wall EC, Chan JM, Gil E, Heyderman RS
Curr Opin Neurol 2021 Jun 1;34(3):386-395. doi: 10.1097/WCO.0000000000000934. PMID: 33767093Free PMC Article
Intrathecal Antibacterial and Antifungal Therapies.
Nau R, Blei C, Eiffert H
Clin Microbiol Rev 2020 Jun 17;33(3) Epub 2020 Apr 29 doi: 10.1128/CMR.00190-19. PMID: 32349999Free PMC Article
Bacterial Infections of the Central Nervous System.
Suthar R, Sankhyan N
Indian J Pediatr 2019 Jan;86(1):60-69. Epub 2018 Jan 3 doi: 10.1007/s12098-017-2477-z. PMID: 29297142
Central Nervous System Infections.
Giovane RA, Lavender PD
Prim Care 2018 Sep;45(3):505-518. Epub 2018 Jul 9 doi: 10.1016/j.pop.2018.05.007. PMID: 30115337

Prognosis

Cerebrospinal Fluid Analysis.
Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features.
Schaller MA, Wicke F, Foerch C, Weidauer S
Clin Neuroradiol 2019 Mar;29(1):3-18. Epub 2018 Sep 17 doi: 10.1007/s00062-018-0726-9. PMID: 30225516
Central Nervous System Infections.
Giovane RA, Lavender PD
Prim Care 2018 Sep;45(3):505-518. Epub 2018 Jul 9 doi: 10.1016/j.pop.2018.05.007. PMID: 30115337
Neurosyphilis: Knowledge Gaps and Controversies.
Tuddenham S, Ghanem KG
Sex Transm Dis 2018 Mar;45(3):147-151. doi: 10.1097/OLQ.0000000000000723. PMID: 29420441Free PMC Article
Clinical characteristics and outcome of brain abscess: systematic review and meta-analysis.
Brouwer MC, Coutinho JM, van de Beek D
Neurology 2014 Mar 4;82(9):806-13. Epub 2014 Jan 29 doi: 10.1212/WNL.0000000000000172. PMID: 24477107

Clinical prediction guides

Progress and Challenges in Bacterial Meningitis: A Review.
Hasbun R
JAMA 2022 Dec 6;328(21):2147-2154. doi: 10.1001/jama.2022.20521. PMID: 36472590
A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections.
Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Hoyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN)
JAMA Pediatr 2019 Apr 1;173(4):342-351. doi: 10.1001/jamapediatrics.2018.5501. PMID: 30776077Free PMC Article
Infections of the cerebellum.
Pruitt AA
Neurol Clin 2014 Nov;32(4):1117-31. Epub 2014 Oct 24 doi: 10.1016/j.ncl.2014.07.009. PMID: 25439297
Fulminant bacterial meningitis.
Radetsky M
Pediatr Infect Dis J 2014 Feb;33(2):204-7. doi: 10.1097/01.inf.0000435508.67490.f0. PMID: 24413408
Bacterial meningitis.
Roos KL, van de Beek D
Handb Clin Neurol 2010;96:51-63. Epub 2010 Jan 19 doi: 10.1016/S0072-9752(09)96004-3. PMID: 20109674

Recent systematic reviews

Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis.
Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article
How do I manage nocardiosis?
Margalit I, Lebeaux D, Tishler O, Goldberg E, Bishara J, Yahav D, Coussement J
Clin Microbiol Infect 2021 Apr;27(4):550-558. Epub 2021 Jan 5 doi: 10.1016/j.cmi.2020.12.019. PMID: 33418019
Global etiology of bacterial meningitis: A systematic review and meta-analysis.
Oordt-Speets AM, Bolijn R, van Hoorn RC, Bhavsar A, Kyaw MH
PLoS One 2018;13(6):e0198772. Epub 2018 Jun 11 doi: 10.1371/journal.pone.0198772. PMID: 29889859Free PMC Article
Corticosteroids for acute bacterial meningitis.
Brouwer MC, McIntyre P, Prasad K, van de Beek D
Cochrane Database Syst Rev 2015 Sep 12;2015(9):CD004405. doi: 10.1002/14651858.CD004405.pub5. PMID: 26362566Free PMC Article
Clinical characteristics and outcome of brain abscess: systematic review and meta-analysis.
Brouwer MC, Coutinho JM, van de Beek D
Neurology 2014 Mar 4;82(9):806-13. Epub 2014 Jan 29 doi: 10.1212/WNL.0000000000000172. PMID: 24477107

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...