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Weil disease

MedGen UID:
21912
•Concept ID:
C0043102
•
Disease or Syndrome
Synonym: Weil's disease
SNOMED CT: Weil's disease (398067003); Icteric leptospirosis (398067003); Weil disease (398067003)
 
Monarch Initiative: MONDO:0043004

Definition

A jauncice caused by severe leptospirosis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWeil disease

Professional guidelines

PubMed

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study.
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Non-invasive diagnosis and follow-up of portal hypertension.
Thabut D, Weil D, Bouzbib C, Rudler M, Cassinotto C, Castéra L, Serste T, Oberti F, Ganne-Carrié N, de Lédinghen V, Bourlière M, Bureau C
Clin Res Hepatol Gastroenterol 2022 Oct;46(8):101767. Epub 2021 Jul 29 doi: 10.1016/j.clinre.2021.101767. PMID: 34332128
Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries.
Getahun H, Matteelli A, Abubakar I, Aziz MA, Baddeley A, Barreira D, Den Boon S, Borroto Gutierrez SM, Bruchfeld J, Burhan E, Cavalcante S, Cedillos R, Chaisson R, Chee CB, Chesire L, Corbett E, Dara M, Denholm J, de Vries G, Falzon D, Ford N, Gale-Rowe M, Gilpin C, Girardi E, Go UY, Govindasamy D, D Grant A, Grzemska M, Harris R, Horsburgh CR Jr, Ismayilov A, Jaramillo E, Kik S, Kranzer K, Lienhardt C, LoBue P, Lönnroth K, Marks G, Menzies D, Migliori GB, Mosca D, Mukadi YD, Mwinga A, Nelson L, Nishikiori N, Oordt-Speets A, Rangaka MX, Reis A, Rotz L, Sandgren A, Sañé Schepisi M, Schünemann HJ, Sharma SK, Sotgiu G, Stagg HR, Sterling TR, Tayeb T, Uplekar M, van der Werf MJ, Vandevelde W, van Kessel F, van't Hoog A, Varma JK, Vezhnina N, Voniatis C, Vonk Noordegraaf-Schouten M, Weil D, Weyer K, Wilkinson RJ, Yoshiyama T, Zellweger JP, Raviglione M
Eur Respir J 2015 Dec;46(6):1563-76. Epub 2015 Sep 24 doi: 10.1183/13993003.01245-2015. PMID: 26405286Free PMC Article

Recent clinical studies

Etiology

Endothelial biomarkers as predictors for haemodialysis need in severe leptospirosis patients (Weil's disease).
Meneses GC, de Carvalho Gomes PEA, Galdino GS, Bezerra GF, de Souza Santos RS, Martins AMC, da Silva Junior GB, Libório AB, Pires Neto RDJ, Daher EF
Trop Med Int Health 2022 Aug;27(8):727-734. Epub 2022 Jul 11 doi: 10.1111/tmi.13796. PMID: 35761507
Leptospirosis in South-western Spain.
Rodríguez-Vidigal FF, Vera-Tomé A, Nogales-Muñoz N, Muñoz-García-Borruel M, Muñoz-Sanz A
Rev Clin Esp (Barc) 2014 Jun-Jul;214(5):247-52. Epub 2014 Apr 1 doi: 10.1016/j.rce.2014.02.009. PMID: 24703813
Association between age and severity to leptospirosis in children.
Guerrier G, Hie P, Gourinat AC, Huguon E, Polfrit Y, Goarant C, D'Ortenzio E, Missotte I
PLoS Negl Trop Dis 2013;7(9):e2436. Epub 2013 Sep 26 doi: 10.1371/journal.pntd.0002436. PMID: 24086780Free PMC Article
Leptospiral nephropathy.
Andrade L, de Francesco Daher E, Seguro AC
Semin Nephrol 2008 Jul;28(4):383-394. doi: 10.1016/j.semnephrol.2008.04.008. PMID: 18620961
Human leptospirosis.
Feigin RD, Anderson DC
CRC Crit Rev Clin Lab Sci 1975 Mar;5(4):413-67. doi: 10.3109/10408367509107050. PMID: 237740

Diagnosis

Leptospirosis in South-western Spain.
Rodríguez-Vidigal FF, Vera-Tomé A, Nogales-Muñoz N, Muñoz-García-Borruel M, Muñoz-Sanz A
Rev Clin Esp (Barc) 2014 Jun-Jul;214(5):247-52. Epub 2014 Apr 1 doi: 10.1016/j.rce.2014.02.009. PMID: 24703813
Leptospirosis and Weil's disease in the UK.
Forbes AE, Zochowski WJ, Dubrey SW, Sivaprakasam V
QJM 2012 Dec;105(12):1151-62. Epub 2012 Jul 27 doi: 10.1093/qjmed/hcs145. PMID: 22843698
Bat-associated leptospirosis.
Vashi NA, Reddy P, Wayne DB, Sabin B
J Gen Intern Med 2010 Feb;25(2):162-4. Epub 2009 Dec 9 doi: 10.1007/s11606-009-1210-7. PMID: 20012224Free PMC Article
Leptospirosis in Latin America.
Lomar AV, Diament D, Torres JR
Infect Dis Clin North Am 2000 Mar;14(1):23-39, vii-viii. doi: 10.1016/s0891-5520(05)70216-6. PMID: 10738671
Human leptospirosis.
Feigin RD, Anderson DC
CRC Crit Rev Clin Lab Sci 1975 Mar;5(4):413-67. doi: 10.3109/10408367509107050. PMID: 237740

Therapy

Report of Weil's disease with a fatal course triggered by Jarisch-Herxheimer reaction.
Chiko Y, Shiokawa K, Namihira I, Itagaki K, Maruyama K, Tachibana Y, Ryu Y, Sakai T
J Infect Chemother 2023 Aug;29(8):800-802. Epub 2023 Apr 17 doi: 10.1016/j.jiac.2023.04.009. PMID: 37075979
Weil's disease with haemoptysis and acute respiratory distress syndrome.
Roumpou A, Papaioannou I, Lampropoulos C
BMJ Case Rep 2019 May 30;12(5) doi: 10.1136/bcr-2019-229350. PMID: 31151976Free PMC Article
Leptospirosis: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine.
Jiménez JIS, Marroquin JLH, Richards GA, Amin P
J Crit Care 2018 Feb;43:361-365. Epub 2017 Nov 10 doi: 10.1016/j.jcrc.2017.11.005. PMID: 29129539
Clinical observation and treatment of leptospirosis.
Kobayashi Y
J Infect Chemother 2001 Jun;7(2):59-68. doi: 10.1007/s101560100011. PMID: 11455495
Spirochetal infections.
Taber LH, Feigin RD
Pediatr Clin North Am 1979 May;26(2):377-413. doi: 10.1016/s0031-3955(16)33713-0. PMID: 379781

Prognosis

Report of Weil's disease with a fatal course triggered by Jarisch-Herxheimer reaction.
Chiko Y, Shiokawa K, Namihira I, Itagaki K, Maruyama K, Tachibana Y, Ryu Y, Sakai T
J Infect Chemother 2023 Aug;29(8):800-802. Epub 2023 Apr 17 doi: 10.1016/j.jiac.2023.04.009. PMID: 37075979
Weil's Disease-Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota.
Petakh P, Isevych V, Kamyshnyi A, Oksenych V
Biomolecules 2022 Dec 7;12(12) doi: 10.3390/biom12121830. PMID: 36551258Free PMC Article
Leptospirosis in South-western Spain.
Rodríguez-Vidigal FF, Vera-Tomé A, Nogales-Muñoz N, Muñoz-García-Borruel M, Muñoz-Sanz A
Rev Clin Esp (Barc) 2014 Jun-Jul;214(5):247-52. Epub 2014 Apr 1 doi: 10.1016/j.rce.2014.02.009. PMID: 24703813
Clinical and imaging manifestations of hemorrhagic pulmonary leptospirosis: a state-of-the-art review.
Marchiori E, Lourenço S, Setúbal S, Zanetti G, Gasparetto TD, Hochhegger B
Lung 2011 Feb;189(1):1-9. Epub 2010 Dec 9 doi: 10.1007/s00408-010-9273-0. PMID: 21152929
Clinical observation and treatment of leptospirosis.
Kobayashi Y
J Infect Chemother 2001 Jun;7(2):59-68. doi: 10.1007/s101560100011. PMID: 11455495

Clinical prediction guides

Report of Weil's disease with a fatal course triggered by Jarisch-Herxheimer reaction.
Chiko Y, Shiokawa K, Namihira I, Itagaki K, Maruyama K, Tachibana Y, Ryu Y, Sakai T
J Infect Chemother 2023 Aug;29(8):800-802. Epub 2023 Apr 17 doi: 10.1016/j.jiac.2023.04.009. PMID: 37075979
Leptospirosis in South-western Spain.
Rodríguez-Vidigal FF, Vera-Tomé A, Nogales-Muñoz N, Muñoz-García-Borruel M, Muñoz-Sanz A
Rev Clin Esp (Barc) 2014 Jun-Jul;214(5):247-52. Epub 2014 Apr 1 doi: 10.1016/j.rce.2014.02.009. PMID: 24703813
Association between age and severity to leptospirosis in children.
Guerrier G, Hie P, Gourinat AC, Huguon E, Polfrit Y, Goarant C, D'Ortenzio E, Missotte I
PLoS Negl Trop Dis 2013;7(9):e2436. Epub 2013 Sep 26 doi: 10.1371/journal.pntd.0002436. PMID: 24086780Free PMC Article
Clinical and imaging manifestations of hemorrhagic pulmonary leptospirosis: a state-of-the-art review.
Marchiori E, Lourenço S, Setúbal S, Zanetti G, Gasparetto TD, Hochhegger B
Lung 2011 Feb;189(1):1-9. Epub 2010 Dec 9 doi: 10.1007/s00408-010-9273-0. PMID: 21152929
Clinical observation and treatment of leptospirosis.
Kobayashi Y
J Infect Chemother 2001 Jun;7(2):59-68. doi: 10.1007/s101560100011. PMID: 11455495

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