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Glassy Cell Carcinoma

MedGen UID:
220403
•Concept ID:
C1265998
•
Neoplastic Process
Synonym: Glassy cell carcinoma
SNOMED CT: Glassy cell carcinoma (128630000)

Definition

A malignant epithelial neoplasm composed of atypical cells with glassy cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlassy Cell Carcinoma

Professional guidelines

PubMed

Glassy cell carcinoma of the cervix: Findings from a combined National Cancer Database analysis and single institution review of treatment patterns and outcomes.
Levine MD, Barrington DA, Meade CE, Lammers SM, McLaughlin EM, Suarez AA, Backes FJ, Copeland LJ, O'Malley DM, Cosgrove CM, Cohn DE, Nagel CI, Felix AS, Bixel KL
Gynecol Oncol 2023 Jun;173:15-21. Epub 2023 Apr 8 doi: 10.1016/j.ygyno.2023.03.023. PMID: 37037083
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781
Glassy cell carcinoma of the cervix: a bimodal treatment strategy.
Lotocki RJ, Krepart GV, Paraskevas M, Vadas G, Heywood M, Fung FK
Gynecol Oncol 1992 Mar;44(3):254-9. doi: 10.1016/0090-8258(92)90052-k. PMID: 1541437

Recent clinical studies

Etiology

Cervical Adenosquamous Carcinoma: Detailed Analysis of Morphology, Immunohistochemical Profile, and Outcome in 59 Cases.
Stolnicu S, Hoang L, Zhou Q, Iasonos A, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Oliva E, Park KJ, Soslow RA
Int J Gynecol Pathol 2023 May 1;42(3):259-269. Epub 2022 Aug 31 doi: 10.1097/PGP.0000000000000921. PMID: 36044310Free PMC Article
Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping.
Jung YY, Nahm JH, Kim HS
Oncotarget 2016 Nov 8;7(45):74152-74161. doi: 10.18632/oncotarget.12361. PMID: 27708230Free PMC Article
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report.
Carocha AI, Pedroso C, Correia L, Gomes A, Jorge AF
J Low Genit Tract Dis 2015 Apr;19(2):e31-4. doi: 10.1097/LGT.0000000000000054. PMID: 25062402
Glassy cell carcinoma of the cervix: a literature review.
Zolciak-Siwinska A, Jonska-Gmyrek J
Eur J Obstet Gynecol Reprod Biol 2014 Aug;179:232-5. Epub 2014 Apr 13 doi: 10.1016/j.ejogrb.2014.03.035. PMID: 24792540
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463

Diagnosis

Immunohistochemical analysis of glassy cell carcinoma of the cervix reveals robust lymphocyte infiltrate and the expression of targetable inhibitory immune checkpoints.
Blake EA, Ross MS, Ross ME, Matsuo K, Silverstein ET, Torno LR, Bhargava R, Post MD, Da Silva DM, Taylor S, Walia S, Roman L, McEachron TA
Arch Gynecol Obstet 2022 Feb;305(2):439-447. Epub 2021 Aug 15 doi: 10.1007/s00404-021-06164-x. PMID: 34392396
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report.
Carocha AI, Pedroso C, Correia L, Gomes A, Jorge AF
J Low Genit Tract Dis 2015 Apr;19(2):e31-4. doi: 10.1097/LGT.0000000000000054. PMID: 25062402
Glassy cell carcinoma of the cervix: a literature review.
Zolciak-Siwinska A, Jonska-Gmyrek J
Eur J Obstet Gynecol Reprod Biol 2014 Aug;179:232-5. Epub 2014 Apr 13 doi: 10.1016/j.ejogrb.2014.03.035. PMID: 24792540
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Therapy

Clinical outcomes of advanced-stage glassy cell carcinoma of the uterine cervix: a need for reappraisal.
Yoon N, Kim JY, Kim HS
Oncotarget 2016 Nov 29;7(48):78448-78454. doi: 10.18632/oncotarget.12905. PMID: 27793022Free PMC Article
Analysis of SEER Glassy Cell Carcinoma Data: Underuse of Radiotherapy and Predicators of Cause Specific Survival.
Cheung R
Asian Pac J Cancer Prev 2016;17(1):353-6. doi: 10.7314/apjcp.2016.17.1.353. PMID: 26838236
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report.
Carocha AI, Pedroso C, Correia L, Gomes A, Jorge AF
J Low Genit Tract Dis 2015 Apr;19(2):e31-4. doi: 10.1097/LGT.0000000000000054. PMID: 25062402
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
A case of glassy cell carcinoma of the uterine cervix that responded to neoadjuvant chemotherapy with paclitaxel and carboplatin.
Takekuma M, Hirashima Y, Takahashi N, Yamamichi G, Furukawa N, Yamada Y, Takakuwa R, Ito I
Anticancer Drugs 2006 Jul;17(6):715-8. doi: 10.1097/01.cad.0000217420.14090.a9. PMID: 16917218

Prognosis

Glassy cell carcinoma of the uterine cervix: 20-year experience from a comprehensive cancer center.
Boustani J, Achkar S, Bertaut A, Genestie C, Gouy S, Pautier P, Morice P, Haie-Meder C, Chargari C
Cancer Radiother 2021 May;25(3):207-212. Epub 2021 Jan 3 doi: 10.1016/j.canrad.2020.07.007. PMID: 33408051
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report.
Carocha AI, Pedroso C, Correia L, Gomes A, Jorge AF
J Low Genit Tract Dis 2015 Apr;19(2):e31-4. doi: 10.1097/LGT.0000000000000054. PMID: 25062402
Glassy cell carcinoma of the cervix: a literature review.
Zolciak-Siwinska A, Jonska-Gmyrek J
Eur J Obstet Gynecol Reprod Biol 2014 Aug;179:232-5. Epub 2014 Apr 13 doi: 10.1016/j.ejogrb.2014.03.035. PMID: 24792540
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
A clinicopathological study on glassy cell carcinoma of the cervix.
Tsukahara Y, Sakai Y, Ishii J, Iwai S, Fukuta T
Acta Obstet Gynaecol Jpn 1981 May;33(5):699-704. PMID: 7234357

Clinical prediction guides

Glassy cell carcinoma of the cervix: Findings from a combined National Cancer Database analysis and single institution review of treatment patterns and outcomes.
Levine MD, Barrington DA, Meade CE, Lammers SM, McLaughlin EM, Suarez AA, Backes FJ, Copeland LJ, O'Malley DM, Cosgrove CM, Cohn DE, Nagel CI, Felix AS, Bixel KL
Gynecol Oncol 2023 Jun;173:15-21. Epub 2023 Apr 8 doi: 10.1016/j.ygyno.2023.03.023. PMID: 37037083
Immunohistochemical analysis of glassy cell carcinoma of the cervix reveals robust lymphocyte infiltrate and the expression of targetable inhibitory immune checkpoints.
Blake EA, Ross MS, Ross ME, Matsuo K, Silverstein ET, Torno LR, Bhargava R, Post MD, Da Silva DM, Taylor S, Walia S, Roman L, McEachron TA
Arch Gynecol Obstet 2022 Feb;305(2):439-447. Epub 2021 Aug 15 doi: 10.1007/s00404-021-06164-x. PMID: 34392396
Cytomorphological characteristics of glassy cell carcinoma of the uterine cervix: histopathological correlation and human papillomavirus genotyping.
Jung YY, Nahm JH, Kim HS
Oncotarget 2016 Nov 8;7(45):74152-74161. doi: 10.18632/oncotarget.12361. PMID: 27708230Free PMC Article
Glassy cell carcinoma of the uterine cervix: histochemical, immunohistochemical, and molecular genetic observations.
Kato N, Katayama Y, Kaimori M, Motoyama T
Int J Gynecol Pathol 2002 Apr;21(2):134-40. doi: 10.1097/00004347-200204000-00005. PMID: 11917222
A novel human glassy-cell carcinoma cell line producing IL-6 and IL-8 from uterine cervix.
Oki A, Nishida M, Satoh T, Tsunoda H, Kasahara K, Saijo K, Kubo T, Ohno T
In Vitro Cell Dev Biol Anim 1998 Apr;34(4):290-7. doi: 10.1007/s11626-998-0005-1. PMID: 9590502

Recent systematic reviews

Glassy cell carcinoma of the cervix: a systematic review and meta-analysis.
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463

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