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Mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma

MedGen UID:
220410
•Concept ID:
C1266036
•
Neoplastic Process
Synonyms: Bronchiolo-alveolar carcinoma, Clara cell and goblet cell type; Bronchiolo-alveolar carcinoma, indeterminate type; Bronchiolo-alveolar carcinoma, mixed mucinous and non-mucinous; Bronchiolo-alveolar carcinoma, type II pneumocyte and goblet cell type; indeterminate bronchioloalveolar carcinoma; Minimally Invasive Lung Mixed Non-Mucinous and Mucinous Adenocarcinoma; mixed mucinous and non-mucinous bronchioloalveolar adenocarcinoma; mixed mucinous and non-mucinous bronchioloalveolar carcinoma; mixed mucinous and non-mucinous bronchioloalveolar lung carcinoma; mixed mucinous and non-mucinous bronchoalveolar lung carcinoma; mixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma
SNOMED CT: Bronchiolo-alveolar carcinoma, type II pneumocyte and goblet cell type (128661009); Bronchiolo-alveolar carcinoma, indeterminate type (128661009); Bronchiolo-alveolar carcinoma, Clara cell and goblet cell type (128661009); Bronchiolo-alveolar carcinoma, mixed mucinous and non-mucinous (128661009)
 
Monarch Initiative: MONDO:0000893

Definition

A morphologic variant of minimally invasive lung adenocarcinoma characterized by the presence of Clara cells and/or type II cells, tall columnar cells, and mucin production. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed mucinous and nonmucinous bronchioloalveolar adenocarcinoma

Professional guidelines

PubMed

Genotype-phenotype correlation in Chinese patients with pulmonary mixed type adenocarcinoma: Relationship between histologic subtypes, TITF-1/SP-A expressions and EGFR mutations.
Jie-Liu, Li XY, Zhao YQ, Liu RQ, Zhang JB, Ma J, Chen LJ, Hu XF
Pathol Res Pract 2014 Mar;210(3):176-81. Epub 2013 Dec 5 doi: 10.1016/j.prp.2013.11.013. PMID: 24370340

Recent clinical studies

Etiology

Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
Zhang Z, Wang A, Sun B, Zhan Z, Chen K, Wang C
J Cardiothorac Surg 2013 Apr 16;8:95. doi: 10.1186/1749-8090-8-95. PMID: 23591077Free PMC Article
Invasive adenocarcinoma with bronchoalveolar features: a population-based evaluation of the extent of resection in bronchoalveolar cell carcinoma.
Whitson BA, Groth SS, Andrade RS, Mitiek MO, Maddaus MA, D'Cunha J
J Thorac Cardiovasc Surg 2012 Mar;143(3):591-600.e1. Epub 2011 Dec 15 doi: 10.1016/j.jtcvs.2011.10.088. PMID: 22177098
Immunohistochemical analysis of lung carcinomas with pure or partial bronchioloalveolar differentiation.
Sarantopoulos GP, Gui D, Shintaku P, Hong L, Wang YY, Yap CS, Fishbein MC
Arch Pathol Lab Med 2004 Apr;128(4):406-14. doi: 10.5858/2004-128-406-IAOLCW. PMID: 15043468
Bronchioloalveolar lung cancer: occurrence, surgical treatment and survival.
Furák J, Troján I, Szoke T, Tiszlavicz L, Morvay Z, Eller J, Balogh A
Eur J Cardiothorac Surg 2003 May;23(5):818-23. doi: 10.1016/s1010-7940(03)00084-8. PMID: 12754039
Bronchioloalveolar lung carcinoma: results of surgical treatment and prognostic factors.
Regnard JF, Santelmo N, Romdhani N, Gharbi N, Bourcereau J, Dulmet E, Levasseur P
Chest 1998 Jul;114(1):45-50. doi: 10.1378/chest.114.1.45. PMID: 9674446

Diagnosis

Genotype-phenotype correlation in Chinese patients with pulmonary mixed type adenocarcinoma: Relationship between histologic subtypes, TITF-1/SP-A expressions and EGFR mutations.
Jie-Liu, Li XY, Zhao YQ, Liu RQ, Zhang JB, Ma J, Chen LJ, Hu XF
Pathol Res Pract 2014 Mar;210(3):176-81. Epub 2013 Dec 5 doi: 10.1016/j.prp.2013.11.013. PMID: 24370340
Diagnosis of lung adenocarcinoma in resected specimens: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, Ishikawa Y, Wistuba I, Flieder DB, Franklin W, Gazdar A, Hasleton PS, Henderson DW, Kerr KM, Nakatani Y, Petersen I, Roggli V, Thunnissen E, Tsao M
Arch Pathol Lab Med 2013 May;137(5):685-705. Epub 2012 Sep 12 doi: 10.5858/arpa.2012-0264-RA. PMID: 22913371
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Differential expression of cytokeratins 7 and 20 and thyroid transcription factor-1 in bronchioloalveolar carcinoma: an immunohistochemical study in fine-needle aspiration biopsy specimens.
Simsir A, Wei XJ, Yee H, Moreira A, Cangiarella J
Am J Clin Pathol 2004 Mar;121(3):350-7. doi: 10.1309/CM20-WA20-RW3T-600L. PMID: 15023039
Bronchioloalveolar lung carcinoma: results of surgical treatment and prognostic factors.
Regnard JF, Santelmo N, Romdhani N, Gharbi N, Bourcereau J, Dulmet E, Levasseur P
Chest 1998 Jul;114(1):45-50. doi: 10.1378/chest.114.1.45. PMID: 9674446

Therapy

Invasive adenocarcinoma with bronchoalveolar features: a population-based evaluation of the extent of resection in bronchoalveolar cell carcinoma.
Whitson BA, Groth SS, Andrade RS, Mitiek MO, Maddaus MA, D'Cunha J
J Thorac Cardiovasc Surg 2012 Mar;143(3):591-600.e1. Epub 2011 Dec 15 doi: 10.1016/j.jtcvs.2011.10.088. PMID: 22177098

Prognosis

Genotype-phenotype correlation in Chinese patients with pulmonary mixed type adenocarcinoma: Relationship between histologic subtypes, TITF-1/SP-A expressions and EGFR mutations.
Jie-Liu, Li XY, Zhao YQ, Liu RQ, Zhang JB, Ma J, Chen LJ, Hu XF
Pathol Res Pract 2014 Mar;210(3):176-81. Epub 2013 Dec 5 doi: 10.1016/j.prp.2013.11.013. PMID: 24370340
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma.
Zhang Z, Wang A, Sun B, Zhan Z, Chen K, Wang C
J Cardiothorac Surg 2013 Apr 16;8:95. doi: 10.1186/1749-8090-8-95. PMID: 23591077Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma.
Al-Salam S, Al-Ashari M
Appl Immunohistochem Mol Morphol 2009 Jul;17(4):351-6. doi: 10.1097/PAI.0b013e31818a9d90. PMID: 18997617
Bronchioloalveolar lung carcinoma: results of surgical treatment and prognostic factors.
Regnard JF, Santelmo N, Romdhani N, Gharbi N, Bourcereau J, Dulmet E, Levasseur P
Chest 1998 Jul;114(1):45-50. doi: 10.1378/chest.114.1.45. PMID: 9674446

Clinical prediction guides

Genotype-phenotype correlation in Chinese patients with pulmonary mixed type adenocarcinoma: Relationship between histologic subtypes, TITF-1/SP-A expressions and EGFR mutations.
Jie-Liu, Li XY, Zhao YQ, Liu RQ, Zhang JB, Ma J, Chen LJ, Hu XF
Pathol Res Pract 2014 Mar;210(3):176-81. Epub 2013 Dec 5 doi: 10.1016/j.prp.2013.11.013. PMID: 24370340
Invasive adenocarcinoma with bronchoalveolar features: a population-based evaluation of the extent of resection in bronchoalveolar cell carcinoma.
Whitson BA, Groth SS, Andrade RS, Mitiek MO, Maddaus MA, D'Cunha J
J Thorac Cardiovasc Surg 2012 Mar;143(3):591-600.e1. Epub 2011 Dec 15 doi: 10.1016/j.jtcvs.2011.10.088. PMID: 22177098
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Bronchioloalveolar carcinoma of mixed mucinous and nonmucinous type: immunohistochemical studies and mutation analysis of the p53 gene.
Sato K, Ueda Y, Shikata H, Katsuda S
Pathol Res Pract 2006;202(10):751-6. Epub 2006 Sep 7 doi: 10.1016/j.prp.2006.07.002. PMID: 16959434
Expression of thyroid transcription factor-1, cytokeratin 7, and cytokeratin 20 in bronchioloalveolar carcinomas: an immunohistochemical evaluation of 67 cases.
Lau SK, Desrochers MJ, Luthringer DJ
Mod Pathol 2002 May;15(5):538-42. doi: 10.1038/modpathol.3880560. PMID: 12011259

Recent systematic reviews

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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