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Malignant Solitary Fibrous Tumor

MedGen UID:
220419
•Concept ID:
C1266120
•
Neoplastic Process

Definition

A malignant neoplasm of probable fibroblastic derivation. It is characterized by the presence of atypical round to spindle-shaped cells, increased cellularity, necrotic change and high mitotic activity. [from NCI]

Professional guidelines

PubMed

Clinical Diagnosis and Treatment of Male Breast Cancer:Analysis of 24 Cases.
Zhang YQ, Zhao HY, Sun Q, Mao F, Zhou YD, Zhou JM
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Aug 20;39(4):568-572. doi: 10.3881/j.issn.1000-503X.2017.04.017. PMID: 28877837
Review of past and present clinical cases with a view to future treatment options.
Martín-Broto J, Reichardt P, Stacchiotti S, Blay JY
Future Oncol 2017 Jun;13(13s):11-28. Epub 2017 May 2 doi: 10.2217/fon-2017-0120. PMID: 28460536
Malignant solitary fibrous tumor: cytopathologic findings and differential diagnosis.
Bishop JA, Rekhtman N, Chun J, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2010 Apr 25;118(2):83-9. doi: 10.1002/cncy.20069. PMID: 20209623

Recent clinical studies

Etiology

Mesenchymal Neoplasms of Salivary Glands: A Clinicopathologic Study of 68 Cases.
Velez Torres JM, Duarte EM, Diaz-Perez JA, Leibowitz J, Weed DT, Thomas G, Sargi Z, Civantos FJ, Arnold DJ, Gomez-Fernandez C, Montgomery EA, Rosenberg AE
Head Neck Pathol 2022 Jun;16(2):353-365. Epub 2021 Jul 12 doi: 10.1007/s12105-021-01360-2. PMID: 34251596Free PMC Article
Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors.
Xu Y, Li Z, Shi J, Fu Y, Zhu L, Fan X, Foo WC
Virchows Arch 2021 Apr;478(4):619-626. Epub 2020 Aug 20 doi: 10.1007/s00428-020-02909-2. PMID: 32820389
Malignant solitary fibrous tumor with high-grade nuclear atypia: an alternate entity for the undetermined tumor group.
Yamada Y, Kohashi K, Bekki H, Ishii T, Iura K, Maekawa A, Yamamoto H, Iwamoto Y, Oda Y
Pathol Res Pract 2015 Feb;211(2):117-24. Epub 2014 Dec 11 doi: 10.1016/j.prp.2014.12.002. PMID: 25554652
Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature.
Alves Filho W, Mahmoud RR, Ramos DM, Araujo-Filho VJ, Lima PP, Cernea CR, Brandão LG
Arq Bras Endocrinol Metabol 2014 Jun;58(4):402-6. doi: 10.1590/0004-2730000003230. PMID: 24936737
Malignant solitary fibrous tumor arising from the pineal region: case study and literature review.
Zhang J, Cheng H, Qiao Q, Zhang JS, Wang YM, Fu X, Li Q
Neuropathology 2010 Jun;30(3):294-8. Epub 2009 Oct 21 doi: 10.1111/j.1440-1789.2009.01064.x. PMID: 19845865

Diagnosis

Recurrent malignant solitary fibrous tumor of pelvis: A case report and treatment approach.
Zhou P, Xu X
Medicine (Baltimore) 2023 Aug 4;102(31):e34520. doi: 10.1097/MD.0000000000034520. PMID: 37543812Free PMC Article
Malignant solitary fibrous tumor of the pleura.
Khouzam MS, Khouzam N
J Cardiothorac Surg 2022 May 3;17(1):92. doi: 10.1186/s13019-022-01842-6. PMID: 35505352Free PMC Article
Malignant solitary fibrous tumor of urinary bladder: A rare clinical entity.
Kratiras Z, Spapis V, Koniaris E, Kozyrakis D, Skriapas K
Arch Ital Urol Androl 2019 Jul 2;91(2) doi: 10.4081/aiua.2019.2.135. PMID: 31266285
A rare case of malignant solitary fibrous tumor in prostate with review of the literature.
Ronchi A, La Mantia E, Gigantino V, Perdonà S, De Sio M, Facchini G, Franco R, De Chiara A
Diagn Pathol 2017 Jul 7;12(1):50. doi: 10.1186/s13000-017-0640-5. PMID: 28687087Free PMC Article
Malignant solitary fibrous tumor: cytopathologic findings and differential diagnosis.
Bishop JA, Rekhtman N, Chun J, Wakely PE Jr, Ali SZ
Cancer Cytopathol 2010 Apr 25;118(2):83-9. doi: 10.1002/cncy.20069. PMID: 20209623

Therapy

Pazopanib-associated secondary adrenal insufficiency in a patient with malignant solitary fibrous tumor.
Er MM, Araz M, Karabacak M, Uğraklı M, Eryılmaz MK, Karaağaç M, Artaç M
J Oncol Pharm Pract 2021 Dec;27(8):2049-2052. Epub 2021 May 12 doi: 10.1177/10781552211016081. PMID: 33977817
Atypical/malignant solitary fibrous tumor of the pancreas with spleen vein invasion: Case report and literature review.
Li J, Li J, Xiong Y, Xu T, Xu J, Li Q, Yang G
Medicine (Baltimore) 2020 Apr;99(17):e19783. doi: 10.1097/MD.0000000000019783. PMID: 32332621Free PMC Article
Review of past and present clinical cases with a view to future treatment options.
Martín-Broto J, Reichardt P, Stacchiotti S, Blay JY
Future Oncol 2017 Jun;13(13s):11-28. Epub 2017 May 2 doi: 10.2217/fon-2017-0120. PMID: 28460536
Massive malignant solitary fibrous tumor arising from the bladder serosa: a case report.
Dozier J, Jameel Z, McCain DA, Hassoun P, Bamboat ZM
J Med Case Rep 2015 Mar 1;9:46. doi: 10.1186/s13256-014-0505-4. PMID: 25884588Free PMC Article
Huge malignant solitary fibrous tumor of the pleura.
Arab WA, Lamoth D, Echavé V, Rizcallah E, Sirois M
Gen Thorac Cardiovasc Surg 2012 Jun;60(6):397-400. Epub 2012 May 8 doi: 10.1007/s11748-012-0014-6. PMID: 22566249

Prognosis

Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors.
Xu Y, Li Z, Shi J, Fu Y, Zhu L, Fan X, Foo WC
Virchows Arch 2021 Apr;478(4):619-626. Epub 2020 Aug 20 doi: 10.1007/s00428-020-02909-2. PMID: 32820389
Salvage carbon ion radiotherapy for recurrent solitary fibrous tumor: A case report and literature review.
Murata K, Endo K, Aihara T, Matsuoka Y, Nishimura H, Suzuki H, Sawaji Y, Yamamoto K, Fukami S, Tanigawa M, Matsubayashi J, Nagao T, Imai R
J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(1):2309499019896099. doi: 10.1177/2309499019896099. PMID: 32101079
Malignant solitary fibrous tumor of urinary bladder: A rare clinical entity.
Kratiras Z, Spapis V, Koniaris E, Kozyrakis D, Skriapas K
Arch Ital Urol Androl 2019 Jul 2;91(2) doi: 10.4081/aiua.2019.2.135. PMID: 31266285
Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature.
Alves Filho W, Mahmoud RR, Ramos DM, Araujo-Filho VJ, Lima PP, Cernea CR, Brandão LG
Arq Bras Endocrinol Metabol 2014 Jun;58(4):402-6. doi: 10.1590/0004-2730000003230. PMID: 24936737
Malignant solitary tumor in a child: a case report and review of the literature.
Wang H, Shen D, Hou Y
J Pediatr Surg 2011 Mar;46(3):e5-9. doi: 10.1016/j.jpedsurg.2010.11.025. PMID: 21376187

Clinical prediction guides

Malignant solitary fibrous tumor of urinary bladder: A rare clinical entity.
Kratiras Z, Spapis V, Koniaris E, Kozyrakis D, Skriapas K
Arch Ital Urol Androl 2019 Jul 2;91(2) doi: 10.4081/aiua.2019.2.135. PMID: 31266285
A rare case of malignant solitary fibrous tumor in prostate with review of the literature.
Ronchi A, La Mantia E, Gigantino V, Perdonà S, De Sio M, Facchini G, Franco R, De Chiara A
Diagn Pathol 2017 Jul 7;12(1):50. doi: 10.1186/s13000-017-0640-5. PMID: 28687087Free PMC Article
Massive malignant solitary fibrous tumor arising from the bladder serosa: a case report.
Dozier J, Jameel Z, McCain DA, Hassoun P, Bamboat ZM
J Med Case Rep 2015 Mar 1;9:46. doi: 10.1186/s13256-014-0505-4. PMID: 25884588Free PMC Article
A huge malignant solitary fibrous tumor of kidney: case report and review of the literature.
Wang H, Liao Q, Liao X, Wen G, Li Z, Lin C, Zhao L
Diagn Pathol 2014 Jan 20;9:13. doi: 10.1186/1746-1596-9-13. PMID: 24443842Free PMC Article
Malignant solitary tumor in a child: a case report and review of the literature.
Wang H, Shen D, Hou Y
J Pediatr Surg 2011 Mar;46(3):e5-9. doi: 10.1016/j.jpedsurg.2010.11.025. PMID: 21376187

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