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Desmoplastic Mesothelioma

MedGen UID:
220861
•Concept ID:
C1270206
•
Neoplastic Process
Synonym: Desmoplastic mesothelioma
SNOMED CT: Desmoplastic mesothelioma (388650006)

Definition

A malignant neoplasm arising from mesothelial cells. It is characterized by the presence of a dense collagenous tissue and atypical neoplastic cells. Sarcomatoid features, collagenous necrosis, and infiltration of muscle and adipose tissue may be present. It occurs in the pleura and less commonly in the peritoneum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDesmoplastic Mesothelioma

Professional guidelines

PubMed

Peritoneal disease: key imaging findings that help in the differential diagnosis.
Campos NMF, Almeida V, Curvo Semedo L
Br J Radiol 2022 Feb 1;95(1130):20210346. Epub 2021 Nov 23 doi: 10.1259/bjr.20210346. PMID: 34767464Free PMC Article
Role of hyperthermic intraoperative peritoneal chemotherapy in the management of peritoneal metastases.
Elias D, Goéré D, Dumont F, Honoré C, Dartigues P, Stoclin A, Malka D, Boige V, Ducreux M
Eur J Cancer 2014 Jan;50(2):332-40. Epub 2013 Oct 21 doi: 10.1016/j.ejca.2013.09.024. PMID: 24157254
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Recent clinical studies

Diagnosis

Challenges and limitation of MTAP immunohistochemistry in diagnosing desmoplastic mesothelioma/sarcomatoid pleural mesothelioma with desmoplastic features.
Sa-Ngiamwibool P, Hamasaki M, Kinoshita Y, Matsumoto S, Sato A, Tsujimura T, Kasai T, Hiroshima K, Kushitani K, Takeshima Y, Kawahara K, Iwasaki A, Nabeshima K
Ann Diagn Pathol 2022 Oct;60:152004. Epub 2022 Jun 30 doi: 10.1016/j.anndiagpath.2022.152004. PMID: 35797798
GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung.
Berg KB, Churg A
Am J Surg Pathol 2017 Sep;41(9):1221-1225. doi: 10.1097/PAS.0000000000000825. PMID: 28614203
Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers.
Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S
J Clin Pathol 2013 Oct;66(10):847-53. Epub 2013 Jun 27 doi: 10.1136/jclinpath-2012-201303. PMID: 23814259
Desmoplastic malignant mesothelioma.
Baççioğlu A, Kaba E, Ozmen SA, Demirci M
J Bronchology Interv Pulmonol 2013 Apr;20(2):155-8. doi: 10.1097/LBR.0b013e31828e1aa2. PMID: 23609252
Sarcomatoid neoplasms of the lung and pleura.
Travis WD
Arch Pathol Lab Med 2010 Nov;134(11):1645-58. doi: 10.5858/2010-0086-RAR.1. PMID: 21043818

Therapy

Desmoplastic malignant mesothelioma of the pleura: autopsy reveals asbestos exposure.
Ishikawa R, Kikuchi E, Jin M, Fujita M, Itoh T, Sawa H, Nagashima K
Pathol Int 2003 Jun;53(6):401-6. doi: 10.1046/j.1440-1827.2003.01488.x. PMID: 12787316
Desmoplastic malignant mesothelioma: a review of 17 cases.
Wilson GE, Hasleton PS, Chatterjee AK
J Clin Pathol 1992 Apr;45(4):295-8. doi: 10.1136/jcp.45.4.295. PMID: 1577967Free PMC Article

Prognosis

The potential utility of GATA binding protein 3 for diagnosis of malignant pleural mesotheliomas.
Prabhakaran S, Hocking A, Kim C, Hussey M, Klebe S
Hum Pathol 2020 Nov;105:1-8. Epub 2020 Sep 2 doi: 10.1016/j.humpath.2020.08.005. PMID: 32888937
Challenges and controversies in the diagnosis of malignant mesothelioma: Part 2. Malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA.
Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S
J Clin Pathol 2013 Oct;66(10):854-61. Epub 2013 Jul 6 doi: 10.1136/jclinpath-2013-201609. PMID: 23833051
Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers.
Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S
J Clin Pathol 2013 Oct;66(10):847-53. Epub 2013 Jun 27 doi: 10.1136/jclinpath-2012-201303. PMID: 23814259
Sarcomatoid neoplasms of the lung and pleura.
Travis WD
Arch Pathol Lab Med 2010 Nov;134(11):1645-58. doi: 10.5858/2010-0086-RAR.1. PMID: 21043818
Desmoplastic malignant mesothelioma: a review of 17 cases.
Wilson GE, Hasleton PS, Chatterjee AK
J Clin Pathol 1992 Apr;45(4):295-8. doi: 10.1136/jcp.45.4.295. PMID: 1577967Free PMC Article

Clinical prediction guides

The potential utility of GATA binding protein 3 for diagnosis of malignant pleural mesotheliomas.
Prabhakaran S, Hocking A, Kim C, Hussey M, Klebe S
Hum Pathol 2020 Nov;105:1-8. Epub 2020 Sep 2 doi: 10.1016/j.humpath.2020.08.005. PMID: 32888937
A combination of MTAP and BAP1 immunohistochemistry is effective for distinguishing sarcomatoid mesothelioma from fibrous pleuritis.
Kinoshita Y, Hamasaki M, Yoshimura M, Matsumoto S, Sato A, Tsujimura T, Ueda H, Makihata S, Kato F, Iwasaki A, Nabeshima K
Lung Cancer 2018 Nov;125:198-204. Epub 2018 Sep 26 doi: 10.1016/j.lungcan.2018.09.019. PMID: 30429020
GATA3 Immunohistochemistry for Distinguishing Sarcomatoid and Desmoplastic Mesothelioma From Sarcomatoid Carcinoma of the Lung.
Berg KB, Churg A
Am J Surg Pathol 2017 Sep;41(9):1221-1225. doi: 10.1097/PAS.0000000000000825. PMID: 28614203
Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers.
Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S
J Clin Pathol 2013 Oct;66(10):847-53. Epub 2013 Jun 27 doi: 10.1136/jclinpath-2012-201303. PMID: 23814259
CD-34 and keratin expression distinguishes solitary fibrous tumor (fibrous mesothelioma) of pleura from desmoplastic mesothelioma.
Flint A, Weiss SW
Hum Pathol 1995 Apr;26(4):428-31. doi: 10.1016/0046-8177(95)90145-0. PMID: 7535740

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