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Diffuse Malignant Mesothelioma

MedGen UID:
97895
•Concept ID:
C0392400
•
Neoplastic Process
Synonym: Malignant Diffuse Mesothelioma

Definition

A diffuse malignant neoplasm that arises from mesothelial cells, usually in the pleura or peritoneum. Histologic variants include biphasic, epithelioid, sarcomatoid, and desmoplastic mesothelioma. [from NCI]

Professional guidelines

PubMed

Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies.
Cagle PT, Churg A
Arch Pathol Lab Med 2005 Nov;129(11):1421-7. doi: 10.5858/2005-129-1421-DDOBAM. PMID: 16253023
Diagnosis and treatment of pleural mesothelioma.
Rusch VW
Semin Surg Oncol 1990;6(5):279-85. doi: 10.1002/ssu.2980060510. PMID: 2237087

Recent clinical studies

Etiology

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
Advanced malignant mesothelioma mimicking acute contained thoracic aortic rupture.
Mouawad NJ, Daniel VC, Starr JE
Interact Cardiovasc Thorac Surg 2014 Feb;18(2):242-4. Epub 2013 Oct 30 doi: 10.1093/icvts/ivt465. PMID: 24174122Free PMC Article
Diffuse malignant pleural mesotheslioma at CAMC: a retrospective study of 50 patients.
Jubelirer SJ, Garcelon J
W V Med J 1997 May-Jun;93(3):120-5. PMID: 9197186
Papillary peritoneal tumors in women.
Foyle A, Al-Jabi M, McCaughey WT
Am J Surg Pathol 1981 Apr;5(3):241-9. doi: 10.1097/00000478-198104000-00004. PMID: 7235119

Diagnosis

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Advanced malignant mesothelioma mimicking acute contained thoracic aortic rupture.
Mouawad NJ, Daniel VC, Starr JE
Interact Cardiovasc Thorac Surg 2014 Feb;18(2):242-4. Epub 2013 Oct 30 doi: 10.1093/icvts/ivt465. PMID: 24174122Free PMC Article
Diffuse malignant mesothelioma.
Oviedo SP, Cagle PT
Arch Pathol Lab Med 2012 Aug;136(8):882-8. doi: 10.5858/arpa.2012-0142-CR. PMID: 22849735
Primary tumors of the lung other than lung cancer.
Pierce WC, Figlin RA
Curr Opin Oncol 1993 Mar;5(2):343-52. doi: 10.1097/00001622-199303000-00013. PMID: 8384495
Papillary peritoneal tumors in women.
Foyle A, Al-Jabi M, McCaughey WT
Am J Surg Pathol 1981 Apr;5(3):241-9. doi: 10.1097/00000478-198104000-00004. PMID: 7235119

Therapy

Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
Mechanisms of pleurodesis.
Rodriguez-Panadero F, Montes-Worboys A
Respiration 2012;83(2):91-8. Epub 2012 Jan 20 doi: 10.1159/000335419. PMID: 22286268
Mechanisms of asbestos-induced carcinogenesis.
Toyokuni S
Nagoya J Med Sci 2009 Feb;71(1-2):1-10. PMID: 19358470Free PMC Article
Therapeutic options in malignant mesothelioma.
Moreno de la Santa P, Butchart EG
Curr Opin Oncol 1995 Mar;7(2):134-7. doi: 10.1097/00001622-199503000-00007. PMID: 7538792
Phase II evaluation of recombinant interferon-beta (IFN-beta ser) in patients with diffuse mesothelioma: a Southwest Oncology Group study.
Von Hoff DD, Metch B, Lucas JG, Balcerzak SP, Grunberg SM, Rivkin SE
J Interferon Res 1990 Oct;10(5):531-4. doi: 10.1089/jir.1990.10.531. PMID: 2273299

Prognosis

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
Advanced malignant mesothelioma mimicking acute contained thoracic aortic rupture.
Mouawad NJ, Daniel VC, Starr JE
Interact Cardiovasc Thorac Surg 2014 Feb;18(2):242-4. Epub 2013 Oct 30 doi: 10.1093/icvts/ivt465. PMID: 24174122Free PMC Article
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765
Localized malignant mesothelioma.
Allen TC, Cagle PT, Churg AM, Colby TV, Gibbs AR, Hammar SP, Corson JM, Grimes MM, Ordonez NG, Roggli V, Travis WD, Wick MR
Am J Surg Pathol 2005 Jul;29(7):866-73. doi: 10.1097/01.pas.0000165529.78945.dc. PMID: 15958850
Diffuse malignant pleural mesotheslioma at CAMC: a retrospective study of 50 patients.
Jubelirer SJ, Garcelon J
W V Med J 1997 May-Jun;93(3):120-5. PMID: 9197186

Clinical prediction guides

Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations.
Carbone M, Pass HI, Ak G, Alexander HR Jr, Baas P, Baumann F, Blakely AM, Bueno R, Bzura A, Cardillo G, Churpek JE, Dianzani I, De Rienzo A, Emi M, Emri S, Felley-Bosco E, Fennell DA, Flores RM, Grosso F, Hayward NK, Hesdorffer M, Hoang CD, Johansson PA, Kindler HL, Kittaneh M, Krausz T, Mansfield A, Metintas M, Minaai M, Mutti L, Nielsen M, O'Byrne K, Opitz I, Pastorino S, Pentimalli F, de Perrot M, Pritchard A, Ripley RT, Robinson B, Rusch V, Taioli E, Takinishi Y, Tanji M, Tsao AS, Tuncer AM, Walpole S, Wolf A, Yang H, Yoshikawa Y, Zolondick A, Schrump DS, Hassan R
J Thorac Oncol 2022 Jul;17(7):873-889. Epub 2022 Apr 21 doi: 10.1016/j.jtho.2022.03.014. PMID: 35462085Free PMC Article
Malignant peritoneal mesothelioma and Crohn disease.
Butnor KJ, Pavlisko EN, Sporn TA, Roggli VL
J Clin Pathol 2017 Mar;70(3):228-232. Epub 2016 Aug 2 doi: 10.1136/jclinpath-2016-203945. PMID: 27484913
Advanced malignant mesothelioma mimicking acute contained thoracic aortic rupture.
Mouawad NJ, Daniel VC, Starr JE
Interact Cardiovasc Thorac Surg 2014 Feb;18(2):242-4. Epub 2013 Oct 30 doi: 10.1093/icvts/ivt465. PMID: 24174122Free PMC Article
Animal models of malignant mesothelioma.
Kane AB
Inhal Toxicol 2006 Nov;18(12):1001-4. doi: 10.1080/08958370600835393. PMID: 16920675
Pleural mesothelioma associated with indoor pollution of asbestos.
Schneider J, Rödelsperger K, Brückel B, Kleineberg J, Woitowitz HJ
J Cancer Res Clin Oncol 2001 Feb;127(2):123-7. doi: 10.1007/s004320000175. PMID: 11216913

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