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Diffuse Malignant Mesothelioma

MedGen UID:
97895
•Concept ID:
C0392400
•
Neoplastic Process
Synonym: Malignant Diffuse Mesothelioma

Definition

A diffuse malignant neoplasm that arises from mesothelial cells, usually in the pleura or peritoneum. Histologic variants include biphasic, epithelioid, sarcomatoid, and desmoplastic mesothelioma. [from NCI]

Professional guidelines

PubMed

Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies.
Cagle PT, Churg A
Arch Pathol Lab Med 2005 Nov;129(11):1421-7. doi: 10.5858/2005-129-1421-DDOBAM. PMID: 16253023
Diagnosis and treatment of pleural mesothelioma.
Rusch VW
Semin Surg Oncol 1990;6(5):279-85. doi: 10.1002/ssu.2980060510. PMID: 2237087

Recent clinical studies

Etiology

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
The Diagnosis of Pleural Tumors Other Than Mesothelioma.
Attanoos RL, Pugh MR
Arch Pathol Lab Med 2018 Aug;142(8):902-913. doi: 10.5858/arpa.2017-0537-RA. PMID: 30040453
Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma.
Vivero M, Bueno R, Chirieac LR
Mod Pathol 2018 Jan;31(1):122-131. Epub 2017 Sep 8 doi: 10.1038/modpathol.2017.108. PMID: 28884745Free PMC Article
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765
Diffuse malignant mesothelioma: a review.
Rom WN, Lockey JE
West J Med 1982 Dec;137(6):548-54. PMID: 6761970Free PMC Article

Diagnosis

Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations.
Carbone M, Pass HI, Ak G, Alexander HR Jr, Baas P, Baumann F, Blakely AM, Bueno R, Bzura A, Cardillo G, Churpek JE, Dianzani I, De Rienzo A, Emi M, Emri S, Felley-Bosco E, Fennell DA, Flores RM, Grosso F, Hayward NK, Hesdorffer M, Hoang CD, Johansson PA, Kindler HL, Kittaneh M, Krausz T, Mansfield A, Metintas M, Minaai M, Mutti L, Nielsen M, O'Byrne K, Opitz I, Pastorino S, Pentimalli F, de Perrot M, Pritchard A, Ripley RT, Robinson B, Rusch V, Taioli E, Takinishi Y, Tanji M, Tsao AS, Tuncer AM, Walpole S, Wolf A, Yang H, Yoshikawa Y, Zolondick A, Schrump DS, Hassan R
J Thorac Oncol 2022 Jul;17(7):873-889. Epub 2022 Apr 21 doi: 10.1016/j.jtho.2022.03.014. PMID: 35462085Free PMC Article
Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
The Diagnosis of Pleural Tumors Other Than Mesothelioma.
Attanoos RL, Pugh MR
Arch Pathol Lab Med 2018 Aug;142(8):902-913. doi: 10.5858/arpa.2017-0537-RA. PMID: 30040453
Diffuse malignant mesothelioma.
Oviedo SP, Cagle PT
Arch Pathol Lab Med 2012 Aug;136(8):882-8. doi: 10.5858/arpa.2012-0142-CR. PMID: 22849735
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765

Therapy

Sepsis in the Postpneumonectomy Space: Pathogenesis, Recognition, and Management.
Shamji FM
Thorac Surg Clin 2021 Nov;31(4):407-416. doi: 10.1016/j.thorsurg.2021.08.001. PMID: 34696853
Malignant peritoneal mesothelioma in patients with endometriosis.
Butnor KJ, Rueckert J, Pavlisko EN, Sporn TA, Roggli VL
J Clin Pathol 2018 Nov;71(11):971-974. Epub 2018 May 23 doi: 10.1136/jclinpath-2018-205099. PMID: 29794065
Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases.
Butnor KJ, Brownlee NA, Mahar A, Pavlisko EN, Sporn TA, Roggli VL
Lung Cancer 2016 May;95:1-7. Epub 2016 Feb 18 doi: 10.1016/j.lungcan.2016.02.007. PMID: 27040844
Mechanisms of pleurodesis.
Rodriguez-Panadero F, Montes-Worboys A
Respiration 2012;83(2):91-8. Epub 2012 Jan 20 doi: 10.1159/000335419. PMID: 22286268
Mechanisms of asbestos-induced carcinogenesis.
Toyokuni S
Nagoya J Med Sci 2009 Feb;71(1-2):1-10. PMID: 19358470

Prognosis

Solid papillary mesothelial tumor.
Churg A, Le Stang N, Dacic S, Pissaloux D, Begueret H, Dartigues P, Giusiano-Courcambeck S, Sequeiros R, Pairon JC, Tirode F, Galateau-Sallé F
Mod Pathol 2022 Jan;35(1):69-76. Epub 2021 Sep 3 doi: 10.1038/s41379-021-00899-3. PMID: 34480081
The Diagnosis of Pleural Tumors Other Than Mesothelioma.
Attanoos RL, Pugh MR
Arch Pathol Lab Med 2018 Aug;142(8):902-913. doi: 10.5858/arpa.2017-0537-RA. PMID: 30040453
Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma.
Vivero M, Bueno R, Chirieac LR
Mod Pathol 2018 Jan;31(1):122-131. Epub 2017 Sep 8 doi: 10.1038/modpathol.2017.108. PMID: 28884745Free PMC Article
Pulmonary sarcomatous tumors.
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765
Localized malignant mesothelioma.
Allen TC, Cagle PT, Churg AM, Colby TV, Gibbs AR, Hammar SP, Corson JM, Grimes MM, Ordonez NG, Roggli V, Travis WD, Wick MR
Am J Surg Pathol 2005 Jul;29(7):866-73. doi: 10.1097/01.pas.0000165529.78945.dc. PMID: 15958850

Clinical prediction guides

Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations.
Carbone M, Pass HI, Ak G, Alexander HR Jr, Baas P, Baumann F, Blakely AM, Bueno R, Bzura A, Cardillo G, Churpek JE, Dianzani I, De Rienzo A, Emi M, Emri S, Felley-Bosco E, Fennell DA, Flores RM, Grosso F, Hayward NK, Hesdorffer M, Hoang CD, Johansson PA, Kindler HL, Kittaneh M, Krausz T, Mansfield A, Metintas M, Minaai M, Mutti L, Nielsen M, O'Byrne K, Opitz I, Pastorino S, Pentimalli F, de Perrot M, Pritchard A, Ripley RT, Robinson B, Rusch V, Taioli E, Takinishi Y, Tanji M, Tsao AS, Tuncer AM, Walpole S, Wolf A, Yang H, Yoshikawa Y, Zolondick A, Schrump DS, Hassan R
J Thorac Oncol 2022 Jul;17(7):873-889. Epub 2022 Apr 21 doi: 10.1016/j.jtho.2022.03.014. PMID: 35462085Free PMC Article
Malignant peritoneal mesothelioma and Crohn disease.
Butnor KJ, Pavlisko EN, Sporn TA, Roggli VL
J Clin Pathol 2017 Mar;70(3):228-232. Epub 2016 Aug 2 doi: 10.1136/jclinpath-2016-203945. PMID: 27484913
Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases.
Butnor KJ, Brownlee NA, Mahar A, Pavlisko EN, Sporn TA, Roggli VL
Lung Cancer 2016 May;95:1-7. Epub 2016 Feb 18 doi: 10.1016/j.lungcan.2016.02.007. PMID: 27040844
Animal models of malignant mesothelioma.
Kane AB
Inhal Toxicol 2006 Nov;18(12):1001-4. doi: 10.1080/08958370600835393. PMID: 16920675
Diffuse malignant mesothelioma of the pleura: a clinicopathological study of six patients with a prolonged symptom-free interval or extended survival after biopsy and a review of the literature of long-term survival.
Mark EJ, Shin DH
Virchows Arch A Pathol Anat Histopathol 1993;422(6):445-51. doi: 10.1007/BF01606452. PMID: 8333148

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