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Thyroid gland atypical follicular adenoma

MedGen UID:: 224756
•Concept ID:: C1266046
•: Neoplastic Process

Synonym:	Atypical follicular adenoma
SNOMED CT:	Atypical follicular adenoma (128892009)

Monarch Initiative:	MONDO:0004524

Definition

An encapsulated or well-circumscribed thyroid gland tumor composed of well-differentiated follicular cells with well-developed or partially developed nuclear features of papillary thyroid carcinoma and with questionable capsular or vascular invasion. This is a tumor indeterminate between follicular adenoma and follicular carcinoma. Tumors in which vascular invasion has been excluded by all means are called non-invasive follicular thyroid neoplasms with papillary-like nuclear features. (WHO) [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVThyroid gland atypical follicular adenoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Neoplasm of Uncertain Malignant Potential
        Thyroid gland atypical follicular adenoma

Professional guidelines

PubMed

Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.

Lakomý R, Poprach A, Kazda T
Klin Onkol 2020 Winter;33(1):15-19. doi: 10.14735/amko202015. PMID: 32075383

Management of thyroid nodules with atypical cytology on fine-needle aspiration biopsy.

Nagarkatti SS, Faquin WC, Lubitz CC, Garcia DM, Barbesino G, Ross DS, Hodin RA, Daniels GH, Parangi S
Ann Surg Oncol 2013 Jan;20(1):60-5. Epub 2012 Sep 1 doi: 10.1245/s10434-012-2601-2. PMID: 22941160 Free PMC Article

Challenging lesions in the differential diagnosis of endocrine tumors: parathyroid carcinoma.

Delellis RA
Endocr Pathol 2008 Winter;19(4):221-5. doi: 10.1007/s12022-008-9050-2. PMID: 19058032

See all (9)

Recent clinical studies

Etiology

Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature.

Bentestuen M, Gossili F, Almasi CE, Zacho HD
Cancer Imaging 2022 Sep 3;22(1):44. doi: 10.1186/s40644-022-00484-0. PMID: 36057635 Free PMC Article

Assessment of The Bethesda System for Reporting Thyroid Cytopathology.

Sauter JL, Lehrke H, Zhang X, Al Badri OT, Rodriguez-Gutierrez R, Delivanis DA, Singh Ospina N, Donegan D, Hamidi O, Iñiguez-Ariza N, Sharma A, Kittah NEN, Tamhane SU, Hurtado Andrade MD, Kotwal A, Jenkins SM, Spears G, Rivera M, Dean DS, Henry MR
Am J Clin Pathol 2019 Sep 9;152(4):502-511. doi: 10.1093/ajcp/aqz076. PMID: 31305880 Free PMC Article

Overview of the 2017 WHO Classification of Pituitary Tumors.

Mete O, Lopes MB
Endocr Pathol 2017 Sep;28(3):228-243. doi: 10.1007/s12022-017-9498-z. PMID: 28766057

Is there an association between thyroid function abnormalities and breast cancer?

Angelousi A, Diamanti-Kandarakis E, Zapanti E, Nonni A, Ktenas E, Mantzou A, Kontzoglou K, Kouraklis G
Arch Endocrinol Metab 2017 Jan-Feb;61(1):54-61. Epub 2016 Aug 25 doi: 10.1590/2359-3997000000191. PMID: 28273204 Free PMC Article

Atypical follicular cells with equivocal features of papillary thyroid carcinoma is not a low-risk cytologic diagnosis.

Luu MH, Fischer AH, Stockl TJ, Pisharodi L, Owens CL
Acta Cytol 2011;55(6):526-30. Epub 2011 Dec 9 doi: 10.1159/000333227. PMID: 22156461

See all (96)

Diagnosis

Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature.

Bentestuen M, Gossili F, Almasi CE, Zacho HD
Cancer Imaging 2022 Sep 3;22(1):44. doi: 10.1186/s40644-022-00484-0. PMID: 36057635 Free PMC Article

Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.

Lakomý R, Poprach A, Kazda T
Klin Onkol 2020 Winter;33(1):15-19. doi: 10.14735/amko202015. PMID: 32075383

C Cell and Follicular Epithelial Cell Precursor Lesions of the Thyroid.

Scognamiglio T
Arch Pathol Lab Med 2017 Dec;141(12):1646-1652. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0399-RA. PMID: 28644684

Thyrotoxicosis.

Kannan CR, Seshadri KG
Dis Mon 1997 Sep;43(9):601-77. PMID: 9301645

Neurofibromatosis update.

Riccardi VM
Neurofibromatosis 1989;2(5-6):284-91. PMID: 2518510

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Therapy

Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.

Lakomý R, Poprach A, Kazda T
Klin Onkol 2020 Winter;33(1):15-19. doi: 10.14735/amko202015. PMID: 32075383

Radiofrequency ablation is a thyroid function-preserving treatment for patients with bilateral benign thyroid nodules.

Ji Hong M, Baek JH, Choi YJ, Lee JH, Lim HK, Shong YK, Hong SJ
J Vasc Interv Radiol 2015 Jan;26(1):55-61. Epub 2014 Nov 18 doi: 10.1016/j.jvir.2014.09.015. PMID: 25446422

Infiltration of the thyroid gland by T-cell prolymphocytic leukemia.

Fujiwara K, Fukuhara T, Kitano H, Okazaki T
Thyroid 2014 Aug;24(8):1314-8. Epub 2014 Jun 18 doi: 10.1089/thy.2013.0462. PMID: 24762052

Primary thyroid lymphoma associated with Graves' disease.

Doi Y, Goto A, Murakami T, Yamashita H, Yamashita H, Noguchi S
Thyroid 2004 Sep;14(9):772-6. doi: 10.1089/thy.2004.14.772. PMID: 15361265

Histologic changes in Graves' thyroid gland after 131I therapy for hyperthyroidism.

Mizukami Y, Michigishi T, Nonomura A, Hashimoto T, Noguchi M, Ohmura K, Matsubara F
Acta Pathol Jpn 1992 Jun;42(6):419-26. doi: 10.1111/j.1440-1827.1992.tb03247.x. PMID: 1502902

See all (17)

Prognosis

Synchronous mucoepidermoid carcinoma and papillary microcarcinomas of the thyroid gland.

Gupta KK, Garas G, Wilkes J, De M
BMJ Case Rep 2022 Nov 22;15(11) doi: 10.1136/bcr-2022-252117. PMID: 36414338 Free PMC Article

Management of Immune-Related Endocrinopathies in Anticancer Treatment with Checkpoint Inhibitors.

Lakomý R, Poprach A, Kazda T
Klin Onkol 2020 Winter;33(1):15-19. doi: 10.14735/amko202015. PMID: 32075383

Assessment of The Bethesda System for Reporting Thyroid Cytopathology.

Is there an association between thyroid function abnormalities and breast cancer?

Atypical follicular cells with equivocal features of papillary thyroid carcinoma is not a low-risk cytologic diagnosis.

Luu MH, Fischer AH, Stockl TJ, Pisharodi L, Owens CL
Acta Cytol 2011;55(6):526-30. Epub 2011 Dec 9 doi: 10.1159/000333227. PMID: 22156461

See all (82)

Clinical prediction guides

The Role of Cell Blocks and Immunohistochemistry in Thyroid Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Bethesda Category.

Abram M, Huhtamella R, Kalfert D, Hakso-Mäkinen H, Ludvíková M, Kholová I
Acta Cytol 2021;65(3):257-263. Epub 2021 Mar 31 doi: 10.1159/000514906. PMID: 33789274

Assessment of The Bethesda System for Reporting Thyroid Cytopathology.

Atypical follicular cells with equivocal features of papillary thyroid carcinoma is not a low-risk cytologic diagnosis.

Luu MH, Fischer AH, Stockl TJ, Pisharodi L, Owens CL
Acta Cytol 2011;55(6):526-30. Epub 2011 Dec 9 doi: 10.1159/000333227. PMID: 22156461

Clinical and ultrasound features of cytology diagnosed follicular neoplasm.

Choi YJ, Yun JS, Kim DH
Endocr J 2009;56(3):383-9. Epub 2009 Jan 22 doi: 10.1507/endocrj.k08e-310. PMID: 19164864

Thyroid disease in the elderly.

Levy EG
Med Clin North Am 1991 Jan;75(1):151-67. doi: 10.1016/s0025-7125(16)30476-x. PMID: 1987440

See all (66)