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Malignant type AB thymoma

MedGen UID:
224760
•Concept ID:
C1266093
•
Neoplastic Process
Synonyms: malignant thymoma type AB; Malignant Type AB Thymoma; malignant type AB thymoma; thymoma type AB, malignant; Thymoma, mixed type, malignant; thymoma, mixed type, malignant; Thymoma, type AB, malignant
SNOMED CT: Thymoma, mixed type, malignant (128710005); Thymoma, type AB, malignant (128710005)
 
Monarch Initiative: MONDO:0003976

Definition

A type AB thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant type AB thymoma

Professional guidelines

PubMed

Significance of YAP1-MAML2 rearrangement and GTF2I mutation in the diagnosis and differential diagnosis of metaplastic thymoma.
Wang M, Xu H, Han Q, Wang L
Ann Med 2023;55(2):2237040. doi: 10.1080/07853890.2023.2237040. PMID: 37489594Free PMC Article
Systemic treatment of advanced thymic malignancies.
Kelly RJ
Am Soc Clin Oncol Educ Book 2014:e367-73. doi: 10.14694/EdBook_AM.2014.34.e367. PMID: 24857125
ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting.
Marx A, Ströbel P, Badve SS, Chalabreysse L, Chan JK, Chen G, de Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD
J Thorac Oncol 2014 May;9(5):596-611. doi: 10.1097/JTO.0000000000000154. PMID: 24722150

Recent clinical studies

Etiology

Type A and AB thymomas: histological features associated with increased stage.
Green AC, Marx A, Ströbel P, Mason M, Lim E, Jordan S, Ladas G, Dusmet M, Rice A, Nicholson AG
Histopathology 2015 May;66(6):884-91. Epub 2014 Nov 10 doi: 10.1111/his.12512. PMID: 25382290
Systemic treatment of advanced thymic malignancies.
Kelly RJ
Am Soc Clin Oncol Educ Book 2014:e367-73. doi: 10.14694/EdBook_AM.2014.34.e367. PMID: 24857125
WHO types A and AB thymomas: not always benign.
Jain RK, Mehta RJ, Henley JD, Kesler KA, Loehrer PJ, Badve S
Mod Pathol 2010 Dec;23(12):1641-9. Epub 2010 Sep 10 doi: 10.1038/modpathol.2010.172. PMID: 20834239
Recurrent myasthenia gravis due to a pleural implant 3 years after radical thymectomy.
Heyman SR, De Raeve H, Mercelis R, De Pooter C, Van Schil P
Ann Thorac Surg 2008 Jul;86(1):299-301. doi: 10.1016/j.athoracsur.2008.01.030. PMID: 18573446
Polymorphic markers in MHC class II/III region: a study on Italian patients with myasthenia gravis.
Franciotta D, Cuccia M, Dondi E, Piccolo G, Cosi V
J Neurol Sci 2001 Sep 15;190(1-2):11-6. doi: 10.1016/s0022-510x(01)00573-1. PMID: 11574100

Diagnosis

Ectopic cervical thymoma accompanied by Good's syndrome.
Nagoya A, Kanzaki R, Nakagiri T, Inoue M, Susaki Y, Inoue S, Okumura M
Ann Thorac Cardiovasc Surg 2014;20 Suppl:531-4. Epub 2013 Jan 31 doi: 10.5761/atcs.cr.12.02027. PMID: 23364225
Ectopic pleural thymoma mimicking a giant solitary fibrous tumour of the pleura.
Filosso PL, Delsedime L, Cristofori RC, Sandri A
Interact Cardiovasc Thorac Surg 2012 Nov;15(5):930-2. Epub 2012 Aug 23 doi: 10.1093/icvts/ivs360. PMID: 22922387Free PMC Article
Good syndrome accompanied by pure red cell aplasia.
Taniguchi T, Usami N, Kawaguchi K, Yokoi K
Interact Cardiovasc Thorac Surg 2009 Oct;9(4):750-2. Epub 2009 Jul 16 doi: 10.1510/icvts.2009.210393. PMID: 19608562
Huge thymoma: role of preoperative WHO histological classification.
Takeda S, Koma M, Maeda H
Interact Cardiovasc Thorac Surg 2008 Dec;7(6):1196-8. Epub 2008 Aug 19 doi: 10.1510/icvts.2008.177162. PMID: 18713780
Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis.
Maclennan CA, Vincent A, Marx A, Willcox N, Gilhus NE, Newsom-Davis J, Beeson D
J Neuroimmunol 2008 Sep 15;201-202:28-32. Epub 2008 Jul 26 doi: 10.1016/j.jneuroim.2008.06.016. PMID: 18657869

Therapy

Neovascularization of Thymoma From Left Internal Mammary Artery Bypass Graft.
Dubique JY, Turbendian H, Chu D
Ann Thorac Surg 2017 Mar;103(3):e247-e248. doi: 10.1016/j.athoracsur.2016.08.047. PMID: 28219559
Systemic treatment of advanced thymic malignancies.
Kelly RJ
Am Soc Clin Oncol Educ Book 2014:e367-73. doi: 10.14694/EdBook_AM.2014.34.e367. PMID: 24857125
Ectopic cervical thymoma accompanied by Good's syndrome.
Nagoya A, Kanzaki R, Nakagiri T, Inoue M, Susaki Y, Inoue S, Okumura M
Ann Thorac Cardiovasc Surg 2014;20 Suppl:531-4. Epub 2013 Jan 31 doi: 10.5761/atcs.cr.12.02027. PMID: 23364225
Recurrent myasthenia gravis due to a pleural implant 3 years after radical thymectomy.
Heyman SR, De Raeve H, Mercelis R, De Pooter C, Van Schil P
Ann Thorac Surg 2008 Jul;86(1):299-301. doi: 10.1016/j.athoracsur.2008.01.030. PMID: 18573446
Radical operation for invasive thymoma with intracaval, intracardiac, and lung invasion.
Shudo Y, Takahashi T, Ohta M, Ikeda N, Matsue H, Taniguchi K
J Card Surg 2007 Jul-Aug;22(4):330-2. doi: 10.1111/j.1540-8191.2007.00417.x. PMID: 17661777

Prognosis

Characteristics of Good's Syndrome in China: A Systematic Review.
Dong JP, Gao W, Teng GG, Tian Y, Wang HH
Chin Med J (Engl) 2017 Jul 5;130(13):1604-1609. doi: 10.4103/0366-6999.208234. PMID: 28639577Free PMC Article
Ectopic cervical thymoma accompanied by Good's syndrome.
Nagoya A, Kanzaki R, Nakagiri T, Inoue M, Susaki Y, Inoue S, Okumura M
Ann Thorac Cardiovasc Surg 2014;20 Suppl:531-4. Epub 2013 Jan 31 doi: 10.5761/atcs.cr.12.02027. PMID: 23364225
Ectopic pleural thymoma mimicking a giant solitary fibrous tumour of the pleura.
Filosso PL, Delsedime L, Cristofori RC, Sandri A
Interact Cardiovasc Thorac Surg 2012 Nov;15(5):930-2. Epub 2012 Aug 23 doi: 10.1093/icvts/ivs360. PMID: 22922387Free PMC Article
Recurrent myasthenia gravis due to a pleural implant 3 years after radical thymectomy.
Heyman SR, De Raeve H, Mercelis R, De Pooter C, Van Schil P
Ann Thorac Surg 2008 Jul;86(1):299-301. doi: 10.1016/j.athoracsur.2008.01.030. PMID: 18573446
Radical operation for invasive thymoma with intracaval, intracardiac, and lung invasion.
Shudo Y, Takahashi T, Ohta M, Ikeda N, Matsue H, Taniguchi K
J Card Surg 2007 Jul-Aug;22(4):330-2. doi: 10.1111/j.1540-8191.2007.00417.x. PMID: 17661777

Clinical prediction guides

Histological Classification and Invasion Prediction of Thymoma by Machine Learning-Based Computed Tomography Imaging.
Wang D, Zhang Y, Li B, Zhuang Q, Zhang X, Lin D
Contrast Media Mol Imaging 2022;2022:4594757. Epub 2022 Aug 5 doi: 10.1155/2022/4594757. PMID: 36051922Free PMC Article
Type A and AB thymomas: histological features associated with increased stage.
Green AC, Marx A, Ströbel P, Mason M, Lim E, Jordan S, Ladas G, Dusmet M, Rice A, Nicholson AG
Histopathology 2015 May;66(6):884-91. Epub 2014 Nov 10 doi: 10.1111/his.12512. PMID: 25382290
Ectopic cervical thymoma accompanied by Good's syndrome.
Nagoya A, Kanzaki R, Nakagiri T, Inoue M, Susaki Y, Inoue S, Okumura M
Ann Thorac Cardiovasc Surg 2014;20 Suppl:531-4. Epub 2013 Jan 31 doi: 10.5761/atcs.cr.12.02027. PMID: 23364225
Ectopic pleural thymoma mimicking a giant solitary fibrous tumour of the pleura.
Filosso PL, Delsedime L, Cristofori RC, Sandri A
Interact Cardiovasc Thorac Surg 2012 Nov;15(5):930-2. Epub 2012 Aug 23 doi: 10.1093/icvts/ivs360. PMID: 22922387Free PMC Article
Thymomas.
LeGolvan DP, Abell MR
Cancer 1977 May;39(5):2142-57. doi: 10.1002/1097-0142(197705)39:5<2142::aid-cncr2820390531>3.0.co;2-q. PMID: 558046

Recent systematic reviews

When the Good Syndrome Goes Bad: A Systematic Literature Review.
Shi Y, Wang C
Front Immunol 2021;12:679556. Epub 2021 May 25 doi: 10.3389/fimmu.2021.679556. PMID: 34113351Free PMC Article
Characteristics of Good's Syndrome in China: A Systematic Review.
Dong JP, Gao W, Teng GG, Tian Y, Wang HH
Chin Med J (Engl) 2017 Jul 5;130(13):1604-1609. doi: 10.4103/0366-6999.208234. PMID: 28639577Free PMC Article

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