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Wound botulism

MedGen UID:
224933
•Concept ID:
C1306794
•
Disease or Syndrome
Synonyms: Botulism, Wound; Wound Botulism; Wound Botulisms
SNOMED CT: Wound botulism (398530003)
 
Monarch Initiative: MONDO:0015803
Orphanet: ORPHA178475

Definition

Wound botulism is a rare infectious form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis due to botulinum neurotoxins (BoNTs), produced after infection of wounds by <i>Clostridium botulinum</i>. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWound botulism
Follow this link to review classifications for Wound botulism in Orphanet.

Professional guidelines

PubMed

Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Medical treatment for botulism.
Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Medical treatment for botulism.
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013

Recent clinical studies

Etiology

Wound Botulism Among Persons Who Inject Black Tar Heroin in New Mexico, 2016.
Middaugh N, Edwards L, Chatham-Stephens K, Arguello DF
Front Public Health 2021;9:744179. Epub 2021 Dec 16 doi: 10.3389/fpubh.2021.744179. PMID: 34976915Free PMC Article
Medical treatment for botulism.
Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Medical treatment for botulism.
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013
Medical treatment for botulism.
Chalk C, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2011 Mar 16;(3):CD008123. doi: 10.1002/14651858.CD008123.pub2. PMID: 21412916
Wound botulism.
Mechem CC, Walter FG
Vet Hum Toxicol 1994 Jun;36(3):233-7. PMID: 8066973

Diagnosis

Lambert-Eaton Myasthenic Syndrome and Botulism.
Raja SM
Continuum (Minneap Minn) 2022 Dec 1;28(6):1596-1614. doi: 10.1212/CON.0000000000001205. PMID: 36537971
Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Adult Intestinal Toxemia Botulism.
Harris RA, Anniballi F, Austin JW
Toxins (Basel) 2020 Jan 24;12(2) doi: 10.3390/toxins12020081. PMID: 31991691Free PMC Article
Botulism.
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636
Wound botulism.
Mechem CC, Walter FG
Vet Hum Toxicol 1994 Jun;36(3):233-7. PMID: 8066973

Therapy

Lambert-Eaton Myasthenic Syndrome and Botulism.
Raja SM
Continuum (Minneap Minn) 2022 Dec 1;28(6):1596-1614. doi: 10.1212/CON.0000000000001205. PMID: 36537971
Medical treatment for botulism.
Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Medical treatment for botulism.
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013
Medical treatment for botulism.
Chalk C, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2011 Mar 16;(3):CD008123. doi: 10.1002/14651858.CD008123.pub2. PMID: 21412916
Botulism.
Sobel J
Clin Infect Dis 2005 Oct 15;41(8):1167-73. Epub 2005 Aug 29 doi: 10.1086/444507. PMID: 16163636

Prognosis

Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis.
Guidon AC
Continuum (Minneap Minn) 2019 Dec;25(6):1785-1806. doi: 10.1212/CON.0000000000000807. PMID: 31794471
Botulinum toxin.
Horowitz BZ
Crit Care Clin 2005 Oct;21(4):825-39, viii. doi: 10.1016/j.ccc.2005.06.008. PMID: 16168317
Botulism in the United States: a clinical and epidemiologic review.
Shapiro RL, Hatheway C, Swerdlow DL
Ann Intern Med 1998 Aug 1;129(3):221-8. doi: 10.7326/0003-4819-129-3-199808010-00011. PMID: 9696731
Wound botulism.
Mechem CC, Walter FG
Vet Hum Toxicol 1994 Jun;36(3):233-7. PMID: 8066973
Wound botulism.
Cherington M, Ginsburg S
Arch Surg 1975 Apr;110(4):436-8. doi: 10.1001/archsurg.1975.01360100078014. PMID: 1147760

Clinical prediction guides

Black Tar Heroin Skin Popping as a Cause of Wound Botulism.
Qureshi IA, Qureshi MA, Rauf Afzal M, Maud A, Rodriguez GJ, Cruz-Flores S, Kassar D
Neurocrit Care 2017 Dec;27(3):415-419. doi: 10.1007/s12028-017-0415-6. PMID: 28569348
Prevalence and correlates of neck injection among people who inject drugs in Tijuana, Mexico.
Rafful C, Wagner KD, Werb D, González-Zúñiga PE, Verdugo S, Rangel G, Strathdee SA
Drug Alcohol Rev 2015 Nov;34(6):630-6. Epub 2015 Apr 13 doi: 10.1111/dar.12264. PMID: 25867795Free PMC Article
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin.
Galldiks N, Nolden-Hoverath S, Kosinski CM, Stegelmeyer U, Schmidt S, Dohmen C, Kuhn J, Gerbershagen K, Bewermeyer H, Walger P, Biniek R, Neveling M, Jacobs AH, Haupt WF
Neurocrit Care 2007;6(1):30-4. doi: 10.1385/NCC:6:1:30. PMID: 17356188
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism.
Sandrock CE, Murin S
Chest 2001 Aug;120(2):562-6. doi: 10.1378/chest.120.2.562. PMID: 11502659
Necrotizing soft-tissue infections.
Bosshardt TL, Henderson VJ, Organ CH Jr
Arch Surg 1996 Aug;131(8):846-52; discussion 852-4. doi: 10.1001/archsurg.1996.01430200056011. PMID: 8712909

Recent systematic reviews

Medical treatment for botulism.
Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Clinical Features of Foodborne and Wound Botulism: A Systematic Review of the Literature, 1932-2015.
Chatham-Stephens K, Fleck-Derderian S, Johnson SD, Sobel J, Rao AK, Meaney-Delman D
Clin Infect Dis 2017 Dec 27;66(suppl_1):S11-S16. doi: 10.1093/cid/cix811. PMID: 29293923
Medical treatment for botulism.
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013
Medical treatment for botulism.
Chalk C, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2011 Mar 16;(3):CD008123. doi: 10.1002/14651858.CD008123.pub2. PMID: 21412916

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