U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wound botulism

MedGen UID:
224933
Concept ID:
C1306794
Disease or Syndrome
Synonyms: Botulism, Wound; Wound Botulism; Wound Botulisms
SNOMED CT: Wound botulism (398530003)
 
Monarch Initiative: MONDO:0015803
Orphanet: ORPHA178475

Definition

Wound botulism is a rare infectious form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis due to botulinum neurotoxins (BoNTs), produced after infection of wounds by <i>Clostridium botulinum</i>. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWound botulism
Follow this link to review classifications for Wound botulism in Orphanet.

Professional guidelines

PubMed

Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013

Recent clinical studies

Etiology

Edwards LD, Gomez I, Wada S, Swaney EM, Caruthers MB, Cody I, Tobolowsky FA, Dykes J, Ford L, Davis KR, Griffin CT, Chung W
MMWR Morb Mortal Wkly Rep 2022 Apr 15;71(15):556-557. doi: 10.15585/mmwr.mm7115a3. PMID: 35421074Free PMC Article
Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC
J Biol Chem 2010 Sep 3;285(36):28220-8. Epub 2010 Jun 25 doi: 10.1074/jbc.M110.118554. PMID: 20581111Free PMC Article
Wheeler C, Inami G, Mohle-Boetani J, Vugia D
Clin Infect Dis 2009 Jun 15;48(12):1669-73. doi: 10.1086/599029. PMID: 19435438
Brett MM, Hood J, Brazier JS, Duerden BI, Hahné SJ
Epidemiol Infect 2005 Aug;133(4):575-82. doi: 10.1017/s0950268805003845. PMID: 16050501Free PMC Article
Josko D
Clin Lab Sci 2004 Winter;17(1):30-4. PMID: 15011978

Diagnosis

Elrayes M, Al Bachari S, Macdonagh R, Peel A, Khurshid S, Hamzah J, Holzmann T, Chaouch A, Cummins G, McKee D, Richardson A, Kobylecki C
Pract Neurol 2024 Jul 16;24(4):320-325. doi: 10.1136/pn-2023-004036. PMID: 38290842
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Beth Z, Hahn D, Kramer B, Tirre C, Kruse D, Stone PA
J Foot Ankle Surg 2021 May-Jun;60(3):600-604. Epub 2021 Feb 27 doi: 10.1053/j.jfas.2019.04.020. PMID: 33653654
Horowitz BZ
Crit Care Clin 2005 Oct;21(4):825-39, viii. doi: 10.1016/j.ccc.2005.06.008. PMID: 16168317
Tunkel AR, Pradhan SK
Infect Dis Clin North Am 2002 Sep;16(3):589-605. doi: 10.1016/s0891-5520(02)00015-6. PMID: 12371117

Therapy

Elrayes M, Al Bachari S, Macdonagh R, Peel A, Khurshid S, Hamzah J, Holzmann T, Chaouch A, Cummins G, McKee D, Richardson A, Kobylecki C
Pract Neurol 2024 Jul 16;24(4):320-325. doi: 10.1136/pn-2023-004036. PMID: 38290842
Centers for Disease Control and Prevention (CDC)
MMWR Morb Mortal Wkly Rep 1995 Dec 8;44(48):889-92. PMID: 7476845
Davis LE
West J Med 1993 Jan;158(1):25-9. PMID: 8470380Free PMC Article
Swedberg J, Wendel TH, Deiss F
West J Med 1987 Sep;147(3):335-8. PMID: 3314158Free PMC Article
Hikes DC, Manoli A 2nd
J Trauma 1981 Jan;21(1):68-71. doi: 10.1097/00005373-198101000-00016. PMID: 7463544

Prognosis

Wheeler C, Inami G, Mohle-Boetani J, Vugia D
Clin Infect Dis 2009 Jun 15;48(12):1669-73. doi: 10.1086/599029. PMID: 19435438
Barry J, Ward M, Cotter S, Macdiarmada J, Hannan M, Sweeney B, Grant KA, McKeown P
Euro Surveill 2009 Jan 8;14(1) PMID: 19161713
Preuss SF, Veelken F, Galldiks N, Klussmann JP, Neugebauer P, Nolden-Hoverath S, Huttenbrink KB
Laryngoscope 2006 May;116(5):831-2. doi: 10.1097/01.mlg.0000214868.76123.a4. PMID: 16652098
Horowitz BZ
Crit Care Clin 2005 Oct;21(4):825-39, viii. doi: 10.1016/j.ccc.2005.06.008. PMID: 16168317
Brett MM, Hood J, Brazier JS, Duerden BI, Hahné SJ
Epidemiol Infect 2005 Aug;133(4):575-82. doi: 10.1017/s0950268805003845. PMID: 16050501Free PMC Article

Clinical prediction guides

Qureshi IA, Qureshi MA, Rauf Afzal M, Maud A, Rodriguez GJ, Cruz-Flores S, Kassar D
Neurocrit Care 2017 Dec;27(3):415-419. doi: 10.1007/s12028-017-0415-6. PMID: 28569348
Galldiks N, Nolden-Hoverath S, Kosinski CM, Stegelmeyer U, Schmidt S, Dohmen C, Kuhn J, Gerbershagen K, Bewermeyer H, Walger P, Biniek R, Neveling M, Jacobs AH, Haupt WF
Neurocrit Care 2007;6(1):30-4. doi: 10.1385/NCC:6:1:30. PMID: 17356188
Sandrock CE, Murin S
Chest 2001 Aug;120(2):562-6. doi: 10.1378/chest.120.2.562. PMID: 11502659
Passaro DJ, Werner SB, McGee J, Mac Kenzie WR, Vugia DJ
JAMA 1998 Mar 18;279(11):859-63. doi: 10.1001/jama.279.11.859. PMID: 9516001
Bosshardt TL, Henderson VJ, Organ CH Jr
Arch Surg 1996 Aug;131(8):846-52; discussion 852-4. doi: 10.1001/archsurg.1996.01430200056011. PMID: 8712909

Recent systematic reviews

Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Chatham-Stephens K, Fleck-Derderian S, Johnson SD, Sobel J, Rao AK, Meaney-Delman D
Clin Infect Dis 2017 Dec 27;66(suppl_1):S11-S16. doi: 10.1093/cid/cix811. PMID: 29293923
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013
Chalk C, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2011 Mar 16;(3):CD008123. doi: 10.1002/14651858.CD008123.pub2. PMID: 21412916

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...