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Botulism

MedGen UID:
14204
•Concept ID:
C0006057
•
Injury or Poisoning
Synonyms: Botulism, Toxico Infectious; Botulism, Toxico-Infectious; Clostridium botulinum Infection; Clostridium botulinum Infections; Infection, Clostridium botulinum; Toxico Infectious Botulism; Toxico-Infectious Botulism
SNOMED CT: Botulism (398565003); Lame sickness (398565003); Infection caused by Clostridium botulinum (398565003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005498
Orphanet: ORPHA1267

Definition

Botulism is a rare acquired neuromuscular junction disease, characterized by descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), including four clinical forms with different modes of acquisition. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBotulism
Follow this link to review classifications for Botulism in Orphanet.

Professional guidelines

PubMed

Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.
Rao AK, Sobel J, Chatham-Stephens K, Luquez C
MMWR Recomm Rep 2021 May 7;70(2):1-30. doi: 10.15585/mmwr.rr7002a1. PMID: 33956777Free PMC Article
Foodborne Botulism: Clinical Diagnosis and Medical Treatment.
Lonati D, Schicchi A, Crevani M, Buscaglia E, Scaravaggi G, Maida F, Cirronis M, Petrolini VM, Locatelli CA
Toxins (Basel) 2020 Aug 7;12(8) doi: 10.3390/toxins12080509. PMID: 32784744Free PMC Article
Botulinum toxin as a biological weapon: medical and public health management.
Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Fine AD, Hauer J, Layton M, Lillibridge S, Osterholm MT, O'Toole T, Parker G, Perl TM, Russell PK, Swerdlow DL, Tonat K; Working Group on Civilian Biodefense
JAMA 2001 Feb 28;285(8):1059-70. doi: 10.1001/jama.285.8.1059. PMID: 11209178

Recent systematic reviews

Emerging off-label esthetic uses of botulinum toxin in dermatology.
Phan K, Younessi S, Dubin D, Lin MJ, Khorasani H
Dermatol Ther 2022 Jan;35(1):e15205. Epub 2021 Dec 13 doi: 10.1111/dth.15205. PMID: 34792262
Medical treatment for botulism.
Chalk CH, Benstead TJ, Pound JD, Keezer MR
Cochrane Database Syst Rev 2019 Apr 17;4(4):CD008123. doi: 10.1002/14651858.CD008123.pub4. PMID: 30993666Free PMC Article
Botulism During Pregnancy and the Postpartum Period: A Systematic Review.
Badell ML, Rimawi BH, Rao AK, Jamieson DJ, Rasmussen S, Meaney-Delman D
Clin Infect Dis 2017 Dec 27;66(suppl_1):S30-S37. doi: 10.1093/cid/cix813. PMID: 29293925
Medical treatment for botulism.
Chalk CH, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2014 Feb 20;(2):CD008123. doi: 10.1002/14651858.CD008123.pub3. PMID: 24558013
Medical treatment for botulism.
Chalk C, Benstead TJ, Keezer M
Cochrane Database Syst Rev 2011 Mar 16;(3):CD008123. doi: 10.1002/14651858.CD008123.pub2. PMID: 21412916

Supplemental Content

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