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Vitamin B deficiency

MedGen UID:
22669
•Concept ID:
C0042850
•
Disease or Syndrome
Synonyms: Deficiencies, Vitamin B; Deficiency, Vitamin B; Vitamin B Deficiencies; Vitamin B Deficiency
SNOMED CT: Deficiency of vitamin B (47903000); Vitamin B-complex deficiency (190631007); Vitamin B deficiency (47903000)
 
Monarch Initiative: MONDO:0042976

Definition

Abnormally low concentrations of vitamin B in the blood. [from NCI]

Professional guidelines

PubMed

B Vitamins as Adjunctive Treatment for Chronic Heart Failure.
Dkhillon D, Samogulova A, Kolobov B
Cardiovasc Hematol Disord Drug Targets 2023;23(1):64-71. doi: 10.2174/1871529X23666230719090419. PMID: 37464830
The role of B vitamins in the management of heart failure.
Azizi-Namini P, Ahmed M, Yan AT, Keith M
Nutr Clin Pract 2012 Jun;27(3):363-74. Epub 2012 Apr 19 doi: 10.1177/0884533612444539. PMID: 22516940
WERNICKE'S ENCEPHALOPATHY AND ALCOHOLISM. THE COURSE AND TREATMENT OF AN UNUSUAL CASE.
WARIN EM
Nurs Times 1963 Oct 18;59:1310-2. PMID: 14068096

Recent clinical studies

Etiology

A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals.
Young LM, Pipingas A, White DJ, Gauci S, Scholey A
Nutrients 2019 Sep 16;11(9) doi: 10.3390/nu11092232. PMID: 31527485Free PMC Article
B Vitamins and Ageing.
Mikkelsen K, Apostolopoulos V
Subcell Biochem 2018;90:451-470. doi: 10.1007/978-981-13-2835-0_15. PMID: 30779018
The Effects of Homocysteine on the Skeleton.
Saito M, Marumo K
Curr Osteoporos Rep 2018 Oct;16(5):554-560. doi: 10.1007/s11914-018-0469-1. PMID: 30116976
B-Group Vitamins: Chemoprevention?
Gruber BM
Adv Clin Exp Med 2016 May-Jun;25(3):561-8. doi: 10.17219/acem/33847. PMID: 27629746
B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review.
Kennedy DO
Nutrients 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. PMID: 26828517Free PMC Article

Diagnosis

Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals.
Young LM, Pipingas A, White DJ, Gauci S, Scholey A
Nutrients 2019 Sep 16;11(9) doi: 10.3390/nu11092232. PMID: 31527485Free PMC Article
B vitamins for stroke prevention.
Hankey GJ
Stroke Vasc Neurol 2018 Jun;3(2):51-58. Epub 2018 Jun 6 doi: 10.1136/svn-2018-000156. PMID: 30022794Free PMC Article
Hyperhomocysteinemia: Impact on Neurodegenerative Diseases.
Sharma M, Tiwari M, Tiwari RK
Basic Clin Pharmacol Toxicol 2015 Nov;117(5):287-96. Epub 2015 Jun 19 doi: 10.1111/bcpt.12424. PMID: 26036286
Biotin: biochemical, physiological and clinical aspects.
Said HM
Subcell Biochem 2012;56:1-19. doi: 10.1007/978-94-007-2199-9_1. PMID: 22116691

Therapy

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence.
Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A
Nutrients 2020 Jan 16;12(1) doi: 10.3390/nu12010228. PMID: 31963141Free PMC Article
The Effects of Vitamin B in Depression.
Mikkelsen K, Stojanovska L, Apostolopoulos V
Curr Med Chem 2016;23(38):4317-4337. doi: 10.2174/0929867323666160920110810. PMID: 27655070
B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review.
Kennedy DO
Nutrients 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. PMID: 26828517Free PMC Article
Vitamin B-6.
Stover PJ, Field MS
Adv Nutr 2015 Jan;6(1):132-3. Epub 2015 Jan 15 doi: 10.3945/an.113.005207. PMID: 25593152Free PMC Article
Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
Depeint F, Bruce WR, Shangari N, Mehta R, O'Brien PJ
Chem Biol Interact 2006 Oct 27;163(1-2):94-112. Epub 2006 May 1 doi: 10.1016/j.cbi.2006.04.014. PMID: 16765926

Prognosis

Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
B vitamins for stroke prevention.
Hankey GJ
Stroke Vasc Neurol 2018 Jun;3(2):51-58. Epub 2018 Jun 6 doi: 10.1136/svn-2018-000156. PMID: 30022794Free PMC Article
Neurologic Manifestations of Vitamin B Deficiency after Bariatric Surgery.
Punchai S, Hanipah ZN, Meister KM, Schauer PR, Brethauer SA, Aminian A
Obes Surg 2017 Aug;27(8):2079-2082. doi: 10.1007/s11695-017-2607-8. PMID: 28213665
Hyperhomocysteinemia: Impact on Neurodegenerative Diseases.
Sharma M, Tiwari M, Tiwari RK
Basic Clin Pharmacol Toxicol 2015 Nov;117(5):287-96. Epub 2015 Jun 19 doi: 10.1111/bcpt.12424. PMID: 26036286
B-vitamins, homocysteine metabolism and CVD.
Strain JJ, Dowey L, Ward M, Pentieva K, McNulty H
Proc Nutr Soc 2004 Nov;63(4):597-603. doi: 10.1079/pns2004390. PMID: 15831132

Clinical prediction guides

Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
B vitamins for stroke prevention.
Hankey GJ
Stroke Vasc Neurol 2018 Jun;3(2):51-58. Epub 2018 Jun 6 doi: 10.1136/svn-2018-000156. PMID: 30022794Free PMC Article
Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing.
Porter K, Hoey L, Hughes CF, Ward M, McNulty H
Nutrients 2016 Nov 16;8(11) doi: 10.3390/nu8110725. PMID: 27854316Free PMC Article
Thiamin deficiency in people with obesity.
Kerns JC, Arundel C, Chawla LS
Adv Nutr 2015 Mar;6(2):147-53. Epub 2015 Mar 13 doi: 10.3945/an.114.007526. PMID: 25770253Free PMC Article
Secondary carnitine deficiency.
Duran M, Loof NE, Ketting D, Dorland L
J Clin Chem Clin Biochem 1990 May;28(5):359-63. PMID: 2199597

Recent systematic reviews

Vitamin B Complex Deficiency After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy-a Systematic Review and Meta-Analysis.
Nunes R, Santos-Sousa H, Vieira S, Nogueiro J, Bouça-Machado R, Pereira A, Carneiro S, Costa-Pinho A, Lima-da-Costa E, Preto J, Group CRI
Obes Surg 2022 Mar;32(3):873-891. Epub 2022 Jan 4 doi: 10.1007/s11695-021-05783-2. PMID: 34982396
A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals.
Young LM, Pipingas A, White DJ, Gauci S, Scholey A
Nutrients 2019 Sep 16;11(9) doi: 10.3390/nu11092232. PMID: 31527485Free PMC Article
Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis.
Ford AH, Almeida OP
Drugs Aging 2019 May;36(5):419-434. doi: 10.1007/s40266-019-00649-w. PMID: 30949983
Association of some specific nutrient deficiencies with periodontal disease in elderly people: A systematic literature review.
van der Putten GJ, Vanobbergen J, De Visschere L, Schols J, de Baat C
Nutrition 2009 Jul-Aug;25(7-8):717-22. doi: 10.1016/j.nut.2009.01.012. PMID: 19539173
The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review.
Herrmann M, Peter Schmidt J, Umanskaya N, Wagner A, Taban-Shomal O, Widmann T, Colaianni G, Wildemann B, Herrmann W
Clin Chem Lab Med 2007;45(12):1621-32. doi: 10.1515/CCLM.2007.362. PMID: 18067447

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