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Reduced circulating vitamin B6 circulating

MedGen UID:
215231
Concept ID:
C0936215
Disease or Syndrome
Synonyms: B6 Deficiencies, Vitamin; B6 Deficiency, Vitamin; B6 Vitamin Deficiencies; B6 Vitamin Deficiency; Deficiencies, B6 Vitamin; Deficiencies, Vitamin B6; Deficiency, B6 Vitamin; Deficiency, Vitamin B 6; Deficiency, Vitamin B6; Vitamin B 6 Deficiency; Vitamin B6 Deficiencies; Vitamin B6 Deficiency; Vitamin Deficiencies, B6; Vitamin Deficiency, B6
SNOMED CT: Vitamin B6 deficiency (386080007)
 
HPO: HP:0008326

Definition

An abnormally decreased concentration of vitamin B6 in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating vitamin B6 circulating

Conditions with this feature

Carpal tunnel syndrome 1
MedGen UID:
1830382
Concept ID:
C5779776
Disease or Syndrome
Carpal tunnel syndrome-1 (CTS1) is characterized by hand pain and numbness in the distribution of the median nerve, with onset in the sixth decade of life. Amyloid deposits are observed in synovial tissue of the wrist and in the transverse carpal ligament (Murakami et al., 1994). Genetic Heterogeneity of Carpal Tunnel Syndrome CTS2 (619161) is caused by mutation in the COMP gene (600310) on chromosome 19p13. Susceptibility to the development of mononeuropathy of the median (MNMN; 613353) may be conferred by heterozygous mutation in the SH3TC2 gene (608206) on chromosome 5q32. Carpal tunnel syndrome has been described as a feature in amyloid neuropathy (see 176300) and in mucopolysaccharidoses (e.g., 253200) and mucolipidoses (252600).

Professional guidelines

PubMed

Qureshi SS, Gupta JK, Goyal A, Narayan Yadav H
Med Hypotheses 2019 Aug;129:109245. Epub 2019 May 23 doi: 10.1016/j.mehy.2019.109245. PMID: 31371071
Zhang SM
Curr Opin Obstet Gynecol 2004 Feb;16(1):19-25. doi: 10.1097/00001703-200402000-00005. PMID: 15128003
Ubbink JB
J Inherit Metab Dis 1997 Jun;20(2):316-25. doi: 10.1023/a:1005329427711. PMID: 9211204

Recent clinical studies

Etiology

Liu K, Chen Y, Chen J, Chen W, Sun X, Mao Y, Ye D
Sci Rep 2024 Jan 11;14(1):1105. doi: 10.1038/s41598-024-51609-3. PMID: 38212362Free PMC Article
Chen J, Ruan X, Yuan S, Deng M, Zhang H, Sun J, Yu L, Satsangi J, Larsson SC, Therdoratou E, Wang X, Li X
Aliment Pharmacol Ther 2023 Feb;57(4):399-408. Epub 2023 Jan 16 doi: 10.1111/apt.17392. PMID: 36645152
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC
BMC Med 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102Free PMC Article
Takagi H, Umemoto T; Alice (All-Literature Investigation of Cardiovascular Evidence) group
Int Angiol 2017 Feb;36(1):21-30. Epub 2015 Nov 23 doi: 10.23736/S0392-9590.16.03618-X. PMID: 26603433

Diagnosis

Liu K, Chen Y, Chen J, Chen W, Sun X, Mao Y, Ye D
Sci Rep 2024 Jan 11;14(1):1105. doi: 10.1038/s41598-024-51609-3. PMID: 38212362Free PMC Article
Chen J, Ruan X, Yuan S, Deng M, Zhang H, Sun J, Yu L, Satsangi J, Larsson SC, Therdoratou E, Wang X, Li X
Aliment Pharmacol Ther 2023 Feb;57(4):399-408. Epub 2023 Jan 16 doi: 10.1111/apt.17392. PMID: 36645152
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Koole JL, Bours MJL, Geijsen AJMR, Gigic B, Ulvik A, Kok DE, Brezina S, Ose J, Baierl A, Böhm J, Brenner H, Breukink SO, Chang-Claude J, van Duijnhoven FJB, van Duijvendijk P, Gumpenberger T, Habermann N, van Halteren HK, Hoffmeister M, Holowatyj AN, Janssen-Heijnen MLG, Keulen ETP, Kiblawi R, Kruyt FM, Li CI, Lin T, Midttun Ø, Peoples AR, van Roekel EH, Schneider MA, Schrotz-King P, Ulrich AB, Vickers K, Wesselink E, de Wilt JHW, Gsur A, Ueland PM, Ulrich CM, Kampman E, Weijenberg MP
Am J Clin Nutr 2021 Jun 1;113(6):1468-1481. doi: 10.1093/ajcn/nqaa422. PMID: 33668069Free PMC Article
Holstein JH, Herrmann M, Splett C, Herrmann W, Garcia P, Histing T, Klein M, Kurz K, Siebel T, Pohlemann T, Menger MD
Clin Chem Lab Med 2010 Jun;48(6):821-7. doi: 10.1515/CCLM.2010.155. PMID: 20345232

Therapy

Liu K, Chen Y, Chen J, Chen W, Sun X, Mao Y, Ye D
Sci Rep 2024 Jan 11;14(1):1105. doi: 10.1038/s41598-024-51609-3. PMID: 38212362Free PMC Article
Ahlskog JE
Parkinsonism Relat Disord 2023 Apr;109:105357. Epub 2023 Mar 6 doi: 10.1016/j.parkreldis.2023.105357. PMID: 36922273
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC
BMC Med 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102Free PMC Article
Takagi H, Umemoto T; Alice (All-Literature Investigation of Cardiovascular Evidence) group
Int Angiol 2017 Feb;36(1):21-30. Epub 2015 Nov 23 doi: 10.23736/S0392-9590.16.03618-X. PMID: 26603433

Prognosis

Liu K, Chen Y, Chen J, Chen W, Sun X, Mao Y, Ye D
Sci Rep 2024 Jan 11;14(1):1105. doi: 10.1038/s41598-024-51609-3. PMID: 38212362Free PMC Article
Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, Reims HM, Björk I, Grzyb K, Abildgaard A, Småstuen MC, Folseraas T, Trøseid M, Ulvik A, Ueland PM, Melum E, Line PD, Høivik ML, Grønbæk H, Karlsen TH, Vesterhus M, Hov JR
J Hepatol 2023 Oct;79(4):955-966. Epub 2023 Jun 14 doi: 10.1016/j.jhep.2023.05.038. PMID: 37328069
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC
BMC Med 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102Free PMC Article
Takagi H, Umemoto T; Alice (All-Literature Investigation of Cardiovascular Evidence) group
Int Angiol 2017 Feb;36(1):21-30. Epub 2015 Nov 23 doi: 10.23736/S0392-9590.16.03618-X. PMID: 26603433

Clinical prediction guides

Liu K, Chen Y, Chen J, Chen W, Sun X, Mao Y, Ye D
Sci Rep 2024 Jan 11;14(1):1105. doi: 10.1038/s41598-024-51609-3. PMID: 38212362Free PMC Article
Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, Reims HM, Björk I, Grzyb K, Abildgaard A, Småstuen MC, Folseraas T, Trøseid M, Ulvik A, Ueland PM, Melum E, Line PD, Høivik ML, Grønbæk H, Karlsen TH, Vesterhus M, Hov JR
J Hepatol 2023 Oct;79(4):955-966. Epub 2023 Jun 14 doi: 10.1016/j.jhep.2023.05.038. PMID: 37328069
Chen J, Ruan X, Yuan S, Deng M, Zhang H, Sun J, Yu L, Satsangi J, Larsson SC, Therdoratou E, Wang X, Li X
Aliment Pharmacol Ther 2023 Feb;57(4):399-408. Epub 2023 Jan 16 doi: 10.1111/apt.17392. PMID: 36645152
Yan H, Jin X, Yin L, Zhu C, Feng G
Nutrients 2022 Oct 31;14(21) doi: 10.3390/nu14214569. PMID: 36364831Free PMC Article
Yuan S, Mason AM, Carter P, Burgess S, Larsson SC
BMC Med 2021 Apr 23;19(1):97. doi: 10.1186/s12916-021-01977-8. PMID: 33888102Free PMC Article

Recent systematic reviews

Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M
Cochrane Database Syst Rev 2017 Aug 17;8(8):CD006612. doi: 10.1002/14651858.CD006612.pub5. PMID: 28816346Free PMC Article
Martí-Carvajal AJ, Solà I, Lathyris D, Salanti G
Cochrane Database Syst Rev 2009 Oct 7;(4):CD006612. doi: 10.1002/14651858.CD006612.pub2. PMID: 19821378Free PMC Article
Potter K, Hankey GJ, Green DJ, Eikelboom J, Jamrozik K, Arnolda LF
BMC Cardiovasc Disord 2008 Sep 20;8:24. doi: 10.1186/1471-2261-8-24. PMID: 18803866Free PMC Article

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