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Meningeal melanocytoma

MedGen UID:
226842
Concept ID:
C1266113
Neoplastic Process
Synonyms: Leptomeningeal Melanocytoma; leptomeningeal melanocytoma; Melanocytoma of meninges; Melanocytoma of Meninges; melanocytoma of meninges; Melanocytoma of the Meninges; melanocytoma of the meninges; Meningeal Melanocytoma; meningeal melanocytoma; Meninges Melanocytoma; meninges melanocytoma
SNOMED CT: Meningeal melanocytoma (128730009); Melanocytoma of meninges (277527003)
 
Monarch Initiative: MONDO:0016746
Orphanet: ORPHA252046

Definition

A rare nervous system tumor characterized by a benign pigmented space-occupying lesion derived from leptomeningeal melanocytes. Symptoms typically show insidious onset and are related to the mass effect on adjacent tissues. Depending on the location of the tumor, they include focal neurological deficits, increased intracranial pressure, seizures, and spinal cord compression, among others. Although the tumor may behave aggressively, prognosis is good after complete surgical resection. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningeal melanocytoma
Follow this link to review classifications for Meningeal melanocytoma in Orphanet.

Professional guidelines

PubMed

Sakar M, Erdogan O, Bozkurt SU, Dagcinar A
Turk Neurosurg 2022;32(1):166-170. doi: 10.5137/1019-5149.JTN.34672-21.4. PMID: 34664706
Adib SD, Ebner FH, Bornemann A, Hempel JM, Tatagiba M
World Neurosurg 2019 Aug;128:e835-e840. Epub 2019 May 10 doi: 10.1016/j.wneu.2019.05.004. PMID: 31082560

Recent clinical studies

Etiology

Ferreira de Araújo MG, Almondes Santana Lemos LE, Negromonte Guerra PL, Marcia Dos Santos Lima Didjurgeit F, Batista Cezar A Jr, Faquini IV, Cirne de Azevedo Filho HR
Pathol Oncol Res 2023;29:1611482. Epub 2024 Jan 4 doi: 10.3389/pore.2023.1611482. PMID: 38239282Free PMC Article
Yin M, Ma J, Ye J, Xu H, Mo W
World Neurosurg 2019 Sep;129:143-147. Epub 2019 Jun 7 doi: 10.1016/j.wneu.2019.05.147. PMID: 31426249
Yang C, Fang J, Li G, Jia W, Liu H, Qi W, Xu Y
J Neurooncol 2016 Apr;127(2):279-86. Epub 2016 Mar 3 doi: 10.1007/s11060-015-2006-8. PMID: 26940907
Rahimi-Movaghar V, Karimi M
Surg Neurol 2003 Mar;59(3):200-10. doi: 10.1016/s0090-3019(02)01052-2. PMID: 12681556
Classen J, Hehr T, Paulus W, Plate K, Bamberg M
J Neurooncol 2002 May;58(1):39-46. doi: 10.1023/a:1015872207398. PMID: 12160139

Diagnosis

Chhabra R, Misra S, Prasad P, Khati S
Neurol India 2022 Sep-Oct;70(5):2153-2155. doi: 10.4103/0028-3886.359256. PMID: 36352627
Chan IYM, Li H, Shi T, Hammond RR, Jurkiewicz MT
Can J Neurol Sci 2021 Sep;48(5):719-721. Epub 2020 Nov 20 doi: 10.1017/cjn.2020.256. PMID: 33213533
Mathai AM, Naik R, Pai MR, Kini JR, Kumar S, Ballal CK
Orbit 2008;27(5):383-7. doi: 10.1080/01676830802333626. PMID: 18836939
Turhan T, Oner K, Yurtseven T, Akalin T, Ovul I
J Neurosurg 2004 Mar;100(3 Suppl Spine):287-90. PMID: 15029918
Hamasaki O, Nakahara T, Sakamoto S, Kutsuna M, Sakoda K
Neurol Med Chir (Tokyo) 2002 Nov;42(11):504-9. doi: 10.2176/nmc.42.504. PMID: 12472216

Therapy

Ramos AA, Ferrara P, Fernández VM, Sanchez CR, Alvarez Vega MA
Neurol India 2022 Sep-Oct;70(Supplement):S318-S321. doi: 10.4103/0028-3886.360914. PMID: 36412389
Hean V, Bouleftour W, Ramirez C, Forest F, Boutet C, Rivoirard R
Medicine (Baltimore) 2021 May 14;100(19):e25862. doi: 10.1097/MD.0000000000025862. PMID: 34106633Free PMC Article
Maeda M, Tsukahara H, Terada H, Nakaji S, Nakamura H, Oba H, Igarashi O, Arasaki K, Machida T, Takeda K, Takanashi JI
J Neuroradiol 2006 Oct;33(4):229-36. doi: 10.1016/s0150-9861(06)77268-6. PMID: 17041527
de Tella OI Jr, Agner C, Aguiar PH, Herculano MA, Prandini MN, Stavile JN
Acta Neurochir (Wien) 2003 Dec;145(12):1121-6. Epub 2003 Oct 13 doi: 10.1007/s00701-003-0121-3. PMID: 14663571
Verma DS, Spitzer G, Legha S, McCredie KB
JAMA 1979 Nov 30;242(22):2435-6. PMID: 490860

Prognosis

Chhabra R, Misra S, Prasad P, Khati S
Neurol India 2022 Sep-Oct;70(5):2153-2155. doi: 10.4103/0028-3886.359256. PMID: 36352627
Yang C, Fang J, Li G, Jia W, Liu H, Qi W, Xu Y
J Neurooncol 2016 Apr;127(2):279-86. Epub 2016 Mar 3 doi: 10.1007/s11060-015-2006-8. PMID: 26940907
Lin B, Yang H, Qu L, Li Y, Yu J
World J Surg Oncol 2012 Jul 3;10:135. doi: 10.1186/1477-7819-10-135. PMID: 22759717Free PMC Article
Rahimi-Movaghar V, Karimi M
Surg Neurol 2003 Mar;59(3):200-10. doi: 10.1016/s0090-3019(02)01052-2. PMID: 12681556
Hamasaki O, Nakahara T, Sakamoto S, Kutsuna M, Sakoda K
Neurol Med Chir (Tokyo) 2002 Nov;42(11):504-9. doi: 10.2176/nmc.42.504. PMID: 12472216

Clinical prediction guides

Yin M, Ma J, Ye J, Xu H, Mo W
World Neurosurg 2019 Sep;129:143-147. Epub 2019 Jun 7 doi: 10.1016/j.wneu.2019.05.147. PMID: 31426249
Sakata K, Miyoshi J, Takeshige N, Komaki S, Miyagi N, Nakashima S, Morioka M, Sugita Y
Pituitary 2015 Oct;18(5):685-94. doi: 10.1007/s11102-015-0635-8. PMID: 25583147
Roser F, Nakamura M, Brandis A, Hans V, Vorkapic P, Samii M
J Neurosurg 2004 Sep;101(3):528-31. doi: 10.3171/jns.2004.101.3.0528. PMID: 15352613
Classen J, Hehr T, Paulus W, Plate K, Bamberg M
J Neurooncol 2002 May;58(1):39-46. doi: 10.1023/a:1015872207398. PMID: 12160139
Jellinger K, Böck F, Brenner H
Acta Neurochir (Wien) 1988;94(1-2):78-87. doi: 10.1007/BF01406621. PMID: 3051898

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