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Atypical hyperplasia of breast

MedGen UID:
226961
Concept ID:
C1297929
Pathologic Function
Synonyms: Atypical Breast Hyperplasia; Atypical Hyperplasia of Breast; Atypical Hyperplasia of the Breast; Breast Atypical Hyperplasia
SNOMED CT: Atypical hyperplasia of breast (369462000)

Definition

A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma. Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia. [from NCI]

Professional guidelines

PubMed

Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K
N Engl J Med 2015 Jan 1;372(1):78-89. doi: 10.1056/NEJMsr1407164. PMID: 25551530Free PMC Article

Recent clinical studies

Etiology

Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K
N Engl J Med 2015 Jan 1;372(1):78-89. doi: 10.1056/NEJMsr1407164. PMID: 25551530Free PMC Article

Diagnosis

Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Heller SL, Gao Y
Radiographics 2023 Oct;43(10):e220188. doi: 10.1148/rg.220188. PMID: 37676825
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Therapy

Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K
N Engl J Med 2015 Jan 1;372(1):78-89. doi: 10.1056/NEJMsr1407164. PMID: 25551530Free PMC Article
Saslow D, Boetes C, Burke W, Harms S, Leach MO, Lehman CD, Morris E, Pisano E, Schnall M, Sener S, Smith RA, Warner E, Yaffe M, Andrews KS, Russell CA; American Cancer Society Breast Cancer Advisory Group
CA Cancer J Clin 2007 Mar-Apr;57(2):75-89. doi: 10.3322/canjclin.57.2.75. PMID: 17392385
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

Prognosis

Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K
N Engl J Med 2015 Jan 1;372(1):78-89. doi: 10.1056/NEJMsr1407164. PMID: 25551530Free PMC Article
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

Clinical prediction guides

Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
González Mariño MA
Breast Dis 2022;41(1):545-550. doi: 10.3233/BD-220029. PMID: 36683493
Gandhi S, Sudheendra P, Rafferty W, Loveland-Jones C
Clin Breast Cancer 2018 Oct;18(5):e751-e754. Epub 2018 Jul 5 doi: 10.1016/j.clbc.2018.07.001. PMID: 30131245
Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS
Breast Cancer Res Treat 2017 Sep;165(2):285-291. Epub 2017 Jun 6 doi: 10.1007/s10549-017-4320-7. PMID: 28589368Free PMC Article
Dyrstad SW, Yan Y, Fowler AM, Colditz GA
Breast Cancer Res Treat 2015 Feb;149(3):569-75. Epub 2015 Jan 31 doi: 10.1007/s10549-014-3254-6. PMID: 25636589

Recent systematic reviews

Baker J, Noguchi N, Marinovich ML, Sprague BL, Salisbury E, Houssami N
Breast 2024 Dec;78:103807. Epub 2024 Sep 11 doi: 10.1016/j.breast.2024.103807. PMID: 39270543Free PMC Article
González Mariño MA
Breast Dis 2022;41(1):545-550. doi: 10.3233/BD-220029. PMID: 36683493
Schiaffino S, Calabrese M, Melani EF, Trimboli RM, Cozzi A, Carbonaro LA, Di Leo G, Sardanelli F
Radiology 2020 Jan;294(1):76-86. Epub 2019 Oct 29 doi: 10.1148/radiol.2019190748. PMID: 31660803
Luo L, Luo B, Zheng Y, Zhang H, Li J, Sidell N
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD009458. doi: 10.1002/14651858.CD009458.pub3. PMID: 30521671Free PMC Article
Dyrstad SW, Yan Y, Fowler AM, Colditz GA
Breast Cancer Res Treat 2015 Feb;149(3):569-75. Epub 2015 Jan 31 doi: 10.1007/s10549-014-3254-6. PMID: 25636589

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