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Atypical hyperplasia of breast

MedGen UID:
226961
•Concept ID:
C1297929
•
Pathologic Function
Synonyms: Atypical Breast Hyperplasia; Atypical Hyperplasia of Breast; Atypical Hyperplasia of the Breast; Breast Atypical Hyperplasia
SNOMED CT: Atypical hyperplasia of breast (369462000)

Definition

A general term that refers to atypical hyperplastic proliferations of the epithelial cells in the breast parenchyma. Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and columnar cell hyperplasia with atypia. [from NCI]

Professional guidelines

PubMed

Atypical hyperplasia of the breast: Clinical cases and management strategies.
Vegunta S, Mussallem DM, Kaur AS, Pruthi S, Klassen CL
Cleve Clin J Med 2023 Jul 3;90(7):423-431. doi: 10.3949/ccjm.90a.22098. PMID: 37400158
Management of breast complaints and high-risk lesions.
Pleasant V
Best Pract Res Clin Obstet Gynaecol 2022 Sep;83:46-59. Epub 2022 Apr 4 doi: 10.1016/j.bpobgyn.2022.03.017. PMID: 35570155
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Recent clinical studies

Etiology

Atypical hyperplasia of the breast: Clinical cases and management strategies.
Vegunta S, Mussallem DM, Kaur AS, Pruthi S, Klassen CL
Cleve Clin J Med 2023 Jul 3;90(7):423-431. doi: 10.3949/ccjm.90a.22098. PMID: 37400158
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Management of High-Risk Breast Lesions.
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Preneoplasia of the Breast and Molecular Landscape.
Alvarado-Cabrero I, Valencia-Cedillo R, Estevez-Castro R
Arch Med Res 2020 Nov;51(8):845-850. Epub 2020 Sep 21 doi: 10.1016/j.arcmed.2020.09.011. PMID: 32972772

Diagnosis

Atypical hyperplasia of the breast: Clinical cases and management strategies.
Vegunta S, Mussallem DM, Kaur AS, Pruthi S, Klassen CL
Cleve Clin J Med 2023 Jul 3;90(7):423-431. doi: 10.3949/ccjm.90a.22098. PMID: 37400158
Lobular Neoplasia.
Lunt L, Coogan A, Perez CB
Surg Clin North Am 2022 Dec;102(6):947-963. doi: 10.1016/j.suc.2022.07.001. PMID: 36335930
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737

Therapy

Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.
Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758
Progesterone and endometrial cancer.
Gompel A
Best Pract Res Clin Obstet Gynaecol 2020 Nov;69:95-107. Epub 2020 Jun 9 doi: 10.1016/j.bpobgyn.2020.05.003. PMID: 32732107
Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
Diagnosis and Management of High-Risk Breast Lesions.
Thomas PS
J Natl Compr Canc Netw 2018 Nov;16(11):1391-1396. doi: 10.6004/jnccn.2018.7099. PMID: 30442737
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

Prognosis

Active Surveillance for Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ.
Miceli R, Mercado CL, Hernandez O, Chhor C
J Breast Imaging 2023 Jul 28;5(4):396-415. doi: 10.1093/jbi/wbad026. PMID: 38416903
Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study.
Lazzeroni M, Puntoni M, Guerrieri-Gonzaga A, Serrano D, Boni L, Buttiron Webber T, Fava M, Briata IM, Giordano L, Digennaro M, Cortesi L, Falcini F, Serra P, Avino F, Millo F, Cagossi K, Gallerani E, De Simone A, Cariello A, Aprile G, Renne M, Bonanni B, DeCensi A
J Clin Oncol 2023 Jun 10;41(17):3116-3121. Epub 2023 Mar 14 doi: 10.1200/JCO.22.02900. PMID: 36917758
Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia.
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
Reassessing risk models for atypical hyperplasia: age may not matter.
Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS
Breast Cancer Res Treat 2017 Sep;165(2):285-291. Epub 2017 Jun 6 doi: 10.1007/s10549-017-4320-7. PMID: 28589368Free PMC Article
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
An update on the management of breast atypical ductal hyperplasia.
Schiaffino S, Cozzi A, Sardanelli F
Br J Radiol 2020 Jun;93(1110):20200117. Epub 2020 Apr 1 doi: 10.1259/bjr.20200117. PMID: 32207989Free PMC Article
Reassessing risk models for atypical hyperplasia: age may not matter.
Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS
Breast Cancer Res Treat 2017 Sep;165(2):285-291. Epub 2017 Jun 6 doi: 10.1007/s10549-017-4320-7. PMID: 28589368Free PMC Article
Noninvasive papillary proliferations.
Oyama T, Koerner FC
Semin Diagn Pathol 2004 Feb;21(1):32-41. doi: 10.1053/j.semdp.2003.10.011. PMID: 15074557

Recent systematic reviews

Conservative re-treatment of women with atypical endometrial hyperplasia and early endometrial carcinoma: We can hope, at least.
Raffone A, Raimondo D, Rovero G, Travaglino A, Lopez G, Di Maio CM, Neola D, Raspollini A, Renzulli F, Filippelli A, Casadio P, Seracchioli R, Guida M
Int J Gynaecol Obstet 2024 May;165(2):542-551. Epub 2023 Sep 29 doi: 10.1002/ijgo.15146. PMID: 37772342
Inter-observer agreement in the diagnosis of breast atypical ductal hyperplasia: A systematic review.
González Mariño MA
Breast Dis 2022;41(1):545-550. doi: 10.3233/BD-220029. PMID: 36683493
Oral and intrauterine progestogens for atypical endometrial hyperplasia.
Luo L, Luo B, Zheng Y, Zhang H, Li J, Sidell N
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD009458. doi: 10.1002/14651858.CD009458.pub3. PMID: 30521671Free PMC Article
Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis.
Thomas ET, Del Mar C, Glasziou P, Wright G, Barratt A, Bell KJL
BMC Cancer 2017 Dec 2;17(1):808. doi: 10.1186/s12885-017-3808-1. PMID: 29197354Free PMC Article
Breast cancer risk associated with benign breast disease: systematic review and meta-analysis.
Dyrstad SW, Yan Y, Fowler AM, Colditz GA
Breast Cancer Res Treat 2015 Feb;149(3):569-75. Epub 2015 Jan 31 doi: 10.1007/s10549-014-3254-6. PMID: 25636589

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