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Atypical hyperplasia

MedGen UID:
90732
•Concept ID:
C0333977
•
Pathologic Function
Synonym: Atypical Hyperplasia
SNOMED CT: Atypical hyperplasia (32416003)

Professional guidelines

PubMed

Chronic neutrophilic leukemia and atypical chronic myeloid leukemia: 2024 update on diagnosis, genetics, risk stratification, and management.
Szuber N, Orazi A, Tefferi A
Am J Hematol 2024 Jul;99(7):1360-1387. Epub 2024 Apr 21 doi: 10.1002/ajh.27321. PMID: 38644693
Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933Free PMC Article
Endometrial polyps. An evidence-based diagnosis and management guide.
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339

Recent clinical studies

Etiology

Endometrial Hyperplasia.
Ring KL, Mills AM, Modesitt SC
Obstet Gynecol 2022 Dec 1;140(6):1061-1075. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004989. PMID: 36357974
Benign Breast Disorders.
Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773
Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer.
Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS
Am J Obstet Gynecol 2021 Feb;224(2):191.e1-191.e15. Epub 2020 Aug 15 doi: 10.1016/j.ajog.2020.08.032. PMID: 32805208Free PMC Article
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article

Diagnosis

Endometrial Hyperplasia.
Ring KL, Mills AM, Modesitt SC
Obstet Gynecol 2022 Dec 1;140(6):1061-1075. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004989. PMID: 36357974
Benign Breast Disorders.
Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article

Therapy

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933Free PMC Article
Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471
Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer.
Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS
Am J Obstet Gynecol 2021 Feb;224(2):191.e1-191.e15. Epub 2020 Aug 15 doi: 10.1016/j.ajog.2020.08.032. PMID: 32805208Free PMC Article
Progesterone and endometrial cancer.
Gompel A
Best Pract Res Clin Obstet Gynaecol 2020 Nov;69:95-107. Epub 2020 Jun 9 doi: 10.1016/j.bpobgyn.2020.05.003. PMID: 32732107
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article

Prognosis

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933Free PMC Article
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer.
Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS
Am J Obstet Gynecol 2021 Feb;224(2):191.e1-191.e15. Epub 2020 Aug 15 doi: 10.1016/j.ajog.2020.08.032. PMID: 32805208Free PMC Article
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Reassessing risk models for atypical hyperplasia: age may not matter.
Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS
Breast Cancer Res Treat 2017 Sep;165(2):285-291. Epub 2017 Jun 6 doi: 10.1007/s10549-017-4320-7. PMID: 28589368Free PMC Article

Clinical prediction guides

Effective Surveillance of High-Risk Women.
Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241
Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer.
Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS
Am J Obstet Gynecol 2021 Feb;224(2):191.e1-191.e15. Epub 2020 Aug 15 doi: 10.1016/j.ajog.2020.08.032. PMID: 32805208Free PMC Article
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
Reassessing risk models for atypical hyperplasia: age may not matter.
Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS
Breast Cancer Res Treat 2017 Sep;165(2):285-291. Epub 2017 Jun 6 doi: 10.1007/s10549-017-4320-7. PMID: 28589368Free PMC Article
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

Recent systematic reviews

Metformin and progestins in women with atypical hyperplasia or endometrial cancer: systematic review and meta-analysis.
Adamyan L, Pivazyan L, Isaeva S, Shapovalenko R, Zakaryan A
Arch Gynecol Obstet 2024 Jun;309(6):2289-2305. Epub 2024 Mar 19 doi: 10.1007/s00404-024-07416-2. PMID: 38503850
Efficacy, tolerability, and endometrial safety of ospemifene compared with current therapies for the treatment of vulvovaginal atrophy: a systematic literature review and network meta-analysis.
Simon JA, Ferenczy A, Black D, Castonguay A, Royer C, Marouf R, Beauchemin C
Menopause 2023 Aug 1;30(8):855-866. Epub 2023 Jun 27 doi: 10.1097/GME.0000000000002211. PMID: 37369079Free PMC Article
Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Oral and intrauterine progestogens for atypical endometrial hyperplasia.
Luo L, Luo B, Zheng Y, Zhang H, Li J, Sidell N
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD009458. doi: 10.1002/14651858.CD009458.pub3. PMID: 30521671Free PMC Article

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