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Atypical hyperplasia

MedGen UID:
90732
•Concept ID:
C0333977
•
Pathologic Function
Synonym: Atypical Hyperplasia
SNOMED CT: Atypical hyperplasia (32416003)

Professional guidelines

PubMed

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933Free PMC Article
Endometrial polyps. An evidence-based diagnosis and management guide.
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Fertility-sparing management for endometrial cancer: review of the literature.
Garzon S, Uccella S, Zorzato PC, Bosco M, Franchi MP, Student V, Mariani A
Minerva Med 2021 Feb;112(1):55-69. Epub 2020 Nov 18 doi: 10.23736/S0026-4806.20.07072-X. PMID: 33205638

Recent clinical studies

Etiology

Endometrial Hyperplasia.
Ring KL, Mills AM, Modesitt SC
Obstet Gynecol 2022 Dec 1;140(6):1061-1075. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004989. PMID: 36357974
Ductal metaplasia in pancreas.
Li S, Xie K
Biochim Biophys Acta Rev Cancer 2022 Mar;1877(2):188698. Epub 2022 Feb 15 doi: 10.1016/j.bbcan.2022.188698. PMID: 35176433
Progesterone and endometrial cancer.
Gompel A
Best Pract Res Clin Obstet Gynaecol 2020 Nov;69:95-107. Epub 2020 Jun 9 doi: 10.1016/j.bpobgyn.2020.05.003. PMID: 32732107
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article

Diagnosis

Endometrial Hyperplasia.
Ring KL, Mills AM, Modesitt SC
Obstet Gynecol 2022 Dec 1;140(6):1061-1075. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004989. PMID: 36357974
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Atypical Ductal Hyperplasia and Lobular Neoplasia: Update and Easing of Guidelines.
Lewin AA, Mercado CL
AJR Am J Roentgenol 2020 Feb;214(2):265-275. Epub 2019 Dec 11 doi: 10.2214/AJR.19.21991. PMID: 31825261
New concepts for an old problem: the diagnosis of endometrial hyperplasia.
Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066Free PMC Article

Therapy

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933Free PMC Article
Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471
Fertility-sparing management for endometrial cancer: review of the literature.
Garzon S, Uccella S, Zorzato PC, Bosco M, Franchi MP, Student V, Mariani A
Minerva Med 2021 Feb;112(1):55-69. Epub 2020 Nov 18 doi: 10.23736/S0026-4806.20.07072-X. PMID: 33205638
Progesterone and endometrial cancer.
Gompel A
Best Pract Res Clin Obstet Gynaecol 2020 Nov;69:95-107. Epub 2020 Jun 9 doi: 10.1016/j.bpobgyn.2020.05.003. PMID: 32732107
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article

Prognosis

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933Free PMC Article
Atypical Endometrial Hyperplasia, Low-grade: "Much ADO About Nothing".
D'Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J
Am J Surg Pathol 2021 Jul 1;45(7):988-996. doi: 10.1097/PAS.0000000000001705. PMID: 34105519
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer.
Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS
Am J Obstet Gynecol 2021 Feb;224(2):191.e1-191.e15. Epub 2020 Aug 15 doi: 10.1016/j.ajog.2020.08.032. PMID: 32805208Free PMC Article
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article

Clinical prediction guides

Atypical Endometrial Hyperplasia, Low-grade: "Much ADO About Nothing".
D'Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J
Am J Surg Pathol 2021 Jul 1;45(7):988-996. doi: 10.1097/PAS.0000000000001705. PMID: 34105519
Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer.
Westin SN, Fellman B, Sun CC, Broaddus RR, Woodall ML, Pal N, Urbauer DL, Ramondetta LM, Schmeler KM, Soliman PT, Fleming ND, Burzawa JK, Nick AM, Milbourne AM, Yuan Y, Lu KH, Bodurka DC, Coleman RL, Yates MS
Am J Obstet Gynecol 2021 Feb;224(2):191.e1-191.e15. Epub 2020 Aug 15 doi: 10.1016/j.ajog.2020.08.032. PMID: 32805208Free PMC Article
Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.
Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286
Reassessing risk models for atypical hyperplasia: age may not matter.
Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS
Breast Cancer Res Treat 2017 Sep;165(2):285-291. Epub 2017 Jun 6 doi: 10.1007/s10549-017-4320-7. PMID: 28589368Free PMC Article
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

Recent systematic reviews

Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.
De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471
Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.
Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732Free PMC Article
Oral and intrauterine progestogens for atypical endometrial hyperplasia.
Luo L, Luo B, Zheng Y, Zhang H, Li J, Sidell N
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD009458. doi: 10.1002/14651858.CD009458.pub3. PMID: 30521671Free PMC Article
Sampling in Atypical Endometrial Hyperplasia: Which Method Results in the Lowest Underestimation of Endometrial Cancer? A Systematic Review and Meta-analysis.
Bourdel N, Chauvet P, Tognazza E, Pereira B, Botchorishvili R, Canis M
J Minim Invasive Gynecol 2016 Jul-Aug;23(5):692-701. Epub 2016 Apr 4 doi: 10.1016/j.jmig.2016.03.017. PMID: 27058769
The accuracy of endometrial sampling in women with postmenopausal bleeding: a systematic review and meta-analysis.
van Hanegem N, Prins MM, Bongers MY, Opmeer BC, Sahota DS, Mol BW, Timmermans A
Eur J Obstet Gynecol Reprod Biol 2016 Feb;197:147-55. Epub 2015 Dec 19 doi: 10.1016/j.ejogrb.2015.12.008. PMID: 26748390

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