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Blackwater fever

MedGen UID:
2277
•Concept ID:
C0005681
•
Disease or Syndrome
Synonyms: Black Water Fever; Black Water Fevers; Blackwater Fever; Blackwater Fevers; Fever, Black Water; Fever, Blackwater; Fevers, Black Water; Fevers, Blackwater; Hemolytic Malaria; Hemolytic Malarias; Malaria, Hemolytic; Malarias, Hemolytic
SNOMED CT: Blackwater fever (56625005); Black water fever (56625005); Malarial hemoglobinuria (56625005); Hemoglobinuric fever (56625005)
 
Monarch Initiative: MONDO:0005670

Definition

A complication of malaria resulting from hemolysis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlackwater fever

Professional guidelines

PubMed

Treatment of blackwater fever with prednisone.
TROWELL HC, VAIZEY JM
Lancet 1956 Dec 22;271(6956):1281-2. doi: 10.1016/s0140-6736(56)91433-7. PMID: 13386233
Antevenene in the treatment of black-water fever.
ROY JB
Indian Med J 1947 Mar;41(3):48. PMID: 20294696
A further note on the treatment of black water fever with antivenene.
SINGH I
J Indian Med Assoc 1945-1946;15:147. PMID: 21022544

Recent clinical studies

Etiology

Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance.
Conroy AL, Hawkes MT, Leligdowicz A, Mufumba I, Starr MC, Zhong K, Namasopo S, John CC, Opoka RO, Kain KC
BMC Med 2022 Jul 1;20(1):221. doi: 10.1186/s12916-022-02410-4. PMID: 35773743Free PMC Article
A MINI OVERVIEW OF MALARIA IN PREGNANCY.
Ahmadal-Agroudi M, El-Mawla Megahed LA, Abdallah EM, Morsy TA
J Egypt Soc Parasitol 2017 Apr;47(1):177-196. PMID: 30157347
The Multifactorial Epidemiology of Blackwater Fever.
Shanks GD
Am J Trop Med Hyg 2017 Dec;97(6):1804-1807. Epub 2017 Sep 28 doi: 10.4269/ajtmh.17-0533. PMID: 29016337Free PMC Article
Historical Review: Problematic Malaria Prophylaxis with Quinine.
Shanks GD
Am J Trop Med Hyg 2016 Aug 3;95(2):269-72. Epub 2016 May 16 doi: 10.4269/ajtmh.16-0138. PMID: 27185766Free PMC Article
Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review.
Bruneel F, Gachot B, Wolff M, Régnier B, Danis M, Vachon F; Corresponding Group
Clin Infect Dis 2001 Apr 15;32(8):1133-40. Epub 2001 Apr 2 doi: 10.1086/319743. PMID: 11283802

Diagnosis

Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance.
Conroy AL, Hawkes MT, Leligdowicz A, Mufumba I, Starr MC, Zhong K, Namasopo S, John CC, Opoka RO, Kain KC
BMC Med 2022 Jul 1;20(1):221. doi: 10.1186/s12916-022-02410-4. PMID: 35773743Free PMC Article
Mystery of blackwater fever from an Australian perspective.
Shanks GD
Intern Med J 2022 Apr;52(4):686-688. doi: 10.1111/imj.15734. PMID: 35419958
Malaria and acute kidney injury.
Brown DD, Solomon S, Lerner D, Del Rio M
Pediatr Nephrol 2020 Apr;35(4):603-608. Epub 2019 Jan 31 doi: 10.1007/s00467-018-4191-0. PMID: 30706124
A MINI OVERVIEW OF MALARIA IN PREGNANCY.
Ahmadal-Agroudi M, El-Mawla Megahed LA, Abdallah EM, Morsy TA
J Egypt Soc Parasitol 2017 Apr;47(1):177-196. PMID: 30157347
The treatment of malaria.
Hall AP
Br Med J 1976 Feb 7;1(6005):323-8. doi: 10.1136/bmj.1.6005.323. PMID: 764937Free PMC Article

Therapy

Mystery of blackwater fever from an Australian perspective.
Shanks GD
Intern Med J 2022 Apr;52(4):686-688. doi: 10.1111/imj.15734. PMID: 35419958
The Multifactorial Epidemiology of Blackwater Fever.
Shanks GD
Am J Trop Med Hyg 2017 Dec;97(6):1804-1807. Epub 2017 Sep 28 doi: 10.4269/ajtmh.17-0533. PMID: 29016337Free PMC Article
Historical Review: Problematic Malaria Prophylaxis with Quinine.
Shanks GD
Am J Trop Med Hyg 2016 Aug 3;95(2):269-72. Epub 2016 May 16 doi: 10.4269/ajtmh.16-0138. PMID: 27185766Free PMC Article
Autoimmunity: from black water fever to regulatory function.
Chang C
J Autoimmun 2014 Feb-Mar;48-49:1-9. Epub 2014 Feb 1 doi: 10.1016/j.jaut.2013.12.019. PMID: 24491820
The treatment of malaria.
Hall AP
Br Med J 1976 Feb 7;1(6005):323-8. doi: 10.1136/bmj.1.6005.323. PMID: 764937Free PMC Article

Prognosis

Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance.
Conroy AL, Hawkes MT, Leligdowicz A, Mufumba I, Starr MC, Zhong K, Namasopo S, John CC, Opoka RO, Kain KC
BMC Med 2022 Jul 1;20(1):221. doi: 10.1186/s12916-022-02410-4. PMID: 35773743Free PMC Article
Predictors of prolonged hospitalisation and mortality among children admitted with blackwater fever in eastern Uganda.
Paasi G, Ndila C, Okello F, Olupot-Olupot P
Trop Doct 2022 Jan;52(1):61-67. Epub 2021 Dec 23 doi: 10.1177/00494755211046782. PMID: 34939462
Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial.
von Seidlein L, Olaosebikan R, Hendriksen IC, Lee SJ, Adedoyin OT, Agbenyega T, Nguah SB, Bojang K, Deen JL, Evans J, Fanello CI, Gomes E, Pedro AJ, Kahabuka C, Karema C, Kivaya E, Maitland K, Mokuolu OA, Mtove G, Mwanga-Amumpaire J, Nadjm B, Nansumba M, Ngum WP, Onyamboko MA, Reyburn H, Sakulthaew T, Silamut K, Tshefu AK, Umulisa N, Gesase S, Day NP, White NJ, Dondorp AM
Clin Infect Dis 2012 Apr;54(8):1080-90. Epub 2012 Mar 12 doi: 10.1093/cid/cis034. PMID: 22412067Free PMC Article
Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia.
Thuma PE, van Dijk J, Bucala R, Debebe Z, Nekhai S, Kuddo T, Nouraie M, Weiss G, Gordeuk VR
J Infect Dis 2011 Jan 15;203(2):211-9. doi: 10.1093/infdis/jiq041. PMID: 21288821Free PMC Article
The treatment of malaria.
Hall AP
Br Med J 1976 Feb 7;1(6005):323-8. doi: 10.1136/bmj.1.6005.323. PMID: 764937Free PMC Article

Clinical prediction guides

Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance.
Conroy AL, Hawkes MT, Leligdowicz A, Mufumba I, Starr MC, Zhong K, Namasopo S, John CC, Opoka RO, Kain KC
BMC Med 2022 Jul 1;20(1):221. doi: 10.1186/s12916-022-02410-4. PMID: 35773743Free PMC Article
Predictors of prolonged hospitalisation and mortality among children admitted with blackwater fever in eastern Uganda.
Paasi G, Ndila C, Okello F, Olupot-Olupot P
Trop Doct 2022 Jan;52(1):61-67. Epub 2021 Dec 23 doi: 10.1177/00494755211046782. PMID: 34939462
Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case-control study in Congolese children.
Bodi JM, Nsibu CN, Longenge RL, Aloni MN, Akilimali PZ, Kayembe PK, Omar AH, Verhaegen J, Tshibassu PM, Lukusa PT, Lumaka A, Hirayama K
Malar J 2020 Jan 15;19(1):25. doi: 10.1186/s12936-020-3100-8. PMID: 31941497Free PMC Article
The Multifactorial Epidemiology of Blackwater Fever.
Shanks GD
Am J Trop Med Hyg 2017 Dec;97(6):1804-1807. Epub 2017 Sep 28 doi: 10.4269/ajtmh.17-0533. PMID: 29016337Free PMC Article
Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors.
Bodi JM, Nsibu CN, Longenge RL, Aloni MN, Akilimali PZ, Tshibassu PM, Kayembe PK, Omar AH, Hirayama K, Verhaegen J
Malar J 2013 Jun 15;12:205. doi: 10.1186/1475-2875-12-205. PMID: 23767699Free PMC Article

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