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Adult xanthogranuloma

MedGen UID:
231363
•Concept ID:
C1332220
•
Neoplastic Process
Synonyms: Adult Xanthogranuloma; adult xanthogranuloma; xanthogranuloma of adults
 
Monarch Initiative: MONDO:0004385

Definition

A xanthogranuloma that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult xanthogranuloma

Professional guidelines

PubMed

Adult Orbital Xanthogranulomatous Disease: A Review with Emphasis on Etiology, Systemic Associations, Diagnostic Tools, and Treatment.
Kerstetter J, Wang J
Dermatol Clin 2015 Jul;33(3):457-63. Epub 2015 May 8 doi: 10.1016/j.det.2015.03.010. PMID: 26143425

Recent clinical studies

Etiology

Juvenile and adult xanthogranuloma: A 30-year single-center experience and review of the disorder and its relationship to other histiocytoses.
Salari B, Dehner LP
Ann Diagn Pathol 2022 Jun;58:151940. Epub 2022 Mar 30 doi: 10.1016/j.anndiagpath.2022.151940. PMID: 35378409
Cutaneous adult xanthogranuloma with a small portion of BRAF(V) (600E) mutated Langerhans cell histiocytosis populations: A case report and the review of published work.
Ishikawa M, Endo Y, Uehara A, Suto M, Yasuda M, Motegi SI, Ishikawa O
J Dermatol 2019 Feb;46(2):161-165. Epub 2018 Dec 7 doi: 10.1111/1346-8138.14725. PMID: 30536719
Multiple adult xanthogranuloma: case report and literature review.
Saad N, Skowron F, Dalle S, Forestier JY, Balme B, Thomas L
Dermatology 2006;212(1):73-6. doi: 10.1159/000089027. PMID: 16319479

Diagnosis

Juvenile and adult xanthogranuloma: A 30-year single-center experience and review of the disorder and its relationship to other histiocytoses.
Salari B, Dehner LP
Ann Diagn Pathol 2022 Jun;58:151940. Epub 2022 Mar 30 doi: 10.1016/j.anndiagpath.2022.151940. PMID: 35378409
Multiple adult xanthogranuloma.
Almeida RDC, Tellechea Ó, Pereira MP, Mascarenhas RCC
An Bras Dermatol 2020 Jan-Feb;95(1):113-115. Epub 2019 Dec 18 doi: 10.1016/j.abd.2019.02.010. PMID: 31883764Free PMC Article
Cutaneous adult xanthogranuloma with a small portion of BRAF(V) (600E) mutated Langerhans cell histiocytosis populations: A case report and the review of published work.
Ishikawa M, Endo Y, Uehara A, Suto M, Yasuda M, Motegi SI, Ishikawa O
J Dermatol 2019 Feb;46(2):161-165. Epub 2018 Dec 7 doi: 10.1111/1346-8138.14725. PMID: 30536719
Adult xanthogranulomatous disease of the orbit and ocular adnexa: new immunohistochemical findings and clinical review.
Sivak-Callcott JA, Rootman J, Rasmussen SL, Nugent RA, White VA, Paridaens D, Currie Z, Rose G, Clark B, McNab AA, Buffam FV, Neigel JM, Kazim M
Br J Ophthalmol 2006 May;90(5):602-8. doi: 10.1136/bjo.2005.085894. PMID: 16622091Free PMC Article
Xanthogranuloma in adults.
Rodriguez J, Ackerman AB
Arch Dermatol 1976 Jan;112(1):43-4. PMID: 1247291

Therapy

Disseminated adult xanthogranuloma successfully treated with doxycycline.
Ikuno Y, Kokubu H, Yamaguchi A, Takahashi T, Fujimoto N
Eur J Dermatol 2023 Jun 1;33(3):317-319. doi: 10.1684/ejd.2023.4495. PMID: 37594351
Multiple Xanthogranulomas in an Adult: Known Entity, New Association.
Vadeboncoeur S, Provost N
J Cutan Med Surg 2016 Sep;20(5):474-7. Epub 2016 Mar 22 doi: 10.1177/1203475416640795. PMID: 27006313

Prognosis

Adult Xanthogranuloma, Reticulohistiocytosis, and Rosai-Dorfman Disease.
Chisolm SS, Schulman JM, Fox LP
Dermatol Clin 2015 Jul;33(3):465-72; discussion 473. doi: 10.1016/j.det.2015.03.011. PMID: 26143426
Multiple adult xanthogranuloma: case report and literature review.
Saad N, Skowron F, Dalle S, Forestier JY, Balme B, Thomas L
Dermatology 2006;212(1):73-6. doi: 10.1159/000089027. PMID: 16319479

Clinical prediction guides

Ossifying adult xanthogranuloma.
Salamanca J, Rodriguez-Peralto JL, Gonzalez-Lois C, Azorin D
Arch Pathol Lab Med 2003 Oct;127(10):e409-10. doi: 10.5858/2003-127-e409-OAX. PMID: 14521441
Juvenile and adult xanthogranuloma. A histological and immunohistochemical comparison.
Zelger B, Cerio R, Orchard G, Wilson-Jones E
Am J Surg Pathol 1994 Feb;18(2):126-35. doi: 10.1097/00000478-199402000-00002. PMID: 8291651
A case of fibrous histiocytoma associated with xanthogranulomatous alteration.
Maruyama M, Sato S, Tsuchida T, Toda K
J Dermatol 1994 Apr;21(4):280-2. doi: 10.1111/j.1346-8138.1994.tb01738.x. PMID: 8056904
Solitary adult xanthogranuloma: a case report with new observation on lipid droplet formation.
Niizuma K
Acta Derm Venereol 1980;60(6):477-83. PMID: 6162331

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