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Classic pulmonary blastoma

MedGen UID:
231445
•Concept ID:
C1332556
•
Neoplastic Process
Synonyms: Biphasic Pulmonary Blastoma; biphasic pulmonary blastoma; classic pulmonary blastoma
 
Monarch Initiative: MONDO:0003128

Definition

A pulmonary blastoma composed of a mixture of irregular tubular structures and mesenchymal elements. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassic pulmonary blastoma

Recent clinical studies

Etiology

Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma.
Nakatani Y, Miyagi Y, Takemura T, Oka T, Yokoi T, Takagi M, Yokoyama S, Kashima K, Hara K, Yamada T, Nozawa A, Inayama Y, Sakamoto K, Ogawa N, Kitamura H, Resl M, Cho SH, Koss MN, Mark EJ
Am J Surg Pathol 2004 Jul;28(7):921-7. doi: 10.1097/00000478-200407000-00012. PMID: 15223963

Diagnosis

Classic pulmonary blastoma: a subtype of biphasic pulmonary blastoma.
Nakayama T, Ohtsuka T, Kazama A, Watanabe K
Ann Thorac Cardiovasc Surg 2012;18(2):125-7. Epub 2011 Oct 17 doi: 10.5761/atcs.cr.11.01693. PMID: 22001215
Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma.
Nakatani Y, Miyagi Y, Takemura T, Oka T, Yokoi T, Takagi M, Yokoyama S, Kashima K, Hara K, Yamada T, Nozawa A, Inayama Y, Sakamoto K, Ogawa N, Kitamura H, Resl M, Cho SH, Koss MN, Mark EJ
Am J Surg Pathol 2004 Jul;28(7):921-7. doi: 10.1097/00000478-200407000-00012. PMID: 15223963

Prognosis

Classic pulmonary blastoma: a subtype of biphasic pulmonary blastoma.
Nakayama T, Ohtsuka T, Kazama A, Watanabe K
Ann Thorac Cardiovasc Surg 2012;18(2):125-7. Epub 2011 Oct 17 doi: 10.5761/atcs.cr.11.01693. PMID: 22001215

Clinical prediction guides

Classic pulmonary blastoma: a subtype of biphasic pulmonary blastoma.
Nakayama T, Ohtsuka T, Kazama A, Watanabe K
Ann Thorac Cardiovasc Surg 2012;18(2):125-7. Epub 2011 Oct 17 doi: 10.5761/atcs.cr.11.01693. PMID: 22001215

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