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Appendix Mucinous Cystadenoma

MedGen UID:
231939
•Concept ID:
C1332518
•
Neoplastic Process
Synonyms: Colloid Appendiceal Cystadenoma; Colloid Cystadenoma of Appendix; Colloidal Cystadenoma of Appendix; Mucinous Appendiceal Cystadenoma; Mucinous Appendix Cystadenoma; Mucinous Cystadenoma of Appendix; Mucinous Cystadenoma of the Appendix

Definition

A cystically dilated epithelial neoplasm arising from the appendix. It is characterized by the presence of a cystic structure that is filled with mucus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Mucinous Cystadenoma

Professional guidelines

PubMed

Appendiceal tumors in patients undergoing primary surgery for mucinous ovarian tumors in a tertiary hospital, in Southern Thailand.
Nanthamongkolkul K, Wattanapaisal P, Boonyapipat S, Suphasynth Y, Pichatechaiyoot A, Geater AF, Kayasut K, Peeyananjarassri K
Taiwan J Obstet Gynecol 2022 Jul;61(4):657-662. doi: 10.1016/j.tjog.2022.03.042. PMID: 35779917
Intraperitoneal hyperthermia in the management of pseudomyxoma peritonei.
Hsu KH, Chou CY, Chang YC
Hepatogastroenterology 2007 Jan-Feb;54(73):47-52. PMID: 17419229

Recent clinical studies

Etiology

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Mucinous cystadenoma of the mesocolon, a rare entity frequently presenting with features of malignity: two case reports and review of the literature.
Cauchy F, Lefevre JH, Mourra N, Parc Y, Tiret E, Balladur P
Clin Res Hepatol Gastroenterol 2012 Feb;36(1):e12-6. Epub 2011 Nov 9 doi: 10.1016/j.clinre.2011.09.006. PMID: 22074643
Mucinous cystadenoma of the appendix: a rare cause of acute abdomen.
Calişkan K, Yildirim S, Bal N, Nursal TZ, Akdur AC, Moray G
Ulus Travma Acil Cerrahi Derg 2008 Oct;14(4):303-7. PMID: 18988054
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765

Diagnosis

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Mucocoele and mucinous tumours of the appendix: A review of the literature.
Rymer B, Forsythe RO, Husada G
Int J Surg 2015 Jun;18:132-5. Epub 2015 Apr 24 doi: 10.1016/j.ijsu.2015.04.052. PMID: 25917270
Simultaneous giant mucinous cystadenoma of the appendix and intestinal schistosomiasis: 'case report and brief review'.
Lin C, Li X, Guo Y, Hu G, Zhang Y, Yang K, Gan Y, Zhou J, Lv L, Gao K, Du J
World J Surg Oncol 2014 Dec 17;12:385. doi: 10.1186/1477-7819-12-385. PMID: 25518977Free PMC Article
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765

Therapy

Unexpected findings in the routine histopathological examinations of appendectomy specimens A retrospective analysis of 1,970 patients.
Dincel O, Goksu M, Turk BA, Pehlivanoglu B, Isler S
Ann Ital Chir 2017;88:519-525. PMID: 29339597
Appendiceal carcinoid and mucinous cystadenoma in renal transplant recipients: case reports.
Basic-Jukic N, Furic-Cunko V, Coric M, Bubic-Filipi LJ, Kastelan Z, Pasini J, Kes P
Transplant Proc 2010 Jun;42(5):1704-7. doi: 10.1016/j.transproceed.2009.11.045. PMID: 20620505
Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal.
Bellizzi AM, Rock J, Marsh WL, Frankel WL
Am J Clin Pathol 2010 Apr;133(4):623-32. doi: 10.1309/AJCP1UJPX6UURLCH. PMID: 20231616
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Multifocal neoplasia involving the colon and appendix in ulcerative colitis: pathological and molecular features.
Lyda MH, Noffsinger A, Belli J, Fischer J, Fenoglio-Preiser CM
Gastroenterology 1998 Dec;115(6):1566-73. doi: 10.1016/s0016-5085(98)70037-x. PMID: 9834286

Prognosis

Mucinous cystadenoma of the appendix - case report.
Janczak D, Szponder M, Janczak D, Leśniak M, Ziomek A, Chabowski M
Pol Przegl Chir 2017 Apr 30;89(2):65-68. doi: 10.5604/01.3001.0009.9160. PMID: 28537568
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Mucocoele and mucinous tumours of the appendix: A review of the literature.
Rymer B, Forsythe RO, Husada G
Int J Surg 2015 Jun;18:132-5. Epub 2015 Apr 24 doi: 10.1016/j.ijsu.2015.04.052. PMID: 25917270
Mucinous cystadenoma of the mesocolon, a rare entity frequently presenting with features of malignity: two case reports and review of the literature.
Cauchy F, Lefevre JH, Mourra N, Parc Y, Tiret E, Balladur P
Clin Res Hepatol Gastroenterol 2012 Feb;36(1):e12-6. Epub 2011 Nov 9 doi: 10.1016/j.clinre.2011.09.006. PMID: 22074643
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765

Clinical prediction guides

Histopathological features of incidental appendectomy specimens obtained from living liver donors.
Akbulut S, Koç C, Sarıcı B, Özcan M, Şamdancı E, Yılmaz S
Turk J Gastroenterol 2020 Mar;31(3):257-263. doi: 10.5152/tjg.2020.19010. PMID: 32343238Free PMC Article
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Appendiceal pathology at the time of oophorectomy for ovarian neoplasms.
Timofeev J, Galgano MT, Stoler MH, Lachance JA, Modesitt SC, Jazaeri AA
Obstet Gynecol 2010 Dec;116(6):1348-1353. doi: 10.1097/AOG.0b013e3181fae628. PMID: 21099601
Mucinous cystadenoma of the appendix associated with muscular and neuromatous hyperplasia: report of a case.
Hibi K, Mizutani M, Imazawa M, Nakamura T, Nonoyama M, Shibata H
Nagoya J Med Sci 2008 Mar;70(1-2):35-40. PMID: 18807294
The coexistence of low-grade mucinous neoplasms of the appendix and appendiceal diverticula: a possible role in the pathogenesis of pseudomyxoma peritonei.
Lamps LW, Gray GF Jr, Dilday BR, Washington MK
Mod Pathol 2000 May;13(5):495-501. doi: 10.1038/modpathol.3880086. PMID: 10824920

Recent systematic reviews

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

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