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Borderline Lesion

MedGen UID:
231955
•Concept ID:
C1332594
•
Finding

Definition

A lesion characterized by the presence of atypical or low-grade neoplastic cells, which may or may not exhibit stromal microinvasion and cannot be qualified as completely malignant. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Lesion

Professional guidelines

PubMed

Can imaging criteria distinguish enchondroma from grade 1 chondrosarcoma?
Crim J, Schmidt R, Layfield L, Hanrahan C, Manaster BJ
Eur J Radiol 2015 Nov;84(11):2222-30. Epub 2015 Jul 17 doi: 10.1016/j.ejrad.2015.06.033. PMID: 26220916
Utility of 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography in differential diagnosis of benign and malignant intraductal papillary-mucinous neoplasm of the pancreas.
Tomimaru Y, Takeda Y, Tatsumi M, Kim T, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Kitagawa T, Nagano H, Umeshita K, Wakasa K, Doki Y, Mori M
Oncol Rep 2010 Sep;24(3):613-20. doi: 10.3892/or_00000899. PMID: 20664965
Small cell malignant melanoma: a variant of naevoid melanoma. Clinicopathological features and histological differential diagnosis.
Blessing K, Grant JJ, Sanders DS, Kennedy MM, Husain A, Coburn P
J Clin Pathol 2000 Aug;53(8):591-5. doi: 10.1136/jcp.53.8.591. PMID: 11002761Free PMC Article

Recent clinical studies

Etiology

Quantitative Ultrasound Image Analysis Helps in the Differentiation of Hepatocellular Carcinoma (HCC) From Borderline Lesions and Predicting the Histologic Grade of HCC and Microvascular Invasion.
Matsumoto N, Ogawa M, Kaneko M, Kumagawa M, Watanabe Y, Hirayama M, Nakagawara H, Masuzaki R, Kanda T, Moriyama M, Takayama T, Sugitani M
J Ultrasound Med 2021 Apr;40(4):689-698. Epub 2020 Aug 25 doi: 10.1002/jum.15439. PMID: 32840896
Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY
World J Gastroenterol 2019 Jan 28;25(4):469-484. doi: 10.3748/wjg.v25.i4.469. PMID: 30700943Free PMC Article
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma.
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y
World J Gastroenterol 2018 Mar 28;24(12):1332-1342. doi: 10.3748/wjg.v24.i12.1332. PMID: 29599608Free PMC Article
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article
What sentinel node biopsy in patients with melanoma (or patients whose doctors worry that they could have melanoma) might and might not do.
LeBoit PE
Clin Dermatol 2009 Nov-Dec;27(6):588-93. doi: 10.1016/j.clindermatol.2008.09.016. PMID: 19880045

Diagnosis

Quantitative Ultrasound Image Analysis Helps in the Differentiation of Hepatocellular Carcinoma (HCC) From Borderline Lesions and Predicting the Histologic Grade of HCC and Microvascular Invasion.
Matsumoto N, Ogawa M, Kaneko M, Kumagawa M, Watanabe Y, Hirayama M, Nakagawara H, Masuzaki R, Kanda T, Moriyama M, Takayama T, Sugitani M
J Ultrasound Med 2021 Apr;40(4):689-698. Epub 2020 Aug 25 doi: 10.1002/jum.15439. PMID: 32840896
Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY
World J Gastroenterol 2019 Jan 28;25(4):469-484. doi: 10.3748/wjg.v25.i4.469. PMID: 30700943Free PMC Article
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma.
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y
World J Gastroenterol 2018 Mar 28;24(12):1332-1342. doi: 10.3748/wjg.v24.i12.1332. PMID: 29599608Free PMC Article
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article
What sentinel node biopsy in patients with melanoma (or patients whose doctors worry that they could have melanoma) might and might not do.
LeBoit PE
Clin Dermatol 2009 Nov-Dec;27(6):588-93. doi: 10.1016/j.clindermatol.2008.09.016. PMID: 19880045

Therapy

Single coronary artery originating from the right sinus Valsalva presenting as typical angina pectoris.
Lamberti M, Ratti G, Tedeschi C, Capogrosso C
BMJ Case Rep 2016 Mar 7;2016 doi: 10.1136/bcr-2015-213798. PMID: 26951439Free PMC Article
Regression of coronary disease after bypass surgery: Urban myth or common finding?
Zhu YY, Nguyen TT, Buxton BF, Hare DL, Hayward PA
J Thorac Cardiovasc Surg 2014 Jul;148(1):53-9. Epub 2013 Sep 13 doi: 10.1016/j.jtcvs.2013.07.029. PMID: 24035380
Vienna experience of ABO-incompatible living-donor kidney transplantation.
Haidinger M, Schmaldienst S, Körmöczi G, Regele H, Soleiman A, Schwartz D, Derfler K, Steininger R, Mühlbacher F, Böhmig GA
Wien Klin Wochenschr 2009;121(7-8):247-55. doi: 10.1007/s00508-009-1161-3. PMID: 19562281
Borderline coronary lesions may lead to serious coronary events--long-term outcome in 65 conservatively treated patients.
Rzeczuch K, Szajn G, Jankowska E, Kaczmarek A, Derkacz A, Porada A, Telichowski A, Banasiak W, Ponikowski P
Kardiol Pol 2005 Jul;63(7):50-6; discussion 57. PMID: 16136429
Duplex study of the carotid and femoral arteries of patients with rheumatoid arthritis: a controlled study.
Abu-Shakra M, Polychuck I, Szendro G, Bolotin A, Jonathan BS, Flusser D, Buskila D, Sukenik S
Semin Arthritis Rheum 2005 Aug;35(1):18-23. doi: 10.1016/j.semarthrit.2004.11.007. PMID: 16084220

Prognosis

Quantitative Ultrasound Image Analysis Helps in the Differentiation of Hepatocellular Carcinoma (HCC) From Borderline Lesions and Predicting the Histologic Grade of HCC and Microvascular Invasion.
Matsumoto N, Ogawa M, Kaneko M, Kumagawa M, Watanabe Y, Hirayama M, Nakagawara H, Masuzaki R, Kanda T, Moriyama M, Takayama T, Sugitani M
J Ultrasound Med 2021 Apr;40(4):689-698. Epub 2020 Aug 25 doi: 10.1002/jum.15439. PMID: 32840896
Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY
World J Gastroenterol 2019 Jan 28;25(4):469-484. doi: 10.3748/wjg.v25.i4.469. PMID: 30700943Free PMC Article
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma.
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y
World J Gastroenterol 2018 Mar 28;24(12):1332-1342. doi: 10.3748/wjg.v24.i12.1332. PMID: 29599608Free PMC Article
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article
What sentinel node biopsy in patients with melanoma (or patients whose doctors worry that they could have melanoma) might and might not do.
LeBoit PE
Clin Dermatol 2009 Nov-Dec;27(6):588-93. doi: 10.1016/j.clindermatol.2008.09.016. PMID: 19880045

Clinical prediction guides

Quantitative Ultrasound Image Analysis Helps in the Differentiation of Hepatocellular Carcinoma (HCC) From Borderline Lesions and Predicting the Histologic Grade of HCC and Microvascular Invasion.
Matsumoto N, Ogawa M, Kaneko M, Kumagawa M, Watanabe Y, Hirayama M, Nakagawara H, Masuzaki R, Kanda T, Moriyama M, Takayama T, Sugitani M
J Ultrasound Med 2021 Apr;40(4):689-698. Epub 2020 Aug 25 doi: 10.1002/jum.15439. PMID: 32840896
Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY
World J Gastroenterol 2019 Jan 28;25(4):469-484. doi: 10.3748/wjg.v25.i4.469. PMID: 30700943Free PMC Article
Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma.
Shiraki T, Kuroda H, Takada A, Nakazato Y, Kubota K, Imai Y
World J Gastroenterol 2018 Mar 28;24(12):1332-1342. doi: 10.3748/wjg.v24.i12.1332. PMID: 29599608Free PMC Article
Diagnostic accuracy of oral cancer cytology in a pilot study.
Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H
Diagn Pathol 2017 Mar 16;12(1):27. doi: 10.1186/s13000-017-0618-3. PMID: 28298213Free PMC Article
Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT?
Kawamoto S, Horton KM, Lawler LP, Hruban RH, Fishman EK
Radiographics 2005 Nov-Dec;25(6):1451-68; discussion 1468-70. doi: 10.1148/rg.256055036. PMID: 16284127

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