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Breast fibrocystic change, proliferative type

MedGen UID:
231967
•Concept ID:
C1332629
•
Disease or Syndrome
Synonyms: Benign Proliferative Breast Disease; benign proliferative breast disease; Breast Fibrocystic Change, Proliferative Type; breast fibrocystic change, proliferative type; fibrocystic change, proliferative type with atypia; fibrocystic disease, proliferative type with atypia; proliferating lesion of breast without atypia; proliferating lesion of the breast without atypia; Proliferative Breast Disease; proliferative breast disease; Proliferative Breast Lesion; proliferative breast lesion; Proliferative Fibrocystic Change; Proliferative Type Fibrocystic Change of Breast; proliferative type fibrocystic change of breast; Proliferative Type Fibrocystic Change of the Breast; proliferative type fibrocystic change of the breast
 
Monarch Initiative: MONDO:0002585

Definition

Breast fibrocystic change characterized by the presence of epithelial cell hyperplasia. Epithelial atypia may be present or absent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast fibrocystic change, proliferative type

Professional guidelines

PubMed

Differences in breast cancer risk after benign breast disease by type of screening diagnosis.
Louro J, Román M, Posso M, Comerma L, Vidal C, Saladié F, Alcantara R, Sanchez M, Quintana MJ, Del Riego J, Ferrer J, Peñalva L, Bargalló X, Prieto M, Sala M, Castells X
Breast 2020 Dec;54:343-348. Epub 2020 Oct 3 doi: 10.1016/j.breast.2020.09.005. PMID: 33023825Free PMC Article
Management of radial sclerosing lesions of the breast diagnosed using percutaneous vacuum-assisted core needle biopsy: recommendations for excision based on seven years' of experience at a single institution.
Resetkova E, Edelweiss M, Albarracin CT, Yang WT
Breast Cancer Res Treat 2011 Jun;127(2):335-43. Epub 2008 Jul 15 doi: 10.1007/s10549-008-0119-x. PMID: 18626769

Recent clinical studies

Etiology

Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
Lukavenko IM, Kolnoguz AV, Levchenko ZM, Harbuzova VY
Exp Oncol 2021 Dec;43(4):341-345. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-4.16852. PMID: 34967547
Differences in breast cancer risk after benign breast disease by type of screening diagnosis.
Louro J, Román M, Posso M, Comerma L, Vidal C, Saladié F, Alcantara R, Sanchez M, Quintana MJ, Del Riego J, Ferrer J, Peñalva L, Bargalló X, Prieto M, Sala M, Castells X
Breast 2020 Dec;54:343-348. Epub 2020 Oct 3 doi: 10.1016/j.breast.2020.09.005. PMID: 33023825Free PMC Article
Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases.
Meares AL, Frank RD, Degnim AC, Vierkant RA, Frost MH, Hartmann LC, Winham SJ, Visscher DW
Hum Pathol 2016 Mar;49:33-8. Epub 2015 Oct 31 doi: 10.1016/j.humpath.2015.10.004. PMID: 26826407Free PMC Article
Radial scars in benign breast-biopsy specimens and the risk of breast cancer.
Jacobs TW, Byrne C, Colditz G, Connolly JL, Schnitt SJ
N Engl J Med 1999 Feb 11;340(6):430-6. doi: 10.1056/NEJM199902113400604. PMID: 9971867
Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types.
Marshall LM, Hunter DJ, Connolly JL, Schnitt SJ, Byrne C, London SJ, Colditz GA
Cancer Epidemiol Biomarkers Prev 1997 May;6(5):297-301. PMID: 9149887

Diagnosis

Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
Lukavenko IM, Kolnoguz AV, Levchenko ZM, Harbuzova VY
Exp Oncol 2021 Dec;43(4):341-345. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-4.16852. PMID: 34967547
Differences in breast cancer risk after benign breast disease by type of screening diagnosis.
Louro J, Román M, Posso M, Comerma L, Vidal C, Saladié F, Alcantara R, Sanchez M, Quintana MJ, Del Riego J, Ferrer J, Peñalva L, Bargalló X, Prieto M, Sala M, Castells X
Breast 2020 Dec;54:343-348. Epub 2020 Oct 3 doi: 10.1016/j.breast.2020.09.005. PMID: 33023825Free PMC Article
Salivary gland-type mammary carcinoma arising in microglandular adenosis: A case report and clinicopathological review of the literature.
Rico V, Shibahara Y, Monteiro M, Slodkowska E, Tam S, Zaki P, De Angelis C, Chow E, Jerzak KJ
Cancer Treat Res Commun 2020;24:100178. Epub 2020 May 12 doi: 10.1016/j.ctarc.2020.100178. PMID: 32454386
Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases.
Meares AL, Frank RD, Degnim AC, Vierkant RA, Frost MH, Hartmann LC, Winham SJ, Visscher DW
Hum Pathol 2016 Mar;49:33-8. Epub 2015 Oct 31 doi: 10.1016/j.humpath.2015.10.004. PMID: 26826407Free PMC Article
Cell proliferation in fibrocystic disease and postmenopause breast ducts measured by thymidine labeling.
Meyer JS, Connor RE
Cancer 1982 Aug 15;50(4):746-51. doi: 10.1002/1097-0142(19820815)50:4<746::aid-cncr2820500420>3.0.co;2-a. PMID: 7093909

Therapy

Salivary gland-type mammary carcinoma arising in microglandular adenosis: A case report and clinicopathological review of the literature.
Rico V, Shibahara Y, Monteiro M, Slodkowska E, Tam S, Zaki P, De Angelis C, Chow E, Jerzak KJ
Cancer Treat Res Commun 2020;24:100178. Epub 2020 May 12 doi: 10.1016/j.ctarc.2020.100178. PMID: 32454386
ADC mapping of benign and malignant breast tumors.
Woodhams R, Matsunaga K, Kan S, Hata H, Ozaki M, Iwabuchi K, Kuranami M, Watanabe M, Hayakawa K
Magn Reson Med Sci 2005;4(1):35-42. doi: 10.2463/mrms.4.35. PMID: 16127252
Malignant and benign papillary lesions of the breast.
Murad TM, Swaid S, Pritchett P
Hum Pathol 1977 Jul;8(4):379-90. doi: 10.1016/s0046-8177(77)80003-8. PMID: 892792

Prognosis

Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
Lukavenko IM, Kolnoguz AV, Levchenko ZM, Harbuzova VY
Exp Oncol 2021 Dec;43(4):341-345. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-4.16852. PMID: 34967547
Differences in breast cancer risk after benign breast disease by type of screening diagnosis.
Louro J, Román M, Posso M, Comerma L, Vidal C, Saladié F, Alcantara R, Sanchez M, Quintana MJ, Del Riego J, Ferrer J, Peñalva L, Bargalló X, Prieto M, Sala M, Castells X
Breast 2020 Dec;54:343-348. Epub 2020 Oct 3 doi: 10.1016/j.breast.2020.09.005. PMID: 33023825Free PMC Article
Salivary gland-type mammary carcinoma arising in microglandular adenosis: A case report and clinicopathological review of the literature.
Rico V, Shibahara Y, Monteiro M, Slodkowska E, Tam S, Zaki P, De Angelis C, Chow E, Jerzak KJ
Cancer Treat Res Commun 2020;24:100178. Epub 2020 May 12 doi: 10.1016/j.ctarc.2020.100178. PMID: 32454386
Mucocele-like lesions of the breast: a clinical outcome and histologic analysis of 102 cases.
Meares AL, Frank RD, Degnim AC, Vierkant RA, Frost MH, Hartmann LC, Winham SJ, Visscher DW
Hum Pathol 2016 Mar;49:33-8. Epub 2015 Oct 31 doi: 10.1016/j.humpath.2015.10.004. PMID: 26826407Free PMC Article
Age and associated fibrocystic changes are prognostically significant in patients with small node-negative (T1a,bN0) invasive breast cancer.
Durak MG, Gonzalez-Angulo AM, Hanrahan EO, Broglio KR, Valero V, Hortobagyi GN, Hunt KK, Sahin AA
Breast J 2011 Sep-Oct;17(5):462-9. Epub 2011 Jul 5 doi: 10.1111/j.1524-4741.2011.01116.x. PMID: 21726347

Clinical prediction guides

Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
Lukavenko IM, Kolnoguz AV, Levchenko ZM, Harbuzova VY
Exp Oncol 2021 Dec;43(4):341-345. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-4.16852. PMID: 34967547
Age and associated fibrocystic changes are prognostically significant in patients with small node-negative (T1a,bN0) invasive breast cancer.
Durak MG, Gonzalez-Angulo AM, Hanrahan EO, Broglio KR, Valero V, Hortobagyi GN, Hunt KK, Sahin AA
Breast J 2011 Sep-Oct;17(5):462-9. Epub 2011 Jul 5 doi: 10.1111/j.1524-4741.2011.01116.x. PMID: 21726347
Breast cancer in dense breast: detection with contrast-enhanced dynamic MR imaging.
Kawashima H, Matsui O, Suzuki M, Kadoya M, Tawara M, Nonomura A, Noguchi M, Takashima T
J Magn Reson Imaging 2000 Mar;11(3):233-43. doi: 10.1002/(sici)1522-2586(200003)11:3<233::aid-jmri1>3.0.co;2-x. PMID: 10739554
Epidermal growth factor content of breast cyst fluids from women with breast cancer or proliferative disease of the breast.
Torrisi R, Zanardi S, Pensa F, Valenti G, De Franchis V, Nicolo G, Barreca A, Minuto F, Boccardo F
Breast Cancer Res Treat 1995 Mar;33(3):219-24. doi: 10.1007/BF00665946. PMID: 7749149
Xenograft model of progressive human proliferative breast disease.
Miller FR, Soule HD, Tait L, Pauley RJ, Wolman SR, Dawson PJ, Heppner GH
J Natl Cancer Inst 1993 Nov 3;85(21):1725-32. doi: 10.1093/jnci/85.21.1725. PMID: 8411256

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