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Breast fibrocystic disease

MedGen UID:
42015
•Concept ID:
C0016034
•
Disease or Syndrome
Synonyms: Breast Disease, Fibrocystic; Breast Dysplasia; Breast Fibrocystic Change; Breast Fibrocystic Changes; Breast Fibrocystic Disease; Disease, Fibrocystic Breast; Dysplasia, Breast; Dysplasia, Mammary; Fibrocystic Breast Disease; Fibrocystic Changes of Breast; Fibrocystic Disease of Breast; Fibrocystic Mastopathy; Mammary Dysplasia; Mastopathy, Fibrocystic
SNOMED CT: Schimmelbusch's disease (27431007); Fibrocystic breast changes (27431007); Fibrocystic mastopathy (27431007); Fibrocystic change of breast (27431007); Fibrocystic disease of breast (27431007); Diffuse cystic mastopathy (27431007); Gross cystic disease of breast (27431007)
 
Monarch Initiative: MONDO:0005219

Definition

Fibrosis associated with cyst formation in the breast parenchyma. [from NCI]

Professional guidelines

PubMed

Mastalgia: a review of management.
Olawaiye A, Withiam-Leitch M, Danakas G, Kahn K
J Reprod Med 2005 Dec;50(12):933-9. PMID: 16444894
Benign breast pain in women: a practical approach to evaluation and treatment.
Norlock FE
J Am Med Womens Assoc (1972) 2002 Spring;57(2):85-90. PMID: 11991427
Fibrocystic breast disease: pathophysiology, pathomorphology, clinical picture, and management.
Vorherr H
Am J Obstet Gynecol 1986 Jan;154(1):161-79. doi: 10.1016/0002-9378(86)90421-7. PMID: 3511705

Recent clinical studies

Etiology

The Association between Vitamin D Deficiency and Fibrocystic Breast Disorder.
Shabanian S, Rozbeh A, Mohammadi B, Ahmadi A, Arjmand MH
Curr Mol Med 2024;24(7):899-905. doi: 10.2174/1566524023666230623155659. PMID: 37357512
The evaluation of the effect of metformin on breast fibrocystic disease.
Talaei A, Moradi A, Rafiei F
Breast Dis 2017;37(2):49-53. doi: 10.3233/BD-160256. PMID: 28598826
Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.
Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R
Lancet Neurol 2016 Jan;15(1):35-46. Epub 2015 Nov 29 doi: 10.1016/S1474-4422(15)00322-1. PMID: 26621682
Personal history of endometriosis and risk of cutaneous melanoma in a large prospective cohort of French women.
Kvaskoff M, Mesrine S, Fournier A, Boutron-Ruault MC, Clavel-Chapelon F
Arch Intern Med 2007 Oct 22;167(19):2061-5. doi: 10.1001/archinte.167.19.2061. PMID: 17954799Free PMC Article
Immunohistochemical evaluation of vasopressin expression in breast fibrocystic disease and ductal carcinoma in situ (DCIS).
North WG, Wells W, Fay MJ, Mathew RS, Donnelly EM, Memoli VA
Endocr Pathol 2003 Fall;14(3):257-62. doi: 10.1007/s12022-003-0018-y. PMID: 14586071

Diagnosis

Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.
Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R
Lancet Neurol 2016 Jan;15(1):35-46. Epub 2015 Nov 29 doi: 10.1016/S1474-4422(15)00322-1. PMID: 26621682
Breast fibrocystic disease.
De Roeck F, Vanderheyden J, Van Mieghem F, De Vel R, Van Goethem M
JBR-BTR 1999 Jun;82(3):110. PMID: 11155867

Therapy

The evaluation of the effect of metformin on breast fibrocystic disease.
Talaei A, Moradi A, Rafiei F
Breast Dis 2017;37(2):49-53. doi: 10.3233/BD-160256. PMID: 28598826
Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.
Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R
Lancet Neurol 2016 Jan;15(1):35-46. Epub 2015 Nov 29 doi: 10.1016/S1474-4422(15)00322-1. PMID: 26621682

Prognosis

Characterization and modulation of a prolactin receptor mRNA isoform in normal and tumoral human breast tissues.
Laud K, Gourdou I, Belair L, Peyrat JP, Djiane J
Int J Cancer 2000 Mar 15;85(6):771-6. doi: 10.1002/(sici)1097-0215(20000315)85:6<771::aid-ijc5>3.0.co;2-y. PMID: 10709093

Clinical prediction guides

Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.
Voskuhl RR, Wang H, Wu TC, Sicotte NL, Nakamura K, Kurth F, Itoh N, Bardens J, Bernard JT, Corboy JR, Cross AH, Dhib-Jalbut S, Ford CC, Frohman EM, Giesser B, Jacobs D, Kasper LH, Lynch S, Parry G, Racke MK, Reder AT, Rose J, Wingerchuk DM, MacKenzie-Graham AJ, Arnold DL, Tseng CH, Elashoff R
Lancet Neurol 2016 Jan;15(1):35-46. Epub 2015 Nov 29 doi: 10.1016/S1474-4422(15)00322-1. PMID: 26621682
Characterization and modulation of a prolactin receptor mRNA isoform in normal and tumoral human breast tissues.
Laud K, Gourdou I, Belair L, Peyrat JP, Djiane J
Int J Cancer 2000 Mar 15;85(6):771-6. doi: 10.1002/(sici)1097-0215(20000315)85:6<771::aid-ijc5>3.0.co;2-y. PMID: 10709093

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