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EBV-Related Burkitt Lymphoma

MedGen UID:
232467
•Concept ID:
C1333427
•
Neoplastic Process
Synonyms: EBV Related Burkitt's Lymphoma; EBV-Associated Burkitt Lymphoma; EBV-Related Burkitt's Lymphoma; Epstein-Barr Virus-Related Burkitt Lymphoma; Epstein-Barr Virus-Related Burkitt's Lymphoma

Definition

Burkitt lymphoma that is caused by Epstein-Barr virus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV-Related Burkitt Lymphoma

Professional guidelines

PubMed

LMP1 Increases Expression of NADPH Oxidase (NOX) and Its Regulatory Subunit p22 in NP69 Nasopharyngeal Cells and Makes Them Sensitive to a Treatment by a NOX Inhibitor.
Sun J, Hu C, Zhu Y, Sun R, Fang Y, Fan Y, Xu F
PLoS One 2015;10(8):e0134896. Epub 2015 Aug 5 doi: 10.1371/journal.pone.0134896. PMID: 26244812Free PMC Article

Recent clinical studies

Etiology

Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.
Argirion I, Pfeiffer RM, Proietti C, Coghill AE, Yu KJ, Middeldorp JM, Sarathkumara YD, Hsu WL, Chien YC, Lou PJ, Wang CP, Rothman N, Lan Q, Chen CJ, Mbulaiteye SM, Jarrett RF, Glimelius I, Smedby KE, Hjalgrim H, Hildesheim A, Doolan DL, Liu Z
Cancer Epidemiol Biomarkers Prev 2023 May 1;32(5):687-696. doi: 10.1158/1055-9965.EPI-22-0452. PMID: 36788424Free PMC Article
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point.
Linke-Serinsöz E, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2017 Jul;34(4):352-363. Epub 2017 Apr 7 doi: 10.1053/j.semdp.2017.04.003. PMID: 28506687
Adoptive cell therapy against EBV-related malignancies: a survey of clinical results.
Merlo A, Turrini R, Dolcetti R, Zanovello P, Amadori A, Rosato A
Expert Opin Biol Ther 2008 Sep;8(9):1265-94. doi: 10.1517/14712598.8.9.1265. PMID: 18694349
Epstein-Barr virus vaccines.
Morgan AJ
Vaccine 1992;10(9):563-71. doi: 10.1016/0264-410x(92)90434-l. PMID: 1323899
Epstein-Barr virus-associated lymphoproliferative disorders.
Purtilo DT, Strobach RS, Okano M, Davis JR
Lab Invest 1992 Jul;67(1):5-23. PMID: 1320711

Diagnosis

A rapid and sensitive CRISPR/Cas12a based lateral flow biosensor for the detection of Epstein-Barr virus.
Yuan T , Mukama O , Li Z , Chen W , Zhang Y , de Dieu Habimana J , Zhang Y , Zeng R , Nie C , He Z , Zeng L
Analyst 2020 Sep 28;145(19):6388-6394. doi: 10.1039/d0an00663g. PMID: 32985619
Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma.
Zhu S, Chen J, Xiong Y, Kamara S, Gu M, Tang W, Chen S, Dong H, Xue X, Zheng ZM, Zhang L
PLoS Pathog 2020 Jan;16(1):e1008223. Epub 2020 Jan 6 doi: 10.1371/journal.ppat.1008223. PMID: 31905218Free PMC Article
EBV-associated lymphoproliferative disorders: classification and treatment.
Carbone A, Gloghini A, Dotti G
Oncologist 2008 May;13(5):577-85. doi: 10.1634/theoncologist.2008-0036. PMID: 18515742
Haematological associations of Epstein-Barr virus infection.
Okano M
Baillieres Best Pract Res Clin Haematol 2000 Jun;13(2):199-214. doi: 10.1053/beha.1999.0068. PMID: 10942621
Epstein-Barr virus-associated lymphoproliferative disorders.
Purtilo DT, Strobach RS, Okano M, Davis JR
Lab Invest 1992 Jul;67(1):5-23. PMID: 1320711

Therapy

Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
The Ethyl Acetate Subfraction of Polygonum cuspidatum Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis.
Yiu CY, Chiu YJ, Lin TP
Biol Pharm Bull 2021 Dec 1;44(12):1837-1842. Epub 2021 Oct 6 doi: 10.1248/bpb.b21-00508. PMID: 34615812
Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma.
Zhu S, Chen J, Xiong Y, Kamara S, Gu M, Tang W, Chen S, Dong H, Xue X, Zheng ZM, Zhang L
PLoS Pathog 2020 Jan;16(1):e1008223. Epub 2020 Jan 6 doi: 10.1371/journal.ppat.1008223. PMID: 31905218Free PMC Article
Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies.
Abdulkarim B, Sabri S, Zelenika D, Deutsch E, Frascogna V, Klijanienko J, Vainchenker W, Joab I, Bourhis J
Oncogene 2003 Apr 17;22(15):2260-71. doi: 10.1038/sj.onc.1206402. PMID: 12700662
Epstein-Barr virus-driven gene therapy for EBV-related lymphomas.
Franken M, Estabrooks A, Cavacini L, Sherburne B, Wang F, Scadden DT
Nat Med 1996 Dec;2(12):1379-82. doi: 10.1038/nm1296-1379. PMID: 8946840

Prognosis

STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.
McIntosh MT, Koganti S, Boatwright JL, Li X, Spadaro SV, Brantly AC, Ayers JB, Perez RD, Burton EM, Burgula S, MacCarthy T, Bhaduri-McIntosh S
PLoS Pathog 2020 Oct;16(10):e1008849. Epub 2020 Oct 1 doi: 10.1371/journal.ppat.1008849. PMID: 33002095Free PMC Article
A rapid and sensitive CRISPR/Cas12a based lateral flow biosensor for the detection of Epstein-Barr virus.
Yuan T , Mukama O , Li Z , Chen W , Zhang Y , de Dieu Habimana J , Zhang Y , Zeng R , Nie C , He Z , Zeng L
Analyst 2020 Sep 28;145(19):6388-6394. doi: 10.1039/d0an00663g. PMID: 32985619
Global and regional incidence, mortality and disability-adjusted life-years for Epstein-Barr virus-attributable malignancies, 1990-2017.
Khan G, Fitzmaurice C, Naghavi M, Ahmed LA
BMJ Open 2020 Aug 30;10(8):e037505. doi: 10.1136/bmjopen-2020-037505. PMID: 32868361Free PMC Article
Burkitt lymphoma in Iraqi children: A distinctive form of sporadic disease with high incidence of EBV(+) cases and more frequent expression of MUM1/IRF4 protein in cases with head and neck presentation.
Uccini S, Al-Jadiry MF, Cippitelli C, Talerico C, Scarpino S, Al-Darraji AF, Al-Badri SAF, Alsaadawi AR, Al-Hadad SA, Ruco L
Pediatr Blood Cancer 2018 Dec;65(12):e27399. Epub 2018 Sep 11 doi: 10.1002/pbc.27399. PMID: 30207048
Epstein-barr virus-associated malignancies: epidemiologic patterns and etiologic implications.
Hsu JL, Glaser SL
Crit Rev Oncol Hematol 2000 Apr;34(1):27-53. doi: 10.1016/s1040-8428(00)00046-9. PMID: 10781747

Clinical prediction guides

Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.
Argirion I, Pfeiffer RM, Proietti C, Coghill AE, Yu KJ, Middeldorp JM, Sarathkumara YD, Hsu WL, Chien YC, Lou PJ, Wang CP, Rothman N, Lan Q, Chen CJ, Mbulaiteye SM, Jarrett RF, Glimelius I, Smedby KE, Hjalgrim H, Hildesheim A, Doolan DL, Liu Z
Cancer Epidemiol Biomarkers Prev 2023 May 1;32(5):687-696. doi: 10.1158/1055-9965.EPI-22-0452. PMID: 36788424Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.
McIntosh MT, Koganti S, Boatwright JL, Li X, Spadaro SV, Brantly AC, Ayers JB, Perez RD, Burton EM, Burgula S, MacCarthy T, Bhaduri-McIntosh S
PLoS Pathog 2020 Oct;16(10):e1008849. Epub 2020 Oct 1 doi: 10.1371/journal.ppat.1008849. PMID: 33002095Free PMC Article
Global and regional incidence, mortality and disability-adjusted life-years for Epstein-Barr virus-attributable malignancies, 1990-2017.
Khan G, Fitzmaurice C, Naghavi M, Ahmed LA
BMJ Open 2020 Aug 30;10(8):e037505. doi: 10.1136/bmjopen-2020-037505. PMID: 32868361Free PMC Article
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point.
Linke-Serinsöz E, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2017 Jul;34(4):352-363. Epub 2017 Apr 7 doi: 10.1053/j.semdp.2017.04.003. PMID: 28506687

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