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Orbit embryonal rhabdomyosarcoma

MedGen UID:
233267
•Concept ID:
C1335127
•
Neoplastic Process
Synonyms: Embryonal Rhabdomyosarcoma of Orbit; embryonal rhabdomyosarcoma of orbit; Embryonal Rhabdomyosarcoma of the Orbit; embryonal rhabdomyosarcoma of the orbit; Orbit Embryonal Rhabdomyosarcoma; orbit embryonal rhabdomyosarcoma
 
Monarch Initiative: MONDO:0002579

Definition

A malignant mesenchymal neoplasm that arises from the orbit. It is characterized by the presence of skeletal muscle tissue exhibiting embryonic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrbit embryonal rhabdomyosarcoma

Professional guidelines

PubMed

Frequency and Clinical Course of Residual Orbital Masses After Treatment of Orbital Rhabdomyosarcoma.
Sobel RK, Ford JR, Dong W, Shriver E, Griepentrog GJ, Debnam JM, Esmaeli B
Am J Ophthalmol 2022 Feb;234:28-36. Epub 2021 Jul 17 doi: 10.1016/j.ajo.2021.06.035. PMID: 34280364
Pediatric head and neck rhabdomyosarcoma: An analysis of treatment and survival in the United States (1975-2016).
Darwish C, Shim T, Sparks AD, Chillakuru Y, Strum D, Benito DA, Monfared A
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110403. Epub 2020 Sep 25 doi: 10.1016/j.ijporl.2020.110403. PMID: 33049553
Risk-based management: current concepts of treating malignant solid tumors of childhood.
Grosfeld JL
J Am Coll Surg 1999 Oct;189(4):407-25. doi: 10.1016/s1072-7515(99)00167-2. PMID: 10509467

Recent clinical studies

Etiology

Pediatric head and neck rhabdomyosarcoma: An analysis of treatment and survival in the United States (1975-2016).
Darwish C, Shim T, Sparks AD, Chillakuru Y, Strum D, Benito DA, Monfared A
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110403. Epub 2020 Sep 25 doi: 10.1016/j.ijporl.2020.110403. PMID: 33049553
Clinicopathological analysis of head and neck rhabdomyosarcoma: A series of 10 cases and literature review.
Pontes FS, de Oliveira JI, de Souza LL, de Almeida OP, Fregnani ER, Vilela RS, Silva WM, Fonseca FP, Pontes HA
Med Oral Patol Oral Cir Bucal 2018 Mar 1;23(2):e188-e197. doi: 10.4317/medoral.22106. PMID: 29476676Free PMC Article
Rhabdomyosarcoma of the head and neck in children: review and update.
Reilly BK, Kim A, Peña MT, Dong TA, Rossi C, Murnick JG, Choi SS
Int J Pediatr Otorhinolaryngol 2015 Sep;79(9):1477-83. Epub 2015 Jul 3 doi: 10.1016/j.ijporl.2015.06.032. PMID: 26231745
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS
J Clin Oncol 2001 Jun 15;19(12):3091-102. doi: 10.1200/JCO.2001.19.12.3091. PMID: 11408506

Diagnosis

A Review of the Role of Cytogenetics in the Diagnosis of Orbital Rhabdomyosarcoma.
Cortes Barrantes P, Jakobiec FA, Dryja TP
Semin Ophthalmol 2019;34(4):243-251. Epub 2019 May 30 doi: 10.1080/08820538.2019.1620802. PMID: 31146616
Genetic profiling of rhabdomyosarcoma with clinicopathological and radiological correlation.
Albalawi ED, Alkatan HM, Elkhamary SM, Safieh LA, Maktabi AMY
Can J Ophthalmol 2019 Apr;54(2):247-257. Epub 2018 May 18 doi: 10.1016/j.jcjo.2018.03.011. PMID: 30975350
Clinicopathological analysis of head and neck rhabdomyosarcoma: A series of 10 cases and literature review.
Pontes FS, de Oliveira JI, de Souza LL, de Almeida OP, Fregnani ER, Vilela RS, Silva WM, Fonseca FP, Pontes HA
Med Oral Patol Oral Cir Bucal 2018 Mar 1;23(2):e188-e197. doi: 10.4317/medoral.22106. PMID: 29476676Free PMC Article
Congenital Eyelid Rhabdomyosarcoma.
Lee YC, Hsu YH, Yang SH, Huang TL
Ophthalmic Plast Reconstr Surg 2016 Sep-Oct;32(5):e104-6. doi: 10.1097/IOP.0000000000000290. PMID: 25216197
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992

Therapy

45 GyRBE for group III orbital embryonal rhabdomyosarcoma.
Indelicato DJ, Rotondo RL, Mailhot Vega RB, Uezono H, Bradfield S, Agarwal V, Hol ML, Bradley JA
Acta Oncol 2019 Oct;58(10):1404-1409. Epub 2019 Sep 18 doi: 10.1080/0284186X.2019.1627412. PMID: 31530120
Worse Outcomes for Head and Neck Rhabdomyosarcoma Secondary to Reduced-Dose Cyclophosphamide.
Casey DL, Wexler LH, Wolden SL
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1151-1157. Epub 2018 Nov 30 doi: 10.1016/j.ijrobp.2018.11.049. PMID: 30508617Free PMC Article
Rhabdomyosarcoma of the head and neck in children: review and update.
Reilly BK, Kim A, Peña MT, Dong TA, Rossi C, Murnick JG, Choi SS
Int J Pediatr Otorhinolaryngol 2015 Sep;79(9):1477-83. Epub 2015 Jul 3 doi: 10.1016/j.ijporl.2015.06.032. PMID: 26231745
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS
J Clin Oncol 2001 Jun 15;19(12):3091-102. doi: 10.1200/JCO.2001.19.12.3091. PMID: 11408506

Prognosis

Pediatric head and neck rhabdomyosarcoma: An analysis of treatment and survival in the United States (1975-2016).
Darwish C, Shim T, Sparks AD, Chillakuru Y, Strum D, Benito DA, Monfared A
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110403. Epub 2020 Sep 25 doi: 10.1016/j.ijporl.2020.110403. PMID: 33049553
A Review of the Role of Cytogenetics in the Diagnosis of Orbital Rhabdomyosarcoma.
Cortes Barrantes P, Jakobiec FA, Dryja TP
Semin Ophthalmol 2019;34(4):243-251. Epub 2019 May 30 doi: 10.1080/08820538.2019.1620802. PMID: 31146616
Rhabdomyosarcoma of the head and neck in children: review and update.
Reilly BK, Kim A, Peña MT, Dong TA, Rossi C, Murnick JG, Choi SS
Int J Pediatr Otorhinolaryngol 2015 Sep;79(9):1477-83. Epub 2015 Jul 3 doi: 10.1016/j.ijporl.2015.06.032. PMID: 26231745
Orbital rhabdomyosarcoma.
Karcioglu ZA, Hadjistilianou D, Rozans M, DeFrancesco S
Cancer Control 2004 Sep-Oct;11(5):328-33. doi: 10.1177/107327480401100507. PMID: 15377992
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS
J Clin Oncol 2001 Jun 15;19(12):3091-102. doi: 10.1200/JCO.2001.19.12.3091. PMID: 11408506

Clinical prediction guides

Adult head and neck rhabdomyosarcoma: radiotherapy- based treatment, outcomes, and predictors of survival.
Zhao D, Zhou F, Liu W, Huang Z, Xu X, Zheng B, Liu C, Bai C, Liu J, Sun Y, Wang W, Xiao S
BMC Cancer 2024 Mar 14;24(1):340. doi: 10.1186/s12885-024-12079-y. PMID: 38486204Free PMC Article
MRI features of different types of sinonasan rhabdomyosarcomas: a series of eleven cases.
Zeng J, Liu L, Li J, Huang Q, Pi L, Jin K
Dentomaxillofac Radiol 2021 Dec 1;50(8):20210030. Epub 2021 Apr 9 doi: 10.1259/dmfr.20210030. PMID: 33835837Free PMC Article
45 GyRBE for group III orbital embryonal rhabdomyosarcoma.
Indelicato DJ, Rotondo RL, Mailhot Vega RB, Uezono H, Bradfield S, Agarwal V, Hol ML, Bradley JA
Acta Oncol 2019 Oct;58(10):1404-1409. Epub 2019 Sep 18 doi: 10.1080/0284186X.2019.1627412. PMID: 31530120
Rhabdomyosarcoma of the head and neck in children.
Hicks J, Flaitz C
Oral Oncol 2002 Jul;38(5):450-9. doi: 10.1016/s1368-8375(01)00105-1. PMID: 12110339
Risk-based management: current concepts of treating malignant solid tumors of childhood.
Grosfeld JL
J Am Coll Surg 1999 Oct;189(4):407-25. doi: 10.1016/s1072-7515(99)00167-2. PMID: 10509467

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