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Brain abscess

MedGen UID:
2335
Concept ID:
C0006105
Disease or Syndrome
Synonyms: Abscess, Brain; Brain Abscess; Brain Abscesses
SNOMED CT: Abscess of brain (441806004); Brain abscess (441806004)
 
HPO: HP:0030049

Definition

A collection of pus, immune cells, and other material in the brain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrain abscess

Conditions with this feature

Telangiectasia, hereditary hemorrhagic, type 2
MedGen UID:
324960
Concept ID:
C1838163
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are characteristically found on the lips, tongue, buccal and gastrointestinal (GI) mucosa, face, and fingers. The appearance of telangiectases is generally later than epistaxis but may be during childhood. Large AVMs occur most often in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. A minority of individuals with HHT have GI bleeding, which is rarely seen before age 50 years.
Autoimmune pulmonary alveolar proteinosis
MedGen UID:
410079
Concept ID:
C1970472
Disease or Syndrome
Pulmonary alveolar proteinosis is a pathologic entity characterized by intraalveolar surfactant accumulation. There are 3 clinically distinct forms: hereditary (usually congenital), secondary, and acquired. The acquired form of pulmonary alveolar proteinosis is the most common form, accounting for approximately 90% of cases. The mean age at diagnosis is 39 years and it is associated with smoking in 72% of cases. The estimated incidence and prevalence are 0.36 and 3.70 cases per million, respectively (Trapnell et al., 2003; Seymour and Presneill, 2002). Secondary pulmonary alveolar proteinosis develops in association with conditions involving functional impairment or reduced numbers of alveolar macrophages. Such conditions include some hematologic cancers, pharmacologic immunosuppression, inhalation of inorganic dust or toxic fumes, and certain infections. Congenital pulmonary alveolar proteinosis is a rare, severe, often fatal disorder of newborns associated with pulmonary surfactant metabolism dysfunction caused by mutations in genes involved in surfactant metabolism (see, e.g., SMDP1, 265120) (Trapnell et al., 2003). See 300770 for information on congenital PAP due to CSF2RA (306250) deficiency.
Severe achondroplasia-developmental delay-acanthosis nigricans syndrome
MedGen UID:
393098
Concept ID:
C2674173
Congenital Abnormality
SADDAN dysplasia (severe achondroplasia with developmental delay and acanthosis nigricans) is a very rare skeletal dysplasia characterized by the constellation of these features. Radiology reveals 'ram's horn' shaped clavicles and reverse bowing of lower limbs. Approximately half of patients die before the fourth week of life secondary to respiratory failure (summary by Zankl et al., 2008).
Telangiectasia, hereditary hemorrhagic, type 1
MedGen UID:
1643786
Concept ID:
C4551861
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are characteristically found on the lips, tongue, buccal and gastrointestinal (GI) mucosa, face, and fingers. The appearance of telangiectases is generally later than epistaxis but may be during childhood. Large AVMs occur most often in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. A minority of individuals with HHT have GI bleeding, which is rarely seen before age 50 years.

Professional guidelines

PubMed

Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Corsini Campioli C, Castillo Almeida NE, O'Horo JC, Esquer Garrigos Z, Wilson WR, Cano E, DeSimone DC, Baddour LM, Van Gompel JJ, Sohail MR
Am J Med 2021 Oct;134(10):1210-1217.e2. Epub 2021 Jul 21 doi: 10.1016/j.amjmed.2021.05.027. PMID: 34297973
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Recent clinical studies

Etiology

Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Venkatesan A
Continuum (Minneap Minn) 2021 Aug 1;27(4):855-886. doi: 10.1212/CON.0000000000001006. PMID: 34623096
Corsini Campioli C, Castillo Almeida NE, O'Horo JC, Esquer Garrigos Z, Wilson WR, Cano E, DeSimone DC, Baddour LM, Van Gompel JJ, Sohail MR
Am J Med 2021 Oct;134(10):1210-1217.e2. Epub 2021 Jul 21 doi: 10.1016/j.amjmed.2021.05.027. PMID: 34297973
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Sonneville R, Ruimy R, Benzonana N, Riffaud L, Carsin A, Tadié JM, Piau C, Revest M, Tattevin P; ESCMID Study Group for Infectious Diseases of the Brain (ESGIB)
Clin Microbiol Infect 2017 Sep;23(9):614-620. Epub 2017 May 10 doi: 10.1016/j.cmi.2017.05.004. PMID: 28501669

Diagnosis

Venkatesan A
Continuum (Minneap Minn) 2021 Aug 1;27(4):855-886. doi: 10.1212/CON.0000000000001006. PMID: 34623096
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Sonneville R, Ruimy R, Benzonana N, Riffaud L, Carsin A, Tadié JM, Piau C, Revest M, Tattevin P; ESCMID Study Group for Infectious Diseases of the Brain (ESGIB)
Clin Microbiol Infect 2017 Sep;23(9):614-620. Epub 2017 May 10 doi: 10.1016/j.cmi.2017.05.004. PMID: 28501669
Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D
N Engl J Med 2014 Jul 31;371(5):447-56. doi: 10.1056/NEJMra1301635. PMID: 25075836
Muzumdar D, Jhawar S, Goel A
Int J Surg 2011;9(2):136-44. Epub 2010 Nov 16 doi: 10.1016/j.ijsu.2010.11.005. PMID: 21087684

Therapy

Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Corsini Campioli C, Castillo Almeida NE, O'Horo JC, Esquer Garrigos Z, Wilson WR, Cano E, DeSimone DC, Baddour LM, Van Gompel JJ, Sohail MR
Am J Med 2021 Oct;134(10):1210-1217.e2. Epub 2021 Jul 21 doi: 10.1016/j.amjmed.2021.05.027. PMID: 34297973
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI
Cochrane Database Syst Rev 2018 Sep 10;9(9):CD006089. doi: 10.1002/14651858.CD006089.pub5. PMID: 30198548Free PMC Article
Brouwer MC, Tunkel AR, McKhann GM 2nd, van de Beek D
N Engl J Med 2014 Jul 31;371(5):447-56. doi: 10.1056/NEJMra1301635. PMID: 25075836
Muzumdar D, Jhawar S, Goel A
Int J Surg 2011;9(2):136-44. Epub 2010 Nov 16 doi: 10.1016/j.ijsu.2010.11.005. PMID: 21087684

Prognosis

Gibson M, Yang N, Waller JL, Young L, Bollag WB, Kheda M, Mohammed A, Baer SL
J Investig Med 2022 Jan;70(1):36-45. Epub 2021 Aug 23 doi: 10.1136/jim-2021-001783. PMID: 34426458
Khairy S, Azzubi M
World Neurosurg 2017 May;101:811.e7-811.e8. Epub 2017 Feb 27 doi: 10.1016/j.wneu.2017.02.074. PMID: 28245993
Brouwer MC, Coutinho JM, van de Beek D
Neurology 2014 Mar 4;82(9):806-13. Epub 2014 Jan 29 doi: 10.1212/WNL.0000000000000172. PMID: 24477107
Cartin-Ceba R, Swanson KL, Krowka MJ
Chest 2013 Sep;144(3):1033-1044. doi: 10.1378/chest.12-0924. PMID: 24008954
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202

Clinical prediction guides

Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Welkoborsky HJ, Pitz S, Grass S, Breuer B, Holte APV, Bertram O, Wiechens B
Dtsch Arztebl Int 2022 Jan 21;119(3):31-37. doi: 10.3238/arztebl.m2021.0379. PMID: 34874263Free PMC Article
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202

Recent systematic reviews

Cobo F
Rev Esp Quimioter 2023 Apr;36(2):152-159. Epub 2023 Feb 3 doi: 10.37201/req/114.2022. PMID: 36733997Free PMC Article
Lemiengre MB, van Driel ML, Merenstein D, Liira H, Mäkelä M, De Sutter AI
Cochrane Database Syst Rev 2018 Sep 10;9(9):CD006089. doi: 10.1002/14651858.CD006089.pub5. PMID: 30198548Free PMC Article
Champey J, Pavese P, Bouvaist H, Kastler A, Krainik A, Francois P
Eur J Clin Microbiol Infect Dis 2016 Feb;35(2):159-68. Epub 2015 Nov 19 doi: 10.1007/s10096-015-2523-6. PMID: 26585337Free PMC Article
Zhai Y, Wei X, Chen R, Guo Z, Raj Singh R, Zhang Y
Br J Neurosurg 2016;30(1):29-34. Epub 2015 Nov 16 doi: 10.3109/02688697.2015.1109059. PMID: 26569628
Brouwer MC, Coutinho JM, van de Beek D
Neurology 2014 Mar 4;82(9):806-13. Epub 2014 Jan 29 doi: 10.1212/WNL.0000000000000172. PMID: 24477107

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