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Nipple duct carcinoma

MedGen UID:
233757
•Concept ID:
C1334967
•
Neoplastic Process
Synonyms: Nipple Duct Carcinoma; nipple duct carcinoma
 
Monarch Initiative: MONDO:0004409

Definition

A carcinoma that develops in the ducts of the nipple. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNipple duct carcinoma

Professional guidelines

PubMed

Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
Precision surgery and avoiding over-treatment.
Hosseini A, Khoury AL, Esserman LJ
Eur J Surg Oncol 2017 May;43(5):938-943. Epub 2017 Feb 11 doi: 10.1016/j.ejso.2017.02.003. PMID: 28238520
Ductoscopy: defining its role in the management of breast cancer.
Dooley WC, Spiegel A, Cox C, Henderson R, Richardson L, Zabora J
Breast J 2004 Jul-Aug;10(4):271-2. doi: 10.1111/j.1075-122X.2004.21595.x. PMID: 15239784

Recent clinical studies

Etiology

Ultrasound-Guided Vacuum-Assisted Excision to Treat Intraductal Papilloma.
He P, Lei YT, Chen W, Shen WW, Fu P, Zhao HM, Cui LG
World J Surg 2023 Mar;47(3):699-706. Epub 2023 Jan 9 doi: 10.1007/s00268-022-06735-2. PMID: 36624311
Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindications.
Galimberti V, Vicini E, Corso G, Morigi C, Fontana S, Sacchini V, Veronesi P
Breast 2017 Aug;34 Suppl 1(Suppl 1):S82-S84. Epub 2017 Jun 30 doi: 10.1016/j.breast.2017.06.034. PMID: 28673535Free PMC Article
Extended indications for nipple-sparing mastectomy.
Niemeyer M, Paepke S, Schmid R, Plattner B, Müller D, Kiechle M
Breast J 2011 May-Jun;17(3):296-9. Epub 2011 Mar 31 doi: 10.1111/j.1524-4741.2011.01079.x. PMID: 21450018
Skin-reducing mastectomy.
Nava MB, Cortinovis U, Ottolenghi J, Riggio E, Pennati A, Catanuto G, Greco M, Rovere GQ
Plast Reconstr Surg 2006 Sep;118(3):603-10; discussion 611-3. doi: 10.1097/01.prs.0000233024.08392.14. PMID: 16932166
Male breast cancer.
Fentiman IS, Fourquet A, Hortobagyi GN
Lancet 2006 Feb 18;367(9510):595-604. doi: 10.1016/S0140-6736(06)68226-3. PMID: 16488803

Diagnosis

Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Nipple discharge screening.
Zervoudis S, Iatrakis G, Economides P, Polyzos D, Navrozoglou I
Womens Health (Lond) 2010 Jan;6(1):135-51. doi: 10.2217/whe.09.81. PMID: 20050819
Paget's disease of the nipple.
Seetharam S, Fentiman IS
Womens Health (Lond) 2009 Jul;5(4):397-402. doi: 10.2217/whe.09.23. PMID: 19586431
The management of Paget's disease of the breast.
Marcus E
Curr Treat Options Oncol 2004 Apr;5(2):153-60. doi: 10.1007/s11864-004-0047-x. PMID: 14990209

Therapy

Safety and Effectiveness of Areola-sparing Mastectomy for Breast Cancer With Intraductal Lesions.
Tokisawa H, Aruga T, Honda Y, Ishiba T, Yonekura R, Iwamoto N, Kumaki Y, Tomita S, Fujii M, Terao Y
Anticancer Res 2021 Nov;41(11):5723-5728. doi: 10.21873/anticanres.15388. PMID: 34732445
Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindications.
Galimberti V, Vicini E, Corso G, Morigi C, Fontana S, Sacchini V, Veronesi P
Breast 2017 Aug;34 Suppl 1(Suppl 1):S82-S84. Epub 2017 Jun 30 doi: 10.1016/j.breast.2017.06.034. PMID: 28673535Free PMC Article
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Skin-reducing mastectomy.
Nava MB, Cortinovis U, Ottolenghi J, Riggio E, Pennati A, Catanuto G, Greco M, Rovere GQ
Plast Reconstr Surg 2006 Sep;118(3):603-10; discussion 611-3. doi: 10.1097/01.prs.0000233024.08392.14. PMID: 16932166
Current management of ductal carcinoma in situ.
Barth A, Brenner RJ, Giuliano AE
West J Med 1995 Oct;163(4):360-6. PMID: 7483593Free PMC Article

Prognosis

Problem-solving Breast MRI.
Reig B, Kim E, Chhor CM, Moy L, Lewin AA, Heacock L
Radiographics 2023 Oct;43(10):e230026. doi: 10.1148/rg.230026. PMID: 37733618
Management of Neuroendocrine Ductal Carcinoma In Situ of the Breast.
Ma BL, Rooks CO, Christopher WO, Berry SM
Am Surg 2023 Aug;89(8):3526-3527. Epub 2023 Mar 3 doi: 10.1177/00031348231161080. PMID: 36866802
Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk?
Coopey SB, Kartal K, Li C, Yala A, Barzilay R, Faulkner HR, King TA, Acevedo F, Garber JE, Guidi AJ, Hughes KS
Breast Cancer Res Treat 2019 May;175(1):1-4. Epub 2019 Jan 21 doi: 10.1007/s10549-018-05117-4. PMID: 30666539
Paget's disease of the nipple.
Sandoval-Leon AC, Drews-Elger K, Gomez-Fernandez CR, Yepes MM, Lippman ME
Breast Cancer Res Treat 2013 Aug;141(1):1-12. Epub 2013 Aug 9 doi: 10.1007/s10549-013-2661-4. PMID: 23929251
Skin-reducing mastectomy.
Nava MB, Cortinovis U, Ottolenghi J, Riggio E, Pennati A, Catanuto G, Greco M, Rovere GQ
Plast Reconstr Surg 2006 Sep;118(3):603-10; discussion 611-3. doi: 10.1097/01.prs.0000233024.08392.14. PMID: 16932166

Clinical prediction guides

Preoperative breast MRI positively impacts surgical outcomes of needle biopsy-diagnosed pure DCIS: a patient-matched analysis from the MIPA study.
Cozzi A, Di Leo G, Houssami N, Gilbert FJ, Helbich TH, Álvarez Benito M, Balleyguier C, Bazzocchi M, Bult P, Calabrese M, Camps Herrero J, Cartia F, Cassano E, Clauser P, de Lima Docema MF, Depretto C, Dominelli V, Forrai G, Girometti R, Harms SE, Hilborne S, Ienzi R, Lobbes MBI, Losio C, Mann RM, Montemezzi S, Obdeijn IM, Aksoy Ozcan U, Pediconi F, Pinker K, Preibsch H, Raya Povedano JL, Rossi Saccarelli C, Sacchetto D, Scaperrotta GP, Schlooz M, Szabó BK, Taylor DB, Ulus SÖ, Van Goethem M, Veltman J, Weigel S, Wenkel E, Zuiani C, Sardanelli F
Eur Radiol 2024 Jun;34(6):3970-3980. Epub 2023 Nov 24 doi: 10.1007/s00330-023-10409-5. PMID: 37999727Free PMC Article
Low Cancer Occurrence Rate following Prophylactic Nipple-Sparing Mastectomy.
Boyd CJ, Ramesh S, Bekisz JM, Guth AA, Axelrod DM, Shapiro RL, Hiotis K, Schnabel FR, Karp NS, Choi M
Plast Reconstr Surg 2024 Jan 1;153(1):37e-43e. Epub 2023 Mar 30 doi: 10.1097/PRS.0000000000010481. PMID: 36999997
Problem-solving Breast MRI.
Reig B, Kim E, Chhor CM, Moy L, Lewin AA, Heacock L
Radiographics 2023 Oct;43(10):e230026. doi: 10.1148/rg.230026. PMID: 37733618
Safety and Effectiveness of Areola-sparing Mastectomy for Breast Cancer With Intraductal Lesions.
Tokisawa H, Aruga T, Honda Y, Ishiba T, Yonekura R, Iwamoto N, Kumaki Y, Tomita S, Fujii M, Terao Y
Anticancer Res 2021 Nov;41(11):5723-5728. doi: 10.21873/anticanres.15388. PMID: 34732445
Evaluating the risk of underlying malignancy in patients with pathologic nipple discharge.
Li GZ, Wong SM, Lester S, Nakhlis F
Breast J 2018 Jul;24(4):624-627. Epub 2018 Mar 8 doi: 10.1111/tbj.13018. PMID: 29520933

Recent systematic reviews

Spare the Nipple: A Systematic Review of Tumor Nipple-Distance and Oncologic Outcomes in Nipple-Sparing Mastectomy.
Youn S, Lee E, Peiris L, Olson D, Lesniak D, Rajaee N
Ann Surg Oncol 2023 Dec;30(13):8381-8388. Epub 2023 Aug 24 doi: 10.1245/s10434-023-14143-6. PMID: 37620525
Role of duct excision surgery in the treatment of pathological nipple discharge and detection of breast carcinoma: systematic review.
Makineli S, van Wijnbergen JWM, Vriens MR, van Diest PJ, Witkamp AJ
BJS Open 2023 Jul 10;7(4) doi: 10.1093/bjsopen/zrad066. PMID: 37459137Free PMC Article
Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Nipple- and areola-sparing mastectomy for the treatment of breast cancer.
Mota BS, Riera R, Ricci MD, Barrett J, de Castria TB, Atallah ÁN, Bevilacqua JL
Cochrane Database Syst Rev 2016 Nov 29;11(11):CD008932. doi: 10.1002/14651858.CD008932.pub3. PMID: 27898991Free PMC Article
Predictive factors of nipple involvement in breast cancer: a systematic review and meta-analysis.
Zhang H, Li Y, Moran MS, Haffty BG, Yang Q
Breast Cancer Res Treat 2015 Jun;151(2):239-49. Epub 2015 Apr 19 doi: 10.1007/s10549-015-3385-4. PMID: 25893590

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