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Nipple duct carcinoma

MedGen UID:
233757
•Concept ID:
C1334967
•
Neoplastic Process
Synonyms: Nipple Duct Carcinoma; nipple duct carcinoma
 
Monarch Initiative: MONDO:0004409

Definition

A carcinoma that develops in the ducts of the nipple. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNipple duct carcinoma

Professional guidelines

PubMed

Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
Precision surgery and avoiding over-treatment.
Hosseini A, Khoury AL, Esserman LJ
Eur J Surg Oncol 2017 May;43(5):938-943. Epub 2017 Feb 11 doi: 10.1016/j.ejso.2017.02.003. PMID: 28238520
Current management and treatment strategies for breast cancer.
Howard JH, Bland KI
Curr Opin Obstet Gynecol 2012 Feb;24(1):44-8. doi: 10.1097/GCO.0b013e32834da4b1. PMID: 22123219

Recent clinical studies

Etiology

Problem-solving Breast MRI.
Reig B, Kim E, Chhor CM, Moy L, Lewin AA, Heacock L
Radiographics 2023 Oct;43(10):e230026. doi: 10.1148/rg.230026. PMID: 37733618
Duct carcinoma in situ: A personal perspective.
Lagios MD
Breast J 2020 Jun;26(6):1132-1137. Epub 2020 May 10 doi: 10.1111/tbj.13860. PMID: 32390260
Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindications.
Galimberti V, Vicini E, Corso G, Morigi C, Fontana S, Sacchini V, Veronesi P
Breast 2017 Aug;34 Suppl 1(Suppl 1):S82-S84. Epub 2017 Jun 30 doi: 10.1016/j.breast.2017.06.034. PMID: 28673535Free PMC Article
Skin-sparing mastectomy.
Cunnick GH, Mokbel K
Am J Surg 2004 Jul;188(1):78-84. doi: 10.1016/j.amjsurg.2004.02.004. PMID: 15219490
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000

Diagnosis

Problem-solving Breast MRI.
Reig B, Kim E, Chhor CM, Moy L, Lewin AA, Heacock L
Radiographics 2023 Oct;43(10):e230026. doi: 10.1148/rg.230026. PMID: 37733618
The nipple-areolar complex: comprehensive imaging review.
Lyons D, Wahab RA, Vijapura C, Mahoney MC
Clin Radiol 2021 Mar;76(3):172-184. Epub 2020 Oct 17 doi: 10.1016/j.crad.2020.09.013. PMID: 33077158
Nipple Ultrasound: A Pictorial Essay.
Chiorean A, Pintican RM, Szep M, Feier D, Rogojan L, Fetica B, Dindelegan G, Vlad B, Duma M
Korean J Radiol 2020 Aug;21(8):955-966. doi: 10.3348/kjr.2019.0831. PMID: 32677380Free PMC Article
Precision surgery and avoiding over-treatment.
Hosseini A, Khoury AL, Esserman LJ
Eur J Surg Oncol 2017 May;43(5):938-943. Epub 2017 Feb 11 doi: 10.1016/j.ejso.2017.02.003. PMID: 28238520
Nipple discharge screening.
Zervoudis S, Iatrakis G, Economides P, Polyzos D, Navrozoglou I
Womens Health (Lond) 2010 Jan;6(1):135-51. doi: 10.2217/whe.09.81. PMID: 20050819

Therapy

Neoadjuvant Chemotherapy and Nipple-Sparing Mastectomy: Timing and Postoperative Complications.
Bartholomew AJ, Dervishaj OA, Sosin M, Kerivan LT, Tung SS, Caragacianu DL, Willey SC, Tousimis EA
Ann Surg Oncol 2019 Sep;26(9):2768-2772. Epub 2019 May 23 doi: 10.1245/s10434-019-07418-4. PMID: 31123933
Current Therapeutic Approaches to DCIS.
Doke K, Butler S, Mitchell MP
J Mammary Gland Biol Neoplasia 2018 Dec;23(4):279-291. Epub 2018 Sep 29 doi: 10.1007/s10911-018-9415-1. PMID: 30267199
Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindications.
Galimberti V, Vicini E, Corso G, Morigi C, Fontana S, Sacchini V, Veronesi P
Breast 2017 Aug;34 Suppl 1(Suppl 1):S82-S84. Epub 2017 Jun 30 doi: 10.1016/j.breast.2017.06.034. PMID: 28673535Free PMC Article
Nipple- and areola-sparing mastectomy for the treatment of breast cancer.
Mota BS, Riera R, Ricci MD, Barrett J, de Castria TB, Atallah ÁN, Bevilacqua JL
Cochrane Database Syst Rev 2016 Nov 29;11(11):CD008932. doi: 10.1002/14651858.CD008932.pub3. PMID: 27898991Free PMC Article
Management of positive sub-areolar/nipple duct margins in nipple-sparing mastectomies.
Camp MS, Coopey SB, Tang R, Colwell A, Specht M, Greenup RA, Gadd MA, Brachtel E, Austen WG Jr, Smith BL
Breast J 2014 Jul-Aug;20(4):402-7. Epub 2014 Jun 2 doi: 10.1111/tbj.12279. PMID: 24890641

Prognosis

Problem-solving Breast MRI.
Reig B, Kim E, Chhor CM, Moy L, Lewin AA, Heacock L
Radiographics 2023 Oct;43(10):e230026. doi: 10.1148/rg.230026. PMID: 37733618
Duct carcinoma in situ: A personal perspective.
Lagios MD
Breast J 2020 Jun;26(6):1132-1137. Epub 2020 May 10 doi: 10.1111/tbj.13860. PMID: 32390260
Neoadjuvant Chemotherapy and Nipple-Sparing Mastectomy: Timing and Postoperative Complications.
Bartholomew AJ, Dervishaj OA, Sosin M, Kerivan LT, Tung SS, Caragacianu DL, Willey SC, Tousimis EA
Ann Surg Oncol 2019 Sep;26(9):2768-2772. Epub 2019 May 23 doi: 10.1245/s10434-019-07418-4. PMID: 31123933
Nipple Resection and Reconstruction After Attempted Nipple-Sparing Mastectomy.
Dent BL, Chao JW, Eden DJ, Stone BV, Swistel A, Talmor M
Ann Plast Surg 2017 Jan;78(1):28-34. doi: 10.1097/SAP.0000000000000823. PMID: 27015336
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000

Clinical prediction guides

Problem-solving Breast MRI.
Reig B, Kim E, Chhor CM, Moy L, Lewin AA, Heacock L
Radiographics 2023 Oct;43(10):e230026. doi: 10.1148/rg.230026. PMID: 37733618
Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Magnetic resonance imaging in the evaluation of pathologic nipple discharge: indications and imaging findings.
Samreen N, Madsen LB, Chacko C, Heller SL
Br J Radiol 2021 Apr 1;94(1120):20201013. Epub 2021 Feb 5 doi: 10.1259/bjr.20201013. PMID: 33544650Free PMC Article
Neoadjuvant Chemotherapy and Nipple-Sparing Mastectomy: Timing and Postoperative Complications.
Bartholomew AJ, Dervishaj OA, Sosin M, Kerivan LT, Tung SS, Caragacianu DL, Willey SC, Tousimis EA
Ann Surg Oncol 2019 Sep;26(9):2768-2772. Epub 2019 May 23 doi: 10.1245/s10434-019-07418-4. PMID: 31123933
Nipple- and areola-sparing mastectomy for the treatment of breast cancer.
Mota BS, Riera R, Ricci MD, Barrett J, de Castria TB, Atallah ÁN, Bevilacqua JL
Cochrane Database Syst Rev 2016 Nov 29;11(11):CD008932. doi: 10.1002/14651858.CD008932.pub3. PMID: 27898991Free PMC Article

Recent systematic reviews

Spare the Nipple: A Systematic Review of Tumor Nipple-Distance and Oncologic Outcomes in Nipple-Sparing Mastectomy.
Youn S, Lee E, Peiris L, Olson D, Lesniak D, Rajaee N
Ann Surg Oncol 2023 Dec;30(13):8381-8388. Epub 2023 Aug 24 doi: 10.1245/s10434-023-14143-6. PMID: 37620525
Role of duct excision surgery in the treatment of pathological nipple discharge and detection of breast carcinoma: systematic review.
Makineli S, van Wijnbergen JWM, Vriens MR, van Diest PJ, Witkamp AJ
BJS Open 2023 Jul 10;7(4) doi: 10.1093/bjsopen/zrad066. PMID: 37459137Free PMC Article
Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Nipple- and areola-sparing mastectomy for the treatment of breast cancer.
Mota BS, Riera R, Ricci MD, Barrett J, de Castria TB, Atallah ÁN, Bevilacqua JL
Cochrane Database Syst Rev 2016 Nov 29;11(11):CD008932. doi: 10.1002/14651858.CD008932.pub3. PMID: 27898991Free PMC Article
Predictive factors of nipple involvement in breast cancer: a systematic review and meta-analysis.
Zhang H, Li Y, Moran MS, Haffty BG, Yang Q
Breast Cancer Res Treat 2015 Jun;151(2):239-49. Epub 2015 Apr 19 doi: 10.1007/s10549-015-3385-4. PMID: 25893590

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