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Ampulla of vater small cell neuroendocrine carcinoma

MedGen UID:
233974
Concept ID:
C1332250
Neoplastic Process
Synonyms: Ampulla of Vater Small Cell Carcinoma; ampulla of Vater small cell carcinoma; Ampulla of Vater Small Cell NEC; ampulla of Vater small cell NEC; Ampulla of Vater Small Cell Neuroendocrine Carcinoma; ampulla of vater small cell neuroendocrine carcinoma; ampulla of Vater small cell neuroendocrine carcinoma; Ampullary Small Cell Carcinoma; ampullary small cell carcinoma; hepatopancreatic ampulla small cell carcinoma; Small Cell Neuroendocrine Carcinoma of the Ampullary Region; small cell neuroendocrine carcinoma of the ampullary region
 
Monarch Initiative: MONDO:0004117

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the ampulla of Vater and the periampullary region. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAmpulla of vater small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Recent clinical studies

Etiology

Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Lagana S, Hsiao S, Bao F, Sepulveda A, Moreira R, Lefkowitch J, Remotti H
Arch Pathol Lab Med 2015 Jun;139(6):791-5. doi: 10.5858/arpa.2013-0249-OA. PMID: 26030248
Lu B, Cai X, Lu W, Huang Y, Jin X
JSLS 2006 Jan-Mar;10(1):97-100. PMID: 16709370Free PMC Article
Li L, Chen QH, Sullivan JD, Breuer FU
Ann Clin Lab Sci 2004 Autumn;34(4):471-5. PMID: 15648791
Sakhuja P, Malhotra V, Gondal R, Dutt N, Choudhary A
J Clin Gastroenterol 2001 Aug;33(2):154-6. doi: 10.1097/00004836-200108000-00013. PMID: 11468445

Diagnosis

Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791Free PMC Article
Fujii M, Okamoto Y, Fujioka S, Yoshioka M, Shiode J
Clin J Gastroenterol 2022 Feb;15(1):205-209. Epub 2022 Feb 3 doi: 10.1007/s12328-021-01553-w. PMID: 35113343
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Sun JH, Chao M, Zhang SZ, Zhang GQ, Li B, Wu JJ
World J Gastroenterol 2008 Aug 7;14(29):4709-12. doi: 10.3748/wjg.14.4709. PMID: 18698690Free PMC Article
Selvakumar E, Rajendran S, Balachandar TG, Kannan DG, Jeswanth S, Ravichandran P, Surendran R
Hepatobiliary Pancreat Dis Int 2008 Aug;7(4):422-5. PMID: 18693180

Therapy

Yoon JG, Kim MH, Jang M, Kim H, Hwang HK, Kang CM, Lee WJ, Kang B, Lee CK, Lee MG, Chung HC, Choi HJ, Park YN
Hepatology 2021 Oct;74(4):1914-1931. Epub 2021 Jul 29 doi: 10.1002/hep.31862. PMID: 33884649
Fukaya M, Abe T, Yokoyama Y, Itatsu K, Nagino M
Surg Today 2014 May;44(5):967-71. Epub 2013 Mar 17 doi: 10.1007/s00595-013-0549-x. PMID: 23504004
Iwasa S, Morizane C, Okusaka T, Ueno H, Ikeda M, Kondo S, Tanaka T, Nakachi K, Mitsunaga S, Kojima Y, Hagihara A, Hiraoka N
Jpn J Clin Oncol 2010 Apr;40(4):313-8. Epub 2010 Jan 4 doi: 10.1093/jjco/hyp173. PMID: 20047862
Hazama K, Suzuki Y, Takahashi M, Takahashi Y, Yoshioka T, Takano S, Kondoh S, Katoh H
Surg Today 2003;33(11):870-2. doi: 10.1007/s00595-003-2594-3. PMID: 14605962
Sarker AB, Hoshida Y, Akagi S, Hayashi K, Murakami I, Jeon HJ, Takahashi K, Akagi T
Acta Pathol Jpn 1992 Jul;42(7):529-35. doi: 10.1111/j.1440-1827.1992.tb03101.x. PMID: 1384272

Prognosis

Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791Free PMC Article
Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, Arai E, Sugiyama Y, Matsuzaki J, Uchida R, Yoshikawa N, Furukawa R, Saito H
Cell Rep 2019 Apr 23;27(4):1265-1276.e4. doi: 10.1016/j.celrep.2019.03.088. PMID: 31018139
Selvakumar E, Rajendran S, Balachandar TG, Kannan DG, Jeswanth S, Ravichandran P, Surendran R
Hepatobiliary Pancreat Dis Int 2008 Aug;7(4):422-5. PMID: 18693180
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080
Li L, Chen QH, Sullivan JD, Breuer FU
Ann Clin Lab Sci 2004 Autumn;34(4):471-5. PMID: 15648791

Clinical prediction guides

Reiswich V, Gorbokon N, Luebke AM, Burandt E, Menz A, Kluth M, Hube-Magg C, Wittmer C, Weidemann S, Fraune C, Möller K, Lebok P, Sauter G, Simon R, Uhlig R, Wilczak W, Jacobsen F, Minner S, Krech R, Bernreuther C, Marx A, Steurer S, Clauditz T, Krech T
J Pathol Clin Res 2021 Nov;7(6):577-589. Epub 2021 Aug 7 doi: 10.1002/cjp2.237. PMID: 34363325Free PMC Article
Yoon JG, Kim MH, Jang M, Kim H, Hwang HK, Kang CM, Lee WJ, Kang B, Lee CK, Lee MG, Chung HC, Choi HJ, Park YN
Hepatology 2021 Oct;74(4):1914-1931. Epub 2021 Jul 29 doi: 10.1002/hep.31862. PMID: 33884649
Fraune C, Burandt E, Simon R, Hube-Magg C, Makrypidi-Fraune G, Kluth M, Büscheck F, Höflmayer D, Blessin NC, Mandelkow T, Li W, Perez D, Izbicki JR, Wilczak W, Sauter G, Schrader J, Neipp M, Mofid H, Daniels T, Isbert C, Clauditz TS, Steurer S
Ann Surg Oncol 2020 Oct;27(10):3997-4006. Epub 2020 Feb 27 doi: 10.1245/s10434-020-08209-y. PMID: 32108923Free PMC Article
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080
Hamada Y, Nakayama Y, Mizoguchi M, Ikeda S, Kuroki M, Iwasaki H
Cancer Lett 2006 Nov 18;243(2):211-6. Epub 2006 Apr 17 doi: 10.1016/j.canlet.2005.11.037. PMID: 16616808

Recent systematic reviews

Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791Free PMC Article

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