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Colon juvenile polyp

MedGen UID:
234160
•Concept ID:
C1333090
•
Disease or Syndrome
Synonyms: Colon Juvenile Polyp; colon juvenile polyp; Colon Retention Polyp; colon retention polyp; Colonic Juvenile Polyp; colonic juvenile polyp; Colonic Retention Polyp; colonic retention polyp; Juvenile Polyp of Colon; juvenile polyp of colon; Juvenile Polyp of the Colon; juvenile polyp of the colon; Retention Polyp of Colon; retention polyp of colon; Retention Polyp of the Colon; retention polyp of the colon
 
Monarch Initiative: MONDO:0006153

Definition

A non-neoplastic hamartomatous polyp that arises from the colon. It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon juvenile polyp

Professional guidelines

PubMed

Updates in the diagnosis and management of non-ampullary small-bowel polyposis.
Lucaciu L, Yano T, Saurin JC
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101852. Epub 2023 Jul 22 doi: 10.1016/j.bpg.2023.101852. PMID: 37652652
Genotype-defined cancer risk in juvenile polyposis syndrome.
Aytac E, Sulu B, Heald B, O'Malley M, LaGuardia L, Remzi FH, Kalady MF, Burke CA, Church JM
Br J Surg 2015 Jan;102(1):114-8. Epub 2014 Nov 12 doi: 10.1002/bjs.9693. PMID: 25389115
Inherited polyposis syndromes: molecular mechanisms, clinicopathology, and genetic testing.
Doxey BW, Kuwada SK, Burt RW
Clin Gastroenterol Hepatol 2005 Jul;3(7):633-41. doi: 10.1016/s1542-3565(05)00370-8. PMID: 16206494

Recent clinical studies

Etiology

Polypoid disease of colon in children.
Soyer T
Pediatr Surg Int 2020 Apr;36(4):447-455. Epub 2020 Jan 21 doi: 10.1007/s00383-020-04621-3. PMID: 31965250
Pediatric Colonoscopic Polypectomy Technique.
Kay M, Wyllie R
J Pediatr Gastroenterol Nutr 2020 Mar;70(3):280-284. doi: 10.1097/MPG.0000000000002591. PMID: 31860538
Pathology and genetics of hereditary colorectal cancer.
Ma H, Brosens LAA, Offerhaus GJA, Giardiello FM, de Leng WWJ, Montgomery EA
Pathology 2018 Jan;50(1):49-59. Epub 2017 Nov 21 doi: 10.1016/j.pathol.2017.09.004. PMID: 29169633
Juvenile polyposis syndrome.
Brosens LA, Langeveld D, van Hattem WA, Giardiello FM, Offerhaus GJ
World J Gastroenterol 2011 Nov 28;17(44):4839-44. doi: 10.3748/wjg.v17.i44.4839. PMID: 22171123Free PMC Article
Familial adenomatous polyposis.
Half E, Bercovich D, Rozen P
Orphanet J Rare Dis 2009 Oct 12;4:22. doi: 10.1186/1750-1172-4-22. PMID: 19822006Free PMC Article

Diagnosis

JUVENILE POLYP IN ADULTS.
Popović M, Knežević A, Dolinaj Škopelja J, Đolai M
Acta Clin Croat 2022 Aug;61(2):354-358. doi: 10.20471/acc.2022.61.02.23. PMID: 36818922Free PMC Article
The Genetics of Colorectal Cancer.
Jasperson K, Burt RW
Surg Oncol Clin N Am 2015 Oct;24(4):683-703. Epub 2015 Jul 15 doi: 10.1016/j.soc.2015.06.006. PMID: 26363537
Colorectal polyps in childhood.
Thakkar K, Fishman DS, Gilger MA
Curr Opin Pediatr 2012 Oct;24(5):632-7. doi: 10.1097/MOP.0b013e328357419f. PMID: 22890064
Juvenile polyposis syndrome.
Brosens LA, Langeveld D, van Hattem WA, Giardiello FM, Offerhaus GJ
World J Gastroenterol 2011 Nov 28;17(44):4839-44. doi: 10.3748/wjg.v17.i44.4839. PMID: 22171123Free PMC Article
Familial adenomatous polyposis.
Half E, Bercovich D, Rozen P
Orphanet J Rare Dis 2009 Oct 12;4:22. doi: 10.1186/1750-1172-4-22. PMID: 19822006Free PMC Article

Therapy

Disease patterns among Saudi children undergoing colonoscopy for lower gastrointestinal bleeding: Single tertiary care center experience.
Alrashidi S, AlAmery T, Alshanbary A, Aljohani E, Bashir SM, Alsaleem B, Asery A, Al-Hussaini A
Saudi J Gastroenterol 2023 Nov-Dec;29(6):388-395. doi: 10.4103/sjg.sjg_130_23. PMID: 37706419Free PMC Article
Endoscopic Mucosal Resection in Children.
Vitale DS, Wang K, Jamil LH, Park KH, Liu QY
J Pediatr Gastroenterol Nutr 2022 Jan 1;74(1):20-24. doi: 10.1097/MPG.0000000000003275. PMID: 34347680
Colorectal polyps in childhood.
Thakkar K, Fishman DS, Gilger MA
Curr Opin Pediatr 2012 Oct;24(5):632-7. doi: 10.1097/MOP.0b013e328357419f. PMID: 22890064
Risk and surveillance of individuals with heritable factors for colorectal cancer. WHO Collaborating Centre for the Prevention of Colorectal Cancer.
Burt RW, Bishop DT, Lynch HT, Rozen P, Winawer SJ
Bull World Health Organ 1990;68(5):655-65. PMID: 2289301Free PMC Article
Juvenile polyposis--a precancerous condition.
Jass JR, Williams CB, Bussey HJ, Morson BC
Histopathology 1988 Dec;13(6):619-30. doi: 10.1111/j.1365-2559.1988.tb02093.x. PMID: 2853131

Prognosis

Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Hamartomatous polyps - a clinical and molecular genetic study.
Jelsig AM
Dan Med J 2016 Aug;63(8) PMID: 27477802
Juvenile Polyps in Denmark From 1995 to 2014.
Jelsig AM, Ousager LB, Brusgaard K, Qvist N
Dis Colon Rectum 2016 Aug;59(8):751-7. doi: 10.1097/DCR.0000000000000634. PMID: 27384093
Colonic polyps and polyposis syndromes in pediatric patients.
Kay M, Eng K, Wyllie R
Curr Opin Pediatr 2015 Oct;27(5):634-41. doi: 10.1097/MOP.0000000000000265. PMID: 26208235
Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

Clinical prediction guides

Single-cell landscape of the cellular microenvironment in three different colonic polyp subtypes in children.
Deng Y, Li C, Huang L, Xiong P, Li Y, Liu Y, Li S, Chen W, Yin Q, Li Y, Yang Q, Peng H, Wu S, Wang X, Tong Q, Ouyang H, Hu D, Liu X, Li L, You J, Sun Z, Lu X, Xiao Z, Deng Y, Zhao H
Clin Transl Med 2024 Jan;14(1):e1535. doi: 10.1002/ctm2.1535. PMID: 38264936Free PMC Article
An unusual colonic mass in a phlebosclerosis patient.
Ding Y, Yu J, Zhang JY, Lu QQ, Wu XR, Huang WF
Clin Res Hepatol Gastroenterol 2022 Apr;46(4):101865. Epub 2022 Jan 14 doi: 10.1016/j.clinre.2022.101865. PMID: 35038575
Clinical and Histologic Overlap and Distinction Among Various Hamartomatous Polyposis Syndromes.
Gilad O, Rosner G, Fliss-Isakov N, Aharon-Kaspi S, Strul H, Gluck N, Kariv R
Clin Transl Gastroenterol 2019 May 22;10(5):1-9. doi: 10.14309/ctg.0000000000000035. PMID: 31107726Free PMC Article
CLINICAL, EPIDEMIOLOGIC, AND ENDOSCOPIC PROFILE IN CHILDREN AND ADOLESCENTS WITH COLONIC POLYPS IN TWO REFERENCE CENTERS.
Andrade DO, Ferreira AR, Bittencourt PF, Ribeiro DF, Silva RG, Alberti LR
Arq Gastroenterol 2015 Dec;52(4):303-10. doi: 10.1590/S0004-28032015000400010. PMID: 26840472
Colonic polyps and polyposis syndromes in pediatric patients.
Kay M, Eng K, Wyllie R
Curr Opin Pediatr 2015 Oct;27(5):634-41. doi: 10.1097/MOP.0000000000000265. PMID: 26208235

Recent systematic reviews

Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

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