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Esophageal granular cell tumor

MedGen UID:
234228
•Concept ID:
C1333448
•
Neoplastic Process
Synonyms: Esophageal Granular Cell Myoblastoma; esophageal granular cell myoblastoma; Esophageal Granular Cell Neoplasm; esophageal granular cell neoplasm; Esophageal Granular Cell Tumor; esophageal granular cell tumor; esophagus granular cell tumor; Granular Cell Esophageal Tumor; granular cell esophageal tumor; granular cell esophageal tumour; Granular Cell Esophagus Myoblastoma; granular cell esophagus myoblastoma; Granular Cell Esophagus Neoplasm; granular cell esophagus neoplasm; Granular Cell Esophagus Tumor; granular cell esophagus tumor; Granular Cell Myoblastoma of Esophagus; granular cell myoblastoma of esophagus; granular cell myoblastoma of oesophagus; Granular Cell Myoblastoma of the Esophagus; granular cell myoblastoma of the esophagus; granular cell myoblastoma of the oesophagus; Granular cell neoplasm of esophagus; Granular Cell Neoplasm of Esophagus; granular cell neoplasm of esophagus; granular cell neoplasm of oesophagus; Granular Cell Neoplasm of the Esophagus; granular cell neoplasm of the esophagus; granular cell neoplasm of the oesophagus; granular cell oesophagus myoblastoma; granular cell oesophagus neoplasm; granular cell oesophagus tumour; Granular cell tumor of esophagus; Granular Cell Tumor of Esophagus; granular cell tumor of esophagus; Granular Cell Tumor of the Esophagus; granular cell tumor of the esophagus; granular cell tumour of oesophagus; granular cell tumour of the oesophagus; malignant granular cell esophageal tumor; malignant granular cell esophageal tumour; oesophagus granular cell tumour
SNOMED CT: Granular cell neoplasm of esophagus (1196862008); Granular cell tumor of esophagus (1196862008)
 
Monarch Initiative: MONDO:0003251

Definition

A tumor that usually presents with small nodules or small sessile polyps, predominantly in the distal esophagus. Histologically, it is composed of sheets of oval to polygonal cells with a small central nucleus and abundant granular cytoplasm. This is usually a benign tumor. (WHO, 2000) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal granular cell tumor

Professional guidelines

PubMed

Novel diagnosis and treatment of esophageal granular cell tumor: report of 14 cases and review of the literature.
Chen WS, Zheng XL, Jin L, Pan XJ, Ye MF
Ann Thorac Surg 2014 Jan;97(1):296-302. Epub 2013 Oct 17 doi: 10.1016/j.athoracsur.2013.08.042. PMID: 24140217

Recent clinical studies

Etiology

Esophageal granular cell tumor and eosinophils: a multicenter experience.
Reddi D, Chandler C, Cardona D, Schild M, Westerhoff M, McMullen E, Tomizawa Y, Clinton L, Swanson PE
Diagn Pathol 2021 Jun 8;16(1):49. doi: 10.1186/s13000-021-01113-3. PMID: 34103065Free PMC Article
A Statistically Significant Association Between Esophageal Granular Cell Tumors and Eosinophilic Esophagitis: A 16-year Analysis at Two Large Hospitals of 167,434 EGDs.
Nojkov B, Amin M, Ghaith G, Cappell MS
Dig Dis Sci 2017 Dec;62(12):3517-3524. Epub 2017 Oct 24 doi: 10.1007/s10620-017-4802-9. PMID: 29064014
Eosinophilic Esophagitis and Esophageal Granular Cell Tumor: An Unexpected Association.
Riffle ME, Polydorides AD, Niakan J, Chehade M
Am J Surg Pathol 2017 May;41(5):616-621. doi: 10.1097/PAS.0000000000000832. PMID: 28296675
Endoscopic submucosal dissection of esophageal granular cell tumor.
Lu W, Xu MD, Zhou PH, Zhang YQ, Chen WF, Zhong YS, Yao LQ
World J Surg Oncol 2014 Jul 17;12:221. doi: 10.1186/1477-7819-12-221. PMID: 25030028Free PMC Article
Novel diagnosis and treatment of esophageal granular cell tumor: report of 14 cases and review of the literature.
Chen WS, Zheng XL, Jin L, Pan XJ, Ye MF
Ann Thorac Surg 2014 Jan;97(1):296-302. Epub 2013 Oct 17 doi: 10.1016/j.athoracsur.2013.08.042. PMID: 24140217

Diagnosis

Esophageal Granular Cell Tumor in Children: A Clinicopathologic Study of 11 Cases and Review of the Literature.
Malik F, Bernieh A, Saad AG
Am J Clin Pathol 2023 Jul 5;160(1):106-112. doi: 10.1093/ajcp/aqad025. PMID: 37026754
Esophageal Granular Cell Tumor.
Bashir A, Suchi M, Martinez AM, Lerner D
J Pediatr Gastroenterol Nutr 2021 Dec 1;73(6):e126. doi: 10.1097/MPG.0000000000003274. PMID: 34347679
Eosinophilic Esophagitis and Esophageal Granular Cell Tumor: An Unexpected Association.
Riffle ME, Polydorides AD, Niakan J, Chehade M
Am J Surg Pathol 2017 May;41(5):616-621. doi: 10.1097/PAS.0000000000000832. PMID: 28296675
Endoscopic submucosal dissection of esophageal granular cell tumor.
Lu W, Xu MD, Zhou PH, Zhang YQ, Chen WF, Zhong YS, Yao LQ
World J Surg Oncol 2014 Jul 17;12:221. doi: 10.1186/1477-7819-12-221. PMID: 25030028Free PMC Article
Novel diagnosis and treatment of esophageal granular cell tumor: report of 14 cases and review of the literature.
Chen WS, Zheng XL, Jin L, Pan XJ, Ye MF
Ann Thorac Surg 2014 Jan;97(1):296-302. Epub 2013 Oct 17 doi: 10.1016/j.athoracsur.2013.08.042. PMID: 24140217

Therapy

Eosinophilic Esophagitis and Esophageal Granular Cell Tumor: An Unexpected Association.
Riffle ME, Polydorides AD, Niakan J, Chehade M
Am J Surg Pathol 2017 May;41(5):616-621. doi: 10.1097/PAS.0000000000000832. PMID: 28296675

Prognosis

Endoscopic submucosal dissection of esophageal granular cell tumor.
Lu W, Xu MD, Zhou PH, Zhang YQ, Chen WF, Zhong YS, Yao LQ
World J Surg Oncol 2014 Jul 17;12:221. doi: 10.1186/1477-7819-12-221. PMID: 25030028Free PMC Article
Novel diagnosis and treatment of esophageal granular cell tumor: report of 14 cases and review of the literature.
Chen WS, Zheng XL, Jin L, Pan XJ, Ye MF
Ann Thorac Surg 2014 Jan;97(1):296-302. Epub 2013 Oct 17 doi: 10.1016/j.athoracsur.2013.08.042. PMID: 24140217
Coexistence of esophageal granular cell tumor and squamous cell carcinoma: a case report.
Szumilo J, Dabrowski A, Skomra D, Chibowski D
Dis Esophagus 2002;15(1):88-92. doi: 10.1046/j.1442-2050.2002.00232.x. PMID: 12060050
Yttrium-aluminum-garnet laser therapy of esophageal granular cell tumor.
Norberto L, Urso E, Angriman I, Ranzato R, Erroi F, Marino S, Tosato S, Ruffolo C, D'Amico DF
Surg Endosc 2002 Feb;16(2):361-2. Epub 2001 Nov 16 doi: 10.1007/s00464-001-4211-0. PMID: 11967708

Clinical prediction guides

Endoscopic submucosal dissection of esophageal granular cell tumor.
Lu W, Xu MD, Zhou PH, Zhang YQ, Chen WF, Zhong YS, Yao LQ
World J Surg Oncol 2014 Jul 17;12:221. doi: 10.1186/1477-7819-12-221. PMID: 25030028Free PMC Article
Yttrium-aluminum-garnet laser therapy of esophageal granular cell tumor.
Norberto L, Urso E, Angriman I, Ranzato R, Erroi F, Marino S, Tosato S, Ruffolo C, D'Amico DF
Surg Endosc 2002 Feb;16(2):361-2. Epub 2001 Nov 16 doi: 10.1007/s00464-001-4211-0. PMID: 11967708
Minute esophageal granular cell tumor: a case report with immunohistochemical and ultrastructural examination.
Yoshimi N, Tanaka T, Feng QC, Ishizaki N, Kan S, Mori H
Jpn J Clin Oncol 1988 Sep;18(3):275-81. PMID: 2842524

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